Amino acid dipepetide frequency for Streptococcus satellite phage Javan604

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
0.0AlaAla: 0.0 ± 0.0
0.503AlaCys: 0.503 ± 0.414
4.02AlaAsp: 4.02 ± 1.453
2.513AlaGlu: 2.513 ± 0.927
2.513AlaPhe: 2.513 ± 1.196
4.02AlaGly: 4.02 ± 0.878
0.0AlaHis: 0.0 ± 0.0
3.518AlaIle: 3.518 ± 1.135
4.523AlaLys: 4.523 ± 1.517
4.523AlaLeu: 4.523 ± 1.861
1.508AlaMet: 1.508 ± 1.287
6.03AlaAsn: 6.03 ± 2.261
1.005AlaPro: 1.005 ± 0.556
3.518AlaGln: 3.518 ± 1.537
3.015AlaArg: 3.015 ± 0.651
2.513AlaSer: 2.513 ± 0.845
3.518AlaThr: 3.518 ± 1.185
2.01AlaVal: 2.01 ± 0.591
0.503AlaTrp: 0.503 ± 0.443
3.015AlaTyr: 3.015 ± 0.935
0.0AlaXaa: 0.0 ± 0.0
Cys
0.0CysAla: 0.0 ± 0.0
0.0CysCys: 0.0 ± 0.0
1.005CysAsp: 1.005 ± 0.995
0.0CysGlu: 0.0 ± 0.0
0.503CysPhe: 0.503 ± 0.546
0.503CysGly: 0.503 ± 0.414
0.0CysHis: 0.0 ± 0.0
0.503CysIle: 0.503 ± 0.557
0.503CysLys: 0.503 ± 0.414
0.0CysLeu: 0.0 ± 0.0
0.0CysMet: 0.0 ± 0.0
0.503CysAsn: 0.503 ± 0.414
0.0CysPro: 0.0 ± 0.0
0.0CysGln: 0.0 ± 0.0
0.503CysArg: 0.503 ± 0.443
0.503CysSer: 0.503 ± 0.619
0.0CysThr: 0.0 ± 0.0
0.503CysVal: 0.503 ± 0.557
0.0CysTrp: 0.0 ± 0.0
0.503CysTyr: 0.503 ± 0.502
0.0CysXaa: 0.0 ± 0.0
Asp
0.0AspAla: 0.0 ± 0.0
0.503AspCys: 0.503 ± 0.502
2.01AspAsp: 2.01 ± 0.967
6.533AspGlu: 6.533 ± 2.079
3.518AspPhe: 3.518 ± 0.929
2.513AspGly: 2.513 ± 0.984
1.005AspHis: 1.005 ± 0.799
7.035AspIle: 7.035 ± 2.219
6.533AspLys: 6.533 ± 1.603
4.523AspLeu: 4.523 ± 1.731
2.513AspMet: 2.513 ± 0.99
6.533AspAsn: 6.533 ± 2.016
1.508AspPro: 1.508 ± 1.033
0.0AspGln: 0.0 ± 0.0
1.508AspArg: 1.508 ± 0.741
4.02AspSer: 4.02 ± 1.422
2.513AspThr: 2.513 ± 1.09
3.015AspVal: 3.015 ± 0.778
1.005AspTrp: 1.005 ± 0.828
4.523AspTyr: 4.523 ± 2.101
0.0AspXaa: 0.0 ± 0.0
Glu
6.533GluAla: 6.533 ± 1.526
0.503GluCys: 0.503 ± 0.622
3.015GluAsp: 3.015 ± 1.617
4.523GluGlu: 4.523 ± 1.264
3.518GluPhe: 3.518 ± 1.271
3.518GluGly: 3.518 ± 1.03
1.005GluHis: 1.005 ± 0.615
4.02GluIle: 4.02 ± 1.087
5.528GluLys: 5.528 ± 1.605
12.563GluLeu: 12.563 ± 1.342
1.508GluMet: 1.508 ± 0.809
3.015GluAsn: 3.015 ± 0.93
3.015GluPro: 3.015 ± 1.234
3.015GluGln: 3.015 ± 1.704
3.518GluArg: 3.518 ± 1.287
4.02GluSer: 4.02 ± 1.309
6.03GluThr: 6.03 ± 2.264
1.508GluVal: 1.508 ± 0.963
0.0GluTrp: 0.0 ± 0.0
3.015GluTyr: 3.015 ± 1.179
0.0GluXaa: 0.0 ± 0.0
Phe
0.503PheAla: 0.503 ± 0.414
0.0PheCys: 0.0 ± 0.0
4.02PheAsp: 4.02 ± 1.002
4.523PheGlu: 4.523 ± 1.851
0.0PhePhe: 0.0 ± 0.0
3.015PheGly: 3.015 ± 1.129
0.503PheHis: 0.503 ± 0.443
3.518PheIle: 3.518 ± 1.473
4.02PheLys: 4.02 ± 1.341
4.523PheLeu: 4.523 ± 0.985
0.503PheMet: 0.503 ± 0.524
4.523PheAsn: 4.523 ± 2.256
0.503PhePro: 0.503 ± 0.557
0.503PheGln: 0.503 ± 0.414
1.508PheArg: 1.508 ± 0.786
2.513PheSer: 2.513 ± 0.942
1.508PheThr: 1.508 ± 0.869
1.005PheVal: 1.005 ± 0.712
0.503PheTrp: 0.503 ± 0.414
1.508PheTyr: 1.508 ± 0.693
0.0PheXaa: 0.0 ± 0.0
Gly
1.508GlyAla: 1.508 ± 0.693
1.005GlyCys: 1.005 ± 0.727
4.02GlyAsp: 4.02 ± 1.954
3.518GlyGlu: 3.518 ± 1.0
4.02GlyPhe: 4.02 ± 1.224
1.005GlyGly: 1.005 ± 0.556
0.503GlyHis: 0.503 ± 0.443
3.518GlyIle: 3.518 ± 1.007
3.518GlyLys: 3.518 ± 1.438
6.03GlyLeu: 6.03 ± 2.631
0.503GlyMet: 0.503 ± 0.557
4.523GlyAsn: 4.523 ± 2.21
0.0GlyPro: 0.0 ± 0.0
1.005GlyGln: 1.005 ± 0.628
2.01GlyArg: 2.01 ± 0.902
1.005GlySer: 1.005 ± 0.886
3.015GlyThr: 3.015 ± 1.511
5.528GlyVal: 5.528 ± 1.808
1.005GlyTrp: 1.005 ± 0.828
4.523GlyTyr: 4.523 ± 1.93
0.0GlyXaa: 0.0 ± 0.0
His
2.513HisAla: 2.513 ± 1.125
0.0HisCys: 0.0 ± 0.0
0.0HisAsp: 0.0 ± 0.0
2.01HisGlu: 2.01 ± 0.905
1.508HisPhe: 1.508 ± 0.846
1.508HisGly: 1.508 ± 1.052
0.0HisHis: 0.0 ± 0.0
0.503HisIle: 0.503 ± 0.443
0.503HisLys: 0.503 ± 0.443
1.005HisLeu: 1.005 ± 0.585
0.0HisMet: 0.0 ± 0.0
0.503HisAsn: 0.503 ± 0.546
0.503HisPro: 0.503 ± 0.681
1.005HisGln: 1.005 ± 0.931
0.503HisArg: 0.503 ± 0.443
0.503HisSer: 0.503 ± 0.443
2.01HisThr: 2.01 ± 1.151
1.005HisVal: 1.005 ± 0.686
0.0HisTrp: 0.0 ± 0.0
1.508HisTyr: 1.508 ± 0.633
0.0HisXaa: 0.0 ± 0.0
Ile
4.523IleAla: 4.523 ± 1.987
0.503IleCys: 0.503 ± 0.546
5.528IleAsp: 5.528 ± 1.802
2.513IleGlu: 2.513 ± 0.937
2.01IlePhe: 2.01 ± 0.835
2.513IleGly: 2.513 ± 0.804
1.508IleHis: 1.508 ± 1.029
2.01IleIle: 2.01 ± 0.968
5.025IleLys: 5.025 ± 1.412
4.02IleLeu: 4.02 ± 1.161
1.508IleMet: 1.508 ± 0.647
3.518IleAsn: 3.518 ± 1.028
3.015IlePro: 3.015 ± 1.599
1.508IleGln: 1.508 ± 0.8
1.005IleArg: 1.005 ± 0.556
2.01IleSer: 2.01 ± 0.774
5.025IleThr: 5.025 ± 1.009
3.518IleVal: 3.518 ± 1.355
1.005IleTrp: 1.005 ± 1.092
5.025IleTyr: 5.025 ± 1.166
0.0IleXaa: 0.0 ± 0.0
Lys
6.533LysAla: 6.533 ± 1.703
0.503LysCys: 0.503 ± 0.557
4.523LysAsp: 4.523 ± 1.308
8.543LysGlu: 8.543 ± 2.027
4.02LysPhe: 4.02 ± 1.273
6.03LysGly: 6.03 ± 1.468
3.518LysHis: 3.518 ± 1.531
4.523LysIle: 4.523 ± 1.281
11.055LysLys: 11.055 ± 3.598
10.05LysLeu: 10.05 ± 2.679
2.01LysMet: 2.01 ± 0.834
6.03LysAsn: 6.03 ± 1.493
4.02LysPro: 4.02 ± 1.905
5.025LysGln: 5.025 ± 1.283
7.035LysArg: 7.035 ± 1.869
4.02LysSer: 4.02 ± 1.325
4.02LysThr: 4.02 ± 0.946
5.025LysVal: 5.025 ± 1.839
0.503LysTrp: 0.503 ± 0.485
2.01LysTyr: 2.01 ± 0.628
0.0LysXaa: 0.0 ± 0.0
Leu
6.533LeuAla: 6.533 ± 2.136
0.503LeuCys: 0.503 ± 0.414
8.543LeuAsp: 8.543 ± 1.394
9.045LeuGlu: 9.045 ± 2.691
2.01LeuPhe: 2.01 ± 0.882
7.538LeuGly: 7.538 ± 2.562
2.513LeuHis: 2.513 ± 1.641
4.523LeuIle: 4.523 ± 0.866
10.553LeuLys: 10.553 ± 3.19
9.045LeuLeu: 9.045 ± 1.796
2.01LeuMet: 2.01 ± 0.953
4.02LeuAsn: 4.02 ± 1.951
4.02LeuPro: 4.02 ± 1.379
4.523LeuGln: 4.523 ± 1.494
3.015LeuArg: 3.015 ± 1.517
6.03LeuSer: 6.03 ± 1.153
4.523LeuThr: 4.523 ± 1.708
4.523LeuVal: 4.523 ± 1.807
0.503LeuTrp: 0.503 ± 0.414
3.015LeuTyr: 3.015 ± 1.257
0.0LeuXaa: 0.0 ± 0.0
Met
0.503MetAla: 0.503 ± 0.485
0.0MetCys: 0.0 ± 0.0
2.01MetAsp: 2.01 ± 1.183
1.005MetGlu: 1.005 ± 0.828
0.0MetPhe: 0.0 ± 0.0
0.503MetGly: 0.503 ± 0.414
0.0MetHis: 0.0 ± 0.0
1.005MetIle: 1.005 ± 0.615
2.513MetLys: 2.513 ± 1.491
2.01MetLeu: 2.01 ± 1.293
1.005MetMet: 1.005 ± 0.497
2.513MetAsn: 2.513 ± 1.068
0.503MetPro: 0.503 ± 0.557
0.503MetGln: 0.503 ± 0.652
0.503MetArg: 0.503 ± 0.557
1.508MetSer: 1.508 ± 1.093
3.015MetThr: 3.015 ± 1.028
3.015MetVal: 3.015 ± 1.329
0.503MetTrp: 0.503 ± 0.502
1.005MetTyr: 1.005 ± 0.62
0.0MetXaa: 0.0 ± 0.0
Asn
5.025AsnAla: 5.025 ± 1.583
0.0AsnCys: 0.0 ± 0.0
3.518AsnAsp: 3.518 ± 1.24
4.02AsnGlu: 4.02 ± 1.254
0.503AsnPhe: 0.503 ± 0.622
6.03AsnGly: 6.03 ± 1.907
0.503AsnHis: 0.503 ± 0.443
2.513AsnIle: 2.513 ± 1.265
7.538AsnLys: 7.538 ± 1.607
5.025AsnLeu: 5.025 ± 1.826
1.508AsnMet: 1.508 ± 1.305
5.528AsnAsn: 5.528 ± 1.814
3.518AsnPro: 3.518 ± 1.316
0.503AsnGln: 0.503 ± 0.414
2.513AsnArg: 2.513 ± 1.071
7.035AsnSer: 7.035 ± 2.678
5.528AsnThr: 5.528 ± 1.585
3.518AsnVal: 3.518 ± 0.914
0.0AsnTrp: 0.0 ± 0.0
4.523AsnTyr: 4.523 ± 1.235
0.0AsnXaa: 0.0 ± 0.0
Pro
2.01ProAla: 2.01 ± 0.885
0.0ProCys: 0.0 ± 0.0
1.005ProAsp: 1.005 ± 0.716
1.005ProGlu: 1.005 ± 0.78
3.015ProPhe: 3.015 ± 1.244
0.0ProGly: 0.0 ± 0.0
0.503ProHis: 0.503 ± 0.557
1.005ProIle: 1.005 ± 0.556
3.518ProLys: 3.518 ± 1.777
2.513ProLeu: 2.513 ± 0.79
0.0ProMet: 0.0 ± 0.0
5.025ProAsn: 5.025 ± 2.993
2.513ProPro: 2.513 ± 1.362
0.503ProGln: 0.503 ± 0.502
3.015ProArg: 3.015 ± 1.612
1.508ProSer: 1.508 ± 1.033
1.508ProThr: 1.508 ± 0.786
3.015ProVal: 3.015 ± 1.581
0.503ProTrp: 0.503 ± 0.414
1.005ProTyr: 1.005 ± 0.585
0.0ProXaa: 0.0 ± 0.0
Gln
2.01GlnAla: 2.01 ± 0.746
0.0GlnCys: 0.0 ± 0.0
1.005GlnAsp: 1.005 ± 0.761
5.025GlnGlu: 5.025 ± 1.133
1.508GlnPhe: 1.508 ± 0.846
1.508GlnGly: 1.508 ± 0.877
1.005GlnHis: 1.005 ± 0.886
3.015GlnIle: 3.015 ± 1.131
4.02GlnLys: 4.02 ± 1.715
1.005GlnLeu: 1.005 ± 0.843
0.503GlnMet: 0.503 ± 0.546
0.503GlnAsn: 0.503 ± 0.414
1.005GlnPro: 1.005 ± 0.887
2.01GlnGln: 2.01 ± 1.137
1.005GlnArg: 1.005 ± 0.828
3.015GlnSer: 3.015 ± 1.123
4.02GlnThr: 4.02 ± 0.839
1.508GlnVal: 1.508 ± 1.087
0.0GlnTrp: 0.0 ± 0.0
1.005GlnTyr: 1.005 ± 0.62
0.0GlnXaa: 0.0 ± 0.0
Arg
2.513ArgAla: 2.513 ± 1.459
0.0ArgCys: 0.0 ± 0.0
1.508ArgAsp: 1.508 ± 0.745
2.01ArgGlu: 2.01 ± 1.046
0.0ArgPhe: 0.0 ± 0.0
1.508ArgGly: 1.508 ± 1.236
1.005ArgHis: 1.005 ± 0.727
4.02ArgIle: 4.02 ± 1.264
3.015ArgLys: 3.015 ± 1.282
3.015ArgLeu: 3.015 ± 0.848
0.503ArgMet: 0.503 ± 0.455
4.523ArgAsn: 4.523 ± 1.416
1.508ArgPro: 1.508 ± 0.807
2.513ArgGln: 2.513 ± 1.683
1.508ArgArg: 1.508 ± 0.78
1.508ArgSer: 1.508 ± 0.807
4.02ArgThr: 4.02 ± 1.27
4.02ArgVal: 4.02 ± 1.641
0.503ArgTrp: 0.503 ± 0.652
2.513ArgTyr: 2.513 ± 1.135
0.0ArgXaa: 0.0 ± 0.0
Ser
2.513SerAla: 2.513 ± 1.223
0.0SerCys: 0.0 ± 0.0
5.528SerAsp: 5.528 ± 1.184
3.015SerGlu: 3.015 ± 1.7
1.508SerPhe: 1.508 ± 0.873
2.513SerGly: 2.513 ± 0.79
0.503SerHis: 0.503 ± 0.443
3.518SerIle: 3.518 ± 1.367
7.035SerLys: 7.035 ± 1.617
6.03SerLeu: 6.03 ± 1.691
1.005SerMet: 1.005 ± 0.497
4.523SerAsn: 4.523 ± 2.045
0.503SerPro: 0.503 ± 0.443
2.01SerGln: 2.01 ± 1.203
2.513SerArg: 2.513 ± 1.294
2.01SerSer: 2.01 ± 1.63
3.518SerThr: 3.518 ± 1.69
3.015SerVal: 3.015 ± 1.42
2.01SerTrp: 2.01 ± 1.289
2.513SerTyr: 2.513 ± 1.455
0.0SerXaa: 0.0 ± 0.0
Thr
3.518ThrAla: 3.518 ± 0.832
0.0ThrCys: 0.0 ± 0.0
4.02ThrAsp: 4.02 ± 2.275
2.513ThrGlu: 2.513 ± 1.046
5.025ThrPhe: 5.025 ± 2.138
3.015ThrGly: 3.015 ± 1.46
1.508ThrHis: 1.508 ± 0.846
3.518ThrIle: 3.518 ± 2.14
7.538ThrLys: 7.538 ± 1.55
7.538ThrLeu: 7.538 ± 1.733
4.02ThrMet: 4.02 ± 1.121
1.508ThrAsn: 1.508 ± 1.33
2.01ThrPro: 2.01 ± 0.664
1.508ThrGln: 1.508 ± 0.963
2.513ThrArg: 2.513 ± 0.938
3.015ThrSer: 3.015 ± 1.219
2.513ThrThr: 2.513 ± 1.246
8.543ThrVal: 8.543 ± 1.369
0.503ThrTrp: 0.503 ± 0.557
3.518ThrTyr: 3.518 ± 1.385
0.0ThrXaa: 0.0 ± 0.0
Val
5.025ValAla: 5.025 ± 2.049
1.005ValCys: 1.005 ± 0.631
2.01ValAsp: 2.01 ± 1.045
3.015ValGlu: 3.015 ± 1.416
2.513ValPhe: 2.513 ± 0.865
3.015ValGly: 3.015 ± 1.126
0.503ValHis: 0.503 ± 0.443
2.513ValIle: 2.513 ± 1.015
6.03ValLys: 6.03 ± 1.748
7.538ValLeu: 7.538 ± 1.667
0.503ValMet: 0.503 ± 0.535
3.518ValAsn: 3.518 ± 1.557
2.01ValPro: 2.01 ± 1.155
2.01ValGln: 2.01 ± 0.97
1.005ValArg: 1.005 ± 0.73
5.025ValSer: 5.025 ± 2.138
8.04ValThr: 8.04 ± 1.752
5.025ValVal: 5.025 ± 1.391
0.0ValTrp: 0.0 ± 0.0
1.508ValTyr: 1.508 ± 1.318
0.0ValXaa: 0.0 ± 0.0
Trp
0.0TrpAla: 0.0 ± 0.0
0.0TrpCys: 0.0 ± 0.0
0.503TrpAsp: 0.503 ± 0.443
1.005TrpGlu: 1.005 ± 0.783
0.0TrpPhe: 0.0 ± 0.0
0.0TrpGly: 0.0 ± 0.0
0.503TrpHis: 0.503 ± 0.414
0.503TrpIle: 0.503 ± 0.414
1.508TrpLys: 1.508 ± 0.617
1.508TrpLeu: 1.508 ± 1.093
0.503TrpMet: 0.503 ± 0.502
1.005TrpAsn: 1.005 ± 0.722
0.0TrpPro: 0.0 ± 0.0
0.503TrpGln: 0.503 ± 0.414
0.503TrpArg: 0.503 ± 0.414
1.005TrpSer: 1.005 ± 0.585
0.0TrpThr: 0.0 ± 0.0
0.0TrpVal: 0.0 ± 0.0
0.503TrpTrp: 0.503 ± 0.443
0.503TrpTyr: 0.503 ± 0.414
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.005TyrAla: 1.005 ± 0.658
0.503TyrCys: 0.503 ± 0.557
3.518TyrAsp: 3.518 ± 0.847
7.035TyrGlu: 7.035 ± 2.457
1.508TyrPhe: 1.508 ± 1.103
1.508TyrGly: 1.508 ± 0.8
0.503TyrHis: 0.503 ± 0.557
2.01TyrIle: 2.01 ± 0.835
4.523TyrLys: 4.523 ± 1.815
4.523TyrLeu: 4.523 ± 1.561
1.508TyrMet: 1.508 ± 0.775
1.508TyrAsn: 1.508 ± 1.511
2.01TyrPro: 2.01 ± 1.159
2.513TyrGln: 2.513 ± 1.263
3.015TyrArg: 3.015 ± 1.011
3.015TyrSer: 3.015 ± 1.209
3.518TyrThr: 3.518 ± 1.371
2.513TyrVal: 2.513 ± 1.092
0.503TyrTrp: 0.503 ± 0.485
1.508TyrTyr: 1.508 ± 0.991
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 12 proteins (1991 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski