Amino acid dipepetide frequency for Cellulophaga phage phi18:1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.794AlaAla: 4.794 ± 1.34
0.799AlaCys: 0.799 ± 0.27
3.516AlaAsp: 3.516 ± 0.529
3.755AlaGlu: 3.755 ± 0.615
2.637AlaPhe: 2.637 ± 0.517
3.915AlaGly: 3.915 ± 0.522
0.879AlaHis: 0.879 ± 0.261
4.794AlaIle: 4.794 ± 0.68
5.354AlaLys: 5.354 ± 0.815
4.714AlaLeu: 4.714 ± 0.588
1.518AlaMet: 1.518 ± 0.341
2.557AlaAsn: 2.557 ± 0.331
2.078AlaPro: 2.078 ± 0.5
2.637AlaGln: 2.637 ± 0.581
2.397AlaArg: 2.397 ± 0.44
4.555AlaSer: 4.555 ± 0.579
3.196AlaThr: 3.196 ± 0.561
3.356AlaVal: 3.356 ± 0.871
1.199AlaTrp: 1.199 ± 0.29
2.717AlaTyr: 2.717 ± 0.433
0.0AlaXaa: 0.0 ± 0.0
Cys
0.32CysAla: 0.32 ± 0.133
0.24CysCys: 0.24 ± 0.187
0.879CysAsp: 0.879 ± 0.277
0.959CysGlu: 0.959 ± 0.313
0.799CysPhe: 0.799 ± 0.239
0.719CysGly: 0.719 ± 0.278
0.16CysHis: 0.16 ± 0.111
0.4CysIle: 0.4 ± 0.182
0.719CysLys: 0.719 ± 0.244
0.879CysLeu: 0.879 ± 0.328
0.24CysMet: 0.24 ± 0.145
0.479CysAsn: 0.479 ± 0.189
0.799CysPro: 0.799 ± 0.243
0.559CysGln: 0.559 ± 0.263
0.879CysArg: 0.879 ± 0.229
1.039CysSer: 1.039 ± 0.224
0.32CysThr: 0.32 ± 0.163
0.479CysVal: 0.479 ± 0.208
0.08CysTrp: 0.08 ± 0.087
0.4CysTyr: 0.4 ± 0.173
0.0CysXaa: 0.0 ± 0.0
Asp
4.714AspAla: 4.714 ± 0.614
0.959AspCys: 0.959 ± 0.313
2.717AspAsp: 2.717 ± 0.453
3.995AspGlu: 3.995 ± 0.606
3.676AspPhe: 3.676 ± 0.513
4.075AspGly: 4.075 ± 0.524
0.799AspHis: 0.799 ± 0.233
5.593AspIle: 5.593 ± 0.59
5.593AspLys: 5.593 ± 0.634
6.632AspLeu: 6.632 ± 0.766
1.678AspMet: 1.678 ± 0.329
3.436AspAsn: 3.436 ± 0.552
3.036AspPro: 3.036 ± 0.533
2.557AspGln: 2.557 ± 0.396
2.477AspArg: 2.477 ± 0.504
3.835AspSer: 3.835 ± 0.646
2.797AspThr: 2.797 ± 0.516
3.596AspVal: 3.596 ± 0.505
1.039AspTrp: 1.039 ± 0.258
1.918AspTyr: 1.918 ± 0.37
0.0AspXaa: 0.0 ± 0.0
Glu
4.714GluAla: 4.714 ± 0.713
0.479GluCys: 0.479 ± 0.185
3.676GluAsp: 3.676 ± 0.523
4.714GluGlu: 4.714 ± 0.776
3.116GluPhe: 3.116 ± 0.476
2.797GluGly: 2.797 ± 0.48
0.479GluHis: 0.479 ± 0.188
5.913GluIle: 5.913 ± 0.648
5.034GluLys: 5.034 ± 0.607
5.993GluLeu: 5.993 ± 0.812
1.918GluMet: 1.918 ± 0.343
3.995GluAsn: 3.995 ± 0.499
1.119GluPro: 1.119 ± 0.315
2.157GluGln: 2.157 ± 0.473
2.477GluArg: 2.477 ± 0.46
3.676GluSer: 3.676 ± 0.615
3.196GluThr: 3.196 ± 0.468
4.634GluVal: 4.634 ± 0.552
1.039GluTrp: 1.039 ± 0.25
2.956GluTyr: 2.956 ± 0.473
0.0GluXaa: 0.0 ± 0.0
Phe
2.956PheAla: 2.956 ± 0.431
0.16PheCys: 0.16 ± 0.107
5.114PheAsp: 5.114 ± 0.578
2.956PheGlu: 2.956 ± 0.452
2.637PhePhe: 2.637 ± 0.483
2.317PheGly: 2.317 ± 0.333
0.479PheHis: 0.479 ± 0.188
3.915PheIle: 3.915 ± 0.576
4.155PheLys: 4.155 ± 0.512
3.995PheLeu: 3.995 ± 0.692
1.358PheMet: 1.358 ± 0.275
3.436PheAsn: 3.436 ± 0.407
1.678PhePro: 1.678 ± 0.389
1.039PheGln: 1.039 ± 0.284
1.518PheArg: 1.518 ± 0.358
3.276PheSer: 3.276 ± 0.487
1.998PheThr: 1.998 ± 0.313
2.557PheVal: 2.557 ± 0.519
0.479PheTrp: 0.479 ± 0.188
1.918PheTyr: 1.918 ± 0.367
0.0PheXaa: 0.0 ± 0.0
Gly
4.155GlyAla: 4.155 ± 0.738
0.559GlyCys: 0.559 ± 0.187
4.555GlyAsp: 4.555 ± 0.753
3.436GlyGlu: 3.436 ± 0.715
4.075GlyPhe: 4.075 ± 0.627
4.475GlyGly: 4.475 ± 0.997
0.719GlyHis: 0.719 ± 0.23
4.555GlyIle: 4.555 ± 0.821
4.235GlyLys: 4.235 ± 0.599
5.433GlyLeu: 5.433 ± 0.57
1.438GlyMet: 1.438 ± 0.269
2.237GlyAsn: 2.237 ± 0.407
1.518GlyPro: 1.518 ± 0.386
2.477GlyGln: 2.477 ± 0.37
1.598GlyArg: 1.598 ± 0.343
5.673GlySer: 5.673 ± 0.859
4.714GlyThr: 4.714 ± 0.759
3.596GlyVal: 3.596 ± 0.494
0.719GlyTrp: 0.719 ± 0.197
2.797GlyTyr: 2.797 ± 0.496
0.0GlyXaa: 0.0 ± 0.0
His
0.799HisAla: 0.799 ± 0.291
0.32HisCys: 0.32 ± 0.155
0.4HisAsp: 0.4 ± 0.185
0.479HisGlu: 0.479 ± 0.176
0.559HisPhe: 0.559 ± 0.207
0.879HisGly: 0.879 ± 0.277
0.0HisHis: 0.0 ± 0.0
1.358HisIle: 1.358 ± 0.423
0.959HisLys: 0.959 ± 0.339
1.518HisLeu: 1.518 ± 0.365
0.4HisMet: 0.4 ± 0.181
0.719HisAsn: 0.719 ± 0.203
0.639HisPro: 0.639 ± 0.255
0.559HisGln: 0.559 ± 0.179
0.559HisArg: 0.559 ± 0.261
1.039HisSer: 1.039 ± 0.245
0.32HisThr: 0.32 ± 0.15
0.719HisVal: 0.719 ± 0.236
0.16HisTrp: 0.16 ± 0.115
0.799HisTyr: 0.799 ± 0.235
0.0HisXaa: 0.0 ± 0.0
Ile
5.194IleAla: 5.194 ± 0.688
0.719IleCys: 0.719 ± 0.255
6.233IleAsp: 6.233 ± 0.695
7.431IleGlu: 7.431 ± 0.952
3.516IlePhe: 3.516 ± 0.478
4.395IleGly: 4.395 ± 0.511
0.639IleHis: 0.639 ± 0.255
5.433IleIle: 5.433 ± 0.532
7.751IleLys: 7.751 ± 0.92
7.431IleLeu: 7.431 ± 0.827
1.758IleMet: 1.758 ± 0.376
5.354IleAsn: 5.354 ± 0.676
2.637IlePro: 2.637 ± 0.617
2.078IleGln: 2.078 ± 0.431
2.797IleArg: 2.797 ± 0.559
5.593IleSer: 5.593 ± 0.794
3.436IleThr: 3.436 ± 0.481
5.274IleVal: 5.274 ± 0.604
0.799IleTrp: 0.799 ± 0.222
2.717IleTyr: 2.717 ± 0.6
0.0IleXaa: 0.0 ± 0.0
Lys
4.874LysAla: 4.874 ± 0.841
0.799LysCys: 0.799 ± 0.249
5.913LysAsp: 5.913 ± 0.62
7.032LysGlu: 7.032 ± 0.907
2.877LysPhe: 2.877 ± 0.446
6.472LysGly: 6.472 ± 0.676
1.518LysHis: 1.518 ± 0.381
7.591LysIle: 7.591 ± 0.869
9.109LysLys: 9.109 ± 1.129
7.032LysLeu: 7.032 ± 0.846
2.797LysMet: 2.797 ± 0.582
4.395LysAsn: 4.395 ± 0.605
3.755LysPro: 3.755 ± 0.486
2.477LysGln: 2.477 ± 0.382
4.155LysArg: 4.155 ± 0.574
5.513LysSer: 5.513 ± 0.718
4.634LysThr: 4.634 ± 0.613
4.475LysVal: 4.475 ± 0.613
1.199LysTrp: 1.199 ± 0.35
3.596LysTyr: 3.596 ± 0.531
0.0LysXaa: 0.0 ± 0.0
Leu
3.436LeuAla: 3.436 ± 0.603
1.199LeuCys: 1.199 ± 0.35
5.913LeuAsp: 5.913 ± 0.757
5.593LeuGlu: 5.593 ± 0.856
3.995LeuPhe: 3.995 ± 0.662
3.995LeuGly: 3.995 ± 0.523
1.358LeuHis: 1.358 ± 0.424
6.233LeuIle: 6.233 ± 0.964
6.632LeuLys: 6.632 ± 0.95
6.712LeuLeu: 6.712 ± 0.696
2.637LeuMet: 2.637 ± 0.525
5.274LeuAsn: 5.274 ± 0.464
3.436LeuPro: 3.436 ± 0.575
2.717LeuGln: 2.717 ± 0.45
3.516LeuArg: 3.516 ± 0.561
6.872LeuSer: 6.872 ± 0.61
4.714LeuThr: 4.714 ± 0.655
3.915LeuVal: 3.915 ± 0.538
0.879LeuTrp: 0.879 ± 0.251
2.717LeuTyr: 2.717 ± 0.405
0.0LeuXaa: 0.0 ± 0.0
Met
1.438MetAla: 1.438 ± 0.341
0.24MetCys: 0.24 ± 0.116
0.959MetAsp: 0.959 ± 0.218
1.518MetGlu: 1.518 ± 0.267
0.959MetPhe: 0.959 ± 0.244
1.119MetGly: 1.119 ± 0.272
0.4MetHis: 0.4 ± 0.224
1.918MetIle: 1.918 ± 0.364
2.397MetLys: 2.397 ± 0.42
1.358MetLeu: 1.358 ± 0.301
0.639MetMet: 0.639 ± 0.324
2.317MetAsn: 2.317 ± 0.373
1.278MetPro: 1.278 ± 0.316
1.438MetGln: 1.438 ± 0.306
1.358MetArg: 1.358 ± 0.317
2.397MetSer: 2.397 ± 0.474
1.598MetThr: 1.598 ± 0.388
1.358MetVal: 1.358 ± 0.358
0.24MetTrp: 0.24 ± 0.123
0.959MetTyr: 0.959 ± 0.283
0.0MetXaa: 0.0 ± 0.0
Asn
3.116AsnAla: 3.116 ± 0.511
1.199AsnCys: 1.199 ± 0.302
3.116AsnAsp: 3.116 ± 0.443
2.557AsnGlu: 2.557 ± 0.503
2.797AsnPhe: 2.797 ± 0.528
3.755AsnGly: 3.755 ± 0.57
0.959AsnHis: 0.959 ± 0.25
4.634AsnIle: 4.634 ± 0.538
6.632AsnLys: 6.632 ± 0.823
3.676AsnLeu: 3.676 ± 0.548
1.199AsnMet: 1.199 ± 0.34
2.717AsnAsn: 2.717 ± 0.573
2.237AsnPro: 2.237 ± 0.352
2.157AsnGln: 2.157 ± 0.492
2.397AsnArg: 2.397 ± 0.378
3.436AsnSer: 3.436 ± 0.736
3.036AsnThr: 3.036 ± 0.506
2.717AsnVal: 2.717 ± 0.418
0.479AsnTrp: 0.479 ± 0.227
2.317AsnTyr: 2.317 ± 0.43
0.0AsnXaa: 0.0 ± 0.0
Pro
2.397ProAla: 2.397 ± 0.404
0.559ProCys: 0.559 ± 0.224
2.397ProAsp: 2.397 ± 0.541
1.998ProGlu: 1.998 ± 0.422
1.758ProPhe: 1.758 ± 0.325
2.717ProGly: 2.717 ± 0.557
0.799ProHis: 0.799 ± 0.232
2.637ProIle: 2.637 ± 0.441
3.196ProLys: 3.196 ± 0.604
2.557ProLeu: 2.557 ± 0.473
0.559ProMet: 0.559 ± 0.239
1.998ProAsn: 1.998 ± 0.493
1.358ProPro: 1.358 ± 0.353
1.758ProGln: 1.758 ± 0.504
0.799ProArg: 0.799 ± 0.215
2.477ProSer: 2.477 ± 0.513
1.998ProThr: 1.998 ± 0.467
1.918ProVal: 1.918 ± 0.38
0.32ProTrp: 0.32 ± 0.157
1.518ProTyr: 1.518 ± 0.288
0.0ProXaa: 0.0 ± 0.0
Gln
2.157GlnAla: 2.157 ± 0.439
0.08GlnCys: 0.08 ± 0.085
2.477GlnAsp: 2.477 ± 0.358
2.078GlnGlu: 2.078 ± 0.393
1.438GlnPhe: 1.438 ± 0.341
2.717GlnGly: 2.717 ± 1.226
0.24GlnHis: 0.24 ± 0.114
2.877GlnIle: 2.877 ± 0.356
2.557GlnLys: 2.557 ± 0.434
3.676GlnLeu: 3.676 ± 0.438
1.199GlnMet: 1.199 ± 0.282
2.078GlnAsn: 2.078 ± 0.384
0.32GlnPro: 0.32 ± 0.166
1.039GlnGln: 1.039 ± 0.301
1.918GlnArg: 1.918 ± 0.329
1.598GlnSer: 1.598 ± 0.322
2.078GlnThr: 2.078 ± 0.331
1.758GlnVal: 1.758 ± 0.48
0.559GlnTrp: 0.559 ± 0.173
1.278GlnTyr: 1.278 ± 0.284
0.0GlnXaa: 0.0 ± 0.0
Arg
1.998ArgAla: 1.998 ± 0.38
0.559ArgCys: 0.559 ± 0.19
2.477ArgAsp: 2.477 ± 0.435
2.717ArgGlu: 2.717 ± 0.392
1.119ArgPhe: 1.119 ± 0.286
1.758ArgGly: 1.758 ± 0.361
0.479ArgHis: 0.479 ± 0.174
3.755ArgIle: 3.755 ± 0.486
3.755ArgLys: 3.755 ± 0.484
3.596ArgLeu: 3.596 ± 0.512
1.358ArgMet: 1.358 ± 0.334
1.838ArgAsn: 1.838 ± 0.419
0.879ArgPro: 0.879 ± 0.299
1.358ArgGln: 1.358 ± 0.288
1.039ArgArg: 1.039 ± 0.377
2.397ArgSer: 2.397 ± 0.516
1.918ArgThr: 1.918 ± 0.349
2.078ArgVal: 2.078 ± 0.404
0.719ArgTrp: 0.719 ± 0.212
1.758ArgTyr: 1.758 ± 0.417
0.0ArgXaa: 0.0 ± 0.0
Ser
4.155SerAla: 4.155 ± 0.434
0.879SerCys: 0.879 ± 0.264
4.475SerAsp: 4.475 ± 0.477
3.436SerGlu: 3.436 ± 0.584
3.436SerPhe: 3.436 ± 0.336
5.593SerGly: 5.593 ± 0.882
1.039SerHis: 1.039 ± 0.247
6.312SerIle: 6.312 ± 0.699
6.792SerLys: 6.792 ± 0.596
5.114SerLeu: 5.114 ± 0.576
1.998SerMet: 1.998 ± 0.365
3.755SerAsn: 3.755 ± 0.685
1.998SerPro: 1.998 ± 0.34
3.116SerGln: 3.116 ± 0.448
2.157SerArg: 2.157 ± 0.442
4.555SerSer: 4.555 ± 0.609
3.835SerThr: 3.835 ± 0.639
2.877SerVal: 2.877 ± 0.449
1.039SerTrp: 1.039 ± 0.253
3.036SerTyr: 3.036 ± 0.476
0.0SerXaa: 0.0 ± 0.0
Thr
3.436ThrAla: 3.436 ± 0.414
0.559ThrCys: 0.559 ± 0.201
3.196ThrAsp: 3.196 ± 0.44
2.717ThrGlu: 2.717 ± 0.422
2.477ThrPhe: 2.477 ± 0.491
5.194ThrGly: 5.194 ± 0.761
0.639ThrHis: 0.639 ± 0.23
4.475ThrIle: 4.475 ± 0.604
4.634ThrLys: 4.634 ± 0.65
3.356ThrLeu: 3.356 ± 0.478
0.799ThrMet: 0.799 ± 0.264
2.797ThrAsn: 2.797 ± 0.38
2.717ThrPro: 2.717 ± 0.617
1.278ThrGln: 1.278 ± 0.285
1.838ThrArg: 1.838 ± 0.291
3.676ThrSer: 3.676 ± 0.559
2.797ThrThr: 2.797 ± 0.586
2.557ThrVal: 2.557 ± 0.403
1.119ThrTrp: 1.119 ± 0.26
2.397ThrTyr: 2.397 ± 0.624
0.0ThrXaa: 0.0 ± 0.0
Val
2.637ValAla: 2.637 ± 0.437
0.32ValCys: 0.32 ± 0.137
4.634ValAsp: 4.634 ± 0.623
3.676ValGlu: 3.676 ± 0.489
2.317ValPhe: 2.317 ± 0.458
2.637ValGly: 2.637 ± 0.386
0.639ValHis: 0.639 ± 0.211
4.235ValIle: 4.235 ± 0.476
5.433ValLys: 5.433 ± 0.597
4.075ValLeu: 4.075 ± 0.607
1.119ValMet: 1.119 ± 0.274
2.797ValAsn: 2.797 ± 0.449
2.717ValPro: 2.717 ± 0.512
1.278ValGln: 1.278 ± 0.311
1.998ValArg: 1.998 ± 0.44
4.395ValSer: 4.395 ± 0.581
2.797ValThr: 2.797 ± 0.441
3.676ValVal: 3.676 ± 0.594
1.039ValTrp: 1.039 ± 0.249
2.557ValTyr: 2.557 ± 0.474
0.0ValXaa: 0.0 ± 0.0
Trp
1.199TrpAla: 1.199 ± 0.341
0.08TrpCys: 0.08 ± 0.079
1.039TrpAsp: 1.039 ± 0.199
1.119TrpGlu: 1.119 ± 0.288
0.799TrpPhe: 0.799 ± 0.211
0.879TrpGly: 0.879 ± 0.265
0.32TrpHis: 0.32 ± 0.155
1.199TrpIle: 1.199 ± 0.273
1.039TrpLys: 1.039 ± 0.339
1.039TrpLeu: 1.039 ± 0.274
0.32TrpMet: 0.32 ± 0.145
0.479TrpAsn: 0.479 ± 0.216
0.0TrpPro: 0.0 ± 0.0
0.4TrpGln: 0.4 ± 0.193
0.479TrpArg: 0.479 ± 0.229
0.799TrpSer: 0.799 ± 0.185
1.119TrpThr: 1.119 ± 0.371
0.959TrpVal: 0.959 ± 0.268
0.08TrpTrp: 0.08 ± 0.067
0.639TrpTyr: 0.639 ± 0.274
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.877TyrAla: 2.877 ± 0.442
0.639TyrCys: 0.639 ± 0.232
1.438TyrAsp: 1.438 ± 0.344
1.918TyrGlu: 1.918 ± 0.33
2.956TyrPhe: 2.956 ± 0.569
2.557TyrGly: 2.557 ± 0.425
0.639TyrHis: 0.639 ± 0.175
3.356TyrIle: 3.356 ± 0.517
4.235TyrLys: 4.235 ± 0.523
3.036TyrLeu: 3.036 ± 0.512
0.879TyrMet: 0.879 ± 0.19
2.477TyrAsn: 2.477 ± 0.432
1.518TyrPro: 1.518 ± 0.274
1.039TyrGln: 1.039 ± 0.33
1.199TyrArg: 1.199 ± 0.273
2.797TyrSer: 2.797 ± 0.391
2.157TyrThr: 2.157 ± 0.273
2.477TyrVal: 2.477 ± 0.561
0.799TyrTrp: 0.799 ± 0.282
2.237TyrTyr: 2.237 ± 0.445
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 65 proteins (12516 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski