Amino acid dipepetide frequency for Plasmodium falciparum Tanzania (2000708)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	0.972AlaAla: 0.972 ± 0.031	0.595AlaCys: 0.595 ± 0.018	1.137AlaAsp: 1.137 ± 0.023	1.261AlaGlu: 1.261 ± 0.027	0.971AlaPhe: 0.971 ± 0.015	0.791AlaGly: 0.791 ± 0.018	0.578AlaHis: 0.578 ± 0.014	1.636AlaIle: 1.636 ± 0.026	1.883AlaLys: 1.883 ± 0.035	1.955AlaLeu: 1.955 ± 0.026	0.392AlaMet: 0.392 ± 0.011	1.617AlaAsn: 1.617 ± 0.023	0.65AlaPro: 0.65 ± 0.02	0.731AlaGln: 0.731 ± 0.014	0.625AlaArg: 0.625 ± 0.017	1.526AlaSer: 1.526 ± 0.024	1.049AlaThr: 1.049 ± 0.022	0.874AlaVal: 0.874 ± 0.018	0.143AlaTrp: 0.143 ± 0.005	1.11AlaTyr: 1.11 ± 0.02	0.0AlaXaa: 0.0 ± 0.0
Cys	0.612CysAla: 0.612 ± 0.015	0.318CysCys: 0.318 ± 0.01	1.315CysAsp: 1.315 ± 0.021	1.181CysGlu: 1.181 ± 0.018	0.862CysPhe: 0.862 ± 0.017	0.801CysGly: 0.801 ± 0.02	0.332CysHis: 0.332 ± 0.009	1.829CysIle: 1.829 ± 0.022	1.823CysLys: 1.823 ± 0.033	1.578CysLeu: 1.578 ± 0.022	0.405CysMet: 0.405 ± 0.01	1.961CysAsn: 1.961 ± 0.025	0.519CysPro: 0.519 ± 0.014	0.394CysGln: 0.394 ± 0.011	0.597CysArg: 0.597 ± 0.018	1.506CysSer: 1.506 ± 0.024	1.066CysThr: 1.066 ± 0.023	0.935CysVal: 0.935 ± 0.017	0.073CysTrp: 0.073 ± 0.004	0.862CysTyr: 0.862 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	1.308AspAla: 1.308 ± 0.026	0.794AspCys: 0.794 ± 0.019	6.456AspAsp: 6.456 ± 0.092	5.682AspGlu: 5.682 ± 0.052	2.201AspPhe: 2.201 ± 0.025	1.797AspGly: 1.797 ± 0.033	1.42AspHis: 1.42 ± 0.026	7.266AspIle: 7.266 ± 0.055	6.712AspLys: 6.712 ± 0.052	3.82AspLeu: 3.82 ± 0.032	1.659AspMet: 1.659 ± 0.02	8.546AspAsn: 8.546 ± 0.081	1.038AspPro: 1.038 ± 0.019	1.435AspGln: 1.435 ± 0.022	1.188AspArg: 1.188 ± 0.021	3.161AspSer: 3.161 ± 0.035	2.726AspThr: 2.726 ± 0.029	2.839AspVal: 2.839 ± 0.04	0.262AspTrp: 0.262 ± 0.009	2.876AspTyr: 2.876 ± 0.03	0.0AspXaa: 0.0 ± 0.0
Glu	1.55GluAla: 1.55 ± 0.031	1.176GluCys: 1.176 ± 0.02	4.692GluAsp: 4.692 ± 0.053	7.77GluGlu: 7.77 ± 0.082	2.083GluPhe: 2.083 ± 0.029	2.08GluGly: 2.08 ± 0.037	1.812GluHis: 1.812 ± 0.025	5.252GluIle: 5.252 ± 0.044	10.64GluLys: 10.64 ± 0.068	4.531GluLeu: 4.531 ± 0.044	1.343GluMet: 1.343 ± 0.021	8.89GluAsn: 8.89 ± 0.058	1.011GluPro: 1.011 ± 0.019	2.639GluGln: 2.639 ± 0.035	2.074GluArg: 2.074 ± 0.029	3.27GluSer: 3.27 ± 0.032	2.486GluThr: 2.486 ± 0.03	2.016GluVal: 2.016 ± 0.026	0.604GluTrp: 0.604 ± 0.022	3.684GluTyr: 3.684 ± 0.034	0.0GluXaa: 0.0 ± 0.0
Phe	0.865PheAla: 0.865 ± 0.016	1.072PheCys: 1.072 ± 0.016	2.471PheAsp: 2.471 ± 0.022	2.37PheGlu: 2.37 ± 0.027	3.516PhePhe: 3.516 ± 0.05	1.169PheGly: 1.169 ± 0.021	1.135PheHis: 1.135 ± 0.017	4.346PheIle: 4.346 ± 0.051	3.793PheLys: 3.793 ± 0.033	5.227PheLeu: 5.227 ± 0.048	0.919PheMet: 0.919 ± 0.016	4.338PheAsn: 4.338 ± 0.039	1.002PhePro: 1.002 ± 0.018	1.143PheGln: 1.143 ± 0.016	1.025PheArg: 1.025 ± 0.016	3.287PheSer: 3.287 ± 0.032	1.594PheThr: 1.594 ± 0.02	1.995PheVal: 1.995 ± 0.025	0.221PheTrp: 0.221 ± 0.007	2.992PheTyr: 2.992 ± 0.032	0.0PheXaa: 0.0 ± 0.0
Gly	0.894GlyAla: 0.894 ± 0.021	0.567GlyCys: 0.567 ± 0.012	2.229GlyAsp: 2.229 ± 0.043	1.982GlyGlu: 1.982 ± 0.033	1.098GlyPhe: 1.098 ± 0.019	1.699GlyGly: 1.699 ± 0.044	0.632GlyHis: 0.632 ± 0.014	2.399GlyIle: 2.399 ± 0.03	3.28GlyLys: 3.28 ± 0.045	1.962GlyLeu: 1.962 ± 0.027	0.618GlyMet: 0.618 ± 0.014	3.102GlyAsn: 3.102 ± 0.038	0.574GlyPro: 0.574 ± 0.016	0.719GlyGln: 0.719 ± 0.016	0.947GlyArg: 0.947 ± 0.022	2.05GlySer: 2.05 ± 0.033	1.587GlyThr: 1.587 ± 0.031	1.348GlyVal: 1.348 ± 0.021	0.187GlyTrp: 0.187 ± 0.007	1.515GlyTyr: 1.515 ± 0.023	0.0GlyXaa: 0.0 ± 0.0
His	0.466HisAla: 0.466 ± 0.01	0.323HisCys: 0.323 ± 0.01	1.358HisAsp: 1.358 ± 0.022	1.321HisGlu: 1.321 ± 0.019	1.35HisPhe: 1.35 ± 0.019	0.612HisGly: 0.612 ± 0.014	0.72HisHis: 0.72 ± 0.019	2.919HisIle: 2.919 ± 0.035	2.268HisLys: 2.268 ± 0.029	1.909HisLeu: 1.909 ± 0.023	0.845HisMet: 0.845 ± 0.016	3.279HisAsn: 3.279 ± 0.041	0.552HisPro: 0.552 ± 0.014	0.533HisGln: 0.533 ± 0.012	0.523HisArg: 0.523 ± 0.012	1.388HisSer: 1.388 ± 0.022	1.162HisThr: 1.162 ± 0.016	1.154HisVal: 1.154 ± 0.03	0.097HisTrp: 0.097 ± 0.005	1.085HisTyr: 1.085 ± 0.018	0.0HisXaa: 0.0 ± 0.0
Ile	1.473IleAla: 1.473 ± 0.02	2.107IleCys: 2.107 ± 0.025	4.813IleAsp: 4.813 ± 0.047	5.093IleGlu: 5.093 ± 0.043	4.864IlePhe: 4.864 ± 0.051	2.217IleGly: 2.217 ± 0.026	2.608IleHis: 2.608 ± 0.026	8.474IleIle: 8.474 ± 0.081	10.746IleLys: 10.746 ± 0.083	8.399IleLeu: 8.399 ± 0.073	1.661IleMet: 1.661 ± 0.021	12.638IleAsn: 12.638 ± 0.117	2.362IlePro: 2.362 ± 0.026	2.943IleGln: 2.943 ± 0.034	2.325IleArg: 2.325 ± 0.025	6.125IleSer: 6.125 ± 0.047	3.503IleThr: 3.503 ± 0.033	2.85IleVal: 2.85 ± 0.027	0.539IleTrp: 0.539 ± 0.013	6.494IleTyr: 6.494 ± 0.062	0.0IleXaa: 0.0 ± 0.0
Lys	1.923LysAla: 1.923 ± 0.032	2.244LysCys: 2.244 ± 0.03	7.011LysAsp: 7.011 ± 0.055	10.131LysGlu: 10.131 ± 0.071	3.237LysPhe: 3.237 ± 0.029	3.55LysGly: 3.55 ± 0.036	2.403LysHis: 2.403 ± 0.028	9.644LysIle: 9.644 ± 0.069	19.831LysLys: 19.831 ± 0.149	7.547LysLeu: 7.547 ± 0.058	2.565LysMet: 2.565 ± 0.03	16.863LysAsn: 16.863 ± 0.106	1.567LysPro: 1.567 ± 0.027	3.229LysGln: 3.229 ± 0.036	4.279LysArg: 4.279 ± 0.036	6.162LysSer: 6.162 ± 0.042	4.33LysThr: 4.33 ± 0.04	3.365LysVal: 3.365 ± 0.034	0.698LysTrp: 0.698 ± 0.018	7.128LysTyr: 7.128 ± 0.055	0.0LysXaa: 0.0 ± 0.0
Leu	1.573LeuAla: 1.573 ± 0.024	1.89LeuCys: 1.89 ± 0.028	3.604LeuAsp: 3.604 ± 0.035	4.492LeuGlu: 4.492 ± 0.045	4.539LeuPhe: 4.539 ± 0.051	2.026LeuGly: 2.026 ± 0.027	1.873LeuHis: 1.873 ± 0.025	6.276LeuIle: 6.276 ± 0.062	9.244LeuLys: 9.244 ± 0.064	7.602LeuLeu: 7.602 ± 0.061	1.303LeuMet: 1.303 ± 0.022	8.828LeuAsn: 8.828 ± 0.068	1.829LeuPro: 1.829 ± 0.026	2.442LeuGln: 2.442 ± 0.024	2.429LeuArg: 2.429 ± 0.03	5.614LeuSer: 5.614 ± 0.047	2.924LeuThr: 2.924 ± 0.028	2.343LeuVal: 2.343 ± 0.031	0.505LeuTrp: 0.505 ± 0.012	5.083LeuTyr: 5.083 ± 0.049	0.0LeuXaa: 0.0 ± 0.0
Met	0.392MetAla: 0.392 ± 0.011	0.469MetCys: 0.469 ± 0.012	1.517MetAsp: 1.517 ± 0.023	1.48MetGlu: 1.48 ± 0.022	0.921MetPhe: 0.921 ± 0.014	0.586MetGly: 0.586 ± 0.018	0.44MetHis: 0.44 ± 0.012	1.562MetIle: 1.562 ± 0.021	2.862MetLys: 2.862 ± 0.033	1.705MetLeu: 1.705 ± 0.021	0.498MetMet: 0.498 ± 0.014	3.83MetAsn: 3.83 ± 0.065	0.403MetPro: 0.403 ± 0.01	0.532MetGln: 0.532 ± 0.013	0.543MetArg: 0.543 ± 0.013	1.366MetSer: 1.366 ± 0.021	0.686MetThr: 0.686 ± 0.013	0.687MetVal: 0.687 ± 0.014	0.131MetTrp: 0.131 ± 0.006	1.181MetTyr: 1.181 ± 0.021	0.0MetXaa: 0.0 ± 0.0
Asn	1.957AsnAla: 1.957 ± 0.027	1.675AsnCys: 1.675 ± 0.023	9.583AsnAsp: 9.583 ± 0.084	9.321AsnGlu: 9.321 ± 0.08	4.785AsnPhe: 4.785 ± 0.044	3.231AsnGly: 3.231 ± 0.046	2.727AsnHis: 2.727 ± 0.037	15.952AsnIle: 15.952 ± 0.147	15.257AsnLys: 15.257 ± 0.114	7.579AsnLeu: 7.579 ± 0.056	3.918AsnMet: 3.918 ± 0.058	31.466AsnAsn: 31.466 ± 0.455	1.764AsnPro: 1.764 ± 0.025	2.796AsnGln: 2.796 ± 0.04	2.482AsnArg: 2.482 ± 0.028	7.57AsnSer: 7.57 ± 0.075	5.411AsnThr: 5.411 ± 0.05	6.053AsnVal: 6.053 ± 0.05	0.351AsnTrp: 0.351 ± 0.009	7.01AsnTyr: 7.01 ± 0.071	0.0AsnXaa: 0.0 ± 0.0
Pro	0.5ProAla: 0.5 ± 0.016	0.548ProCys: 0.548 ± 0.018	0.868ProAsp: 0.868 ± 0.018	1.119ProGlu: 1.119 ± 0.024	1.227ProPhe: 1.227 ± 0.02	0.583ProGly: 0.583 ± 0.017	0.539ProHis: 0.539 ± 0.012	1.655ProIle: 1.655 ± 0.023	1.738ProLys: 1.738 ± 0.025	1.87ProLeu: 1.87 ± 0.027	0.359ProMet: 0.359 ± 0.01	1.99ProAsn: 1.99 ± 0.028	0.987ProPro: 0.987 ± 0.033	0.777ProGln: 0.777 ± 0.021	0.599ProArg: 0.599 ± 0.016	1.636ProSer: 1.636 ± 0.023	1.052ProThr: 1.052 ± 0.024	0.776ProVal: 0.776 ± 0.016	0.146ProTrp: 0.146 ± 0.007	1.328ProTyr: 1.328 ± 0.021	0.0ProXaa: 0.0 ± 0.0
Gln	0.629GlnAla: 0.629 ± 0.013	0.456GlnCys: 0.456 ± 0.014	1.393GlnAsp: 1.393 ± 0.02	1.993GlnGlu: 1.993 ± 0.026	1.002GlnPhe: 1.002 ± 0.015	0.787GlnGly: 0.787 ± 0.015	0.739GlnHis: 0.739 ± 0.018	2.437GlnIle: 2.437 ± 0.031	3.729GlnLys: 3.729 ± 0.04	1.942GlnLeu: 1.942 ± 0.027	0.707GlnMet: 0.707 ± 0.014	4.186GlnAsn: 4.186 ± 0.05	0.582GlnPro: 0.582 ± 0.015	1.121GlnGln: 1.121 ± 0.039	0.85GlnArg: 0.85 ± 0.014	1.45GlnSer: 1.45 ± 0.022	1.313GlnThr: 1.313 ± 0.021	0.959GlnVal: 0.959 ± 0.015	0.192GlnTrp: 0.192 ± 0.008	1.403GlnTyr: 1.403 ± 0.021	0.0GlnXaa: 0.0 ± 0.0
Arg	0.669ArgAla: 0.669 ± 0.015	0.47ArgCys: 0.47 ± 0.013	1.524ArgAsp: 1.524 ± 0.026	1.798ArgGlu: 1.798 ± 0.025	1.007ArgPhe: 1.007 ± 0.017	1.058ArgGly: 1.058 ± 0.023	0.578ArgHis: 0.578 ± 0.016	2.167ArgIle: 2.167 ± 0.027	3.985ArgLys: 3.985 ± 0.044	1.779ArgLeu: 1.779 ± 0.024	0.537ArgMet: 0.537 ± 0.011	3.407ArgAsn: 3.407 ± 0.035	0.471ArgPro: 0.471 ± 0.013	0.75ArgGln: 0.75 ± 0.018	1.505ArgArg: 1.505 ± 0.029	1.66ArgSer: 1.66 ± 0.025	1.158ArgThr: 1.158 ± 0.018	0.879ArgVal: 0.879 ± 0.016	0.277ArgTrp: 0.277 ± 0.011	1.375ArgTyr: 1.375 ± 0.018	0.0ArgXaa: 0.0 ± 0.0
Ser	1.441SerAla: 1.441 ± 0.023	1.281SerCys: 1.281 ± 0.02	3.924SerAsp: 3.924 ± 0.036	3.454SerGlu: 3.454 ± 0.037	3.574SerPhe: 3.574 ± 0.033	2.192SerGly: 2.192 ± 0.044	1.503SerHis: 1.503 ± 0.03	5.467SerIle: 5.467 ± 0.042	5.661SerLys: 5.661 ± 0.042	5.326SerLeu: 5.326 ± 0.042	1.172SerMet: 1.172 ± 0.019	8.029SerAsn: 8.029 ± 0.077	1.389SerPro: 1.389 ± 0.022	1.629SerGln: 1.629 ± 0.025	1.588SerArg: 1.588 ± 0.023	6.392SerSer: 6.392 ± 0.073	3.106SerThr: 3.106 ± 0.029	2.558SerVal: 2.558 ± 0.03	0.293SerTrp: 0.293 ± 0.01	3.807SerTyr: 3.807 ± 0.038	0.0SerXaa: 0.0 ± 0.0
Thr	0.998ThrAla: 0.998 ± 0.024	1.08ThrCys: 1.08 ± 0.02	2.087ThrAsp: 2.087 ± 0.03	2.123ThrGlu: 2.123 ± 0.033	2.278ThrPhe: 2.278 ± 0.026	1.171ThrGly: 1.171 ± 0.021	1.219ThrHis: 1.219 ± 0.019	3.198ThrIle: 3.198 ± 0.034	4.139ThrLys: 4.139 ± 0.037	3.448ThrLeu: 3.448 ± 0.03	0.688ThrMet: 0.688 ± 0.014	5.632ThrAsn: 5.632 ± 0.057	1.228ThrPro: 1.228 ± 0.027	1.395ThrGln: 1.395 ± 0.02	0.955ThrArg: 0.955 ± 0.014	3.246ThrSer: 3.246 ± 0.032	2.339ThrThr: 2.339 ± 0.036	1.369ThrVal: 1.369 ± 0.022	0.224ThrTrp: 0.224 ± 0.008	2.811ThrTyr: 2.811 ± 0.032	0.0ThrXaa: 0.0 ± 0.0
Val	0.959ValAla: 0.959 ± 0.021	0.897ValCys: 0.897 ± 0.017	2.59ValAsp: 2.59 ± 0.03	2.717ValGlu: 2.717 ± 0.03	1.623ValPhe: 1.623 ± 0.023	1.28ValGly: 1.28 ± 0.022	1.214ValHis: 1.214 ± 0.021	2.992ValIle: 2.992 ± 0.032	3.592ValLys: 3.592 ± 0.035	3.35ValLeu: 3.35 ± 0.034	0.681ValMet: 0.681 ± 0.013	3.924ValAsn: 3.924 ± 0.04	1.131ValPro: 1.131 ± 0.022	1.331ValGln: 1.331 ± 0.02	1.016ValArg: 1.016 ± 0.018	2.606ValSer: 2.606 ± 0.061	1.597ValThr: 1.597 ± 0.019	1.662ValVal: 1.662 ± 0.025	0.261ValTrp: 0.261 ± 0.009	1.948ValTyr: 1.948 ± 0.026	0.0ValXaa: 0.0 ± 0.0
Trp	0.191TrpAla: 0.191 ± 0.008	0.103TrpCys: 0.103 ± 0.005	0.316TrpAsp: 0.316 ± 0.01	0.379TrpGlu: 0.379 ± 0.013	0.289TrpPhe: 0.289 ± 0.009	0.247TrpGly: 0.247 ± 0.009	0.092TrpHis: 0.092 ± 0.005	0.534TrpIle: 0.534 ± 0.015	0.753TrpLys: 0.753 ± 0.02	0.442TrpLeu: 0.442 ± 0.012	0.122TrpMet: 0.122 ± 0.006	0.545TrpAsn: 0.545 ± 0.013	0.099TrpPro: 0.099 ± 0.006	0.109TrpGln: 0.109 ± 0.006	0.193TrpArg: 0.193 ± 0.007	0.326TrpSer: 0.326 ± 0.01	0.218TrpThr: 0.218 ± 0.008	0.257TrpVal: 0.257 ± 0.009	0.145TrpTrp: 0.145 ± 0.008	0.22TrpTyr: 0.22 ± 0.008	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.125TyrAla: 1.125 ± 0.018	0.9TyrCys: 0.9 ± 0.016	4.299TyrAsp: 4.299 ± 0.046	3.937TyrGlu: 3.937 ± 0.035	3.053TyrPhe: 3.053 ± 0.034	1.514TyrGly: 1.514 ± 0.021	1.299TyrHis: 1.299 ± 0.023	6.229TyrIle: 6.229 ± 0.059	5.775TyrLys: 5.775 ± 0.044	4.446TyrLeu: 4.446 ± 0.041	1.4TyrMet: 1.4 ± 0.021	7.815TyrAsn: 7.815 ± 0.074	1.142TyrPro: 1.142 ± 0.02	1.221TyrGln: 1.221 ± 0.02	1.309TyrArg: 1.309 ± 0.023	3.444TyrSer: 3.444 ± 0.036	2.319TyrThr: 2.319 ± 0.033	2.454TyrVal: 2.454 ± 0.026	0.232TyrTrp: 0.232 ± 0.008	3.476TyrTyr: 3.476 ± 0.047	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 6699 proteins (4073403 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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