Amino acid dipepetide frequency for Phycicoccus sp. HDW14

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
21.373AlaAla: 21.373 ± 0.215
0.977AlaCys: 0.977 ± 0.03
8.463AlaAsp: 8.463 ± 0.097
7.505AlaGlu: 7.505 ± 0.1
3.309AlaPhe: 3.309 ± 0.068
13.389AlaGly: 13.389 ± 0.147
2.716AlaHis: 2.716 ± 0.06
3.218AlaIle: 3.218 ± 0.069
2.383AlaLys: 2.383 ± 0.071
14.584AlaLeu: 14.584 ± 0.179
2.674AlaMet: 2.674 ± 0.056
1.772AlaAsn: 1.772 ± 0.053
7.103AlaPro: 7.103 ± 0.106
3.138AlaGln: 3.138 ± 0.056
10.725AlaArg: 10.725 ± 0.134
6.789AlaSer: 6.789 ± 0.1
8.379AlaThr: 8.379 ± 0.135
13.502AlaVal: 13.502 ± 0.137
2.18AlaTrp: 2.18 ± 0.049
2.163AlaTyr: 2.163 ± 0.05
0.0AlaXaa: 0.0 ± 0.0
Cys
0.966CysAla: 0.966 ± 0.036
0.098CysCys: 0.098 ± 0.012
0.443CysAsp: 0.443 ± 0.022
0.323CysGlu: 0.323 ± 0.017
0.184CysPhe: 0.184 ± 0.014
0.897CysGly: 0.897 ± 0.033
0.162CysHis: 0.162 ± 0.014
0.17CysIle: 0.17 ± 0.013
0.083CysLys: 0.083 ± 0.009
0.577CysLeu: 0.577 ± 0.026
0.102CysMet: 0.102 ± 0.011
0.108CysAsn: 0.108 ± 0.01
0.512CysPro: 0.512 ± 0.023
0.134CysGln: 0.134 ± 0.013
0.641CysArg: 0.641 ± 0.029
0.539CysSer: 0.539 ± 0.026
0.536CysThr: 0.536 ± 0.027
0.56CysVal: 0.56 ± 0.021
0.115CysTrp: 0.115 ± 0.01
0.122CysTyr: 0.122 ± 0.011
0.0CysXaa: 0.0 ± 0.0
Asp
8.351AspAla: 8.351 ± 0.115
0.352AspCys: 0.352 ± 0.021
4.581AspAsp: 4.581 ± 0.08
4.404AspGlu: 4.404 ± 0.084
1.279AspPhe: 1.279 ± 0.037
6.66AspGly: 6.66 ± 0.105
1.44AspHis: 1.44 ± 0.039
1.496AspIle: 1.496 ± 0.045
0.872AspLys: 0.872 ± 0.031
7.177AspLeu: 7.177 ± 0.095
0.654AspMet: 0.654 ± 0.025
0.792AspAsn: 0.792 ± 0.031
4.966AspPro: 4.966 ± 0.074
1.339AspGln: 1.339 ± 0.035
4.842AspArg: 4.842 ± 0.072
2.182AspSer: 2.182 ± 0.056
3.13AspThr: 3.13 ± 0.063
6.409AspVal: 6.409 ± 0.094
0.868AspTrp: 0.868 ± 0.034
0.982AspTyr: 0.982 ± 0.033
0.0AspXaa: 0.0 ± 0.0
Glu
7.422GluAla: 7.422 ± 0.108
0.328GluCys: 0.328 ± 0.022
3.057GluAsp: 3.057 ± 0.064
3.145GluGlu: 3.145 ± 0.07
1.196GluPhe: 1.196 ± 0.037
4.376GluGly: 4.376 ± 0.071
1.697GluHis: 1.697 ± 0.046
1.561GluIle: 1.561 ± 0.047
1.181GluLys: 1.181 ± 0.038
5.567GluLeu: 5.567 ± 0.094
0.78GluMet: 0.78 ± 0.028
0.817GluAsn: 0.817 ± 0.031
3.137GluPro: 3.137 ± 0.079
1.972GluGln: 1.972 ± 0.046
5.339GluArg: 5.339 ± 0.085
2.312GluSer: 2.312 ± 0.045
2.475GluThr: 2.475 ± 0.059
6.03GluVal: 6.03 ± 0.091
0.793GluTrp: 0.793 ± 0.028
0.922GluTyr: 0.922 ± 0.027
0.0GluXaa: 0.0 ± 0.0
Phe
3.36PheAla: 3.36 ± 0.066
0.224PheCys: 0.224 ± 0.017
1.806PheAsp: 1.806 ± 0.049
1.334PheGlu: 1.334 ± 0.035
0.79PhePhe: 0.79 ± 0.036
2.835PheGly: 2.835 ± 0.052
0.514PheHis: 0.514 ± 0.019
0.643PheIle: 0.643 ± 0.029
0.378PheLys: 0.378 ± 0.019
2.357PheLeu: 2.357 ± 0.053
0.347PheMet: 0.347 ± 0.02
0.443PheAsn: 0.443 ± 0.021
1.251PhePro: 1.251 ± 0.034
0.526PheGln: 0.526 ± 0.024
1.667PheArg: 1.667 ± 0.038
1.344PheSer: 1.344 ± 0.036
1.741PheThr: 1.741 ± 0.043
2.715PheVal: 2.715 ± 0.056
0.396PheTrp: 0.396 ± 0.022
0.523PheTyr: 0.523 ± 0.024
0.0PheXaa: 0.0 ± 0.0
Gly
11.43GlyAla: 11.43 ± 0.138
0.815GlyCys: 0.815 ± 0.036
5.265GlyAsp: 5.265 ± 0.081
4.837GlyGlu: 4.837 ± 0.077
2.803GlyPhe: 2.803 ± 0.062
8.813GlyGly: 8.813 ± 0.111
2.227GlyHis: 2.227 ± 0.049
3.275GlyIle: 3.275 ± 0.071
1.947GlyLys: 1.947 ± 0.059
9.867GlyLeu: 9.867 ± 0.111
2.149GlyMet: 2.149 ± 0.048
1.485GlyAsn: 1.485 ± 0.047
5.235GlyPro: 5.235 ± 0.084
2.347GlyGln: 2.347 ± 0.051
8.246GlyArg: 8.246 ± 0.111
6.241GlySer: 6.241 ± 0.105
6.464GlyThr: 6.464 ± 0.089
8.9GlyVal: 8.9 ± 0.1
2.01GlyTrp: 2.01 ± 0.047
2.06GlyTyr: 2.06 ± 0.047
0.0GlyXaa: 0.0 ± 0.0
His
2.572HisAla: 2.572 ± 0.052
0.161HisCys: 0.161 ± 0.011
1.61HisAsp: 1.61 ± 0.043
1.28HisGlu: 1.28 ± 0.038
0.479HisPhe: 0.479 ± 0.02
2.396HisGly: 2.396 ± 0.06
0.722HisHis: 0.722 ± 0.031
0.432HisIle: 0.432 ± 0.022
0.239HisLys: 0.239 ± 0.016
2.496HisLeu: 2.496 ± 0.053
0.247HisMet: 0.247 ± 0.017
0.3HisAsn: 0.3 ± 0.02
1.769HisPro: 1.769 ± 0.045
0.482HisGln: 0.482 ± 0.022
2.087HisArg: 2.087 ± 0.048
0.817HisSer: 0.817 ± 0.03
1.078HisThr: 1.078 ± 0.032
2.269HisVal: 2.269 ± 0.048
0.331HisTrp: 0.331 ± 0.022
0.374HisTyr: 0.374 ± 0.022
0.0HisXaa: 0.0 ± 0.0
Ile
3.895IleAla: 3.895 ± 0.073
0.206IleCys: 0.206 ± 0.013
1.942IleAsp: 1.942 ± 0.047
1.646IleGlu: 1.646 ± 0.046
0.587IlePhe: 0.587 ± 0.026
3.102IleGly: 3.102 ± 0.067
0.534IleHis: 0.534 ± 0.021
0.792IleIle: 0.792 ± 0.035
0.522IleLys: 0.522 ± 0.027
1.944IleLeu: 1.944 ± 0.048
0.338IleMet: 0.338 ± 0.02
0.46IleAsn: 0.46 ± 0.02
1.427IlePro: 1.427 ± 0.041
0.614IleGln: 0.614 ± 0.03
1.868IleArg: 1.868 ± 0.044
1.393IleSer: 1.393 ± 0.041
1.7IleThr: 1.7 ± 0.04
2.481IleVal: 2.481 ± 0.058
0.305IleTrp: 0.305 ± 0.019
0.418IleTyr: 0.418 ± 0.021
0.0IleXaa: 0.0 ± 0.0
Lys
2.458LysAla: 2.458 ± 0.077
0.093LysCys: 0.093 ± 0.01
1.063LysAsp: 1.063 ± 0.038
0.824LysGlu: 0.824 ± 0.037
0.368LysPhe: 0.368 ± 0.02
1.551LysGly: 1.551 ± 0.048
0.322LysHis: 0.322 ± 0.017
0.613LysIle: 0.613 ± 0.028
0.682LysLys: 0.682 ± 0.044
1.357LysLeu: 1.357 ± 0.045
0.281LysMet: 0.281 ± 0.018
0.396LysAsn: 0.396 ± 0.023
0.959LysPro: 0.959 ± 0.037
0.505LysGln: 0.505 ± 0.025
1.167LysArg: 1.167 ± 0.039
0.883LysSer: 0.883 ± 0.034
1.082LysThr: 1.082 ± 0.04
1.747LysVal: 1.747 ± 0.045
0.191LysTrp: 0.191 ± 0.016
0.381LysTyr: 0.381 ± 0.022
0.0LysXaa: 0.0 ± 0.0
Leu
15.707LeuAla: 15.707 ± 0.181
0.604LeuCys: 0.604 ± 0.022
7.205LeuAsp: 7.205 ± 0.105
5.534LeuGlu: 5.534 ± 0.091
2.157LeuPhe: 2.157 ± 0.055
10.357LeuGly: 10.357 ± 0.137
2.095LeuHis: 2.095 ± 0.045
1.863LeuIle: 1.863 ± 0.053
1.362LeuLys: 1.362 ± 0.047
10.792LeuLeu: 10.792 ± 0.162
1.361LeuMet: 1.361 ± 0.037
1.295LeuAsn: 1.295 ± 0.033
5.702LeuPro: 5.702 ± 0.076
1.931LeuGln: 1.931 ± 0.049
8.233LeuArg: 8.233 ± 0.09
4.978LeuSer: 4.978 ± 0.083
6.569LeuThr: 6.569 ± 0.099
11.835LeuVal: 11.835 ± 0.161
1.254LeuTrp: 1.254 ± 0.037
1.357LeuTyr: 1.357 ± 0.039
0.0LeuXaa: 0.0 ± 0.0
Met
2.278MetAla: 2.278 ± 0.049
0.096MetCys: 0.096 ± 0.01
0.904MetAsp: 0.904 ± 0.031
0.701MetGlu: 0.701 ± 0.028
0.459MetPhe: 0.459 ± 0.021
1.368MetGly: 1.368 ± 0.04
0.319MetHis: 0.319 ± 0.019
0.46MetIle: 0.46 ± 0.025
0.347MetLys: 0.347 ± 0.018
1.677MetLeu: 1.677 ± 0.046
0.279MetMet: 0.279 ± 0.019
0.323MetAsn: 0.323 ± 0.018
1.102MetPro: 1.102 ± 0.036
0.422MetGln: 0.422 ± 0.018
1.416MetArg: 1.416 ± 0.039
1.418MetSer: 1.418 ± 0.041
1.696MetThr: 1.696 ± 0.04
1.4MetVal: 1.4 ± 0.039
0.198MetTrp: 0.198 ± 0.018
0.26MetTyr: 0.26 ± 0.014
0.0MetXaa: 0.0 ± 0.0
Asn
1.873AsnAla: 1.873 ± 0.05
0.119AsnCys: 0.119 ± 0.011
0.814AsnAsp: 0.814 ± 0.032
0.62AsnGlu: 0.62 ± 0.025
0.401AsnPhe: 0.401 ± 0.022
1.432AsnGly: 1.432 ± 0.054
0.324AsnHis: 0.324 ± 0.016
0.522AsnIle: 0.522 ± 0.022
0.294AsnLys: 0.294 ± 0.021
1.58AsnLeu: 1.58 ± 0.048
0.221AsnMet: 0.221 ± 0.015
0.313AsnAsn: 0.313 ± 0.016
1.218AsnPro: 1.218 ± 0.042
0.374AsnGln: 0.374 ± 0.018
1.068AsnArg: 1.068 ± 0.033
0.683AsnSer: 0.683 ± 0.033
1.012AsnThr: 1.012 ± 0.06
1.412AsnVal: 1.412 ± 0.044
0.216AsnTrp: 0.216 ± 0.016
0.326AsnTyr: 0.326 ± 0.02
0.0AsnXaa: 0.0 ± 0.0
Pro
8.013ProAla: 8.013 ± 0.123
0.381ProCys: 0.381 ± 0.022
4.495ProAsp: 4.495 ± 0.076
3.741ProGlu: 3.741 ± 0.068
1.532ProPhe: 1.532 ± 0.037
6.257ProGly: 6.257 ± 0.091
1.308ProHis: 1.308 ± 0.037
1.13ProIle: 1.13 ± 0.035
0.922ProLys: 0.922 ± 0.03
4.816ProLeu: 4.816 ± 0.074
1.121ProMet: 1.121 ± 0.035
0.827ProAsn: 0.827 ± 0.031
3.388ProPro: 3.388 ± 0.089
1.351ProGln: 1.351 ± 0.032
4.393ProArg: 4.393 ± 0.086
3.633ProSer: 3.633 ± 0.078
4.084ProThr: 4.084 ± 0.09
6.073ProVal: 6.073 ± 0.091
1.044ProTrp: 1.044 ± 0.035
0.986ProTyr: 0.986 ± 0.033
0.0ProXaa: 0.0 ± 0.0
Gln
3.052GlnAla: 3.052 ± 0.06
0.161GlnCys: 0.161 ± 0.012
1.176GlnAsp: 1.176 ± 0.038
1.073GlnGlu: 1.073 ± 0.034
0.609GlnPhe: 0.609 ± 0.026
1.859GlnGly: 1.859 ± 0.041
0.606GlnHis: 0.606 ± 0.022
0.72GlnIle: 0.72 ± 0.031
0.496GlnLys: 0.496 ± 0.029
2.531GlnLeu: 2.531 ± 0.054
0.455GlnMet: 0.455 ± 0.025
0.419GlnAsn: 0.419 ± 0.018
1.377GlnPro: 1.377 ± 0.041
0.951GlnGln: 0.951 ± 0.032
2.283GlnArg: 2.283 ± 0.053
1.101GlnSer: 1.101 ± 0.032
1.194GlnThr: 1.194 ± 0.034
2.535GlnVal: 2.535 ± 0.055
0.42GlnTrp: 0.42 ± 0.022
0.484GlnTyr: 0.484 ± 0.02
0.0GlnXaa: 0.0 ± 0.0
Arg
10.166ArgAla: 10.166 ± 0.12
0.62ArgCys: 0.62 ± 0.028
4.631ArgAsp: 4.631 ± 0.077
4.567ArgGlu: 4.567 ± 0.081
2.224ArgPhe: 2.224 ± 0.052
6.495ArgGly: 6.495 ± 0.085
2.031ArgHis: 2.031 ± 0.046
2.533ArgIle: 2.533 ± 0.048
1.183ArgLys: 1.183 ± 0.036
8.555ArgLeu: 8.555 ± 0.106
1.911ArgMet: 1.911 ± 0.049
1.072ArgAsn: 1.072 ± 0.04
5.302ArgPro: 5.302 ± 0.101
2.018ArgGln: 2.018 ± 0.041
8.775ArgArg: 8.775 ± 0.133
4.595ArgSer: 4.595 ± 0.074
5.343ArgThr: 5.343 ± 0.076
7.261ArgVal: 7.261 ± 0.1
1.593ArgTrp: 1.593 ± 0.045
1.499ArgTyr: 1.499 ± 0.039
0.0ArgXaa: 0.0 ± 0.0
Ser
6.97SerAla: 6.97 ± 0.104
0.455SerCys: 0.455 ± 0.028
2.768SerAsp: 2.768 ± 0.055
2.18SerGlu: 2.18 ± 0.051
1.544SerPhe: 1.544 ± 0.039
6.127SerGly: 6.127 ± 0.108
0.944SerHis: 0.944 ± 0.03
1.585SerIle: 1.585 ± 0.046
0.827SerLys: 0.827 ± 0.035
4.909SerLeu: 4.909 ± 0.083
1.229SerMet: 1.229 ± 0.038
0.822SerAsn: 0.822 ± 0.03
3.265SerPro: 3.265 ± 0.076
1.124SerGln: 1.124 ± 0.032
4.189SerArg: 4.189 ± 0.071
3.605SerSer: 3.605 ± 0.101
3.936SerThr: 3.936 ± 0.074
4.895SerVal: 4.895 ± 0.078
0.937SerTrp: 0.937 ± 0.029
0.998SerTyr: 0.998 ± 0.034
0.0SerXaa: 0.0 ± 0.0
Thr
8.373ThrAla: 8.373 ± 0.135
0.546ThrCys: 0.546 ± 0.027
3.845ThrAsp: 3.845 ± 0.059
2.876ThrGlu: 2.876 ± 0.056
1.782ThrPhe: 1.782 ± 0.044
6.666ThrGly: 6.666 ± 0.103
1.216ThrHis: 1.216 ± 0.034
1.82ThrIle: 1.82 ± 0.046
1.157ThrLys: 1.157 ± 0.039
5.956ThrLeu: 5.956 ± 0.095
1.024ThrMet: 1.024 ± 0.03
1.0ThrAsn: 1.0 ± 0.038
4.333ThrPro: 4.333 ± 0.083
1.267ThrGln: 1.267 ± 0.048
4.547ThrArg: 4.547 ± 0.066
3.903ThrSer: 3.903 ± 0.083
4.655ThrThr: 4.655 ± 0.095
6.684ThrVal: 6.684 ± 0.11
1.084ThrTrp: 1.084 ± 0.036
1.272ThrTyr: 1.272 ± 0.052
0.0ThrXaa: 0.0 ± 0.0
Val
14.105ValAla: 14.105 ± 0.137
0.718ValCys: 0.718 ± 0.026
6.555ValAsp: 6.555 ± 0.086
5.926ValGlu: 5.926 ± 0.079
2.405ValPhe: 2.405 ± 0.059
8.947ValGly: 8.947 ± 0.106
2.268ValHis: 2.268 ± 0.05
2.664ValIle: 2.664 ± 0.061
1.51ValLys: 1.51 ± 0.04
11.712ValLeu: 11.712 ± 0.172
1.454ValMet: 1.454 ± 0.043
1.535ValAsn: 1.535 ± 0.041
5.695ValPro: 5.695 ± 0.081
2.093ValGln: 2.093 ± 0.046
8.008ValArg: 8.008 ± 0.1
4.964ValSer: 4.964 ± 0.075
6.893ValThr: 6.893 ± 0.125
12.742ValVal: 12.742 ± 0.149
1.256ValTrp: 1.256 ± 0.037
1.342ValTyr: 1.342 ± 0.034
0.0ValXaa: 0.0 ± 0.0
Trp
1.801TrpAla: 1.801 ± 0.049
0.174TrpCys: 0.174 ± 0.015
0.89TrpAsp: 0.89 ± 0.031
0.663TrpGlu: 0.663 ± 0.025
0.585TrpPhe: 0.585 ± 0.025
1.158TrpGly: 1.158 ± 0.036
0.381TrpHis: 0.381 ± 0.02
0.331TrpIle: 0.331 ± 0.018
0.251TrpLys: 0.251 ± 0.018
1.812TrpLeu: 1.812 ± 0.054
0.324TrpMet: 0.324 ± 0.018
0.351TrpAsn: 0.351 ± 0.021
0.833TrpPro: 0.833 ± 0.032
0.488TrpGln: 0.488 ± 0.023
1.389TrpArg: 1.389 ± 0.04
1.057TrpSer: 1.057 ± 0.039
1.025TrpThr: 1.025 ± 0.035
1.624TrpVal: 1.624 ± 0.042
0.45TrpTrp: 0.45 ± 0.021
0.319TrpTyr: 0.319 ± 0.019
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.176TyrAla: 2.176 ± 0.052
0.142TyrCys: 0.142 ± 0.012
1.265TyrAsp: 1.265 ± 0.041
0.926TyrGlu: 0.926 ± 0.032
0.501TyrPhe: 0.501 ± 0.023
1.731TyrGly: 1.731 ± 0.047
0.314TyrHis: 0.314 ± 0.016
0.346TyrIle: 0.346 ± 0.019
0.29TyrLys: 0.29 ± 0.017
1.927TyrLeu: 1.927 ± 0.048
0.171TyrMet: 0.171 ± 0.012
0.294TyrAsn: 0.294 ± 0.018
0.924TyrPro: 0.924 ± 0.031
0.428TyrGln: 0.428 ± 0.02
1.488TyrArg: 1.488 ± 0.041
0.873TyrSer: 0.873 ± 0.03
1.011TyrThr: 1.011 ± 0.043
1.718TyrVal: 1.718 ± 0.042
0.265TyrTrp: 0.265 ± 0.017
0.355TyrTyr: 0.355 ± 0.022
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3383 proteins (1002685 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski