Amino acid dipepetide frequency for Halapricum salinum

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	12.123AlaAla: 12.123 ± 0.165	0.675AlaCys: 0.675 ± 0.029	9.051AlaAsp: 9.051 ± 0.111	8.296AlaGlu: 8.296 ± 0.121	3.69AlaPhe: 3.69 ± 0.067	9.167AlaGly: 9.167 ± 0.116	1.778AlaHis: 1.778 ± 0.04	5.192AlaIle: 5.192 ± 0.077	1.765AlaLys: 1.765 ± 0.045	9.83AlaLeu: 9.83 ± 0.121	2.115AlaMet: 2.115 ± 0.053	2.308AlaAsn: 2.308 ± 0.049	3.598AlaPro: 3.598 ± 0.076	2.481AlaGln: 2.481 ± 0.049	5.934AlaArg: 5.934 ± 0.091	5.64AlaSer: 5.64 ± 0.092	6.935AlaThr: 6.935 ± 0.094	9.774AlaVal: 9.774 ± 0.131	1.121AlaTrp: 1.121 ± 0.039	2.593AlaTyr: 2.593 ± 0.058	0.0AlaXaa: 0.0 ± 0.0
Cys	0.526CysAla: 0.526 ± 0.027	0.077CysCys: 0.077 ± 0.008	0.503CysAsp: 0.503 ± 0.024	0.596CysGlu: 0.596 ± 0.023	0.195CysPhe: 0.195 ± 0.013	0.827CysGly: 0.827 ± 0.032	0.16CysHis: 0.16 ± 0.014	0.26CysIle: 0.26 ± 0.016	0.122CysLys: 0.122 ± 0.011	0.57CysLeu: 0.57 ± 0.023	0.134CysMet: 0.134 ± 0.012	0.174CysAsn: 0.174 ± 0.013	0.518CysPro: 0.518 ± 0.026	0.196CysGln: 0.196 ± 0.013	0.464CysArg: 0.464 ± 0.023	0.434CysSer: 0.434 ± 0.02	0.398CysThr: 0.398 ± 0.02	0.477CysVal: 0.477 ± 0.022	0.102CysTrp: 0.102 ± 0.01	0.221CysTyr: 0.221 ± 0.016	0.0CysXaa: 0.0 ± 0.0
Asp	9.345AspAla: 9.345 ± 0.109	0.638AspCys: 0.638 ± 0.027	7.378AspAsp: 7.378 ± 0.104	7.331AspGlu: 7.331 ± 0.097	2.282AspPhe: 2.282 ± 0.054	7.875AspGly: 7.875 ± 0.128	1.834AspHis: 1.834 ± 0.043	3.272AspIle: 3.272 ± 0.068	0.977AspLys: 0.977 ± 0.032	7.349AspLeu: 7.349 ± 0.103	1.162AspMet: 1.162 ± 0.03	1.452AspAsn: 1.452 ± 0.046	4.854AspPro: 4.854 ± 0.09	2.084AspGln: 2.084 ± 0.049	6.324AspArg: 6.324 ± 0.094	4.381AspSer: 4.381 ± 0.084	4.294AspThr: 4.294 ± 0.078	7.743AspVal: 7.743 ± 0.108	0.985AspTrp: 0.985 ± 0.031	2.03AspTyr: 2.03 ± 0.051	0.0AspXaa: 0.0 ± 0.0
Glu	8.346GluAla: 8.346 ± 0.119	0.554GluCys: 0.554 ± 0.027	6.343GluAsp: 6.343 ± 0.095	6.46GluGlu: 6.46 ± 0.112	2.786GluPhe: 2.786 ± 0.052	5.401GluGly: 5.401 ± 0.081	2.135GluHis: 2.135 ± 0.048	4.365GluIle: 4.365 ± 0.078	1.937GluLys: 1.937 ± 0.052	6.976GluLeu: 6.976 ± 0.103	1.913GluMet: 1.913 ± 0.047	2.299GluAsn: 2.299 ± 0.051	3.84GluPro: 3.84 ± 0.065	3.497GluGln: 3.497 ± 0.07	7.236GluArg: 7.236 ± 0.109	5.538GluSer: 5.538 ± 0.079	7.034GluThr: 7.034 ± 0.089	5.687GluVal: 5.687 ± 0.076	1.166GluTrp: 1.166 ± 0.037	2.63GluTyr: 2.63 ± 0.052	0.0GluXaa: 0.0 ± 0.0
Phe	3.454PheAla: 3.454 ± 0.058	0.267PheCys: 0.267 ± 0.016	3.348PheAsp: 3.348 ± 0.057	3.662PheGlu: 3.662 ± 0.061	1.038PhePhe: 1.038 ± 0.037	3.289PheGly: 3.289 ± 0.063	0.613PheHis: 0.613 ± 0.026	0.925PheIle: 0.925 ± 0.033	0.47PheLys: 0.47 ± 0.022	2.774PheLeu: 2.774 ± 0.06	0.512PheMet: 0.512 ± 0.022	0.675PheAsn: 0.675 ± 0.023	1.294PhePro: 1.294 ± 0.038	0.933PheGln: 0.933 ± 0.033	1.769PheArg: 1.769 ± 0.037	1.697PheSer: 1.697 ± 0.045	1.84PheThr: 1.84 ± 0.053	3.402PheVal: 3.402 ± 0.075	0.38PheTrp: 0.38 ± 0.022	0.897PheTyr: 0.897 ± 0.035	0.0PheXaa: 0.0 ± 0.0
Gly	7.491GlyAla: 7.491 ± 0.107	0.7GlyCys: 0.7 ± 0.024	6.387GlyAsp: 6.387 ± 0.09	7.132GlyGlu: 7.132 ± 0.09	3.174GlyPhe: 3.174 ± 0.059	7.554GlyGly: 7.554 ± 0.149	1.735GlyHis: 1.735 ± 0.037	4.193GlyIle: 4.193 ± 0.059	1.796GlyLys: 1.796 ± 0.044	7.386GlyLeu: 7.386 ± 0.108	1.657GlyMet: 1.657 ± 0.043	2.046GlyAsn: 2.046 ± 0.07	3.461GlyPro: 3.461 ± 0.073	2.449GlyGln: 2.449 ± 0.066	4.651GlyArg: 4.651 ± 0.075	5.346GlySer: 5.346 ± 0.085	5.77GlyThr: 5.77 ± 0.097	7.474GlyVal: 7.474 ± 0.111	1.15GlyTrp: 1.15 ± 0.034	2.558GlyTyr: 2.558 ± 0.06	0.0GlyXaa: 0.0 ± 0.0
His	1.979HisAla: 1.979 ± 0.043	0.215HisCys: 0.215 ± 0.015	1.814HisAsp: 1.814 ± 0.041	1.683HisGlu: 1.683 ± 0.038	0.608HisPhe: 0.608 ± 0.026	1.848HisGly: 1.848 ± 0.047	0.548HisHis: 0.548 ± 0.021	0.671HisIle: 0.671 ± 0.026	0.286HisLys: 0.286 ± 0.016	1.649HisLeu: 1.649 ± 0.039	0.262HisMet: 0.262 ± 0.017	0.482HisAsn: 0.482 ± 0.02	1.167HisPro: 1.167 ± 0.037	0.518HisGln: 0.518 ± 0.025	1.309HisArg: 1.309 ± 0.042	0.876HisSer: 0.876 ± 0.033	1.124HisThr: 1.124 ± 0.035	1.94HisVal: 1.94 ± 0.041	0.272HisTrp: 0.272 ± 0.019	0.627HisTyr: 0.627 ± 0.027	0.0HisXaa: 0.0 ± 0.0
Ile	4.913IleAla: 4.913 ± 0.08	0.269IleCys: 0.269 ± 0.017	4.344IleAsp: 4.344 ± 0.062	4.872IleGlu: 4.872 ± 0.083	1.081IlePhe: 1.081 ± 0.035	3.806IleGly: 3.806 ± 0.066	0.845IleHis: 0.845 ± 0.025	1.284IleIle: 1.284 ± 0.04	0.756IleLys: 0.756 ± 0.031	3.098IleLeu: 3.098 ± 0.069	0.502IleMet: 0.502 ± 0.022	0.985IleAsn: 0.985 ± 0.033	2.182IlePro: 2.182 ± 0.051	1.173IleGln: 1.173 ± 0.036	2.629IleArg: 2.629 ± 0.053	2.169IleSer: 2.169 ± 0.052	2.52IleThr: 2.52 ± 0.055	4.075IleVal: 4.075 ± 0.067	0.371IleTrp: 0.371 ± 0.021	1.003IleTyr: 1.003 ± 0.031	0.0IleXaa: 0.0 ± 0.0
Lys	1.719LysAla: 1.719 ± 0.051	0.124LysCys: 0.124 ± 0.012	1.163LysAsp: 1.163 ± 0.037	1.294LysGlu: 1.294 ± 0.043	0.545LysPhe: 0.545 ± 0.023	1.305LysGly: 1.305 ± 0.038	0.477LysHis: 0.477 ± 0.025	0.912LysIle: 0.912 ± 0.035	0.499LysLys: 0.499 ± 0.026	1.706LysLeu: 1.706 ± 0.04	0.372LysMet: 0.372 ± 0.02	0.596LysAsn: 0.596 ± 0.029	0.924LysPro: 0.924 ± 0.031	0.772LysGln: 0.772 ± 0.03	1.604LysArg: 1.604 ± 0.04	1.119LysSer: 1.119 ± 0.034	1.275LysThr: 1.275 ± 0.038	1.227LysVal: 1.227 ± 0.029	0.224LysTrp: 0.224 ± 0.014	0.605LysTyr: 0.605 ± 0.026	0.0LysXaa: 0.0 ± 0.0
Leu	10.815LeuAla: 10.815 ± 0.138	0.542LeuCys: 0.542 ± 0.024	8.162LeuAsp: 8.162 ± 0.112	7.023LeuGlu: 7.023 ± 0.11	3.148LeuPhe: 3.148 ± 0.066	7.609LeuGly: 7.609 ± 0.106	1.4LeuHis: 1.4 ± 0.037	2.855LeuIle: 2.855 ± 0.062	1.592LeuLys: 1.592 ± 0.041	8.825LeuLeu: 8.825 ± 0.139	1.212LeuMet: 1.212 ± 0.039	1.831LeuAsn: 1.831 ± 0.043	4.022LeuPro: 4.022 ± 0.071	2.481LeuGln: 2.481 ± 0.052	5.264LeuArg: 5.264 ± 0.085	5.745LeuSer: 5.745 ± 0.085	5.578LeuThr: 5.578 ± 0.083	8.371LeuVal: 8.371 ± 0.127	0.945LeuTrp: 0.945 ± 0.034	2.318LeuTyr: 2.318 ± 0.052	0.0LeuXaa: 0.0 ± 0.0
Met	1.899MetAla: 1.899 ± 0.043	0.106MetCys: 0.106 ± 0.009	1.373MetAsp: 1.373 ± 0.038	1.081MetGlu: 1.081 ± 0.038	0.467MetPhe: 0.467 ± 0.019	1.388MetGly: 1.388 ± 0.04	0.344MetHis: 0.344 ± 0.02	0.69MetIle: 0.69 ± 0.026	0.407MetLys: 0.407 ± 0.021	1.505MetLeu: 1.505 ± 0.041	0.279MetMet: 0.279 ± 0.021	0.598MetAsn: 0.598 ± 0.025	0.798MetPro: 0.798 ± 0.03	0.536MetGln: 0.536 ± 0.022	1.062MetArg: 1.062 ± 0.037	1.402MetSer: 1.402 ± 0.038	1.417MetThr: 1.417 ± 0.041	1.265MetVal: 1.265 ± 0.036	0.16MetTrp: 0.16 ± 0.011	0.364MetTyr: 0.364 ± 0.018	0.0MetXaa: 0.0 ± 0.0
Asn	2.467AsnAla: 2.467 ± 0.053	0.222AsnCys: 0.222 ± 0.015	1.652AsnAsp: 1.652 ± 0.045	1.742AsnGlu: 1.742 ± 0.049	0.712AsnPhe: 0.712 ± 0.025	2.087AsnGly: 2.087 ± 0.057	0.571AsnHis: 0.571 ± 0.026	0.927AsnIle: 0.927 ± 0.032	0.487AsnLys: 0.487 ± 0.025	2.004AsnLeu: 2.004 ± 0.042	0.42AsnMet: 0.42 ± 0.02	0.618AsnAsn: 0.618 ± 0.03	1.458AsnPro: 1.458 ± 0.041	0.674AsnGln: 0.674 ± 0.031	1.592AsnArg: 1.592 ± 0.04	1.134AsnSer: 1.134 ± 0.041	1.392AsnThr: 1.392 ± 0.049	2.313AsnVal: 2.313 ± 0.046	0.324AsnTrp: 0.324 ± 0.018	0.755AsnTyr: 0.755 ± 0.029	0.0AsnXaa: 0.0 ± 0.0
Pro	4.39ProAla: 4.39 ± 0.077	0.243ProCys: 0.243 ± 0.016	4.626ProAsp: 4.626 ± 0.084	4.937ProGlu: 4.937 ± 0.072	1.499ProPhe: 1.499 ± 0.043	3.753ProGly: 3.753 ± 0.069	0.852ProHis: 0.852 ± 0.03	2.118ProIle: 2.118 ± 0.046	0.87ProLys: 0.87 ± 0.028	3.79ProLeu: 3.79 ± 0.063	0.792ProMet: 0.792 ± 0.027	1.172ProAsn: 1.172 ± 0.036	2.26ProPro: 2.26 ± 0.049	1.19ProGln: 1.19 ± 0.033	2.326ProArg: 2.326 ± 0.051	2.621ProSer: 2.621 ± 0.052	3.15ProThr: 3.15 ± 0.063	3.857ProVal: 3.857 ± 0.06	0.552ProTrp: 0.552 ± 0.022	1.157ProTyr: 1.157 ± 0.035	0.0ProXaa: 0.0 ± 0.0
Gln	2.904GlnAla: 2.904 ± 0.056	0.199GlnCys: 0.199 ± 0.015	1.56GlnAsp: 1.56 ± 0.04	1.931GlnGlu: 1.931 ± 0.047	1.244GlnPhe: 1.244 ± 0.035	1.881GlnGly: 1.881 ± 0.048	0.62GlnHis: 0.62 ± 0.024	1.358GlnIle: 1.358 ± 0.041	0.674GlnLys: 0.674 ± 0.029	2.619GlnLeu: 2.619 ± 0.051	0.527GlnMet: 0.527 ± 0.026	0.859GlnAsn: 0.859 ± 0.03	1.392GlnPro: 1.392 ± 0.04	1.386GlnGln: 1.386 ± 0.053	2.424GlnArg: 2.424 ± 0.054	1.937GlnSer: 1.937 ± 0.045	2.074GlnThr: 2.074 ± 0.048	2.078GlnVal: 2.078 ± 0.044	0.461GlnTrp: 0.461 ± 0.023	0.917GlnTyr: 0.917 ± 0.027	0.0GlnXaa: 0.0 ± 0.0
Arg	6.141ArgAla: 6.141 ± 0.098	0.455ArgCys: 0.455 ± 0.023	4.826ArgAsp: 4.826 ± 0.078	6.856ArgGlu: 6.856 ± 0.1	2.279ArgPhe: 2.279 ± 0.04	4.218ArgGly: 4.218 ± 0.071	1.19ArgHis: 1.19 ± 0.042	2.953ArgIle: 2.953 ± 0.06	1.431ArgLys: 1.431 ± 0.037	6.351ArgLeu: 6.351 ± 0.089	1.234ArgMet: 1.234 ± 0.038	1.598ArgAsn: 1.598 ± 0.039	2.509ArgPro: 2.509 ± 0.057	2.151ArgGln: 2.151 ± 0.051	4.604ArgArg: 4.604 ± 0.088	3.565ArgSer: 3.565 ± 0.061	3.8ArgThr: 3.8 ± 0.065	4.933ArgVal: 4.933 ± 0.077	0.879ArgTrp: 0.879 ± 0.03	1.993ArgTyr: 1.993 ± 0.047	0.0ArgXaa: 0.0 ± 0.0
Ser	5.368SerAla: 5.368 ± 0.078	0.319SerCys: 0.319 ± 0.017	4.539SerAsp: 4.539 ± 0.076	4.749SerGlu: 4.749 ± 0.08	1.862SerPhe: 1.862 ± 0.043	5.677SerGly: 5.677 ± 0.091	1.038SerHis: 1.038 ± 0.038	2.857SerIle: 2.857 ± 0.059	1.254SerLys: 1.254 ± 0.035	4.999SerLeu: 4.999 ± 0.076	1.124SerMet: 1.124 ± 0.033	1.436SerAsn: 1.436 ± 0.044	2.542SerPro: 2.542 ± 0.049	1.597SerGln: 1.597 ± 0.043	3.346SerArg: 3.346 ± 0.061	3.138SerSer: 3.138 ± 0.067	3.752SerThr: 3.752 ± 0.069	5.187SerVal: 5.187 ± 0.07	0.668SerTrp: 0.668 ± 0.026	1.547SerTyr: 1.547 ± 0.049	0.0SerXaa: 0.0 ± 0.0
Thr	6.776ThrAla: 6.776 ± 0.092	0.362ThrCys: 0.362 ± 0.022	5.707ThrAsp: 5.707 ± 0.103	4.554ThrGlu: 4.554 ± 0.072	2.208ThrPhe: 2.208 ± 0.046	5.62ThrGly: 5.62 ± 0.093	1.184ThrHis: 1.184 ± 0.035	3.464ThrIle: 3.464 ± 0.061	1.049ThrLys: 1.049 ± 0.034	6.068ThrLeu: 6.068 ± 0.09	1.061ThrMet: 1.061 ± 0.03	1.537ThrAsn: 1.537 ± 0.047	3.407ThrPro: 3.407 ± 0.062	1.557ThrGln: 1.557 ± 0.046	3.383ThrArg: 3.383 ± 0.059	3.137ThrSer: 3.137 ± 0.059	4.467ThrThr: 4.467 ± 0.093	7.265ThrVal: 7.265 ± 0.124	0.708ThrTrp: 0.708 ± 0.027	1.907ThrTyr: 1.907 ± 0.059	0.0ThrXaa: 0.0 ± 0.0
Val	9.799ValAla: 9.799 ± 0.132	0.644ValCys: 0.644 ± 0.025	7.341ValAsp: 7.341 ± 0.094	8.573ValGlu: 8.573 ± 0.107	3.081ValPhe: 3.081 ± 0.067	7.586ValGly: 7.586 ± 0.102	1.638ValHis: 1.638 ± 0.041	3.261ValIle: 3.261 ± 0.068	1.347ValLys: 1.347 ± 0.038	8.292ValLeu: 8.292 ± 0.13	1.287ValMet: 1.287 ± 0.037	1.804ValAsn: 1.804 ± 0.049	4.139ValPro: 4.139 ± 0.072	2.081ValGln: 2.081 ± 0.046	5.124ValArg: 5.124 ± 0.081	5.148ValSer: 5.148 ± 0.082	6.181ValThr: 6.181 ± 0.098	8.84ValVal: 8.84 ± 0.139	0.874ValTrp: 0.874 ± 0.027	2.18ValTyr: 2.18 ± 0.049	0.0ValXaa: 0.0 ± 0.0
Trp	1.006TrpAla: 1.006 ± 0.034	0.087TrpCys: 0.087 ± 0.01	0.84TrpAsp: 0.84 ± 0.036	0.848TrpGlu: 0.848 ± 0.028	0.448TrpPhe: 0.448 ± 0.025	0.82TrpGly: 0.82 ± 0.031	0.244TrpHis: 0.244 ± 0.016	0.584TrpIle: 0.584 ± 0.024	0.294TrpLys: 0.294 ± 0.015	1.297TrpLeu: 1.297 ± 0.041	0.216TrpMet: 0.216 ± 0.015	0.399TrpAsn: 0.399 ± 0.021	0.466TrpPro: 0.466 ± 0.022	0.462TrpGln: 0.462 ± 0.022	0.879TrpArg: 0.879 ± 0.032	0.677TrpSer: 0.677 ± 0.03	0.842TrpThr: 0.842 ± 0.033	0.885TrpVal: 0.885 ± 0.033	0.226TrpTrp: 0.226 ± 0.018	0.391TrpTyr: 0.391 ± 0.02	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.605TyrAla: 2.605 ± 0.06	0.253TyrCys: 0.253 ± 0.016	2.635TyrAsp: 2.635 ± 0.053	2.525TyrGlu: 2.525 ± 0.046	0.893TyrPhe: 0.893 ± 0.03	2.395TyrGly: 2.395 ± 0.055	0.672TyrHis: 0.672 ± 0.029	0.737TyrIle: 0.737 ± 0.029	0.453TyrLys: 0.453 ± 0.023	2.649TyrLeu: 2.649 ± 0.063	0.356TyrMet: 0.356 ± 0.018	0.683TyrAsn: 0.683 ± 0.029	1.324TyrPro: 1.324 ± 0.034	0.825TyrGln: 0.825 ± 0.029	2.04TyrArg: 2.04 ± 0.043	1.299TyrSer: 1.299 ± 0.035	1.577TyrThr: 1.577 ± 0.051	2.429TyrVal: 2.429 ± 0.052	0.342TyrTrp: 0.342 ± 0.018	0.838TyrTyr: 0.838 ± 0.028	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3303 proteins (1007341 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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