Human papillomavirus type 48

Taxonomy: Viruses; Monodnaviria; Shotokuvirae; Cossaviricota; Papovaviricetes; Zurhausenvirales; Papillomaviridae; Firstpapillomavirinae; Gammapapillomavirus; Gammapapillomavirus 2

Average proteome isoelectric point is 5.96

Get precalculated fractions of proteins

Acidic
pI < 6.8
6.8-7.4
pI > 7.4
Basic
    
All



Virtual 2D-PAGE plot for 7 proteins (isoelectric point calculated using IPC2_protein)

Get csv file with sequences according to given criteria:
        -     Method 

     -  kDa    
                                                                                      

* You can choose from 21 different methods for calculating isoelectric point

Summary statistics related to proteome-wise predictions


    
Protein with the lowest isoelectric point:
>sp|Q80925|VL2_HPV48 Minor capsid protein L2 OS=Human papillomavirus type 48 OX=40538 GN=L2 PE=3 SV=1
MM1 pKa = 7.42SLRR4 pKa = 11.84RR5 pKa = 11.84RR6 pKa = 11.84KK7 pKa = 9.58RR8 pKa = 11.84ASPTDD13 pKa = 3.72LYY15 pKa = 10.02KK16 pKa = 10.6TCLQGGDD23 pKa = 4.92CIPDD27 pKa = 3.32VKK29 pKa = 11.22NKK31 pKa = 10.3FEE33 pKa = 4.39NSTIADD39 pKa = 3.73WLLKK43 pKa = 10.4IFGSLVYY50 pKa = 10.34FGNLGIGSGKK60 pKa = 10.55GSGGSFGYY68 pKa = 10.31RR69 pKa = 11.84PLGSAGSGRR78 pKa = 11.84PATDD82 pKa = 3.66LPVTRR87 pKa = 11.84PNVVIEE93 pKa = 4.36PIGPQSIVPIDD104 pKa = 4.02PGASSIVPLVEE115 pKa = 4.23GGPDD119 pKa = 2.93ISFIAPDD126 pKa = 4.17AGPGIGGEE134 pKa = 4.23DD135 pKa = 2.88IEE137 pKa = 5.67LFTFRR142 pKa = 11.84DD143 pKa = 3.46PATDD147 pKa = 3.13VGGVSGGPTTISTEE161 pKa = 3.94EE162 pKa = 4.27SEE164 pKa = 4.45TAIIDD169 pKa = 3.96ALPSATTPKK178 pKa = 10.36QLFYY182 pKa = 11.2DD183 pKa = 4.47SYY185 pKa = 10.43TQTILQTQVNPFLNNAISDD204 pKa = 4.04TNVFVDD210 pKa = 3.83PLFAGEE216 pKa = 4.44TIGDD220 pKa = 4.07NIFEE224 pKa = 4.99EE225 pKa = 5.14IPLQNLNFSFPRR237 pKa = 11.84EE238 pKa = 4.16STPVKK243 pKa = 9.65PGRR246 pKa = 11.84GLRR249 pKa = 11.84TPAQRR254 pKa = 11.84SYY256 pKa = 11.37SRR258 pKa = 11.84FMEE261 pKa = 4.14QYY263 pKa = 9.85PIQAPEE269 pKa = 4.23FLSQPSRR276 pKa = 11.84LVQFEE281 pKa = 4.31FEE283 pKa = 4.7NPAFDD288 pKa = 4.73PDD290 pKa = 3.98ISIQFQRR297 pKa = 11.84DD298 pKa = 3.7VNSLEE303 pKa = 4.24AAPNPAFADD312 pKa = 3.07IAYY315 pKa = 10.11LSRR318 pKa = 11.84PHH320 pKa = 6.36MSATSEE326 pKa = 3.96GLVRR330 pKa = 11.84VSRR333 pKa = 11.84IGSRR337 pKa = 11.84AVLQTRR343 pKa = 11.84SGLTIGPKK351 pKa = 8.11VHH353 pKa = 6.74YY354 pKa = 10.75YY355 pKa = 9.53MDD357 pKa = 4.44LSAISTEE364 pKa = 4.29AIEE367 pKa = 4.55LQTFADD373 pKa = 4.01SGHH376 pKa = 5.29VHH378 pKa = 6.81TIVDD382 pKa = 3.97DD383 pKa = 4.21FLSVTALDD391 pKa = 4.51DD392 pKa = 3.96PANIADD398 pKa = 3.61INYY401 pKa = 9.1TEE403 pKa = 6.04DD404 pKa = 4.58DD405 pKa = 4.28LLDD408 pKa = 4.27PLLEE412 pKa = 4.38NFNNSHH418 pKa = 6.0ITVQGVDD425 pKa = 3.54EE426 pKa = 4.64EE427 pKa = 5.45GEE429 pKa = 4.6TVALPIPSITNSSKK443 pKa = 9.86TFVTDD448 pKa = 2.96IAEE451 pKa = 4.39NGLFANDD458 pKa = 3.73TDD460 pKa = 4.54SLLTPASTIVPAINWFPLFDD480 pKa = 4.28SYY482 pKa = 11.97SDD484 pKa = 3.77FALDD488 pKa = 3.54PFFIPRR494 pKa = 11.84KK495 pKa = 9.42KK496 pKa = 10.16RR497 pKa = 11.84RR498 pKa = 11.84LDD500 pKa = 3.21ILL502 pKa = 3.81

Molecular weight: 54.44 kDa
Isoelectric point according different methods:





Protein with the highest isoelectric point:
>tr|Q80924|Q80924_HPV48 E4 protein (Fragment) OS=Human papillomavirus type 48 OX=40538 GN=E4 PE=4 SV=1
MM1 pKa = 7.3QPEE4 pKa = 4.43TQEE7 pKa = 4.11SLSTRR12 pKa = 11.84FAAQQEE18 pKa = 4.39IQLTLIEE25 pKa = 4.6KK26 pKa = 10.21EE27 pKa = 4.18SYY29 pKa = 10.22DD30 pKa = 4.36LKK32 pKa = 11.42DD33 pKa = 3.52HH34 pKa = 6.49LAYY37 pKa = 9.5WKK39 pKa = 10.38AVRR42 pKa = 11.84LEE44 pKa = 3.95NVIAYY49 pKa = 7.14YY50 pKa = 10.47ARR52 pKa = 11.84KK53 pKa = 8.84EE54 pKa = 4.2HH55 pKa = 5.73ITKK58 pKa = 10.61LGLQPLPTLAVTEE71 pKa = 4.46YY72 pKa = 10.25KK73 pKa = 10.63AKK75 pKa = 10.27EE76 pKa = 4.14AINIQLLIQSLLKK89 pKa = 10.69SEE91 pKa = 4.67FALEE95 pKa = 3.83RR96 pKa = 11.84WTLAEE101 pKa = 4.27TSAEE105 pKa = 4.39TINSSPRR112 pKa = 11.84NCFKK116 pKa = 10.74KK117 pKa = 10.61VPFIVNVWFDD127 pKa = 3.29NDD129 pKa = 3.34EE130 pKa = 4.48RR131 pKa = 11.84NSFPYY136 pKa = 9.63TCWDD140 pKa = 4.43FIYY143 pKa = 11.11YY144 pKa = 9.93QDD146 pKa = 5.56DD147 pKa = 3.4QNKK150 pKa = 5.75WHH152 pKa = 6.26KK153 pKa = 9.71TEE155 pKa = 4.47GLVDD159 pKa = 3.92HH160 pKa = 6.8NGCYY164 pKa = 10.01YY165 pKa = 11.06VDD167 pKa = 4.08LNGDD171 pKa = 3.98FVYY174 pKa = 8.72FTLFQPDD181 pKa = 3.17AVKK184 pKa = 10.75YY185 pKa = 10.21GKK187 pKa = 8.56TGLWTVRR194 pKa = 11.84FKK196 pKa = 11.58NKK198 pKa = 9.28TISASVTSSSRR209 pKa = 11.84NTNPSSEE216 pKa = 4.21SRR218 pKa = 11.84VGLSTSSSSEE228 pKa = 3.86SPRR231 pKa = 11.84RR232 pKa = 11.84RR233 pKa = 11.84PSISEE238 pKa = 3.8NSNTEE243 pKa = 3.99SPTSSTSRR251 pKa = 11.84LRR253 pKa = 11.84EE254 pKa = 3.48RR255 pKa = 11.84RR256 pKa = 11.84RR257 pKa = 11.84RR258 pKa = 11.84EE259 pKa = 3.56PRR261 pKa = 11.84EE262 pKa = 3.86SGTTDD267 pKa = 2.85TTPRR271 pKa = 11.84RR272 pKa = 11.84RR273 pKa = 11.84GTKK276 pKa = 9.56RR277 pKa = 11.84KK278 pKa = 9.53LGSDD282 pKa = 3.64SAPTPSEE289 pKa = 3.86VGSRR293 pKa = 11.84STTLARR299 pKa = 11.84HH300 pKa = 6.24GYY302 pKa = 9.26SRR304 pKa = 11.84LGRR307 pKa = 11.84LQEE310 pKa = 4.06EE311 pKa = 4.44ARR313 pKa = 11.84DD314 pKa = 3.81PPLVLFTGQQNNLKK328 pKa = 9.65CWRR331 pKa = 11.84NRR333 pKa = 11.84CTTKK337 pKa = 10.56YY338 pKa = 10.96ASLFLCFSSVWKK350 pKa = 9.68WLGPNSDD357 pKa = 3.27GGAAKK362 pKa = 10.53VLVAFKK368 pKa = 10.83SDD370 pKa = 2.94AQRR373 pKa = 11.84QVFLNTVHH381 pKa = 6.59IPKK384 pKa = 9.03GTTITLGRR392 pKa = 11.84LDD394 pKa = 3.68SLL396 pKa = 4.32

Molecular weight: 45.13 kDa
Isoelectric point according different methods:





Peptides (in silico digests for buttom-up proteomics)

Below you can find in silico digests of the whole proteome with Trypsin, Chymotrypsin, Trypsin+LysC, LysN, ArgC proteases suitable for different mass spec machines.

Try
ESI
ChTry
ESI
ArgC
ESI
LysN
ESI
TryLysC
ESI

Try
MALDI
ChTry
MALDI
ArgC
MALDI
LysN
MALDI
TryLysC
MALDI

Try
LTQ
ChTry
LTQ
ArgC
LTQ
LysN
LTQ
TryLysC
LTQ

Try
MSlow
ChTry
MSlow
ArgC
MSlow
LysN
MSlow
TryLysC
MSlow

Try
MShigh
ChTry
MShigh
ArgC
MShigh
LysN
MShigh
TryLysC
MShigh

General Statistics

Number of major isoforms

Number of additional isoforms

Number of all proteins

Number of amino acids

Min. Seq. Length

Max. Seq. Length

Avg. Seq. Length

Avg. Mol. Weight

7

0

7

2372

93

593

338.9

38.31

Amino acid frequency

Ala

Cys

Asp

Glu

Phe

Gly

His

Ile

Lys

Leu

5.818 ± 0.338

2.445 ± 0.752

6.703 ± 0.487

6.282 ± 0.497

5.143 ± 0.559

5.228 ± 0.84

1.56 ± 0.225

5.228 ± 0.736

5.396 ± 0.825

9.612 ± 0.482

Met

Asn

Gln

Pro

Arg

Ser

Thr

Val

Trp

Tyr

1.391 ± 0.412

5.228 ± 0.33

5.776 ± 0.922

3.71 ± 0.264

5.649 ± 0.888

7.715 ± 0.697

6.998 ± 0.409

5.438 ± 0.416

1.391 ± 0.271

3.288 ± 0.511
Note: For amino acid frequency statistics the error has been estimated with the bootstraping (x100) at the protein level

Most of the basic statistics you can see at this page can be downloaded from this CSV file

For dipeptide frequency statistics click here
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski