Amino acid dipepetide frequency for Human papillomavirus type 2a

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.91AlaAla: 5.91 ± 0.707
2.533AlaCys: 2.533 ± 0.733
5.488AlaAsp: 5.488 ± 1.56
1.688AlaGlu: 1.688 ± 0.574
2.955AlaPhe: 2.955 ± 0.91
4.221AlaGly: 4.221 ± 1.079
0.844AlaHis: 0.844 ± 0.397
2.533AlaIle: 2.533 ± 0.454
2.533AlaLys: 2.533 ± 0.94
4.643AlaLeu: 4.643 ± 1.104
1.266AlaMet: 1.266 ± 0.568
2.533AlaAsn: 2.533 ± 0.94
4.221AlaPro: 4.221 ± 2.48
2.955AlaGln: 2.955 ± 1.075
2.111AlaArg: 2.111 ± 0.887
7.176AlaSer: 7.176 ± 1.609
5.065AlaThr: 5.065 ± 1.079
3.799AlaVal: 3.799 ± 0.622
0.422AlaTrp: 0.422 ± 0.391
2.111AlaTyr: 2.111 ± 0.687
0.0AlaXaa: 0.0 ± 0.0
Cys
2.533CysAla: 2.533 ± 1.147
0.422CysCys: 0.422 ± 0.595
0.422CysAsp: 0.422 ± 0.595
0.0CysGlu: 0.0 ± 0.0
0.844CysPhe: 0.844 ± 0.427
2.533CysGly: 2.533 ± 1.736
0.422CysHis: 0.422 ± 0.579
0.844CysIle: 0.844 ± 0.649
2.955CysLys: 2.955 ± 1.594
1.688CysLeu: 1.688 ± 1.127
0.844CysMet: 0.844 ± 0.585
0.422CysAsn: 0.422 ± 0.344
2.111CysPro: 2.111 ± 0.819
1.688CysGln: 1.688 ± 0.678
0.844CysArg: 0.844 ± 0.649
0.844CysSer: 0.844 ± 0.427
1.266CysThr: 1.266 ± 0.649
1.266CysVal: 1.266 ± 0.584
1.266CysTrp: 1.266 ± 0.395
1.266CysTyr: 1.266 ± 1.178
0.0CysXaa: 0.0 ± 0.0
Asp
3.799AspAla: 3.799 ± 1.557
0.422AspCys: 0.422 ± 0.344
2.533AspAsp: 2.533 ± 0.89
5.065AspGlu: 5.065 ± 1.633
1.688AspPhe: 1.688 ± 0.288
4.221AspGly: 4.221 ± 1.189
0.422AspHis: 0.422 ± 0.324
4.643AspIle: 4.643 ± 2.059
0.844AspLys: 0.844 ± 0.505
6.332AspLeu: 6.332 ± 1.576
1.266AspMet: 1.266 ± 0.461
1.688AspAsn: 1.688 ± 0.792
4.221AspPro: 4.221 ± 1.635
1.266AspGln: 1.266 ± 0.395
1.266AspArg: 1.266 ± 0.65
6.332AspSer: 6.332 ± 1.858
5.488AspThr: 5.488 ± 2.0
4.643AspVal: 4.643 ± 1.068
1.266AspTrp: 1.266 ± 0.638
1.266AspTyr: 1.266 ± 0.673
0.0AspXaa: 0.0 ± 0.0
Glu
3.377GluAla: 3.377 ± 1.007
1.266GluCys: 1.266 ± 0.906
5.91GluAsp: 5.91 ± 1.973
7.598GluGlu: 7.598 ± 2.439
0.844GluPhe: 0.844 ± 0.427
1.688GluGly: 1.688 ± 0.934
0.422GluHis: 0.422 ± 0.344
2.111GluIle: 2.111 ± 1.153
1.688GluLys: 1.688 ± 0.712
4.221GluLeu: 4.221 ± 1.335
0.844GluMet: 0.844 ± 0.505
2.533GluAsn: 2.533 ± 0.875
5.91GluPro: 5.91 ± 2.155
4.643GluGln: 4.643 ± 1.618
1.688GluArg: 1.688 ± 1.35
2.533GluSer: 2.533 ± 0.79
4.221GluThr: 4.221 ± 1.117
3.377GluVal: 3.377 ± 0.937
0.422GluTrp: 0.422 ± 0.324
1.688GluTyr: 1.688 ± 0.759
0.0GluXaa: 0.0 ± 0.0
Phe
2.111PheAla: 2.111 ± 0.769
0.422PheCys: 0.422 ± 0.324
1.266PheAsp: 1.266 ± 0.705
1.266PheGlu: 1.266 ± 0.616
2.111PhePhe: 2.111 ± 0.714
3.377PheGly: 3.377 ± 0.82
1.266PheHis: 1.266 ± 0.584
1.688PheIle: 1.688 ± 0.605
2.533PheLys: 2.533 ± 1.144
5.488PheLeu: 5.488 ± 0.988
0.844PheMet: 0.844 ± 0.585
0.844PheAsn: 0.844 ± 0.688
1.266PhePro: 1.266 ± 0.584
1.266PheGln: 1.266 ± 0.356
1.688PheArg: 1.688 ± 0.934
1.266PheSer: 1.266 ± 0.673
1.688PheThr: 1.688 ± 0.577
2.533PheVal: 2.533 ± 0.803
0.844PheTrp: 0.844 ± 0.397
1.266PheTyr: 1.266 ± 0.616
0.0PheXaa: 0.0 ± 0.0
Gly
4.221GlyAla: 4.221 ± 1.234
1.266GlyCys: 1.266 ± 0.395
5.91GlyAsp: 5.91 ± 1.097
3.799GlyGlu: 3.799 ± 1.276
2.533GlyPhe: 2.533 ± 0.672
5.488GlyGly: 5.488 ± 1.25
3.377GlyHis: 3.377 ± 0.678
1.266GlyIle: 1.266 ± 0.967
2.533GlyLys: 2.533 ± 1.136
3.377GlyLeu: 3.377 ± 0.519
1.688GlyMet: 1.688 ± 0.288
3.377GlyAsn: 3.377 ± 1.116
2.533GlyPro: 2.533 ± 1.367
2.955GlyGln: 2.955 ± 1.044
3.799GlyArg: 3.799 ± 0.96
6.332GlySer: 6.332 ± 2.147
7.176GlyThr: 7.176 ± 2.36
5.488GlyVal: 5.488 ± 0.874
0.422GlyTrp: 0.422 ± 0.324
2.111GlyTyr: 2.111 ± 0.547
0.0GlyXaa: 0.0 ± 0.0
His
0.0HisAla: 0.0 ± 0.0
1.266HisCys: 1.266 ± 1.399
1.266HisAsp: 1.266 ± 0.437
0.422HisGlu: 0.422 ± 0.381
1.266HisPhe: 1.266 ± 0.356
2.111HisGly: 2.111 ± 0.508
0.422HisHis: 0.422 ± 0.391
0.422HisIle: 0.422 ± 0.324
1.688HisLys: 1.688 ± 0.834
0.422HisLeu: 0.422 ± 0.391
1.266HisMet: 1.266 ± 0.575
1.266HisAsn: 1.266 ± 0.837
2.533HisPro: 2.533 ± 0.587
0.844HisGln: 0.844 ± 0.622
0.422HisArg: 0.422 ± 0.381
0.422HisSer: 0.422 ± 0.324
1.688HisThr: 1.688 ± 0.574
2.111HisVal: 2.111 ± 0.459
1.688HisTrp: 1.688 ± 0.865
1.688HisTyr: 1.688 ± 0.756
0.0HisXaa: 0.0 ± 0.0
Ile
0.844IleAla: 0.844 ± 0.66
0.844IleCys: 0.844 ± 0.633
1.688IleAsp: 1.688 ± 0.902
2.533IleGlu: 2.533 ± 0.535
1.688IlePhe: 1.688 ± 0.915
2.533IleGly: 2.533 ± 1.332
1.266IleHis: 1.266 ± 0.757
2.111IleIle: 2.111 ± 1.432
1.688IleLys: 1.688 ± 0.803
1.266IleLeu: 1.266 ± 0.707
0.422IleMet: 0.422 ± 0.344
0.844IleAsn: 0.844 ± 0.396
5.065IlePro: 5.065 ± 1.476
0.844IleGln: 0.844 ± 0.649
0.844IleArg: 0.844 ± 0.505
3.799IleSer: 3.799 ± 0.655
3.377IleThr: 3.377 ± 0.698
3.799IleVal: 3.799 ± 1.211
0.422IleTrp: 0.422 ± 0.579
1.266IleTyr: 1.266 ± 0.751
0.0IleXaa: 0.0 ± 0.0
Lys
2.533LysAla: 2.533 ± 1.045
2.533LysCys: 2.533 ± 0.964
2.111LysAsp: 2.111 ± 0.891
1.688LysGlu: 1.688 ± 1.725
2.111LysPhe: 2.111 ± 0.688
2.111LysGly: 2.111 ± 0.733
1.688LysHis: 1.688 ± 0.854
1.266LysIle: 1.266 ± 0.356
2.533LysLys: 2.533 ± 1.045
2.533LysLeu: 2.533 ± 0.805
0.844LysMet: 0.844 ± 0.688
1.688LysAsn: 1.688 ± 1.298
2.111LysPro: 2.111 ± 1.023
1.266LysGln: 1.266 ± 0.73
6.332LysArg: 6.332 ± 0.954
2.533LysSer: 2.533 ± 1.19
2.533LysThr: 2.533 ± 0.886
2.533LysVal: 2.533 ± 1.223
0.844LysTrp: 0.844 ± 0.649
1.266LysTyr: 1.266 ± 0.638
0.0LysXaa: 0.0 ± 0.0
Leu
3.377LeuAla: 3.377 ± 1.146
2.533LeuCys: 2.533 ± 1.346
5.91LeuAsp: 5.91 ± 1.129
4.643LeuGlu: 4.643 ± 1.707
3.799LeuPhe: 3.799 ± 1.226
3.799LeuGly: 3.799 ± 1.185
1.688LeuHis: 1.688 ± 1.146
2.533LeuIle: 2.533 ± 0.796
4.221LeuLys: 4.221 ± 1.466
8.442LeuLeu: 8.442 ± 1.958
1.688LeuMet: 1.688 ± 0.61
2.533LeuAsn: 2.533 ± 1.108
3.377LeuPro: 3.377 ± 1.463
5.488LeuGln: 5.488 ± 2.02
7.598LeuArg: 7.598 ± 1.309
4.643LeuSer: 4.643 ± 1.303
6.332LeuThr: 6.332 ± 1.789
3.799LeuVal: 3.799 ± 1.451
1.688LeuTrp: 1.688 ± 0.638
5.488LeuTyr: 5.488 ± 1.028
0.0LeuXaa: 0.0 ± 0.0
Met
1.266MetAla: 1.266 ± 1.031
0.844MetCys: 0.844 ± 0.397
1.266MetAsp: 1.266 ± 1.031
2.533MetGlu: 2.533 ± 0.587
0.844MetPhe: 0.844 ± 0.688
1.266MetGly: 1.266 ± 0.356
0.422MetHis: 0.422 ± 0.595
0.844MetIle: 0.844 ± 0.427
0.0MetLys: 0.0 ± 0.0
2.111MetLeu: 2.111 ± 0.834
0.0MetMet: 0.0 ± 0.0
0.422MetAsn: 0.422 ± 0.579
0.844MetPro: 0.844 ± 0.425
0.844MetGln: 0.844 ± 0.505
0.422MetArg: 0.422 ± 0.579
3.377MetSer: 3.377 ± 0.896
0.422MetThr: 0.422 ± 0.391
2.111MetVal: 2.111 ± 1.012
0.422MetTrp: 0.422 ± 0.391
0.0MetTyr: 0.0 ± 0.0
0.0MetXaa: 0.0 ± 0.0
Asn
1.688AsnAla: 1.688 ± 0.532
2.111AsnCys: 2.111 ± 0.927
0.844AsnAsp: 0.844 ± 0.397
0.422AsnGlu: 0.422 ± 0.344
0.844AsnPhe: 0.844 ± 0.688
2.111AsnGly: 2.111 ± 0.688
0.844AsnHis: 0.844 ± 0.923
1.688AsnIle: 1.688 ± 1.093
3.377AsnLys: 3.377 ± 1.218
1.266AsnLeu: 1.266 ± 0.638
0.844AsnMet: 0.844 ± 0.397
1.688AsnAsn: 1.688 ± 0.859
2.111AsnPro: 2.111 ± 0.887
0.844AsnGln: 0.844 ± 0.649
3.377AsnArg: 3.377 ± 0.933
1.266AsnSer: 1.266 ± 0.973
2.955AsnThr: 2.955 ± 0.846
2.111AsnVal: 2.111 ± 0.915
0.422AsnTrp: 0.422 ± 0.324
0.844AsnTyr: 0.844 ± 0.439
0.0AsnXaa: 0.0 ± 0.0
Pro
5.91ProAla: 5.91 ± 2.388
0.422ProCys: 0.422 ± 0.579
5.91ProAsp: 5.91 ± 2.022
2.955ProGlu: 2.955 ± 1.122
1.688ProPhe: 1.688 ± 0.994
4.221ProGly: 4.221 ± 1.191
0.844ProHis: 0.844 ± 0.622
2.955ProIle: 2.955 ± 0.583
3.377ProLys: 3.377 ± 0.733
8.442ProLeu: 8.442 ± 1.416
0.422ProMet: 0.422 ± 0.381
1.266ProAsn: 1.266 ± 0.673
8.864ProPro: 8.864 ± 2.003
3.377ProGln: 3.377 ± 1.768
4.643ProArg: 4.643 ± 2.077
3.799ProSer: 3.799 ± 1.802
5.488ProThr: 5.488 ± 1.952
5.065ProVal: 5.065 ± 1.981
0.0ProTrp: 0.0 ± 0.0
2.111ProTyr: 2.111 ± 1.719
0.0ProXaa: 0.0 ± 0.0
Gln
4.221GlnAla: 4.221 ± 1.455
0.422GlnCys: 0.422 ± 0.324
1.688GlnAsp: 1.688 ± 0.574
2.111GlnGlu: 2.111 ± 1.376
2.955GlnPhe: 2.955 ± 1.253
1.688GlnGly: 1.688 ± 0.931
0.844GlnHis: 0.844 ± 0.505
0.844GlnIle: 0.844 ± 0.505
0.844GlnLys: 0.844 ± 0.439
5.065GlnLeu: 5.065 ± 1.691
1.688GlnMet: 1.688 ± 0.793
0.844GlnAsn: 0.844 ± 0.649
2.533GlnPro: 2.533 ± 1.181
2.533GlnGln: 2.533 ± 1.177
2.955GlnArg: 2.955 ± 0.981
2.955GlnSer: 2.955 ± 1.486
3.377GlnThr: 3.377 ± 0.688
2.955GlnVal: 2.955 ± 1.103
0.422GlnTrp: 0.422 ± 0.324
1.688GlnTyr: 1.688 ± 0.701
0.0GlnXaa: 0.0 ± 0.0
Arg
3.799ArgAla: 3.799 ± 1.103
1.266ArgCys: 1.266 ± 0.801
1.688ArgAsp: 1.688 ± 0.729
2.533ArgGlu: 2.533 ± 1.018
1.266ArgPhe: 1.266 ± 0.636
3.377ArgGly: 3.377 ± 0.856
2.111ArgHis: 2.111 ± 0.813
0.0ArgIle: 0.0 ± 0.0
3.799ArgLys: 3.799 ± 0.919
5.91ArgLeu: 5.91 ± 0.746
0.422ArgMet: 0.422 ± 0.344
0.844ArgAsn: 0.844 ± 0.585
5.065ArgPro: 5.065 ± 2.007
2.955ArgGln: 2.955 ± 1.256
4.643ArgArg: 4.643 ± 1.736
3.377ArgSer: 3.377 ± 1.009
5.065ArgThr: 5.065 ± 1.533
6.332ArgVal: 6.332 ± 2.129
1.266ArgTrp: 1.266 ± 0.605
1.266ArgTyr: 1.266 ± 0.395
0.0ArgXaa: 0.0 ± 0.0
Ser
5.488SerAla: 5.488 ± 2.338
1.688SerCys: 1.688 ± 1.093
3.799SerAsp: 3.799 ± 0.993
4.643SerGlu: 4.643 ± 1.356
1.266SerPhe: 1.266 ± 0.356
6.754SerGly: 6.754 ± 2.464
1.688SerHis: 1.688 ± 0.621
3.377SerIle: 3.377 ± 0.995
3.799SerLys: 3.799 ± 1.433
5.488SerLeu: 5.488 ± 1.445
2.955SerMet: 2.955 ± 1.43
2.533SerAsn: 2.533 ± 0.79
3.799SerPro: 3.799 ± 1.314
2.111SerGln: 2.111 ± 1.336
3.799SerArg: 3.799 ± 1.272
10.131SerSer: 10.131 ± 1.648
7.176SerThr: 7.176 ± 2.262
5.91SerVal: 5.91 ± 2.085
2.111SerTrp: 2.111 ± 0.873
1.688SerTyr: 1.688 ± 0.902
0.0SerXaa: 0.0 ± 0.0
Thr
4.643ThrAla: 4.643 ± 0.884
2.955ThrCys: 2.955 ± 1.096
5.065ThrAsp: 5.065 ± 1.182
5.488ThrGlu: 5.488 ± 0.745
2.533ThrPhe: 2.533 ± 0.951
6.754ThrGly: 6.754 ± 2.255
0.422ThrHis: 0.422 ± 0.324
2.111ThrIle: 2.111 ± 0.915
0.0ThrLys: 0.0 ± 0.0
9.709ThrLeu: 9.709 ± 2.846
0.422ThrMet: 0.422 ± 0.324
3.799ThrAsn: 3.799 ± 2.026
7.176ThrPro: 7.176 ± 2.259
2.533ThrGln: 2.533 ± 0.79
2.955ThrArg: 2.955 ± 1.226
6.332ThrSer: 6.332 ± 1.995
4.643ThrThr: 4.643 ± 1.661
7.176ThrVal: 7.176 ± 0.512
0.844ThrTrp: 0.844 ± 0.782
0.844ThrTyr: 0.844 ± 0.439
0.0ThrXaa: 0.0 ± 0.0
Val
4.221ValAla: 4.221 ± 1.181
0.844ValCys: 0.844 ± 0.622
2.955ValAsp: 2.955 ± 0.708
5.488ValGlu: 5.488 ± 0.657
2.533ValPhe: 2.533 ± 0.851
5.488ValGly: 5.488 ± 0.771
2.111ValHis: 2.111 ± 0.887
2.533ValIle: 2.533 ± 0.954
1.266ValLys: 1.266 ± 0.395
3.377ValLeu: 3.377 ± 1.4
1.688ValMet: 1.688 ± 0.82
0.844ValAsn: 0.844 ± 0.439
5.91ValPro: 5.91 ± 1.137
3.799ValGln: 3.799 ± 1.116
4.643ValArg: 4.643 ± 0.828
9.709ValSer: 9.709 ± 1.725
5.488ValThr: 5.488 ± 1.882
3.377ValVal: 3.377 ± 1.329
0.844ValTrp: 0.844 ± 1.158
4.221ValTyr: 4.221 ± 1.428
0.0ValXaa: 0.0 ± 0.0
Trp
1.688TrpAla: 1.688 ± 0.865
0.422TrpCys: 0.422 ± 0.579
0.844TrpAsp: 0.844 ± 0.439
0.844TrpGlu: 0.844 ± 0.66
0.422TrpPhe: 0.422 ± 0.324
2.111TrpGly: 2.111 ± 0.587
1.266TrpHis: 1.266 ± 0.917
0.844TrpIle: 0.844 ± 0.649
1.688TrpLys: 1.688 ± 0.934
0.844TrpLeu: 0.844 ± 0.397
0.0TrpMet: 0.0 ± 0.0
0.422TrpAsn: 0.422 ± 0.344
0.422TrpPro: 0.422 ± 0.381
0.0TrpGln: 0.0 ± 0.0
0.844TrpArg: 0.844 ± 0.633
1.688TrpSer: 1.688 ± 0.828
0.844TrpThr: 0.844 ± 0.66
0.422TrpVal: 0.422 ± 0.324
0.0TrpTrp: 0.0 ± 0.0
0.844TrpTyr: 0.844 ± 0.427
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.799TyrAla: 3.799 ± 1.61
0.0TyrCys: 0.0 ± 0.0
2.111TyrAsp: 2.111 ± 0.714
1.266TyrGlu: 1.266 ± 0.437
0.844TyrPhe: 0.844 ± 0.396
3.799TyrGly: 3.799 ± 1.361
0.844TyrHis: 0.844 ± 0.425
2.533TyrIle: 2.533 ± 0.813
1.688TyrLys: 1.688 ± 0.793
2.955TyrLeu: 2.955 ± 1.188
0.422TyrMet: 0.422 ± 0.391
1.266TyrAsn: 1.266 ± 0.395
1.688TyrPro: 1.688 ± 1.286
0.422TyrGln: 0.422 ± 0.344
2.111TyrArg: 2.111 ± 0.77
1.688TyrSer: 1.688 ± 0.673
2.111TyrThr: 2.111 ± 0.903
2.533TyrVal: 2.533 ± 0.954
0.844TyrTrp: 0.844 ± 0.397
2.533TyrTyr: 2.533 ± 0.758
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 7 proteins (2370 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski