Amino acid dipepetide frequency for Peptoniphilus lacrimalis 315-B

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
2.954AlaAla: 2.954 ± 0.117
0.788AlaCys: 0.788 ± 0.046
2.886AlaAsp: 2.886 ± 0.09
3.072AlaGlu: 3.072 ± 0.109
2.477AlaPhe: 2.477 ± 0.078
3.529AlaGly: 3.529 ± 0.106
0.8AlaHis: 0.8 ± 0.043
5.373AlaIle: 5.373 ± 0.11
5.4AlaLys: 5.4 ± 0.14
5.666AlaLeu: 5.666 ± 0.118
1.529AlaMet: 1.529 ± 0.057
2.898AlaAsn: 2.898 ± 0.097
1.404AlaPro: 1.404 ± 0.062
1.648AlaGln: 1.648 ± 0.066
2.184AlaArg: 2.184 ± 0.066
3.386AlaSer: 3.386 ± 0.096
2.773AlaThr: 2.773 ± 0.09
3.199AlaVal: 3.199 ± 0.096
0.301AlaTrp: 0.301 ± 0.026
2.139AlaTyr: 2.139 ± 0.059
0.0AlaXaa: 0.0 ± 0.0
Cys
0.559CysAla: 0.559 ± 0.034
0.125CysCys: 0.125 ± 0.017
0.602CysAsp: 0.602 ± 0.036
0.487CysGlu: 0.487 ± 0.034
0.352CysPhe: 0.352 ± 0.027
0.993CysGly: 0.993 ± 0.049
0.213CysHis: 0.213 ± 0.02
0.727CysIle: 0.727 ± 0.042
0.806CysLys: 0.806 ± 0.048
0.809CysLeu: 0.809 ± 0.038
0.188CysMet: 0.188 ± 0.018
0.469CysAsn: 0.469 ± 0.034
0.479CysPro: 0.479 ± 0.041
0.391CysGln: 0.391 ± 0.031
0.258CysArg: 0.258 ± 0.02
0.553CysSer: 0.553 ± 0.031
0.383CysThr: 0.383 ± 0.031
0.504CysVal: 0.504 ± 0.032
0.049CysTrp: 0.049 ± 0.009
0.403CysTyr: 0.403 ± 0.032
0.0CysXaa: 0.0 ± 0.0
Asp
3.081AspAla: 3.081 ± 0.099
0.475AspCys: 0.475 ± 0.028
3.555AspAsp: 3.555 ± 0.109
5.219AspGlu: 5.219 ± 0.112
3.746AspPhe: 3.746 ± 0.098
3.705AspGly: 3.705 ± 0.12
0.731AspHis: 0.731 ± 0.043
6.188AspIle: 6.188 ± 0.11
7.023AspLys: 7.023 ± 0.141
6.241AspLeu: 6.241 ± 0.109
1.504AspMet: 1.504 ± 0.064
3.424AspAsn: 3.424 ± 0.091
1.605AspPro: 1.605 ± 0.069
1.279AspGln: 1.279 ± 0.054
2.209AspArg: 2.209 ± 0.07
3.469AspSer: 3.469 ± 0.098
2.573AspThr: 2.573 ± 0.096
3.592AspVal: 3.592 ± 0.097
0.338AspTrp: 0.338 ± 0.032
3.199AspTyr: 3.199 ± 0.083
0.0AspXaa: 0.0 ± 0.0
Glu
3.803GluAla: 3.803 ± 0.1
0.415GluCys: 0.415 ± 0.028
5.158GluAsp: 5.158 ± 0.116
6.577GluGlu: 6.577 ± 0.157
3.308GluPhe: 3.308 ± 0.085
3.428GluGly: 3.428 ± 0.089
0.77GluHis: 0.77 ± 0.036
7.367GluIle: 7.367 ± 0.127
8.896GluLys: 8.896 ± 0.153
6.284GluLeu: 6.284 ± 0.118
1.713GluMet: 1.713 ± 0.06
6.4GluAsn: 6.4 ± 0.125
1.314GluPro: 1.314 ± 0.066
1.289GluGln: 1.289 ± 0.049
2.319GluArg: 2.319 ± 0.074
3.332GluSer: 3.332 ± 0.086
2.374GluThr: 2.374 ± 0.081
4.495GluVal: 4.495 ± 0.111
0.334GluTrp: 0.334 ± 0.027
2.683GluTyr: 2.683 ± 0.082
0.0GluXaa: 0.0 ± 0.0
Phe
2.591PheAla: 2.591 ± 0.071
0.467PheCys: 0.467 ± 0.033
3.058PheAsp: 3.058 ± 0.089
2.906PheGlu: 2.906 ± 0.077
2.294PhePhe: 2.294 ± 0.076
2.769PheGly: 2.769 ± 0.087
0.553PheHis: 0.553 ± 0.032
4.749PheIle: 4.749 ± 0.113
4.407PheLys: 4.407 ± 0.099
4.88PheLeu: 4.88 ± 0.133
1.114PheMet: 1.114 ± 0.051
2.81PheAsn: 2.81 ± 0.066
1.287PhePro: 1.287 ± 0.052
1.095PheGln: 1.095 ± 0.045
1.414PheArg: 1.414 ± 0.054
3.695PheSer: 3.695 ± 0.097
2.565PheThr: 2.565 ± 0.083
2.833PheVal: 2.833 ± 0.068
0.289PheTrp: 0.289 ± 0.026
2.159PheTyr: 2.159 ± 0.069
0.0PheXaa: 0.0 ± 0.0
Gly
3.819GlyAla: 3.819 ± 0.108
0.583GlyCys: 0.583 ± 0.038
3.273GlyAsp: 3.273 ± 0.089
3.867GlyGlu: 3.867 ± 0.104
2.99GlyPhe: 2.99 ± 0.081
4.126GlyGly: 4.126 ± 0.124
0.952GlyHis: 0.952 ± 0.042
5.999GlyIle: 5.999 ± 0.122
6.055GlyLys: 6.055 ± 0.122
5.795GlyLeu: 5.795 ± 0.13
1.423GlyMet: 1.423 ± 0.058
3.132GlyAsn: 3.132 ± 0.102
1.339GlyPro: 1.339 ± 0.059
2.022GlyGln: 2.022 ± 0.063
2.272GlyArg: 2.272 ± 0.078
3.498GlySer: 3.498 ± 0.09
3.076GlyThr: 3.076 ± 0.096
3.746GlyVal: 3.746 ± 0.092
0.428GlyTrp: 0.428 ± 0.046
2.878GlyTyr: 2.878 ± 0.088
0.0GlyXaa: 0.0 ± 0.0
His
0.604HisAla: 0.604 ± 0.034
0.131HisCys: 0.131 ± 0.017
0.614HisAsp: 0.614 ± 0.037
0.851HisGlu: 0.851 ± 0.04
0.634HisPhe: 0.634 ± 0.036
0.95HisGly: 0.95 ± 0.045
0.229HisHis: 0.229 ± 0.019
1.224HisIle: 1.224 ± 0.051
1.04HisLys: 1.04 ± 0.047
1.107HisLeu: 1.107 ± 0.045
0.272HisMet: 0.272 ± 0.026
0.634HisAsn: 0.634 ± 0.036
0.532HisPro: 0.532 ± 0.034
0.332HisGln: 0.332 ± 0.026
0.544HisArg: 0.544 ± 0.032
0.725HisSer: 0.725 ± 0.036
0.563HisThr: 0.563 ± 0.035
0.686HisVal: 0.686 ± 0.037
0.119HisTrp: 0.119 ± 0.017
0.59HisTyr: 0.59 ± 0.033
0.0HisXaa: 0.0 ± 0.0
Ile
4.947IleAla: 4.947 ± 0.115
1.181IleCys: 1.181 ± 0.054
6.315IleAsp: 6.315 ± 0.128
6.82IleGlu: 6.82 ± 0.131
5.025IlePhe: 5.025 ± 0.127
5.668IleGly: 5.668 ± 0.138
1.042IleHis: 1.042 ± 0.046
8.773IleIle: 8.773 ± 0.193
9.018IleLys: 9.018 ± 0.129
9.467IleLeu: 9.467 ± 0.187
1.914IleMet: 1.914 ± 0.074
5.917IleAsn: 5.917 ± 0.11
3.072IlePro: 3.072 ± 0.087
1.619IleGln: 1.619 ± 0.055
3.087IleArg: 3.087 ± 0.083
7.379IleSer: 7.379 ± 0.143
4.02IleThr: 4.02 ± 0.09
5.645IleVal: 5.645 ± 0.13
0.405IleTrp: 0.405 ± 0.028
4.12IleTyr: 4.12 ± 0.102
0.0IleXaa: 0.0 ± 0.0
Lys
5.412LysAla: 5.412 ± 0.143
0.559LysCys: 0.559 ± 0.042
8.054LysAsp: 8.054 ± 0.191
9.393LysGlu: 9.393 ± 0.154
3.924LysPhe: 3.924 ± 0.088
5.142LysGly: 5.142 ± 0.109
0.948LysHis: 0.948 ± 0.043
9.786LysIle: 9.786 ± 0.149
9.888LysLys: 9.888 ± 0.141
8.167LysLeu: 8.167 ± 0.131
2.243LysMet: 2.243 ± 0.067
8.175LysAsn: 8.175 ± 0.148
2.045LysPro: 2.045 ± 0.094
1.576LysGln: 1.576 ± 0.06
3.377LysArg: 3.377 ± 0.072
5.725LysSer: 5.725 ± 0.118
4.618LysThr: 4.618 ± 0.114
5.989LysVal: 5.989 ± 0.118
0.53LysTrp: 0.53 ± 0.034
4.251LysTyr: 4.251 ± 0.102
0.0LysXaa: 0.0 ± 0.0
Leu
5.353LeuAla: 5.353 ± 0.129
0.89LeuCys: 0.89 ± 0.042
5.913LeuAsp: 5.913 ± 0.116
6.572LeuGlu: 6.572 ± 0.123
4.116LeuPhe: 4.116 ± 0.108
5.84LeuGly: 5.84 ± 0.129
0.952LeuHis: 0.952 ± 0.04
8.544LeuIle: 8.544 ± 0.176
9.704LeuLys: 9.704 ± 0.158
7.989LeuLeu: 7.989 ± 0.161
2.278LeuMet: 2.278 ± 0.071
5.965LeuAsn: 5.965 ± 0.133
2.755LeuPro: 2.755 ± 0.077
2.088LeuGln: 2.088 ± 0.066
3.473LeuArg: 3.473 ± 0.074
7.082LeuSer: 7.082 ± 0.148
4.538LeuThr: 4.538 ± 0.107
5.396LeuVal: 5.396 ± 0.1
0.508LeuTrp: 0.508 ± 0.031
3.437LeuTyr: 3.437 ± 0.089
0.0LeuXaa: 0.0 ± 0.0
Met
1.84MetAla: 1.84 ± 0.076
0.207MetCys: 0.207 ± 0.018
1.623MetAsp: 1.623 ± 0.066
1.799MetGlu: 1.799 ± 0.068
0.782MetPhe: 0.782 ± 0.041
1.777MetGly: 1.777 ± 0.071
0.227MetHis: 0.227 ± 0.021
1.949MetIle: 1.949 ± 0.068
2.425MetLys: 2.425 ± 0.065
1.899MetLeu: 1.899 ± 0.064
0.516MetMet: 0.516 ± 0.036
1.433MetAsn: 1.433 ± 0.05
0.851MetPro: 0.851 ± 0.039
0.608MetGln: 0.608 ± 0.034
0.788MetArg: 0.788 ± 0.043
1.466MetSer: 1.466 ± 0.061
1.216MetThr: 1.216 ± 0.048
1.324MetVal: 1.324 ± 0.064
0.119MetTrp: 0.119 ± 0.013
0.649MetTyr: 0.649 ± 0.036
0.0MetXaa: 0.0 ± 0.0
Asn
2.904AsnAla: 2.904 ± 0.09
0.53AsnCys: 0.53 ± 0.035
3.042AsnAsp: 3.042 ± 0.099
3.932AsnGlu: 3.932 ± 0.09
3.48AsnPhe: 3.48 ± 0.091
3.347AsnGly: 3.347 ± 0.097
0.786AsnHis: 0.786 ± 0.043
6.847AsnIle: 6.847 ± 0.126
6.531AsnLys: 6.531 ± 0.142
6.882AsnLeu: 6.882 ± 0.137
1.486AsnMet: 1.486 ± 0.055
4.133AsnAsn: 4.133 ± 0.137
2.335AsnPro: 2.335 ± 0.09
1.459AsnGln: 1.459 ± 0.063
2.211AsnArg: 2.211 ± 0.073
4.006AsnSer: 4.006 ± 0.106
2.7AsnThr: 2.7 ± 0.074
3.128AsnVal: 3.128 ± 0.076
0.358AsnTrp: 0.358 ± 0.026
2.999AsnTyr: 2.999 ± 0.092
0.0AsnXaa: 0.0 ± 0.0
Pro
1.423ProAla: 1.423 ± 0.067
0.289ProCys: 0.289 ± 0.024
1.607ProAsp: 1.607 ± 0.073
1.971ProGlu: 1.971 ± 0.07
1.369ProPhe: 1.369 ± 0.051
1.609ProGly: 1.609 ± 0.063
0.45ProHis: 0.45 ± 0.034
2.649ProIle: 2.649 ± 0.085
2.622ProLys: 2.622 ± 0.099
2.389ProLeu: 2.389 ± 0.073
0.747ProMet: 0.747 ± 0.041
1.629ProAsn: 1.629 ± 0.089
0.608ProPro: 0.608 ± 0.039
0.95ProGln: 0.95 ± 0.044
0.888ProArg: 0.888 ± 0.045
1.897ProSer: 1.897 ± 0.066
1.525ProThr: 1.525 ± 0.059
1.789ProVal: 1.789 ± 0.061
0.16ProTrp: 0.16 ± 0.02
1.245ProTyr: 1.245 ± 0.048
0.0ProXaa: 0.0 ± 0.0
Gln
1.644GlnAla: 1.644 ± 0.062
0.139GlnCys: 0.139 ± 0.018
1.263GlnAsp: 1.263 ± 0.053
1.838GlnGlu: 1.838 ± 0.059
0.8GlnPhe: 0.8 ± 0.042
1.666GlnGly: 1.666 ± 0.057
0.19GlnHis: 0.19 ± 0.021
2.528GlnIle: 2.528 ± 0.072
2.425GlnLys: 2.425 ± 0.082
1.65GlnLeu: 1.65 ± 0.061
0.725GlnMet: 0.725 ± 0.041
1.367GlnAsn: 1.367 ± 0.054
0.444GlnPro: 0.444 ± 0.032
0.405GlnGln: 0.405 ± 0.031
1.124GlnArg: 1.124 ± 0.046
1.333GlnSer: 1.333 ± 0.049
1.156GlnThr: 1.156 ± 0.043
1.766GlnVal: 1.766 ± 0.059
0.145GlnTrp: 0.145 ± 0.017
0.819GlnTyr: 0.819 ± 0.04
0.0GlnXaa: 0.0 ± 0.0
Arg
2.127ArgAla: 2.127 ± 0.062
0.332ArgCys: 0.332 ± 0.027
2.411ArgAsp: 2.411 ± 0.069
3.033ArgGlu: 3.033 ± 0.09
1.609ArgPhe: 1.609 ± 0.058
2.163ArgGly: 2.163 ± 0.07
0.473ArgHis: 0.473 ± 0.028
3.101ArgIle: 3.101 ± 0.081
3.316ArgLys: 3.316 ± 0.084
3.074ArgLeu: 3.074 ± 0.079
0.854ArgMet: 0.854 ± 0.043
2.088ArgAsn: 2.088 ± 0.069
1.111ArgPro: 1.111 ± 0.049
1.111ArgGln: 1.111 ± 0.042
1.509ArgArg: 1.509 ± 0.063
1.775ArgSer: 1.775 ± 0.059
1.529ArgThr: 1.529 ± 0.056
2.186ArgVal: 2.186 ± 0.067
0.178ArgTrp: 0.178 ± 0.023
1.38ArgTyr: 1.38 ± 0.061
0.0ArgXaa: 0.0 ± 0.0
Ser
3.142SerAla: 3.142 ± 0.079
0.583SerCys: 0.583 ± 0.039
3.586SerAsp: 3.586 ± 0.084
3.793SerGlu: 3.793 ± 0.078
3.431SerPhe: 3.431 ± 0.088
4.264SerGly: 4.264 ± 0.107
0.999SerHis: 0.999 ± 0.046
5.948SerIle: 5.948 ± 0.119
6.063SerLys: 6.063 ± 0.131
6.814SerLeu: 6.814 ± 0.132
1.441SerMet: 1.441 ± 0.052
3.519SerAsn: 3.519 ± 0.088
1.793SerPro: 1.793 ± 0.054
2.047SerGln: 2.047 ± 0.067
1.981SerArg: 1.981 ± 0.071
4.339SerSer: 4.339 ± 0.107
2.906SerThr: 2.906 ± 0.081
3.48SerVal: 3.48 ± 0.091
0.461SerTrp: 0.461 ± 0.035
3.269SerTyr: 3.269 ± 0.087
0.0SerXaa: 0.0 ± 0.0
Thr
2.595ThrAla: 2.595 ± 0.089
0.495ThrCys: 0.495 ± 0.032
2.861ThrAsp: 2.861 ± 0.073
2.724ThrGlu: 2.724 ± 0.078
2.325ThrPhe: 2.325 ± 0.086
3.199ThrGly: 3.199 ± 0.108
0.698ThrHis: 0.698 ± 0.039
4.233ThrIle: 4.233 ± 0.096
3.811ThrLys: 3.811 ± 0.094
4.255ThrLeu: 4.255 ± 0.085
1.109ThrMet: 1.109 ± 0.044
2.595ThrAsn: 2.595 ± 0.074
1.537ThrPro: 1.537 ± 0.064
1.005ThrGln: 1.005 ± 0.041
1.719ThrArg: 1.719 ± 0.053
3.029ThrSer: 3.029 ± 0.084
2.364ThrThr: 2.364 ± 0.08
2.954ThrVal: 2.954 ± 0.076
0.311ThrTrp: 0.311 ± 0.027
2.049ThrTyr: 2.049 ± 0.07
0.0ThrXaa: 0.0 ± 0.0
Val
3.236ValAla: 3.236 ± 0.097
0.659ValCys: 0.659 ± 0.038
4.026ValAsp: 4.026 ± 0.1
4.178ValGlu: 4.178 ± 0.098
2.878ValPhe: 2.878 ± 0.079
4.102ValGly: 4.102 ± 0.111
0.696ValHis: 0.696 ± 0.039
5.283ValIle: 5.283 ± 0.115
5.428ValLys: 5.428 ± 0.133
5.428ValLeu: 5.428 ± 0.129
1.269ValMet: 1.269 ± 0.056
3.516ValAsn: 3.516 ± 0.09
1.889ValPro: 1.889 ± 0.073
1.165ValGln: 1.165 ± 0.051
2.039ValArg: 2.039 ± 0.062
4.173ValSer: 4.173 ± 0.109
2.87ValThr: 2.87 ± 0.113
3.748ValVal: 3.748 ± 0.097
0.289ValTrp: 0.289 ± 0.024
2.25ValTyr: 2.25 ± 0.065
0.0ValXaa: 0.0 ± 0.0
Trp
0.401TrpAla: 0.401 ± 0.033
0.053TrpCys: 0.053 ± 0.011
0.444TrpAsp: 0.444 ± 0.033
0.371TrpGlu: 0.371 ± 0.03
0.242TrpPhe: 0.242 ± 0.021
0.399TrpGly: 0.399 ± 0.032
0.088TrpHis: 0.088 ± 0.014
0.499TrpIle: 0.499 ± 0.034
0.467TrpLys: 0.467 ± 0.036
0.393TrpLeu: 0.393 ± 0.028
0.18TrpMet: 0.18 ± 0.018
0.348TrpAsn: 0.348 ± 0.026
0.113TrpPro: 0.113 ± 0.015
0.223TrpGln: 0.223 ± 0.023
0.225TrpArg: 0.225 ± 0.023
0.321TrpSer: 0.321 ± 0.031
0.311TrpThr: 0.311 ± 0.028
0.307TrpVal: 0.307 ± 0.032
0.051TrpTrp: 0.051 ± 0.009
0.24TrpTyr: 0.24 ± 0.023
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.971TyrAla: 1.971 ± 0.056
0.452TyrCys: 0.452 ± 0.033
2.866TyrAsp: 2.866 ± 0.084
2.857TyrGlu: 2.857 ± 0.076
2.153TyrPhe: 2.153 ± 0.071
2.597TyrGly: 2.597 ± 0.07
0.583TyrHis: 0.583 ± 0.034
3.664TyrIle: 3.664 ± 0.091
4.478TyrLys: 4.478 ± 0.109
4.206TyrLeu: 4.206 ± 0.097
0.991TyrMet: 0.991 ± 0.044
2.647TyrAsn: 2.647 ± 0.078
1.306TyrPro: 1.306 ± 0.053
1.114TyrGln: 1.114 ± 0.048
1.74TyrArg: 1.74 ± 0.063
2.677TyrSer: 2.677 ± 0.068
1.805TyrThr: 1.805 ± 0.071
2.354TyrVal: 2.354 ± 0.081
0.301TyrTrp: 0.301 ± 0.035
2.121TyrTyr: 2.121 ± 0.086
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1588 proteins (511444 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski