Amino acid dipepetide frequency for Helicobacter sp. CLO-3

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.977AlaAla: 4.977 ± 0.12
1.24AlaCys: 1.24 ± 0.052
4.309AlaAsp: 4.309 ± 0.101
4.494AlaGlu: 4.494 ± 0.103
4.338AlaPhe: 4.338 ± 0.091
5.35AlaGly: 5.35 ± 0.12
2.15AlaHis: 2.15 ± 0.073
6.32AlaIle: 6.32 ± 0.114
7.948AlaLys: 7.948 ± 0.148
11.532AlaLeu: 11.532 ± 0.179
2.163AlaMet: 2.163 ± 0.067
4.6AlaAsn: 4.6 ± 0.102
4.363AlaPro: 4.363 ± 0.113
5.361AlaGln: 5.361 ± 0.111
5.477AlaArg: 5.477 ± 0.125
7.003AlaSer: 7.003 ± 0.14
4.125AlaThr: 4.125 ± 0.08
3.442AlaVal: 3.442 ± 0.093
0.644AlaTrp: 0.644 ± 0.036
2.954AlaTyr: 2.954 ± 0.08
0.0AlaXaa: 0.0 ± 0.0
Cys
1.633CysAla: 1.633 ± 0.057
0.112CysCys: 0.112 ± 0.015
0.789CysAsp: 0.789 ± 0.043
0.933CysGlu: 0.933 ± 0.043
0.634CysPhe: 0.634 ± 0.036
0.972CysGly: 0.972 ± 0.041
0.267CysHis: 0.267 ± 0.023
0.788CysIle: 0.788 ± 0.039
0.771CysLys: 0.771 ± 0.039
1.043CysLeu: 1.043 ± 0.043
0.27CysMet: 0.27 ± 0.021
0.346CysAsn: 0.346 ± 0.027
0.331CysPro: 0.331 ± 0.023
0.363CysGln: 0.363 ± 0.024
0.296CysArg: 0.296 ± 0.025
0.541CysSer: 0.541 ± 0.035
0.362CysThr: 0.362 ± 0.023
0.98CysVal: 0.98 ± 0.047
0.095CysTrp: 0.095 ± 0.013
0.407CysTyr: 0.407 ± 0.025
0.0CysXaa: 0.0 ± 0.0
Asp
4.365AspAla: 4.365 ± 0.105
0.524AspCys: 0.524 ± 0.029
2.623AspAsp: 2.623 ± 0.085
3.968AspGlu: 3.968 ± 0.076
4.096AspPhe: 4.096 ± 0.105
2.685AspGly: 2.685 ± 0.083
0.463AspHis: 0.463 ± 0.024
4.56AspIle: 4.56 ± 0.105
4.313AspLys: 4.313 ± 0.087
4.494AspLeu: 4.494 ± 0.088
1.778AspMet: 1.778 ± 0.069
1.815AspAsn: 1.815 ± 0.058
1.229AspPro: 1.229 ± 0.043
0.637AspGln: 0.637 ± 0.036
1.66AspArg: 1.66 ± 0.052
7.938AspSer: 7.938 ± 0.192
2.53AspThr: 2.53 ± 0.061
2.79AspVal: 2.79 ± 0.075
0.384AspTrp: 0.384 ± 0.024
1.78AspTyr: 1.78 ± 0.055
0.0AspXaa: 0.0 ± 0.0
Glu
4.656GluAla: 4.656 ± 0.096
0.73GluCys: 0.73 ± 0.04
2.134GluAsp: 2.134 ± 0.066
3.147GluGlu: 3.147 ± 0.1
2.831GluPhe: 2.831 ± 0.074
3.316GluGly: 3.316 ± 0.076
1.041GluHis: 1.041 ± 0.044
5.112GluIle: 5.112 ± 0.106
4.198GluLys: 4.198 ± 0.098
5.572GluLeu: 5.572 ± 0.112
1.469GluMet: 1.469 ± 0.056
3.568GluAsn: 3.568 ± 0.092
1.541GluPro: 1.541 ± 0.055
1.996GluGln: 1.996 ± 0.065
3.037GluArg: 3.037 ± 0.076
7.852GluSer: 7.852 ± 0.164
1.715GluThr: 1.715 ± 0.057
3.821GluVal: 3.821 ± 0.092
0.576GluTrp: 0.576 ± 0.036
2.123GluTyr: 2.123 ± 0.075
0.0GluXaa: 0.0 ± 0.0
Phe
4.783PheAla: 4.783 ± 0.116
1.053PheCys: 1.053 ± 0.048
3.047PheAsp: 3.047 ± 0.081
2.748PheGlu: 2.748 ± 0.062
2.548PhePhe: 2.548 ± 0.073
4.816PheGly: 4.816 ± 0.108
0.624PheHis: 0.624 ± 0.035
3.576PheIle: 3.576 ± 0.084
2.371PheLys: 2.371 ± 0.063
4.688PheLeu: 4.688 ± 0.107
1.23PheMet: 1.23 ± 0.051
1.937PheAsn: 1.937 ± 0.095
1.166PhePro: 1.166 ± 0.045
0.843PheGln: 0.843 ± 0.038
1.555PheArg: 1.555 ± 0.053
3.921PheSer: 3.921 ± 0.091
1.825PheThr: 1.825 ± 0.06
3.51PheVal: 3.51 ± 0.093
0.644PheTrp: 0.644 ± 0.039
2.03PheTyr: 2.03 ± 0.059
0.0PheXaa: 0.0 ± 0.0
Gly
7.738GlyAla: 7.738 ± 0.154
0.745GlyCys: 0.745 ± 0.044
3.397GlyAsp: 3.397 ± 0.09
4.017GlyGlu: 4.017 ± 0.096
3.855GlyPhe: 3.855 ± 0.089
5.019GlyGly: 5.019 ± 0.109
0.935GlyHis: 0.935 ± 0.042
5.107GlyIle: 5.107 ± 0.115
4.451GlyLys: 4.451 ± 0.103
5.579GlyLeu: 5.579 ± 0.109
1.629GlyMet: 1.629 ± 0.06
2.325GlyAsn: 2.325 ± 0.072
0.635GlyPro: 0.635 ± 0.036
1.435GlyGln: 1.435 ± 0.064
2.403GlyArg: 2.403 ± 0.067
3.779GlySer: 3.779 ± 0.085
2.118GlyThr: 2.118 ± 0.069
5.411GlyVal: 5.411 ± 0.125
0.477GlyTrp: 0.477 ± 0.028
2.432GlyTyr: 2.432 ± 0.074
0.0GlyXaa: 0.0 ± 0.0
His
1.746HisAla: 1.746 ± 0.065
0.267HisCys: 0.267 ± 0.021
0.782HisAsp: 0.782 ± 0.039
0.772HisGlu: 0.772 ± 0.033
1.207HisPhe: 1.207 ± 0.045
0.955HisGly: 0.955 ± 0.044
0.473HisHis: 0.473 ± 0.028
1.923HisIle: 1.923 ± 0.059
1.491HisLys: 1.491 ± 0.046
1.638HisLeu: 1.638 ± 0.057
0.313HisMet: 0.313 ± 0.026
0.779HisAsn: 0.779 ± 0.041
0.759HisPro: 0.759 ± 0.039
0.644HisGln: 0.644 ± 0.039
0.781HisArg: 0.781 ± 0.038
1.247HisSer: 1.247 ± 0.047
1.127HisThr: 1.127 ± 0.05
0.477HisVal: 0.477 ± 0.03
0.123HisTrp: 0.123 ± 0.014
0.617HisTyr: 0.617 ± 0.032
0.0HisXaa: 0.0 ± 0.0
Ile
7.977IleAla: 7.977 ± 0.129
1.185IleCys: 1.185 ± 0.046
4.945IleAsp: 4.945 ± 0.103
5.043IleGlu: 5.043 ± 0.117
3.758IlePhe: 3.758 ± 0.108
4.87IleGly: 4.87 ± 0.104
1.289IleHis: 1.289 ± 0.047
6.101IleIle: 6.101 ± 0.132
5.46IleLys: 5.46 ± 0.114
7.127IleLeu: 7.127 ± 0.133
1.497IleMet: 1.497 ± 0.045
3.473IleAsn: 3.473 ± 0.074
2.768IlePro: 2.768 ± 0.065
2.259IleGln: 2.259 ± 0.07
2.434IleArg: 2.434 ± 0.063
5.474IleSer: 5.474 ± 0.091
3.762IleThr: 3.762 ± 0.075
3.99IleVal: 3.99 ± 0.097
0.598IleTrp: 0.598 ± 0.034
2.846IleTyr: 2.846 ± 0.073
0.0IleXaa: 0.0 ± 0.0
Lys
6.425LysAla: 6.425 ± 0.121
0.568LysCys: 0.568 ± 0.038
4.478LysAsp: 4.478 ± 0.094
5.215LysGlu: 5.215 ± 0.127
1.94LysPhe: 1.94 ± 0.059
3.799LysGly: 3.799 ± 0.091
1.332LysHis: 1.332 ± 0.046
6.351LysIle: 6.351 ± 0.11
5.126LysLys: 5.126 ± 0.105
5.8LysLeu: 5.8 ± 0.12
2.026LysMet: 2.026 ± 0.057
4.899LysAsn: 4.899 ± 0.098
2.728LysPro: 2.728 ± 0.08
2.719LysGln: 2.719 ± 0.073
3.255LysArg: 3.255 ± 0.075
6.354LysSer: 6.354 ± 0.131
3.471LysThr: 3.471 ± 0.082
3.562LysVal: 3.562 ± 0.081
0.674LysTrp: 0.674 ± 0.038
2.216LysTyr: 2.216 ± 0.063
0.0LysXaa: 0.0 ± 0.0
Leu
9.158LeuAla: 9.158 ± 0.139
1.475LeuCys: 1.475 ± 0.062
7.189LeuAsp: 7.189 ± 0.133
7.341LeuGlu: 7.341 ± 0.124
4.38LeuPhe: 4.38 ± 0.112
6.794LeuGly: 6.794 ± 0.129
1.731LeuHis: 1.731 ± 0.059
5.971LeuIle: 5.971 ± 0.103
6.763LeuLys: 6.763 ± 0.122
8.8LeuLeu: 8.8 ± 0.147
1.803LeuMet: 1.803 ± 0.053
4.178LeuAsn: 4.178 ± 0.085
3.672LeuPro: 3.672 ± 0.082
3.726LeuGln: 3.726 ± 0.092
4.358LeuArg: 4.358 ± 0.087
7.242LeuSer: 7.242 ± 0.134
3.375LeuThr: 3.375 ± 0.08
4.7LeuVal: 4.7 ± 0.098
0.749LeuTrp: 0.749 ± 0.035
3.023LeuTyr: 3.023 ± 0.075
0.0LeuXaa: 0.0 ± 0.0
Met
1.597MetAla: 1.597 ± 0.059
0.218MetCys: 0.218 ± 0.021
1.146MetAsp: 1.146 ± 0.05
1.124MetGlu: 1.124 ± 0.043
1.31MetPhe: 1.31 ± 0.096
1.6MetGly: 1.6 ± 0.058
0.431MetHis: 0.431 ± 0.026
1.58MetIle: 1.58 ± 0.05
1.416MetLys: 1.416 ± 0.06
2.866MetLeu: 2.866 ± 0.069
0.597MetMet: 0.597 ± 0.035
0.825MetAsn: 0.825 ± 0.037
1.32MetPro: 1.32 ± 0.043
1.415MetGln: 1.415 ± 0.049
1.56MetArg: 1.56 ± 0.056
1.746MetSer: 1.746 ± 0.058
0.794MetThr: 0.794 ± 0.044
1.11MetVal: 1.11 ± 0.047
0.176MetTrp: 0.176 ± 0.017
0.504MetTyr: 0.504 ± 0.03
0.0MetXaa: 0.0 ± 0.0
Asn
5.705AsnAla: 5.705 ± 0.128
0.346AsnCys: 0.346 ± 0.026
2.315AsnAsp: 2.315 ± 0.073
2.44AsnGlu: 2.44 ± 0.065
1.935AsnPhe: 1.935 ± 0.068
2.768AsnGly: 2.768 ± 0.074
0.943AsnHis: 0.943 ± 0.042
4.014AsnIle: 4.014 ± 0.091
2.819AsnLys: 2.819 ± 0.094
5.396AsnLeu: 5.396 ± 0.106
1.188AsnMet: 1.188 ± 0.053
2.028AsnAsn: 2.028 ± 0.071
2.739AsnPro: 2.739 ± 0.082
1.805AsnGln: 1.805 ± 0.085
1.607AsnArg: 1.607 ± 0.049
2.925AsnSer: 2.925 ± 0.09
2.848AsnThr: 2.848 ± 0.081
2.521AsnVal: 2.521 ± 0.102
0.225AsnTrp: 0.225 ± 0.019
1.367AsnTyr: 1.367 ± 0.057
0.0AsnXaa: 0.0 ± 0.0
Pro
2.675ProAla: 2.675 ± 0.08
0.291ProCys: 0.291 ± 0.024
1.44ProAsp: 1.44 ± 0.061
1.994ProGlu: 1.994 ± 0.062
1.644ProPhe: 1.644 ± 0.051
1.107ProGly: 1.107 ± 0.05
0.857ProHis: 0.857 ± 0.043
2.729ProIle: 2.729 ± 0.071
3.41ProLys: 3.41 ± 0.089
3.88ProLeu: 3.88 ± 0.104
0.693ProMet: 0.693 ± 0.036
2.33ProAsn: 2.33 ± 0.069
1.203ProPro: 1.203 ± 0.053
1.619ProGln: 1.619 ± 0.054
1.524ProArg: 1.524 ± 0.055
2.775ProSer: 2.775 ± 0.062
1.807ProThr: 1.807 ± 0.063
1.288ProVal: 1.288 ± 0.047
0.176ProTrp: 0.176 ± 0.017
1.323ProTyr: 1.323 ± 0.051
0.0ProXaa: 0.0 ± 0.0
Gln
3.228GlnAla: 3.228 ± 0.083
0.24GlnCys: 0.24 ± 0.021
2.107GlnAsp: 2.107 ± 0.061
2.704GlnGlu: 2.704 ± 0.086
0.796GlnPhe: 0.796 ± 0.04
1.928GlnGly: 1.928 ± 0.057
0.431GlnHis: 0.431 ± 0.028
3.273GlnIle: 3.273 ± 0.087
3.848GlnLys: 3.848 ± 0.086
1.9GlnLeu: 1.9 ± 0.062
0.894GlnMet: 0.894 ± 0.041
3.889GlnAsn: 3.889 ± 0.097
1.077GlnPro: 1.077 ± 0.06
0.911GlnGln: 0.911 ± 0.049
1.31GlnArg: 1.31 ± 0.049
2.817GlnSer: 2.817 ± 0.073
2.121GlnThr: 2.121 ± 0.073
1.577GlnVal: 1.577 ± 0.048
0.221GlnTrp: 0.221 ± 0.02
0.911GlnTyr: 0.911 ± 0.045
0.0GlnXaa: 0.0 ± 0.0
Arg
4.979ArgAla: 4.979 ± 0.108
0.377ArgCys: 0.377 ± 0.029
2.548ArgAsp: 2.548 ± 0.072
3.204ArgGlu: 3.204 ± 0.079
2.668ArgPhe: 2.668 ± 0.069
2.548ArgGly: 2.548 ± 0.07
0.831ArgHis: 0.831 ± 0.042
3.542ArgIle: 3.542 ± 0.08
2.516ArgLys: 2.516 ± 0.068
4.296ArgLeu: 4.296 ± 0.088
0.902ArgMet: 0.902 ± 0.042
1.69ArgAsn: 1.69 ± 0.054
1.046ArgPro: 1.046 ± 0.049
1.604ArgGln: 1.604 ± 0.051
1.698ArgArg: 1.698 ± 0.068
2.004ArgSer: 2.004 ± 0.054
1.56ArgThr: 1.56 ± 0.052
2.729ArgVal: 2.729 ± 0.071
0.316ArgTrp: 0.316 ± 0.024
1.802ArgTyr: 1.802 ± 0.063
0.0ArgXaa: 0.0 ± 0.0
Ser
9.839SerAla: 9.839 ± 0.218
0.728SerCys: 0.728 ± 0.037
3.792SerAsp: 3.792 ± 0.086
3.949SerGlu: 3.949 ± 0.097
3.889SerPhe: 3.889 ± 0.11
6.023SerGly: 6.023 ± 0.12
1.382SerHis: 1.382 ± 0.058
5.617SerIle: 5.617 ± 0.094
6.464SerLys: 6.464 ± 0.13
7.005SerLeu: 7.005 ± 0.127
1.766SerMet: 1.766 ± 0.058
3.093SerAsn: 3.093 ± 0.09
2.248SerPro: 2.248 ± 0.058
2.998SerGln: 2.998 ± 0.082
3.135SerArg: 3.135 ± 0.085
7.007SerSer: 7.007 ± 0.158
3.906SerThr: 3.906 ± 0.087
4.46SerVal: 4.46 ± 0.095
0.764SerTrp: 0.764 ± 0.072
2.408SerTyr: 2.408 ± 0.062
0.0SerXaa: 0.0 ± 0.0
Thr
2.946ThrAla: 2.946 ± 0.081
0.39ThrCys: 0.39 ± 0.027
1.835ThrAsp: 1.835 ± 0.057
1.438ThrGlu: 1.438 ± 0.051
1.636ThrPhe: 1.636 ± 0.052
2.04ThrGly: 2.04 ± 0.078
1.195ThrHis: 1.195 ± 0.047
3.454ThrIle: 3.454 ± 0.08
3.677ThrLys: 3.677 ± 0.089
5.083ThrLeu: 5.083 ± 0.105
0.921ThrMet: 0.921 ± 0.039
2.361ThrAsn: 2.361 ± 0.075
3.17ThrPro: 3.17 ± 0.077
2.719ThrGln: 2.719 ± 0.075
2.099ThrArg: 2.099 ± 0.058
3.525ThrSer: 3.525 ± 0.092
2.672ThrThr: 2.672 ± 0.089
0.635ThrVal: 0.635 ± 0.043
0.301ThrTrp: 0.301 ± 0.021
1.401ThrTyr: 1.401 ± 0.058
0.0ThrXaa: 0.0 ± 0.0
Val
4.644ValAla: 4.644 ± 0.098
0.923ValCys: 0.923 ± 0.042
3.206ValAsp: 3.206 ± 0.069
3.196ValGlu: 3.196 ± 0.078
3.221ValPhe: 3.221 ± 0.086
4.024ValGly: 4.024 ± 0.1
0.755ValHis: 0.755 ± 0.044
3.895ValIle: 3.895 ± 0.103
3.008ValLys: 3.008 ± 0.083
5.754ValLeu: 5.754 ± 0.107
1.234ValMet: 1.234 ± 0.051
1.854ValAsn: 1.854 ± 0.058
1.501ValPro: 1.501 ± 0.06
1.509ValGln: 1.509 ± 0.051
2.55ValArg: 2.55 ± 0.069
3.911ValSer: 3.911 ± 0.109
1.592ValThr: 1.592 ± 0.068
3.799ValVal: 3.799 ± 0.099
0.548ValTrp: 0.548 ± 0.032
1.724ValTyr: 1.724 ± 0.058
0.0ValXaa: 0.0 ± 0.0
Trp
0.581TrpAla: 0.581 ± 0.034
0.139TrpCys: 0.139 ± 0.016
0.676TrpAsp: 0.676 ± 0.061
0.416TrpGlu: 0.416 ± 0.025
0.338TrpPhe: 0.338 ± 0.024
0.586TrpGly: 0.586 ± 0.03
0.267TrpHis: 0.267 ± 0.024
0.561TrpIle: 0.561 ± 0.035
0.379TrpLys: 0.379 ± 0.024
1.056TrpLeu: 1.056 ± 0.042
0.177TrpMet: 0.177 ± 0.02
0.443TrpAsn: 0.443 ± 0.046
0.063TrpPro: 0.063 ± 0.012
0.389TrpGln: 0.389 ± 0.028
0.51TrpArg: 0.51 ± 0.032
0.414TrpSer: 0.414 ± 0.029
0.189TrpThr: 0.189 ± 0.018
0.461TrpVal: 0.461 ± 0.028
0.117TrpTrp: 0.117 ± 0.016
0.324TrpTyr: 0.324 ± 0.023
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.142TyrAla: 3.142 ± 0.07
0.38TyrCys: 0.38 ± 0.024
1.869TyrAsp: 1.869 ± 0.062
2.29TyrGlu: 2.29 ± 0.071
1.889TyrPhe: 1.889 ± 0.062
2.285TyrGly: 2.285 ± 0.067
0.723TyrHis: 0.723 ± 0.034
2.381TyrIle: 2.381 ± 0.061
2.511TyrLys: 2.511 ± 0.063
2.92TyrLeu: 2.92 ± 0.078
0.781TyrMet: 0.781 ± 0.039
1.504TyrAsn: 1.504 ± 0.056
1.207TyrPro: 1.207 ± 0.047
1.23TyrGln: 1.23 ± 0.05
1.614TyrArg: 1.614 ± 0.053
1.999TyrSer: 1.999 ± 0.071
1.602TyrThr: 1.602 ± 0.052
1.582TyrVal: 1.582 ± 0.052
0.281TyrTrp: 0.281 ± 0.023
1.293TyrTyr: 1.293 ± 0.055
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1846 proteins (591729 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski