Amino acid dipepetide frequency for Rubellimicrobium roseum

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
18.853AlaAla: 18.853 ± 0.179
1.114AlaCys: 1.114 ± 0.033
6.604AlaAsp: 6.604 ± 0.072
9.057AlaGlu: 9.057 ± 0.112
4.357AlaPhe: 4.357 ± 0.069
11.685AlaGly: 11.685 ± 0.105
2.361AlaHis: 2.361 ± 0.041
5.488AlaIle: 5.488 ± 0.062
2.699AlaLys: 2.699 ± 0.066
15.757AlaLeu: 15.757 ± 0.138
3.732AlaMet: 3.732 ± 0.058
2.396AlaAsn: 2.396 ± 0.045
6.755AlaPro: 6.755 ± 0.096
4.762AlaGln: 4.762 ± 0.066
11.21AlaArg: 11.21 ± 0.124
5.731AlaSer: 5.731 ± 0.062
6.539AlaThr: 6.539 ± 0.081
9.507AlaVal: 9.507 ± 0.086
1.904AlaTrp: 1.904 ± 0.037
2.398AlaTyr: 2.398 ± 0.043
0.0AlaXaa: 0.0 ± 0.0
Cys
0.998CysAla: 0.998 ± 0.031
0.094CysCys: 0.094 ± 0.009
0.52CysAsp: 0.52 ± 0.02
0.448CysGlu: 0.448 ± 0.017
0.279CysPhe: 0.279 ± 0.015
0.871CysGly: 0.871 ± 0.029
0.231CysHis: 0.231 ± 0.015
0.306CysIle: 0.306 ± 0.014
0.126CysLys: 0.126 ± 0.01
0.837CysLeu: 0.837 ± 0.024
0.124CysMet: 0.124 ± 0.009
0.177CysAsn: 0.177 ± 0.012
0.482CysPro: 0.482 ± 0.02
0.205CysGln: 0.205 ± 0.012
0.626CysArg: 0.626 ± 0.022
0.385CysSer: 0.385 ± 0.017
0.358CysThr: 0.358 ± 0.018
0.533CysVal: 0.533 ± 0.021
0.109CysTrp: 0.109 ± 0.009
0.157CysTyr: 0.157 ± 0.01
0.0CysXaa: 0.0 ± 0.0
Asp
6.925AspAla: 6.925 ± 0.081
0.443AspCys: 0.443 ± 0.018
3.01AspAsp: 3.01 ± 0.077
3.423AspGlu: 3.423 ± 0.056
2.059AspPhe: 2.059 ± 0.042
5.623AspGly: 5.623 ± 0.07
1.23AspHis: 1.23 ± 0.033
2.355AspIle: 2.355 ± 0.047
1.024AspLys: 1.024 ± 0.03
7.14AspLeu: 7.14 ± 0.071
1.267AspMet: 1.267 ± 0.029
0.976AspAsn: 0.976 ± 0.03
4.179AspPro: 4.179 ± 0.053
1.593AspGln: 1.593 ± 0.034
5.269AspArg: 5.269 ± 0.072
1.952AspSer: 1.952 ± 0.039
2.556AspThr: 2.556 ± 0.059
3.943AspVal: 3.943 ± 0.056
1.292AspTrp: 1.292 ± 0.033
1.299AspTyr: 1.299 ± 0.033
0.0AspXaa: 0.0 ± 0.0
Glu
9.856GluAla: 9.856 ± 0.113
0.29GluCys: 0.29 ± 0.013
3.261GluAsp: 3.261 ± 0.053
4.044GluGlu: 4.044 ± 0.074
1.591GluPhe: 1.591 ± 0.037
5.943GluGly: 5.943 ± 0.08
1.072GluHis: 1.072 ± 0.03
3.113GluIle: 3.113 ± 0.055
1.318GluLys: 1.318 ± 0.038
4.903GluLeu: 4.903 ± 0.06
1.662GluMet: 1.662 ± 0.043
1.223GluAsn: 1.223 ± 0.032
3.313GluPro: 3.313 ± 0.055
1.816GluGln: 1.816 ± 0.037
5.332GluArg: 5.332 ± 0.084
2.285GluSer: 2.285 ± 0.04
3.323GluThr: 3.323 ± 0.06
5.101GluVal: 5.101 ± 0.068
0.759GluTrp: 0.759 ± 0.024
0.832GluTyr: 0.832 ± 0.028
0.0GluXaa: 0.0 ± 0.0
Phe
4.463PheAla: 4.463 ± 0.059
0.34PheCys: 0.34 ± 0.015
2.492PheAsp: 2.492 ± 0.046
1.935PheGlu: 1.935 ± 0.04
1.15PhePhe: 1.15 ± 0.032
3.487PheGly: 3.487 ± 0.058
0.73PheHis: 0.73 ± 0.025
1.218PheIle: 1.218 ± 0.036
0.598PheLys: 0.598 ± 0.02
3.551PheLeu: 3.551 ± 0.063
0.641PheMet: 0.641 ± 0.022
0.797PheAsn: 0.797 ± 0.022
1.515PhePro: 1.515 ± 0.036
0.989PheGln: 0.989 ± 0.029
2.384PheArg: 2.384 ± 0.047
1.664PheSer: 1.664 ± 0.037
1.728PheThr: 1.728 ± 0.039
2.683PheVal: 2.683 ± 0.043
0.567PheTrp: 0.567 ± 0.022
0.763PheTyr: 0.763 ± 0.024
0.0PheXaa: 0.0 ± 0.0
Gly
10.758GlyAla: 10.758 ± 0.106
0.848GlyCys: 0.848 ± 0.027
4.639GlyAsp: 4.639 ± 0.069
5.365GlyGlu: 5.365 ± 0.072
3.49GlyPhe: 3.49 ± 0.048
8.46GlyGly: 8.46 ± 0.122
2.09GlyHis: 2.09 ± 0.042
3.954GlyIle: 3.954 ± 0.05
2.103GlyLys: 2.103 ± 0.041
10.594GlyLeu: 10.594 ± 0.116
2.31GlyMet: 2.31 ± 0.044
1.898GlyAsn: 1.898 ± 0.057
4.711GlyPro: 4.711 ± 0.065
3.354GlyGln: 3.354 ± 0.056
7.966GlyArg: 7.966 ± 0.105
4.43GlySer: 4.43 ± 0.072
5.238GlyThr: 5.238 ± 0.07
6.717GlyVal: 6.717 ± 0.071
1.731GlyTrp: 1.731 ± 0.039
2.054GlyTyr: 2.054 ± 0.044
0.0GlyXaa: 0.0 ± 0.0
His
2.406HisAla: 2.406 ± 0.043
0.189HisCys: 0.189 ± 0.012
1.329HisAsp: 1.329 ± 0.032
1.194HisGlu: 1.194 ± 0.029
0.712HisPhe: 0.712 ± 0.024
2.082HisGly: 2.082 ± 0.041
0.562HisHis: 0.562 ± 0.021
0.705HisIle: 0.705 ± 0.023
0.361HisLys: 0.361 ± 0.017
2.265HisLeu: 2.265 ± 0.044
0.473HisMet: 0.473 ± 0.02
0.391HisAsn: 0.391 ± 0.02
1.53HisPro: 1.53 ± 0.041
0.551HisGln: 0.551 ± 0.02
1.622HisArg: 1.622 ± 0.035
0.787HisSer: 0.787 ± 0.023
0.691HisThr: 0.691 ± 0.022
1.625HisVal: 1.625 ± 0.034
0.371HisTrp: 0.371 ± 0.019
0.487HisTyr: 0.487 ± 0.019
0.0HisXaa: 0.0 ± 0.0
Ile
5.996IleAla: 5.996 ± 0.063
0.443IleCys: 0.443 ± 0.018
2.921IleAsp: 2.921 ± 0.048
3.078IleGlu: 3.078 ± 0.053
1.331IlePhe: 1.331 ± 0.031
4.117IleGly: 4.117 ± 0.056
0.882IleHis: 0.882 ± 0.025
1.439IleIle: 1.439 ± 0.038
0.781IleLys: 0.781 ± 0.027
4.286IleLeu: 4.286 ± 0.064
0.765IleMet: 0.765 ± 0.026
0.957IleAsn: 0.957 ± 0.029
2.196IlePro: 2.196 ± 0.043
1.019IleGln: 1.019 ± 0.031
3.141IleArg: 3.141 ± 0.051
1.955IleSer: 1.955 ± 0.038
2.121IleThr: 2.121 ± 0.039
3.461IleVal: 3.461 ± 0.053
0.578IleTrp: 0.578 ± 0.02
0.934IleTyr: 0.934 ± 0.026
0.0IleXaa: 0.0 ± 0.0
Lys
3.0LysAla: 3.0 ± 0.065
0.101LysCys: 0.101 ± 0.01
1.213LysAsp: 1.213 ± 0.037
1.089LysGlu: 1.089 ± 0.034
0.512LysPhe: 0.512 ± 0.02
2.171LysGly: 2.171 ± 0.041
0.405LysHis: 0.405 ± 0.015
0.847LysIle: 0.847 ± 0.028
0.573LysLys: 0.573 ± 0.025
1.913LysLeu: 1.913 ± 0.045
0.444LysMet: 0.444 ± 0.021
0.424LysAsn: 0.424 ± 0.018
1.282LysPro: 1.282 ± 0.038
0.535LysGln: 0.535 ± 0.019
1.545LysArg: 1.545 ± 0.039
1.038LysSer: 1.038 ± 0.032
1.088LysThr: 1.088 ± 0.034
1.752LysVal: 1.752 ± 0.045
0.22LysTrp: 0.22 ± 0.014
0.353LysTyr: 0.353 ± 0.015
0.0LysXaa: 0.0 ± 0.0
Leu
15.7LeuAla: 15.7 ± 0.156
0.901LeuCys: 0.901 ± 0.029
6.725LeuAsp: 6.725 ± 0.085
5.256LeuGlu: 5.256 ± 0.062
3.23LeuPhe: 3.23 ± 0.055
10.165LeuGly: 10.165 ± 0.111
2.12LeuHis: 2.12 ± 0.04
4.211LeuIle: 4.211 ± 0.061
2.221LeuLys: 2.221 ± 0.049
11.099LeuLeu: 11.099 ± 0.143
2.369LeuMet: 2.369 ± 0.044
2.307LeuAsn: 2.307 ± 0.041
6.326LeuPro: 6.326 ± 0.081
2.673LeuGln: 2.673 ± 0.048
9.213LeuArg: 9.213 ± 0.087
6.505LeuSer: 6.505 ± 0.073
5.834LeuThr: 5.834 ± 0.071
8.193LeuVal: 8.193 ± 0.094
1.57LeuTrp: 1.57 ± 0.042
1.918LeuTyr: 1.918 ± 0.042
0.0LeuXaa: 0.0 ± 0.0
Met
3.343MetAla: 3.343 ± 0.048
0.123MetCys: 0.123 ± 0.011
1.247MetAsp: 1.247 ± 0.031
1.196MetGlu: 1.196 ± 0.029
0.616MetPhe: 0.616 ± 0.022
2.085MetGly: 2.085 ± 0.045
0.38MetHis: 0.38 ± 0.014
1.154MetIle: 1.154 ± 0.035
0.63MetLys: 0.63 ± 0.023
2.291MetLeu: 2.291 ± 0.045
0.59MetMet: 0.59 ± 0.023
0.649MetAsn: 0.649 ± 0.022
1.459MetPro: 1.459 ± 0.034
0.702MetGln: 0.702 ± 0.023
1.92MetArg: 1.92 ± 0.035
1.36MetSer: 1.36 ± 0.03
1.956MetThr: 1.956 ± 0.038
1.649MetVal: 1.649 ± 0.038
0.227MetTrp: 0.227 ± 0.014
0.257MetTyr: 0.257 ± 0.014
0.0MetXaa: 0.0 ± 0.0
Asn
2.609AsnAla: 2.609 ± 0.043
0.197AsnCys: 0.197 ± 0.012
1.265AsnAsp: 1.265 ± 0.041
0.981AsnGlu: 0.981 ± 0.027
0.752AsnPhe: 0.752 ± 0.02
2.044AsnGly: 2.044 ± 0.05
0.446AsnHis: 0.446 ± 0.017
0.948AsnIle: 0.948 ± 0.024
0.373AsnLys: 0.373 ± 0.019
2.377AsnLeu: 2.377 ± 0.042
0.463AsnMet: 0.463 ± 0.018
0.522AsnAsn: 0.522 ± 0.019
1.628AsnPro: 1.628 ± 0.033
0.549AsnGln: 0.549 ± 0.021
1.458AsnArg: 1.458 ± 0.034
0.881AsnSer: 0.881 ± 0.027
0.889AsnThr: 0.889 ± 0.03
1.606AsnVal: 1.606 ± 0.037
0.376AsnTrp: 0.376 ± 0.016
0.493AsnTyr: 0.493 ± 0.024
0.0AsnXaa: 0.0 ± 0.0
Pro
7.201ProAla: 7.201 ± 0.097
0.339ProCys: 0.339 ± 0.017
4.113ProAsp: 4.113 ± 0.049
4.877ProGlu: 4.877 ± 0.079
2.066ProPhe: 2.066 ± 0.044
5.497ProGly: 5.497 ± 0.071
1.126ProHis: 1.126 ± 0.029
2.006ProIle: 2.006 ± 0.035
1.148ProLys: 1.148 ± 0.032
5.54ProLeu: 5.54 ± 0.062
1.266ProMet: 1.266 ± 0.031
1.126ProAsn: 1.126 ± 0.029
3.155ProPro: 3.155 ± 0.061
1.707ProGln: 1.707 ± 0.036
3.971ProArg: 3.971 ± 0.059
2.868ProSer: 2.868 ± 0.051
2.604ProThr: 2.604 ± 0.041
4.784ProVal: 4.784 ± 0.063
0.879ProTrp: 0.879 ± 0.023
1.107ProTyr: 1.107 ± 0.028
0.0ProXaa: 0.0 ± 0.0
Gln
4.509GlnAla: 4.509 ± 0.056
0.154GlnCys: 0.154 ± 0.009
1.646GlnAsp: 1.646 ± 0.037
1.709GlnGlu: 1.709 ± 0.037
0.921GlnPhe: 0.921 ± 0.027
3.068GlnGly: 3.068 ± 0.053
0.509GlnHis: 0.509 ± 0.02
1.458GlnIle: 1.458 ± 0.033
0.689GlnLys: 0.689 ± 0.024
2.5GlnLeu: 2.5 ± 0.041
0.818GlnMet: 0.818 ± 0.023
0.62GlnAsn: 0.62 ± 0.022
1.683GlnPro: 1.683 ± 0.044
0.94GlnGln: 0.94 ± 0.032
2.246GlnArg: 2.246 ± 0.044
1.426GlnSer: 1.426 ± 0.035
1.469GlnThr: 1.469 ± 0.037
2.6GlnVal: 2.6 ± 0.041
0.382GlnTrp: 0.382 ± 0.017
0.456GlnTyr: 0.456 ± 0.019
0.0GlnXaa: 0.0 ± 0.0
Arg
10.165ArgAla: 10.165 ± 0.115
0.515ArgCys: 0.515 ± 0.02
4.817ArgAsp: 4.817 ± 0.054
4.922ArgGlu: 4.922 ± 0.064
2.915ArgPhe: 2.915 ± 0.046
5.717ArgGly: 5.717 ± 0.062
1.936ArgHis: 1.936 ± 0.04
4.036ArgIle: 4.036 ± 0.054
1.667ArgLys: 1.667 ± 0.038
9.94ArgLeu: 9.94 ± 0.104
2.058ArgMet: 2.058 ± 0.037
1.644ArgAsn: 1.644 ± 0.036
4.758ArgPro: 4.758 ± 0.066
2.474ArgGln: 2.474 ± 0.038
7.08ArgArg: 7.08 ± 0.081
3.658ArgSer: 3.658 ± 0.052
3.8ArgThr: 3.8 ± 0.056
5.644ArgVal: 5.644 ± 0.066
1.255ArgTrp: 1.255 ± 0.032
1.416ArgTyr: 1.416 ± 0.034
0.0ArgXaa: 0.0 ± 0.0
Ser
5.408SerAla: 5.408 ± 0.07
0.406SerCys: 0.406 ± 0.021
2.688SerAsp: 2.688 ± 0.048
2.603SerGlu: 2.603 ± 0.048
1.934SerPhe: 1.934 ± 0.038
5.098SerGly: 5.098 ± 0.073
0.988SerHis: 0.988 ± 0.026
1.953SerIle: 1.953 ± 0.043
0.948SerLys: 0.948 ± 0.03
5.119SerLeu: 5.119 ± 0.067
1.096SerMet: 1.096 ± 0.025
1.009SerAsn: 1.009 ± 0.029
2.812SerPro: 2.812 ± 0.043
1.366SerGln: 1.366 ± 0.035
3.63SerArg: 3.63 ± 0.053
2.304SerSer: 2.304 ± 0.045
2.338SerThr: 2.338 ± 0.043
3.533SerVal: 3.533 ± 0.055
0.691SerTrp: 0.691 ± 0.02
1.095SerTyr: 1.095 ± 0.029
0.0SerXaa: 0.0 ± 0.0
Thr
6.165ThrAla: 6.165 ± 0.069
0.454ThrCys: 0.454 ± 0.02
2.931ThrAsp: 2.931 ± 0.052
2.862ThrGlu: 2.862 ± 0.047
1.979ThrPhe: 1.979 ± 0.037
5.414ThrGly: 5.414 ± 0.073
1.05ThrHis: 1.05 ± 0.029
2.302ThrIle: 2.302 ± 0.039
1.035ThrLys: 1.035 ± 0.032
6.024ThrLeu: 6.024 ± 0.071
1.125ThrMet: 1.125 ± 0.026
1.059ThrAsn: 1.059 ± 0.027
3.417ThrPro: 3.417 ± 0.063
1.366ThrGln: 1.366 ± 0.032
3.623ThrArg: 3.623 ± 0.052
2.362ThrSer: 2.362 ± 0.049
2.687ThrThr: 2.687 ± 0.058
4.312ThrVal: 4.312 ± 0.057
0.799ThrTrp: 0.799 ± 0.025
1.11ThrTyr: 1.11 ± 0.033
0.0ThrXaa: 0.0 ± 0.0
Val
10.472ValAla: 10.472 ± 0.097
0.588ValCys: 0.588 ± 0.02
3.939ValAsp: 3.939 ± 0.058
5.045ValGlu: 5.045 ± 0.065
2.553ValPhe: 2.553 ± 0.042
5.913ValGly: 5.913 ± 0.068
1.426ValHis: 1.426 ± 0.034
3.565ValIle: 3.565 ± 0.06
1.506ValLys: 1.506 ± 0.041
8.519ValLeu: 8.519 ± 0.092
1.879ValMet: 1.879 ± 0.041
1.813ValAsn: 1.813 ± 0.037
4.336ValPro: 4.336 ± 0.066
2.109ValGln: 2.109 ± 0.043
5.358ValArg: 5.358 ± 0.062
3.709ValSer: 3.709 ± 0.055
4.988ValThr: 4.988 ± 0.064
6.399ValVal: 6.399 ± 0.065
1.061ValTrp: 1.061 ± 0.027
1.34ValTyr: 1.34 ± 0.034
0.0ValXaa: 0.0 ± 0.0
Trp
1.696TrpAla: 1.696 ± 0.039
0.134TrpCys: 0.134 ± 0.009
0.879TrpAsp: 0.879 ± 0.029
0.764TrpGlu: 0.764 ± 0.022
0.551TrpPhe: 0.551 ± 0.02
1.251TrpGly: 1.251 ± 0.034
0.351TrpHis: 0.351 ± 0.016
0.692TrpIle: 0.692 ± 0.022
0.334TrpLys: 0.334 ± 0.014
1.85TrpLeu: 1.85 ± 0.042
0.39TrpMet: 0.39 ± 0.017
0.414TrpAsn: 0.414 ± 0.016
0.837TrpPro: 0.837 ± 0.025
0.538TrpGln: 0.538 ± 0.023
1.37TrpArg: 1.37 ± 0.031
0.851TrpSer: 0.851 ± 0.025
0.966TrpThr: 0.966 ± 0.026
0.986TrpVal: 0.986 ± 0.027
0.26TrpTrp: 0.26 ± 0.014
0.255TrpTyr: 0.255 ± 0.014
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.386TyrAla: 2.386 ± 0.04
0.194TyrCys: 0.194 ± 0.011
1.316TyrAsp: 1.316 ± 0.033
1.186TyrGlu: 1.186 ± 0.032
0.698TyrPhe: 0.698 ± 0.024
2.02TyrGly: 2.02 ± 0.045
0.438TyrHis: 0.438 ± 0.018
0.651TyrIle: 0.651 ± 0.022
0.373TyrLys: 0.373 ± 0.016
2.031TyrLeu: 2.031 ± 0.042
0.362TyrMet: 0.362 ± 0.016
0.453TyrAsn: 0.453 ± 0.019
1.008TyrPro: 1.008 ± 0.032
0.555TyrGln: 0.555 ± 0.018
1.452TyrArg: 1.452 ± 0.031
0.869TyrSer: 0.869 ± 0.028
0.902TyrThr: 0.902 ± 0.026
1.49TyrVal: 1.49 ± 0.031
0.339TyrTrp: 0.339 ± 0.016
0.457TyrTyr: 0.457 ± 0.018
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4478 proteins (1378203 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski