Amino acid dipepetide frequency for Parapedobacter sp. SGR-10

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.148AlaAla: 5.148 ± 0.088
0.62AlaCys: 0.62 ± 0.028
4.106AlaAsp: 4.106 ± 0.059
4.333AlaGlu: 4.333 ± 0.068
3.2AlaPhe: 3.2 ± 0.053
5.03AlaGly: 5.03 ± 0.086
1.398AlaHis: 1.398 ± 0.038
5.175AlaIle: 5.175 ± 0.072
4.408AlaLys: 4.408 ± 0.078
6.773AlaLeu: 6.773 ± 0.084
1.604AlaMet: 1.604 ± 0.041
3.554AlaAsn: 3.554 ± 0.071
2.242AlaPro: 2.242 ± 0.046
2.926AlaGln: 2.926 ± 0.05
2.858AlaArg: 2.858 ± 0.054
4.353AlaSer: 4.353 ± 0.062
3.93AlaThr: 3.93 ± 0.083
4.892AlaVal: 4.892 ± 0.08
0.812AlaTrp: 0.812 ± 0.026
3.072AlaTyr: 3.072 ± 0.049
0.0AlaXaa: 0.0 ± 0.0
Cys
0.477CysAla: 0.477 ± 0.02
0.116CysCys: 0.116 ± 0.009
0.389CysAsp: 0.389 ± 0.021
0.395CysGlu: 0.395 ± 0.023
0.358CysPhe: 0.358 ± 0.017
0.568CysGly: 0.568 ± 0.023
0.195CysHis: 0.195 ± 0.013
0.541CysIle: 0.541 ± 0.019
0.401CysLys: 0.401 ± 0.017
0.652CysLeu: 0.652 ± 0.023
0.187CysMet: 0.187 ± 0.012
0.323CysAsn: 0.323 ± 0.016
0.317CysPro: 0.317 ± 0.017
0.271CysGln: 0.271 ± 0.014
0.328CysArg: 0.328 ± 0.019
0.462CysSer: 0.462 ± 0.023
0.487CysThr: 0.487 ± 0.021
0.418CysVal: 0.418 ± 0.017
0.087CysTrp: 0.087 ± 0.008
0.308CysTyr: 0.308 ± 0.017
0.0CysXaa: 0.0 ± 0.0
Asp
3.674AspAla: 3.674 ± 0.059
0.352AspCys: 0.352 ± 0.019
2.678AspAsp: 2.678 ± 0.045
3.628AspGlu: 3.628 ± 0.056
3.231AspPhe: 3.231 ± 0.054
4.163AspGly: 4.163 ± 0.064
1.126AspHis: 1.126 ± 0.037
4.623AspIle: 4.623 ± 0.074
3.888AspLys: 3.888 ± 0.064
5.212AspLeu: 5.212 ± 0.072
1.404AspMet: 1.404 ± 0.031
2.947AspAsn: 2.947 ± 0.05
2.32AspPro: 2.32 ± 0.049
1.782AspGln: 1.782 ± 0.035
2.856AspArg: 2.856 ± 0.049
2.775AspSer: 2.775 ± 0.053
2.767AspThr: 2.767 ± 0.053
3.638AspVal: 3.638 ± 0.061
0.847AspTrp: 0.847 ± 0.025
2.679AspTyr: 2.679 ± 0.04
0.0AspXaa: 0.0 ± 0.0
Glu
4.492GluAla: 4.492 ± 0.069
0.334GluCys: 0.334 ± 0.016
3.455GluAsp: 3.455 ± 0.057
4.789GluGlu: 4.789 ± 0.085
2.372GluPhe: 2.372 ± 0.046
4.063GluGly: 4.063 ± 0.059
1.266GluHis: 1.266 ± 0.036
4.649GluIle: 4.649 ± 0.063
4.801GluLys: 4.801 ± 0.067
5.732GluLeu: 5.732 ± 0.069
1.464GluMet: 1.464 ± 0.037
3.517GluAsn: 3.517 ± 0.064
1.712GluPro: 1.712 ± 0.034
2.72GluGln: 2.72 ± 0.053
3.12GluArg: 3.12 ± 0.057
2.959GluSer: 2.959 ± 0.046
3.116GluThr: 3.116 ± 0.055
4.239GluVal: 4.239 ± 0.07
0.704GluTrp: 0.704 ± 0.024
2.281GluTyr: 2.281 ± 0.042
0.0GluXaa: 0.0 ± 0.0
Phe
3.275PheAla: 3.275 ± 0.056
0.392PheCys: 0.392 ± 0.017
3.065PheAsp: 3.065 ± 0.048
2.928PheGlu: 2.928 ± 0.049
2.331PhePhe: 2.331 ± 0.05
3.403PheGly: 3.403 ± 0.056
0.964PheHis: 0.964 ± 0.027
3.049PheIle: 3.049 ± 0.054
2.712PheLys: 2.712 ± 0.051
4.129PheLeu: 4.129 ± 0.067
1.122PheMet: 1.122 ± 0.033
2.475PheAsn: 2.475 ± 0.053
1.778PhePro: 1.778 ± 0.041
1.51PheGln: 1.51 ± 0.034
2.097PheArg: 2.097 ± 0.041
3.406PheSer: 3.406 ± 0.062
2.69PheThr: 2.69 ± 0.042
3.335PheVal: 3.335 ± 0.06
0.595PheTrp: 0.595 ± 0.027
1.938PheTyr: 1.938 ± 0.043
0.0PheXaa: 0.0 ± 0.0
Gly
4.663GlyAla: 4.663 ± 0.073
0.549GlyCys: 0.549 ± 0.02
3.663GlyAsp: 3.663 ± 0.056
3.858GlyGlu: 3.858 ± 0.057
3.443GlyPhe: 3.443 ± 0.059
5.133GlyGly: 5.133 ± 0.097
1.407GlyHis: 1.407 ± 0.034
5.405GlyIle: 5.405 ± 0.071
5.008GlyLys: 5.008 ± 0.07
6.215GlyLeu: 6.215 ± 0.084
1.802GlyMet: 1.802 ± 0.04
3.791GlyAsn: 3.791 ± 0.067
1.549GlyPro: 1.549 ± 0.049
2.589GlyGln: 2.589 ± 0.055
3.165GlyArg: 3.165 ± 0.054
4.353GlySer: 4.353 ± 0.062
4.5GlyThr: 4.5 ± 0.107
4.803GlyVal: 4.803 ± 0.071
0.944GlyTrp: 0.944 ± 0.029
3.389GlyTyr: 3.389 ± 0.059
0.0GlyXaa: 0.0 ± 0.0
His
1.375HisAla: 1.375 ± 0.033
0.2HisCys: 0.2 ± 0.014
1.0HisAsp: 1.0 ± 0.029
1.138HisGlu: 1.138 ± 0.029
1.116HisPhe: 1.116 ± 0.033
1.295HisGly: 1.295 ± 0.035
0.61HisHis: 0.61 ± 0.027
1.801HisIle: 1.801 ± 0.041
1.095HisLys: 1.095 ± 0.034
1.876HisLeu: 1.876 ± 0.041
0.379HisMet: 0.379 ± 0.014
1.005HisAsn: 1.005 ± 0.029
1.045HisPro: 1.045 ± 0.03
0.803HisGln: 0.803 ± 0.028
1.011HisArg: 1.011 ± 0.026
1.152HisSer: 1.152 ± 0.029
1.247HisThr: 1.247 ± 0.034
1.275HisVal: 1.275 ± 0.035
0.309HisTrp: 0.309 ± 0.018
0.967HisTyr: 0.967 ± 0.034
0.0HisXaa: 0.0 ± 0.0
Ile
5.592IleAla: 5.592 ± 0.066
0.641IleCys: 0.641 ± 0.026
4.41IleAsp: 4.41 ± 0.063
4.436IleGlu: 4.436 ± 0.074
3.037IlePhe: 3.037 ± 0.051
5.171IleGly: 5.171 ± 0.068
1.58IleHis: 1.58 ± 0.037
4.558IleIle: 4.558 ± 0.072
4.319IleLys: 4.319 ± 0.072
6.383IleLeu: 6.383 ± 0.077
1.328IleMet: 1.328 ± 0.036
3.436IleAsn: 3.436 ± 0.062
3.116IlePro: 3.116 ± 0.046
2.607IleGln: 2.607 ± 0.038
3.439IleArg: 3.439 ± 0.061
4.808IleSer: 4.808 ± 0.063
3.978IleThr: 3.978 ± 0.078
4.795IleVal: 4.795 ± 0.076
0.797IleTrp: 0.797 ± 0.025
2.619IleTyr: 2.619 ± 0.049
0.0IleXaa: 0.0 ± 0.0
Lys
4.461LysAla: 4.461 ± 0.075
0.265LysCys: 0.265 ± 0.016
4.023LysAsp: 4.023 ± 0.069
5.028LysGlu: 5.028 ± 0.08
2.326LysPhe: 2.326 ± 0.048
4.471LysGly: 4.471 ± 0.067
1.204LysHis: 1.204 ± 0.031
4.595LysIle: 4.595 ± 0.071
4.859LysLys: 4.859 ± 0.085
5.2LysLeu: 5.2 ± 0.072
1.641LysMet: 1.641 ± 0.035
3.808LysAsn: 3.808 ± 0.065
2.403LysPro: 2.403 ± 0.043
2.378LysGln: 2.378 ± 0.049
2.852LysArg: 2.852 ± 0.055
3.751LysSer: 3.751 ± 0.064
3.705LysThr: 3.705 ± 0.059
4.283LysVal: 4.283 ± 0.061
0.827LysTrp: 0.827 ± 0.024
2.706LysTyr: 2.706 ± 0.05
0.0LysXaa: 0.0 ± 0.0
Leu
6.658LeuAla: 6.658 ± 0.093
0.813LeuCys: 0.813 ± 0.027
5.192LeuAsp: 5.192 ± 0.081
5.393LeuGlu: 5.393 ± 0.077
4.496LeuPhe: 4.496 ± 0.068
5.92LeuGly: 5.92 ± 0.076
1.918LeuHis: 1.918 ± 0.044
5.807LeuIle: 5.807 ± 0.082
6.044LeuLys: 6.044 ± 0.087
9.031LeuLeu: 9.031 ± 0.109
2.13LeuMet: 2.13 ± 0.045
4.597LeuAsn: 4.597 ± 0.069
3.95LeuPro: 3.95 ± 0.062
3.555LeuGln: 3.555 ± 0.068
4.197LeuArg: 4.197 ± 0.057
6.954LeuSer: 6.954 ± 0.081
5.195LeuThr: 5.195 ± 0.073
5.629LeuVal: 5.629 ± 0.08
1.022LeuTrp: 1.022 ± 0.03
3.63LeuTyr: 3.63 ± 0.057
0.0LeuXaa: 0.0 ± 0.0
Met
1.795MetAla: 1.795 ± 0.04
0.143MetCys: 0.143 ± 0.011
1.373MetAsp: 1.373 ± 0.034
1.413MetGlu: 1.413 ± 0.035
0.779MetPhe: 0.779 ± 0.023
1.515MetGly: 1.515 ± 0.034
0.401MetHis: 0.401 ± 0.018
1.375MetIle: 1.375 ± 0.035
1.878MetLys: 1.878 ± 0.037
2.044MetLeu: 2.044 ± 0.038
0.604MetMet: 0.604 ± 0.023
1.189MetAsn: 1.189 ± 0.027
0.944MetPro: 0.944 ± 0.026
0.917MetGln: 0.917 ± 0.025
1.037MetArg: 1.037 ± 0.027
1.456MetSer: 1.456 ± 0.032
1.224MetThr: 1.224 ± 0.032
1.448MetVal: 1.448 ± 0.037
0.213MetTrp: 0.213 ± 0.012
0.765MetTyr: 0.765 ± 0.026
0.0MetXaa: 0.0 ± 0.0
Asn
3.508AsnAla: 3.508 ± 0.063
0.311AsnCys: 0.311 ± 0.021
2.595AsnAsp: 2.595 ± 0.048
2.894AsnGlu: 2.894 ± 0.051
2.455AsnPhe: 2.455 ± 0.047
3.816AsnGly: 3.816 ± 0.075
0.948AsnHis: 0.948 ± 0.03
4.154AsnIle: 4.154 ± 0.061
3.252AsnLys: 3.252 ± 0.059
4.568AsnLeu: 4.568 ± 0.06
1.222AsnMet: 1.222 ± 0.03
3.015AsnAsn: 3.015 ± 0.063
2.706AsnPro: 2.706 ± 0.049
1.875AsnGln: 1.875 ± 0.045
2.592AsnArg: 2.592 ± 0.052
3.043AsnSer: 3.043 ± 0.05
3.325AsnThr: 3.325 ± 0.055
3.248AsnVal: 3.248 ± 0.056
0.717AsnTrp: 0.717 ± 0.023
2.284AsnTyr: 2.284 ± 0.049
0.0AsnXaa: 0.0 ± 0.0
Pro
2.532ProAla: 2.532 ± 0.067
0.211ProCys: 0.211 ± 0.013
2.472ProAsp: 2.472 ± 0.044
2.768ProGlu: 2.768 ± 0.049
1.867ProPhe: 1.867 ± 0.039
2.591ProGly: 2.591 ± 0.064
0.828ProHis: 0.828 ± 0.025
2.613ProIle: 2.613 ± 0.047
2.158ProLys: 2.158 ± 0.042
3.41ProLeu: 3.41 ± 0.061
0.707ProMet: 0.707 ± 0.022
1.978ProAsn: 1.978 ± 0.042
1.032ProPro: 1.032 ± 0.035
1.483ProGln: 1.483 ± 0.036
1.375ProArg: 1.375 ± 0.035
2.464ProSer: 2.464 ± 0.054
2.274ProThr: 2.274 ± 0.051
2.817ProVal: 2.817 ± 0.051
0.42ProTrp: 0.42 ± 0.021
1.659ProTyr: 1.659 ± 0.034
0.0ProXaa: 0.0 ± 0.0
Gln
2.728GlnAla: 2.728 ± 0.048
0.182GlnCys: 0.182 ± 0.013
1.949GlnAsp: 1.949 ± 0.038
2.554GlnGlu: 2.554 ± 0.05
1.58GlnPhe: 1.58 ± 0.038
2.468GlnGly: 2.468 ± 0.045
0.94GlnHis: 0.94 ± 0.027
2.529GlnIle: 2.529 ± 0.045
2.602GlnLys: 2.602 ± 0.043
3.578GlnLeu: 3.578 ± 0.06
0.85GlnMet: 0.85 ± 0.024
2.0GlnAsn: 2.0 ± 0.04
1.22GlnPro: 1.22 ± 0.033
1.977GlnGln: 1.977 ± 0.052
1.759GlnArg: 1.759 ± 0.037
2.262GlnSer: 2.262 ± 0.045
2.064GlnThr: 2.064 ± 0.043
2.432GlnVal: 2.432 ± 0.042
0.473GlnTrp: 0.473 ± 0.018
1.643GlnTyr: 1.643 ± 0.032
0.0GlnXaa: 0.0 ± 0.0
Arg
2.868ArgAla: 2.868 ± 0.05
0.242ArgCys: 0.242 ± 0.013
2.388ArgAsp: 2.388 ± 0.045
2.829ArgGlu: 2.829 ± 0.056
2.359ArgPhe: 2.359 ± 0.049
2.67ArgGly: 2.67 ± 0.051
0.977ArgHis: 0.977 ± 0.03
3.581ArgIle: 3.581 ± 0.055
3.144ArgLys: 3.144 ± 0.053
4.359ArgLeu: 4.359 ± 0.064
1.134ArgMet: 1.134 ± 0.032
2.477ArgAsn: 2.477 ± 0.054
1.603ArgPro: 1.603 ± 0.035
1.802ArgGln: 1.802 ± 0.042
2.048ArgArg: 2.048 ± 0.04
2.6ArgSer: 2.6 ± 0.047
2.466ArgThr: 2.466 ± 0.048
2.957ArgVal: 2.957 ± 0.05
0.671ArgTrp: 0.671 ± 0.022
2.319ArgTyr: 2.319 ± 0.042
0.0ArgXaa: 0.0 ± 0.0
Ser
4.298SerAla: 4.298 ± 0.071
0.587SerCys: 0.587 ± 0.023
3.408SerAsp: 3.408 ± 0.056
3.114SerGlu: 3.114 ± 0.056
3.354SerPhe: 3.354 ± 0.056
4.942SerGly: 4.942 ± 0.079
1.169SerHis: 1.169 ± 0.031
4.597SerIle: 4.597 ± 0.07
3.667SerLys: 3.667 ± 0.056
6.032SerLeu: 6.032 ± 0.075
1.241SerMet: 1.241 ± 0.031
3.194SerAsn: 3.194 ± 0.056
2.388SerPro: 2.388 ± 0.048
2.0SerGln: 2.0 ± 0.037
2.801SerArg: 2.801 ± 0.056
4.406SerSer: 4.406 ± 0.073
3.748SerThr: 3.748 ± 0.056
4.275SerVal: 4.275 ± 0.058
0.762SerTrp: 0.762 ± 0.024
2.841SerTyr: 2.841 ± 0.051
0.0SerXaa: 0.0 ± 0.0
Thr
4.408ThrAla: 4.408 ± 0.076
0.351ThrCys: 0.351 ± 0.018
3.306ThrAsp: 3.306 ± 0.058
3.169ThrGlu: 3.169 ± 0.052
2.824ThrPhe: 2.824 ± 0.053
4.58ThrGly: 4.58 ± 0.09
1.125ThrHis: 1.125 ± 0.034
4.223ThrIle: 4.223 ± 0.069
3.152ThrLys: 3.152 ± 0.051
5.465ThrLeu: 5.465 ± 0.076
1.012ThrMet: 1.012 ± 0.03
2.779ThrAsn: 2.779 ± 0.057
2.584ThrPro: 2.584 ± 0.058
1.882ThrGln: 1.882 ± 0.039
2.016ThrArg: 2.016 ± 0.037
3.484ThrSer: 3.484 ± 0.059
3.231ThrThr: 3.231 ± 0.067
4.309ThrVal: 4.309 ± 0.108
0.711ThrTrp: 0.711 ± 0.028
2.47ThrTyr: 2.47 ± 0.048
0.0ThrXaa: 0.0 ± 0.0
Val
4.607ValAla: 4.607 ± 0.081
0.549ValCys: 0.549 ± 0.02
3.94ValAsp: 3.94 ± 0.055
4.044ValGlu: 4.044 ± 0.057
3.235ValPhe: 3.235 ± 0.059
4.41ValGly: 4.41 ± 0.073
1.396ValHis: 1.396 ± 0.036
4.275ValIle: 4.275 ± 0.072
4.049ValLys: 4.049 ± 0.06
6.517ValLeu: 6.517 ± 0.074
1.399ValMet: 1.399 ± 0.033
3.387ValAsn: 3.387 ± 0.059
2.622ValPro: 2.622 ± 0.057
2.512ValGln: 2.512 ± 0.044
3.073ValArg: 3.073 ± 0.051
4.69ValSer: 4.69 ± 0.068
3.694ValThr: 3.694 ± 0.085
4.731ValVal: 4.731 ± 0.08
0.797ValTrp: 0.797 ± 0.028
2.751ValTyr: 2.751 ± 0.052
0.0ValXaa: 0.0 ± 0.0
Trp
0.832TrpAla: 0.832 ± 0.028
0.097TrpCys: 0.097 ± 0.009
0.68TrpAsp: 0.68 ± 0.028
0.791TrpGlu: 0.791 ± 0.027
0.555TrpPhe: 0.555 ± 0.023
0.906TrpGly: 0.906 ± 0.022
0.28TrpHis: 0.28 ± 0.015
0.829TrpIle: 0.829 ± 0.026
0.849TrpLys: 0.849 ± 0.026
1.084TrpLeu: 1.084 ± 0.032
0.376TrpMet: 0.376 ± 0.018
0.685TrpAsn: 0.685 ± 0.025
0.355TrpPro: 0.355 ± 0.02
0.558TrpGln: 0.558 ± 0.023
0.62TrpArg: 0.62 ± 0.024
0.759TrpSer: 0.759 ± 0.028
0.718TrpThr: 0.718 ± 0.028
0.739TrpVal: 0.739 ± 0.027
0.173TrpTrp: 0.173 ± 0.013
0.518TrpTyr: 0.518 ± 0.024
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.041TyrAla: 3.041 ± 0.052
0.326TyrCys: 0.326 ± 0.015
2.5TyrAsp: 2.5 ± 0.046
2.283TyrGlu: 2.283 ± 0.042
2.275TyrPhe: 2.275 ± 0.048
3.116TyrGly: 3.116 ± 0.053
0.968TyrHis: 0.968 ± 0.034
2.671TyrIle: 2.671 ± 0.044
2.499TyrLys: 2.499 ± 0.044
3.872TyrLeu: 3.872 ± 0.058
0.905TyrMet: 0.905 ± 0.029
2.371TyrAsn: 2.371 ± 0.048
1.773TyrPro: 1.773 ± 0.035
1.642TyrGln: 1.642 ± 0.032
2.251TyrArg: 2.251 ± 0.045
2.685TyrSer: 2.685 ± 0.048
2.721TyrThr: 2.721 ± 0.062
2.416TyrVal: 2.416 ± 0.053
0.523TyrTrp: 0.523 ± 0.023
2.017TyrTyr: 2.017 ± 0.043
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3499 proteins (1257881 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski