Amino acid dipepetide frequency for Roseateles depolymerans

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	17.889AlaAla: 17.889 ± 0.184	1.161AlaCys: 1.161 ± 0.025	6.558AlaAsp: 6.558 ± 0.069	6.23AlaGlu: 6.23 ± 0.072	3.625AlaPhe: 3.625 ± 0.056	10.515AlaGly: 10.515 ± 0.112	2.61AlaHis: 2.61 ± 0.043	4.158AlaIle: 4.158 ± 0.048	3.432AlaLys: 3.432 ± 0.073	15.659AlaLeu: 15.659 ± 0.161	3.372AlaMet: 3.372 ± 0.043	2.597AlaAsn: 2.597 ± 0.044	6.874AlaPro: 6.874 ± 0.101	6.554AlaGln: 6.554 ± 0.093	8.899AlaArg: 8.899 ± 0.099	7.788AlaSer: 7.788 ± 0.094	6.298AlaThr: 6.298 ± 0.078	8.934AlaVal: 8.934 ± 0.081	2.027AlaTrp: 2.027 ± 0.038	2.247AlaTyr: 2.247 ± 0.041	0.0AlaXaa: 0.0 ± 0.0
Cys	0.994CysAla: 0.994 ± 0.024	0.095CysCys: 0.095 ± 0.008	0.468CysAsp: 0.468 ± 0.018	0.498CysGlu: 0.498 ± 0.018	0.268CysPhe: 0.268 ± 0.014	0.886CysGly: 0.886 ± 0.025	0.224CysHis: 0.224 ± 0.011	0.308CysIle: 0.308 ± 0.014	0.2CysLys: 0.2 ± 0.012	0.848CysLeu: 0.848 ± 0.028	0.176CysMet: 0.176 ± 0.01	0.202CysAsn: 0.202 ± 0.012	0.442CysPro: 0.442 ± 0.018	0.295CysGln: 0.295 ± 0.013	0.571CysArg: 0.571 ± 0.021	0.477CysSer: 0.477 ± 0.017	0.417CysThr: 0.417 ± 0.016	0.612CysVal: 0.612 ± 0.018	0.129CysTrp: 0.129 ± 0.009	0.172CysTyr: 0.172 ± 0.01	0.0CysXaa: 0.0 ± 0.0
Asp	7.191AspAla: 7.191 ± 0.079	0.436AspCys: 0.436 ± 0.015	2.864AspAsp: 2.864 ± 0.047	3.146AspGlu: 3.146 ± 0.051	1.889AspPhe: 1.889 ± 0.037	4.94AspGly: 4.94 ± 0.065	1.202AspHis: 1.202 ± 0.031	2.122AspIle: 2.122 ± 0.042	1.593AspLys: 1.593 ± 0.038	5.967AspLeu: 5.967 ± 0.071	1.101AspMet: 1.101 ± 0.023	1.217AspAsn: 1.217 ± 0.033	3.208AspPro: 3.208 ± 0.048	2.166AspGln: 2.166 ± 0.052	3.812AspArg: 3.812 ± 0.057	2.419AspSer: 2.419 ± 0.041	2.653AspThr: 2.653 ± 0.04	3.888AspVal: 3.888 ± 0.049	1.108AspTrp: 1.108 ± 0.025	1.339AspTyr: 1.339 ± 0.031	0.0AspXaa: 0.0 ± 0.0
Glu	7.051GluAla: 7.051 ± 0.079	0.348GluCys: 0.348 ± 0.015	2.498GluAsp: 2.498 ± 0.043	2.6GluGlu: 2.6 ± 0.052	1.544GluPhe: 1.544 ± 0.033	3.777GluGly: 3.777 ± 0.054	1.239GluHis: 1.239 ± 0.028	2.201GluIle: 2.201 ± 0.04	1.399GluLys: 1.399 ± 0.035	5.877GluLeu: 5.877 ± 0.068	1.11GluMet: 1.11 ± 0.029	1.024GluAsn: 1.024 ± 0.026	2.498GluPro: 2.498 ± 0.042	2.792GluGln: 2.792 ± 0.049	4.6GluArg: 4.6 ± 0.075	2.499GluSer: 2.499 ± 0.043	2.374GluThr: 2.374 ± 0.04	4.0GluVal: 4.0 ± 0.049	0.746GluTrp: 0.746 ± 0.021	0.837GluTyr: 0.837 ± 0.025	0.0GluXaa: 0.0 ± 0.0
Phe	3.544PheAla: 3.544 ± 0.048	0.337PheCys: 0.337 ± 0.015	2.29PheAsp: 2.29 ± 0.042	1.911PheGlu: 1.911 ± 0.037	1.168PhePhe: 1.168 ± 0.031	2.903PheGly: 2.903 ± 0.051	0.666PheHis: 0.666 ± 0.023	1.282PheIle: 1.282 ± 0.033	1.08PheLys: 1.08 ± 0.025	2.739PheLeu: 2.739 ± 0.045	0.698PheMet: 0.698 ± 0.021	1.08PheAsn: 1.08 ± 0.026	1.402PhePro: 1.402 ± 0.031	1.19PheGln: 1.19 ± 0.028	1.786PheArg: 1.786 ± 0.032	2.09PheSer: 2.09 ± 0.035	1.736PheThr: 1.736 ± 0.036	2.31PheVal: 2.31 ± 0.044	0.484PheTrp: 0.484 ± 0.018	0.759PheTyr: 0.759 ± 0.023	0.0PheXaa: 0.0 ± 0.0
Gly	9.269GlyAla: 9.269 ± 0.109	0.785GlyCys: 0.785 ± 0.025	4.26GlyAsp: 4.26 ± 0.057	4.252GlyGlu: 4.252 ± 0.053	2.957GlyPhe: 2.957 ± 0.043	7.036GlyGly: 7.036 ± 0.11	2.038GlyHis: 2.038 ± 0.045	3.129GlyIle: 3.129 ± 0.051	2.754GlyLys: 2.754 ± 0.053	9.529GlyLeu: 9.529 ± 0.09	2.116GlyMet: 2.116 ± 0.037	2.033GlyAsn: 2.033 ± 0.051	3.635GlyPro: 3.635 ± 0.055	3.956GlyGln: 3.956 ± 0.059	5.885GlyArg: 5.885 ± 0.069	4.932GlySer: 4.932 ± 0.085	4.582GlyThr: 4.582 ± 0.097	6.159GlyVal: 6.159 ± 0.071	1.526GlyTrp: 1.526 ± 0.032	2.014GlyTyr: 2.014 ± 0.04	0.0GlyXaa: 0.0 ± 0.0
His	2.781HisAla: 2.781 ± 0.039	0.259HisCys: 0.259 ± 0.013	1.183HisAsp: 1.183 ± 0.03	1.183HisGlu: 1.183 ± 0.029	0.798HisPhe: 0.798 ± 0.025	2.035HisGly: 2.035 ± 0.047	0.665HisHis: 0.665 ± 0.022	0.726HisIle: 0.726 ± 0.021	0.463HisLys: 0.463 ± 0.016	2.491HisLeu: 2.491 ± 0.048	0.455HisMet: 0.455 ± 0.016	0.439HisAsn: 0.439 ± 0.015	1.579HisPro: 1.579 ± 0.038	0.951HisGln: 0.951 ± 0.027	1.656HisArg: 1.656 ± 0.034	1.06HisSer: 1.06 ± 0.028	0.986HisThr: 0.986 ± 0.024	1.471HisVal: 1.471 ± 0.032	0.462HisTrp: 0.462 ± 0.016	0.619HisTyr: 0.619 ± 0.02	0.0HisXaa: 0.0 ± 0.0
Ile	4.823IleAla: 4.823 ± 0.065	0.34IleCys: 0.34 ± 0.013	2.56IleAsp: 2.56 ± 0.039	2.537IleGlu: 2.537 ± 0.04	1.002IlePhe: 1.002 ± 0.025	3.538IleGly: 3.538 ± 0.057	0.789IleHis: 0.789 ± 0.022	1.278IleIle: 1.278 ± 0.037	1.293IleLys: 1.293 ± 0.033	2.819IleLeu: 2.819 ± 0.045	0.594IleMet: 0.594 ± 0.02	1.27IleAsn: 1.27 ± 0.034	1.756IlePro: 1.756 ± 0.032	1.451IleGln: 1.451 ± 0.032	2.438IleArg: 2.438 ± 0.04	2.26IleSer: 2.26 ± 0.041	2.26IleThr: 2.26 ± 0.044	2.772IleVal: 2.772 ± 0.056	0.411IleTrp: 0.411 ± 0.015	0.772IleTyr: 0.772 ± 0.022	0.0IleXaa: 0.0 ± 0.0
Lys	3.862LysAla: 3.862 ± 0.071	0.127LysCys: 0.127 ± 0.011	1.704LysAsp: 1.704 ± 0.04	1.351LysGlu: 1.351 ± 0.038	0.755LysPhe: 0.755 ± 0.025	2.205LysGly: 2.205 ± 0.047	0.539LysHis: 0.539 ± 0.018	1.107LysIle: 1.107 ± 0.028	1.078LysLys: 1.078 ± 0.042	3.025LysLeu: 3.025 ± 0.051	0.617LysMet: 0.617 ± 0.021	0.752LysAsn: 0.752 ± 0.024	1.937LysPro: 1.937 ± 0.038	1.186LysGln: 1.186 ± 0.031	2.058LysArg: 2.058 ± 0.039	1.602LysSer: 1.602 ± 0.037	1.741LysThr: 1.741 ± 0.033	2.256LysVal: 2.256 ± 0.046	0.292LysTrp: 0.292 ± 0.015	0.524LysTyr: 0.524 ± 0.017	0.0LysXaa: 0.0 ± 0.0
Leu	14.524LeuAla: 14.524 ± 0.125	0.981LeuCys: 0.981 ± 0.026	6.283LeuAsp: 6.283 ± 0.07	5.168LeuGlu: 5.168 ± 0.066	3.159LeuPhe: 3.159 ± 0.053	8.704LeuGly: 8.704 ± 0.085	2.429LeuHis: 2.429 ± 0.045	4.094LeuIle: 4.094 ± 0.054	3.554LeuLys: 3.554 ± 0.054	12.121LeuLeu: 12.121 ± 0.15	2.949LeuMet: 2.949 ± 0.055	2.848LeuAsn: 2.848 ± 0.048	6.669LeuPro: 6.669 ± 0.08	5.011LeuGln: 5.011 ± 0.055	8.507LeuArg: 8.507 ± 0.088	7.448LeuSer: 7.448 ± 0.089	6.103LeuThr: 6.103 ± 0.112	7.938LeuVal: 7.938 ± 0.086	1.438LeuTrp: 1.438 ± 0.038	1.927LeuTyr: 1.927 ± 0.042	0.0LeuXaa: 0.0 ± 0.0
Met	3.036MetAla: 3.036 ± 0.041	0.143MetCys: 0.143 ± 0.009	1.289MetAsp: 1.289 ± 0.031	1.065MetGlu: 1.065 ± 0.027	0.616MetPhe: 0.616 ± 0.02	1.805MetGly: 1.805 ± 0.037	0.477MetHis: 0.477 ± 0.017	0.832MetIle: 0.832 ± 0.024	0.9MetLys: 0.9 ± 0.024	2.571MetLeu: 2.571 ± 0.042	0.586MetMet: 0.586 ± 0.02	0.804MetAsn: 0.804 ± 0.022	1.505MetPro: 1.505 ± 0.031	1.096MetGln: 1.096 ± 0.026	1.713MetArg: 1.713 ± 0.036	1.789MetSer: 1.789 ± 0.032	1.597MetThr: 1.597 ± 0.031	1.598MetVal: 1.598 ± 0.035	0.21MetTrp: 0.21 ± 0.011	0.314MetTyr: 0.314 ± 0.015	0.0MetXaa: 0.0 ± 0.0
Asn	3.148AsnAla: 3.148 ± 0.057	0.204AsnCys: 0.204 ± 0.012	1.298AsnAsp: 1.298 ± 0.029	1.226AsnGlu: 1.226 ± 0.026	0.81AsnPhe: 0.81 ± 0.026	2.327AsnGly: 2.327 ± 0.054	0.463AsnHis: 0.463 ± 0.017	1.011AsnIle: 1.011 ± 0.029	0.724AsnLys: 0.724 ± 0.023	2.373AsnLeu: 2.373 ± 0.037	0.484AsnMet: 0.484 ± 0.017	0.752AsnAsn: 0.752 ± 0.025	1.611AsnPro: 1.611 ± 0.033	0.923AsnGln: 0.923 ± 0.029	1.64AsnArg: 1.64 ± 0.035	1.229AsnSer: 1.229 ± 0.033	1.391AsnThr: 1.391 ± 0.037	1.66AsnVal: 1.66 ± 0.03	0.39AsnTrp: 0.39 ± 0.015	0.62AsnTyr: 0.62 ± 0.023	0.0AsnXaa: 0.0 ± 0.0
Pro	7.611ProAla: 7.611 ± 0.105	0.339ProCys: 0.339 ± 0.016	3.527ProAsp: 3.527 ± 0.055	3.218ProGlu: 3.218 ± 0.053	1.621ProPhe: 1.621 ± 0.035	4.835ProGly: 4.835 ± 0.064	1.176ProHis: 1.176 ± 0.033	1.692ProIle: 1.692 ± 0.032	1.486ProLys: 1.486 ± 0.036	5.777ProLeu: 5.777 ± 0.07	1.432ProMet: 1.432 ± 0.031	1.167ProAsn: 1.167 ± 0.029	3.237ProPro: 3.237 ± 0.072	2.493ProGln: 2.493 ± 0.037	3.323ProArg: 3.323 ± 0.056	3.601ProSer: 3.601 ± 0.064	3.073ProThr: 3.073 ± 0.05	4.546ProVal: 4.546 ± 0.064	0.91ProTrp: 0.91 ± 0.025	1.012ProTyr: 1.012 ± 0.026	0.0ProXaa: 0.0 ± 0.0
Gln	6.785GlnAla: 6.785 ± 0.089	0.287GlnCys: 0.287 ± 0.014	2.116GlnAsp: 2.116 ± 0.045	1.873GlnGlu: 1.873 ± 0.037	1.25GlnPhe: 1.25 ± 0.028	3.669GlnGly: 3.669 ± 0.052	1.067GlnHis: 1.067 ± 0.027	1.721GlnIle: 1.721 ± 0.068	0.987GlnLys: 0.987 ± 0.027	5.082GlnLeu: 5.082 ± 0.07	1.062GlnMet: 1.062 ± 0.025	0.789GlnAsn: 0.789 ± 0.022	2.677GlnPro: 2.677 ± 0.041	2.504GlnGln: 2.504 ± 0.053	4.133GlnArg: 4.133 ± 0.064	2.307GlnSer: 2.307 ± 0.044	2.243GlnThr: 2.243 ± 0.042	3.678GlnVal: 3.678 ± 0.092	0.846GlnTrp: 0.846 ± 0.024	0.764GlnTyr: 0.764 ± 0.023	0.0GlnXaa: 0.0 ± 0.0
Arg	7.84ArgAla: 7.84 ± 0.081	0.624ArgCys: 0.624 ± 0.021	3.833ArgAsp: 3.833 ± 0.051	4.203ArgGlu: 4.203 ± 0.072	2.822ArgPhe: 2.822 ± 0.053	4.644ArgGly: 4.644 ± 0.063	2.03ArgHis: 2.03 ± 0.038	3.166ArgIle: 3.166 ± 0.043	1.841ArgLys: 1.841 ± 0.034	8.841ArgLeu: 8.841 ± 0.096	2.015ArgMet: 2.015 ± 0.036	1.654ArgAsn: 1.654 ± 0.035	3.817ArgPro: 3.817 ± 0.053	3.636ArgGln: 3.636 ± 0.051	5.808ArgArg: 5.808 ± 0.09	4.017ArgSer: 4.017 ± 0.052	3.211ArgThr: 3.211 ± 0.052	5.127ArgVal: 5.127 ± 0.065	1.429ArgTrp: 1.429 ± 0.033	1.78ArgTyr: 1.78 ± 0.029	0.0ArgXaa: 0.0 ± 0.0
Ser	7.54SerAla: 7.54 ± 0.098	0.452SerCys: 0.452 ± 0.019	2.993SerAsp: 2.993 ± 0.055	2.578SerGlu: 2.578 ± 0.039	2.052SerPhe: 2.052 ± 0.042	5.746SerGly: 5.746 ± 0.092	1.226SerHis: 1.226 ± 0.024	2.182SerIle: 2.182 ± 0.037	1.526SerLys: 1.526 ± 0.038	6.678SerLeu: 6.678 ± 0.08	1.338SerMet: 1.338 ± 0.031	1.446SerAsn: 1.446 ± 0.036	3.495SerPro: 3.495 ± 0.063	2.384SerGln: 2.384 ± 0.043	3.959SerArg: 3.959 ± 0.051	3.929SerSer: 3.929 ± 0.074	3.416SerThr: 3.416 ± 0.087	4.135SerVal: 4.135 ± 0.063	0.831SerTrp: 0.831 ± 0.028	1.186SerTyr: 1.186 ± 0.034	0.0SerXaa: 0.0 ± 0.0
Thr	6.552ThrAla: 6.552 ± 0.102	0.358ThrCys: 0.358 ± 0.015	2.724ThrAsp: 2.724 ± 0.059	2.417ThrGlu: 2.417 ± 0.043	1.488ThrPhe: 1.488 ± 0.03	4.894ThrGly: 4.894 ± 0.083	1.15ThrHis: 1.15 ± 0.029	1.754ThrIle: 1.754 ± 0.045	1.167ThrLys: 1.167 ± 0.028	6.608ThrLeu: 6.608 ± 0.073	1.021ThrMet: 1.021 ± 0.027	1.224ThrAsn: 1.224 ± 0.039	3.884ThrPro: 3.884 ± 0.059	2.223ThrGln: 2.223 ± 0.042	3.431ThrArg: 3.431 ± 0.058	3.086ThrSer: 3.086 ± 0.072	3.084ThrThr: 3.084 ± 0.099	4.42ThrVal: 4.42 ± 0.063	0.743ThrTrp: 0.743 ± 0.024	0.979ThrTyr: 0.979 ± 0.028	0.0ThrXaa: 0.0 ± 0.0
Val	9.097ValAla: 9.097 ± 0.09	0.636ValCys: 0.636 ± 0.021	4.035ValAsp: 4.035 ± 0.051	3.922ValGlu: 3.922 ± 0.053	2.332ValPhe: 2.332 ± 0.042	5.552ValGly: 5.552 ± 0.064	1.518ValHis: 1.518 ± 0.032	2.95ValIle: 2.95 ± 0.051	2.242ValLys: 2.242 ± 0.048	8.504ValLeu: 8.504 ± 0.087	1.968ValMet: 1.968 ± 0.037	2.003ValAsn: 2.003 ± 0.04	4.015ValPro: 4.015 ± 0.054	3.261ValGln: 3.261 ± 0.045	4.983ValArg: 4.983 ± 0.057	4.525ValSer: 4.525 ± 0.062	4.082ValThr: 4.082 ± 0.057	6.116ValVal: 6.116 ± 0.071	1.042ValTrp: 1.042 ± 0.028	1.467ValTyr: 1.467 ± 0.029	0.0ValXaa: 0.0 ± 0.0
Trp	1.534TrpAla: 1.534 ± 0.034	0.166TrpCys: 0.166 ± 0.01	0.678TrpAsp: 0.678 ± 0.021	0.576TrpGlu: 0.576 ± 0.019	0.521TrpPhe: 0.521 ± 0.021	1.02TrpGly: 1.02 ± 0.028	0.376TrpHis: 0.376 ± 0.016	0.605TrpIle: 0.605 ± 0.018	0.431TrpLys: 0.431 ± 0.018	2.177TrpLeu: 2.177 ± 0.045	0.49TrpMet: 0.49 ± 0.017	0.404TrpAsn: 0.404 ± 0.015	0.826TrpPro: 0.826 ± 0.022	0.864TrpGln: 0.864 ± 0.026	1.455TrpArg: 1.455 ± 0.034	0.918TrpSer: 0.918 ± 0.023	0.889TrpThr: 0.889 ± 0.027	1.169TrpVal: 1.169 ± 0.031	0.362TrpTrp: 0.362 ± 0.017	0.276TrpTyr: 0.276 ± 0.013	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.356TyrAla: 2.356 ± 0.045	0.205TyrCys: 0.205 ± 0.01	1.099TyrAsp: 1.099 ± 0.034	1.059TyrGlu: 1.059 ± 0.027	0.778TyrPhe: 0.778 ± 0.024	1.817TyrGly: 1.817 ± 0.037	0.377TyrHis: 0.377 ± 0.013	0.649TyrIle: 0.649 ± 0.022	0.572TyrLys: 0.572 ± 0.02	2.169TyrLeu: 2.169 ± 0.041	0.359TyrMet: 0.359 ± 0.015	0.579TyrAsn: 0.579 ± 0.021	1.006TyrPro: 1.006 ± 0.025	0.903TyrGln: 0.903 ± 0.026	1.68TyrArg: 1.68 ± 0.034	1.115TyrSer: 1.115 ± 0.027	1.072TyrThr: 1.072 ± 0.027	1.463TyrVal: 1.463 ± 0.031	0.352TyrTrp: 0.352 ± 0.015	0.539TyrTyr: 0.539 ± 0.021	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4768 proteins (1655302 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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