Amino acid dipepetide frequency for Rathayibacter oskolensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	20.509AlaAla: 20.509 ± 0.2	0.641AlaCys: 0.641 ± 0.025	8.012AlaAsp: 8.012 ± 0.096	8.498AlaGlu: 8.498 ± 0.116	3.988AlaPhe: 3.988 ± 0.063	12.282AlaGly: 12.282 ± 0.131	2.422AlaHis: 2.422 ± 0.056	5.475AlaIle: 5.475 ± 0.071	2.161AlaLys: 2.161 ± 0.046	15.368AlaLeu: 15.368 ± 0.17	2.44AlaMet: 2.44 ± 0.045	2.051AlaAsn: 2.051 ± 0.042	6.977AlaPro: 6.977 ± 0.092	3.326AlaGln: 3.326 ± 0.056	9.579AlaArg: 9.579 ± 0.114	8.415AlaSer: 8.415 ± 0.094	7.711AlaThr: 7.711 ± 0.114	12.834AlaVal: 12.834 ± 0.13	1.795AlaTrp: 1.795 ± 0.042	2.309AlaTyr: 2.309 ± 0.046	0.0AlaXaa: 0.0 ± 0.0
Cys	0.599CysAla: 0.599 ± 0.029	0.04CysCys: 0.04 ± 0.006	0.301CysAsp: 0.301 ± 0.016	0.223CysGlu: 0.223 ± 0.011	0.149CysPhe: 0.149 ± 0.01	0.526CysGly: 0.526 ± 0.024	0.082CysHis: 0.082 ± 0.009	0.174CysIle: 0.174 ± 0.012	0.049CysLys: 0.049 ± 0.006	0.442CysLeu: 0.442 ± 0.023	0.075CysMet: 0.075 ± 0.008	0.077CysAsn: 0.077 ± 0.008	0.274CysPro: 0.274 ± 0.016	0.098CysGln: 0.098 ± 0.01	0.294CysArg: 0.294 ± 0.017	0.345CysSer: 0.345 ± 0.017	0.361CysThr: 0.361 ± 0.018	0.439CysVal: 0.439 ± 0.021	0.065CysTrp: 0.065 ± 0.007	0.099CysTyr: 0.099 ± 0.009	0.0CysXaa: 0.0 ± 0.0
Asp	8.345AspAla: 8.345 ± 0.092	0.261AspCys: 0.261 ± 0.016	4.285AspAsp: 4.285 ± 0.072	4.525AspGlu: 4.525 ± 0.071	1.722AspPhe: 1.722 ± 0.045	6.322AspGly: 6.322 ± 0.094	1.106AspHis: 1.106 ± 0.028	2.077AspIle: 2.077 ± 0.046	0.711AspLys: 0.711 ± 0.029	6.202AspLeu: 6.202 ± 0.079	0.67AspMet: 0.67 ± 0.022	0.769AspAsn: 0.769 ± 0.026	4.435AspPro: 4.435 ± 0.077	1.414AspGln: 1.414 ± 0.035	4.922AspArg: 4.922 ± 0.078	3.296AspSer: 3.296 ± 0.055	2.807AspThr: 2.807 ± 0.05	5.398AspVal: 5.398 ± 0.072	0.933AspTrp: 0.933 ± 0.03	1.319AspTyr: 1.319 ± 0.034	0.0AspXaa: 0.0 ± 0.0
Glu	7.728GluAla: 7.728 ± 0.094	0.221GluCys: 0.221 ± 0.014	2.782GluAsp: 2.782 ± 0.053	3.579GluGlu: 3.579 ± 0.066	1.549GluPhe: 1.549 ± 0.037	4.437GluGly: 4.437 ± 0.069	1.457GluHis: 1.457 ± 0.034	2.678GluIle: 2.678 ± 0.041	1.264GluLys: 1.264 ± 0.038	6.722GluLeu: 6.722 ± 0.088	0.882GluMet: 0.882 ± 0.025	1.196GluAsn: 1.196 ± 0.031	3.307GluPro: 3.307 ± 0.055	2.082GluGln: 2.082 ± 0.043	5.818GluArg: 5.818 ± 0.093	3.32GluSer: 3.32 ± 0.061	3.114GluThr: 3.114 ± 0.049	4.473GluVal: 4.473 ± 0.069	0.961GluTrp: 0.961 ± 0.034	1.126GluTyr: 1.126 ± 0.035	0.0GluXaa: 0.0 ± 0.0
Phe	4.279PheAla: 4.279 ± 0.07	0.169PheCys: 0.169 ± 0.011	2.386PheAsp: 2.386 ± 0.047	1.851PheGlu: 1.851 ± 0.037	1.101PhePhe: 1.101 ± 0.041	3.229PheGly: 3.229 ± 0.057	0.536PheHis: 0.536 ± 0.022	0.929PheIle: 0.929 ± 0.033	0.373PheLys: 0.373 ± 0.02	2.834PheLeu: 2.834 ± 0.059	0.361PheMet: 0.361 ± 0.017	0.517PheAsn: 0.517 ± 0.023	1.403PhePro: 1.403 ± 0.035	0.661PheGln: 0.661 ± 0.027	1.81PheArg: 1.81 ± 0.042	1.892PheSer: 1.892 ± 0.038	2.017PheThr: 2.017 ± 0.044	2.838PheVal: 2.838 ± 0.045	0.487PheTrp: 0.487 ± 0.022	0.641PheTyr: 0.641 ± 0.027	0.0PheXaa: 0.0 ± 0.0
Gly	11.56GlyAla: 11.56 ± 0.119	0.525GlyCys: 0.525 ± 0.021	5.219GlyAsp: 5.219 ± 0.077	4.957GlyGlu: 4.957 ± 0.064	3.279GlyPhe: 3.279 ± 0.058	8.181GlyGly: 8.181 ± 0.11	1.655GlyHis: 1.655 ± 0.043	4.341GlyIle: 4.341 ± 0.07	1.594GlyLys: 1.594 ± 0.042	9.129GlyLeu: 9.129 ± 0.094	1.698GlyMet: 1.698 ± 0.042	1.535GlyAsn: 1.535 ± 0.051	4.065GlyPro: 4.065 ± 0.066	2.074GlyGln: 2.074 ± 0.049	7.077GlyArg: 7.077 ± 0.091	6.134GlySer: 6.134 ± 0.082	5.808GlyThr: 5.808 ± 0.084	8.457GlyVal: 8.457 ± 0.108	1.529GlyTrp: 1.529 ± 0.033	2.224GlyTyr: 2.224 ± 0.039	0.0GlyXaa: 0.0 ± 0.0
His	2.122HisAla: 2.122 ± 0.044	0.104HisCys: 0.104 ± 0.01	1.223HisAsp: 1.223 ± 0.036	1.1HisGlu: 1.1 ± 0.031	0.53HisPhe: 0.53 ± 0.023	1.856HisGly: 1.856 ± 0.044	0.486HisHis: 0.486 ± 0.023	0.544HisIle: 0.544 ± 0.022	0.171HisLys: 0.171 ± 0.013	2.134HisLeu: 2.134 ± 0.05	0.222HisMet: 0.222 ± 0.013	0.287HisAsn: 0.287 ± 0.014	1.471HisPro: 1.471 ± 0.038	0.437HisGln: 0.437 ± 0.018	1.647HisArg: 1.647 ± 0.037	0.946HisSer: 0.946 ± 0.027	0.807HisThr: 0.807 ± 0.027	1.584HisVal: 1.584 ± 0.039	0.276HisTrp: 0.276 ± 0.017	0.421HisTyr: 0.421 ± 0.019	0.0HisXaa: 0.0 ± 0.0
Ile	6.55IleAla: 6.55 ± 0.085	0.233IleCys: 0.233 ± 0.014	3.314IleAsp: 3.314 ± 0.055	2.713IleGlu: 2.713 ± 0.049	0.924IlePhe: 0.924 ± 0.036	4.459IleGly: 4.459 ± 0.078	0.603IleHis: 0.603 ± 0.022	1.373IleIle: 1.373 ± 0.041	0.603IleLys: 0.603 ± 0.025	3.46IleLeu: 3.46 ± 0.063	0.463IleMet: 0.463 ± 0.019	0.69IleAsn: 0.69 ± 0.023	2.161IlePro: 2.161 ± 0.054	0.851IleGln: 0.851 ± 0.029	2.606IleArg: 2.606 ± 0.052	2.005IleSer: 2.005 ± 0.041	2.633IleThr: 2.633 ± 0.05	4.226IleVal: 4.226 ± 0.067	0.432IleTrp: 0.432 ± 0.017	0.646IleTyr: 0.646 ± 0.027	0.0IleXaa: 0.0 ± 0.0
Lys	1.869LysAla: 1.869 ± 0.049	0.043LysCys: 0.043 ± 0.006	0.863LysAsp: 0.863 ± 0.034	0.805LysGlu: 0.805 ± 0.027	0.373LysPhe: 0.373 ± 0.019	1.281LysGly: 1.281 ± 0.039	0.351LysHis: 0.351 ± 0.019	0.691LysIle: 0.691 ± 0.027	0.588LysLys: 0.588 ± 0.029	1.455LysLeu: 1.455 ± 0.043	0.281LysMet: 0.281 ± 0.015	0.445LysAsn: 0.445 ± 0.022	0.933LysPro: 0.933 ± 0.029	0.518LysGln: 0.518 ± 0.023	1.294LysArg: 1.294 ± 0.037	0.886LysSer: 0.886 ± 0.031	1.134LysThr: 1.134 ± 0.035	1.289LysVal: 1.289 ± 0.043	0.19LysTrp: 0.19 ± 0.013	0.366LysTyr: 0.366 ± 0.017	0.0LysXaa: 0.0 ± 0.0
Leu	15.944LeuAla: 15.944 ± 0.165	0.523LeuCys: 0.523 ± 0.021	7.137LeuAsp: 7.137 ± 0.079	5.867LeuGlu: 5.867 ± 0.08	2.807LeuPhe: 2.807 ± 0.061	9.791LeuGly: 9.791 ± 0.116	1.926LeuHis: 1.926 ± 0.042	3.994LeuIle: 3.994 ± 0.081	1.383LeuLys: 1.383 ± 0.039	11.489LeuLeu: 11.489 ± 0.143	1.332LeuMet: 1.332 ± 0.034	1.486LeuAsn: 1.486 ± 0.037	5.839LeuPro: 5.839 ± 0.083	2.39LeuGln: 2.39 ± 0.05	8.135LeuArg: 8.135 ± 0.1	6.169LeuSer: 6.169 ± 0.078	6.115LeuThr: 6.115 ± 0.072	10.205LeuVal: 10.205 ± 0.109	1.239LeuTrp: 1.239 ± 0.035	1.661LeuTyr: 1.661 ± 0.043	0.0LeuXaa: 0.0 ± 0.0
Met	1.749MetAla: 1.749 ± 0.038	0.077MetCys: 0.077 ± 0.008	0.715MetAsp: 0.715 ± 0.024	0.568MetGlu: 0.568 ± 0.022	0.414MetPhe: 0.414 ± 0.02	1.07MetGly: 1.07 ± 0.029	0.3MetHis: 0.3 ± 0.018	0.774MetIle: 0.774 ± 0.026	0.322MetLys: 0.322 ± 0.016	1.636MetLeu: 1.636 ± 0.034	0.237MetMet: 0.237 ± 0.016	0.399MetAsn: 0.399 ± 0.016	0.933MetPro: 0.933 ± 0.029	0.446MetGln: 0.446 ± 0.025	1.222MetArg: 1.222 ± 0.032	1.403MetSer: 1.403 ± 0.034	1.675MetThr: 1.675 ± 0.034	1.153MetVal: 1.153 ± 0.03	0.142MetTrp: 0.142 ± 0.009	0.221MetTyr: 0.221 ± 0.014	0.0MetXaa: 0.0 ± 0.0
Asn	2.177AsnAla: 2.177 ± 0.046	0.111AsnCys: 0.111 ± 0.01	1.021AsnAsp: 1.021 ± 0.033	0.857AsnGlu: 0.857 ± 0.029	0.554AsnPhe: 0.554 ± 0.023	1.765AsnGly: 1.765 ± 0.05	0.325AsnHis: 0.325 ± 0.019	0.704AsnIle: 0.704 ± 0.026	0.295AsnLys: 0.295 ± 0.016	1.643AsnLeu: 1.643 ± 0.038	0.242AsnMet: 0.242 ± 0.015	0.398AsnAsn: 0.398 ± 0.023	1.28AsnPro: 1.28 ± 0.034	0.463AsnGln: 0.463 ± 0.018	1.187AsnArg: 1.187 ± 0.029	0.849AsnSer: 0.849 ± 0.028	1.002AsnThr: 1.002 ± 0.035	1.479AsnVal: 1.479 ± 0.041	0.26AsnTrp: 0.26 ± 0.016	0.439AsnTyr: 0.439 ± 0.022	0.0AsnXaa: 0.0 ± 0.0
Pro	7.406ProAla: 7.406 ± 0.097	0.176ProCys: 0.176 ± 0.013	3.788ProAsp: 3.788 ± 0.061	4.246ProGlu: 4.246 ± 0.067	1.77ProPhe: 1.77 ± 0.039	5.184ProGly: 5.184 ± 0.065	1.003ProHis: 1.003 ± 0.028	1.986ProIle: 1.986 ± 0.041	0.781ProLys: 0.781 ± 0.027	5.372ProLeu: 5.372 ± 0.074	0.821ProMet: 0.821 ± 0.024	0.886ProAsn: 0.886 ± 0.029	2.512ProPro: 2.512 ± 0.067	1.301ProGln: 1.301 ± 0.033	3.711ProArg: 3.711 ± 0.061	3.542ProSer: 3.542 ± 0.059	3.627ProThr: 3.627 ± 0.08	5.191ProVal: 5.191 ± 0.068	0.874ProTrp: 0.874 ± 0.027	1.031ProTyr: 1.031 ± 0.032	0.0ProXaa: 0.0 ± 0.0
Gln	2.939GlnAla: 2.939 ± 0.053	0.124GlnCys: 0.124 ± 0.011	1.142GlnAsp: 1.142 ± 0.037	1.305GlnGlu: 1.305 ± 0.035	0.738GlnPhe: 0.738 ± 0.026	1.856GlnGly: 1.856 ± 0.043	0.469GlnHis: 0.469 ± 0.019	1.204GlnIle: 1.204 ± 0.035	0.58GlnLys: 0.58 ± 0.024	2.857GlnLeu: 2.857 ± 0.053	0.399GlnMet: 0.399 ± 0.018	0.612GlnAsn: 0.612 ± 0.026	1.317GlnPro: 1.317 ± 0.036	0.993GlnGln: 0.993 ± 0.042	2.148GlnArg: 2.148 ± 0.047	1.424GlnSer: 1.424 ± 0.033	1.408GlnThr: 1.408 ± 0.034	2.005GlnVal: 2.005 ± 0.047	0.427GlnTrp: 0.427 ± 0.022	0.624GlnTyr: 0.624 ± 0.026	0.0GlnXaa: 0.0 ± 0.0
Arg	9.783ArgAla: 9.783 ± 0.104	0.302ArgCys: 0.302 ± 0.017	4.223ArgAsp: 4.223 ± 0.068	4.549ArgGlu: 4.549 ± 0.079	2.57ArgPhe: 2.57 ± 0.044	5.75ArgGly: 5.75 ± 0.079	1.524ArgHis: 1.524 ± 0.042	3.674ArgIle: 3.674 ± 0.058	1.035ArgLys: 1.035 ± 0.035	8.183ArgLeu: 8.183 ± 0.109	1.646ArgMet: 1.646 ± 0.039	1.191ArgAsn: 1.191 ± 0.031	4.091ArgPro: 4.091 ± 0.067	1.827ArgGln: 1.827 ± 0.047	7.223ArgArg: 7.223 ± 0.096	5.006ArgSer: 5.006 ± 0.063	4.51ArgThr: 4.51 ± 0.061	6.208ArgVal: 6.208 ± 0.079	1.199ArgTrp: 1.199 ± 0.033	1.564ArgTyr: 1.564 ± 0.04	0.0ArgXaa: 0.0 ± 0.0
Ser	8.294SerAla: 8.294 ± 0.098	0.254SerCys: 0.254 ± 0.015	3.462SerAsp: 3.462 ± 0.053	3.015SerGlu: 3.015 ± 0.058	2.034SerPhe: 2.034 ± 0.043	6.666SerGly: 6.666 ± 0.079	0.932SerHis: 0.932 ± 0.026	2.627SerIle: 2.627 ± 0.047	0.949SerLys: 0.949 ± 0.032	5.908SerLeu: 5.908 ± 0.073	1.124SerMet: 1.124 ± 0.031	1.015SerAsn: 1.015 ± 0.032	3.302SerPro: 3.302 ± 0.06	1.287SerGln: 1.287 ± 0.034	4.267SerArg: 4.267 ± 0.06	4.28SerSer: 4.28 ± 0.08	4.277SerThr: 4.277 ± 0.065	5.471SerVal: 5.471 ± 0.07	0.955SerTrp: 0.955 ± 0.03	1.347SerTyr: 1.347 ± 0.037	0.0SerXaa: 0.0 ± 0.0
Thr	8.808ThrAla: 8.808 ± 0.107	0.244ThrCys: 0.244 ± 0.016	3.479ThrAsp: 3.479 ± 0.059	3.087ThrGlu: 3.087 ± 0.052	1.76ThrPhe: 1.76 ± 0.038	5.95ThrGly: 5.95 ± 0.088	0.935ThrHis: 0.935 ± 0.025	2.586ThrIle: 2.586 ± 0.048	0.964ThrLys: 0.964 ± 0.032	6.287ThrLeu: 6.287 ± 0.096	0.78ThrMet: 0.78 ± 0.025	0.999ThrAsn: 0.999 ± 0.03	4.178ThrPro: 4.178 ± 0.079	1.249ThrGln: 1.249 ± 0.031	3.873ThrArg: 3.873 ± 0.063	3.732ThrSer: 3.732 ± 0.059	4.264ThrThr: 4.264 ± 0.085	6.09ThrVal: 6.09 ± 0.108	0.833ThrTrp: 0.833 ± 0.03	1.022ThrTyr: 1.022 ± 0.034	0.0ThrXaa: 0.0 ± 0.0
Val	12.287ValAla: 12.287 ± 0.121	0.474ValCys: 0.474 ± 0.02	6.07ValAsp: 6.07 ± 0.075	5.225ValGlu: 5.225 ± 0.069	2.855ValPhe: 2.855 ± 0.052	7.468ValGly: 7.468 ± 0.112	1.693ValHis: 1.693 ± 0.039	3.847ValIle: 3.847 ± 0.061	1.281ValLys: 1.281 ± 0.037	10.49ValLeu: 10.49 ± 0.128	1.275ValMet: 1.275 ± 0.038	1.617ValAsn: 1.617 ± 0.043	5.012ValPro: 5.012 ± 0.067	2.132ValGln: 2.132 ± 0.049	6.301ValArg: 6.301 ± 0.078	5.392ValSer: 5.392 ± 0.076	5.791ValThr: 5.791 ± 0.101	9.99ValVal: 9.99 ± 0.104	1.064ValTrp: 1.064 ± 0.034	1.584ValTyr: 1.584 ± 0.04	0.0ValXaa: 0.0 ± 0.0
Trp	1.548TrpAla: 1.548 ± 0.04	0.084TrpCys: 0.084 ± 0.008	0.749TrpAsp: 0.749 ± 0.027	0.668TrpGlu: 0.668 ± 0.024	0.53TrpPhe: 0.53 ± 0.018	1.064TrpGly: 1.064 ± 0.033	0.263TrpHis: 0.263 ± 0.015	0.647TrpIle: 0.647 ± 0.024	0.278TrpLys: 0.278 ± 0.019	1.615TrpLeu: 1.615 ± 0.04	0.264TrpMet: 0.264 ± 0.015	0.434TrpAsn: 0.434 ± 0.019	0.688TrpPro: 0.688 ± 0.023	0.513TrpGln: 0.513 ± 0.025	1.237TrpArg: 1.237 ± 0.039	1.131TrpSer: 1.131 ± 0.035	0.935TrpThr: 0.935 ± 0.03	1.046TrpVal: 1.046 ± 0.028	0.322TrpTrp: 0.322 ± 0.017	0.292TrpTyr: 0.292 ± 0.015	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.297TyrAla: 2.297 ± 0.046	0.106TyrCys: 0.106 ± 0.01	1.349TyrAsp: 1.349 ± 0.035	1.059TyrGlu: 1.059 ± 0.029	0.667TyrPhe: 0.667 ± 0.024	1.905TyrGly: 1.905 ± 0.044	0.302TyrHis: 0.302 ± 0.015	0.62TyrIle: 0.62 ± 0.022	0.273TyrLys: 0.273 ± 0.016	2.205TyrLeu: 2.205 ± 0.039	0.241TyrMet: 0.241 ± 0.016	0.447TyrAsn: 0.447 ± 0.02	1.03TyrPro: 1.03 ± 0.032	0.509TyrGln: 0.509 ± 0.024	1.705TyrArg: 1.705 ± 0.045	1.297TyrSer: 1.297 ± 0.034	1.122TyrThr: 1.122 ± 0.034	1.473TyrVal: 1.473 ± 0.036	0.327TyrTrp: 0.327 ± 0.017	0.509TyrTyr: 0.509 ± 0.025	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3628 proteins (1186705 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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