Amino acid dipepetide frequency for Hydrogenovibrio crunogenus (strain DSM 25203 / XCL-2) (Thiomicrospira crunogena)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
6.45AlaAla: 6.45 ± 0.127
0.748AlaCys: 0.748 ± 0.034
4.316AlaAsp: 4.316 ± 0.08
5.709AlaGlu: 5.709 ± 0.106
3.522AlaPhe: 3.522 ± 0.065
5.372AlaGly: 5.372 ± 0.096
1.677AlaHis: 1.677 ± 0.05
5.688AlaIle: 5.688 ± 0.096
5.075AlaLys: 5.075 ± 0.088
9.687AlaLeu: 9.687 ± 0.12
2.568AlaMet: 2.568 ± 0.053
3.173AlaAsn: 3.173 ± 0.078
2.686AlaPro: 2.686 ± 0.062
3.849AlaGln: 3.849 ± 0.077
3.352AlaArg: 3.352 ± 0.077
5.054AlaSer: 5.054 ± 0.08
4.059AlaThr: 4.059 ± 0.091
5.593AlaVal: 5.593 ± 0.1
1.127AlaTrp: 1.127 ± 0.047
2.553AlaTyr: 2.553 ± 0.059
0.0AlaXaa: 0.0 ± 0.0
Cys
0.53CysAla: 0.53 ± 0.025
0.102CysCys: 0.102 ± 0.013
0.546CysAsp: 0.546 ± 0.026
0.486CysGlu: 0.486 ± 0.025
0.321CysPhe: 0.321 ± 0.022
0.683CysGly: 0.683 ± 0.037
0.296CysHis: 0.296 ± 0.02
0.413CysIle: 0.413 ± 0.026
0.334CysLys: 0.334 ± 0.019
0.843CysLeu: 0.843 ± 0.037
0.148CysMet: 0.148 ± 0.015
0.24CysAsn: 0.24 ± 0.018
0.428CysPro: 0.428 ± 0.03
0.427CysGln: 0.427 ± 0.026
0.368CysArg: 0.368 ± 0.021
0.492CysSer: 0.492 ± 0.027
0.319CysThr: 0.319 ± 0.021
0.465CysVal: 0.465 ± 0.024
0.068CysTrp: 0.068 ± 0.01
0.24CysTyr: 0.24 ± 0.02
0.0CysXaa: 0.0 ± 0.0
Asp
4.627AspAla: 4.627 ± 0.076
0.46AspCys: 0.46 ± 0.026
2.914AspAsp: 2.914 ± 0.062
3.863AspGlu: 3.863 ± 0.081
2.742AspPhe: 2.742 ± 0.072
3.396AspGly: 3.396 ± 0.088
1.173AspHis: 1.173 ± 0.041
3.852AspIle: 3.852 ± 0.073
3.148AspLys: 3.148 ± 0.062
5.721AspLeu: 5.721 ± 0.09
1.425AspMet: 1.425 ± 0.049
2.004AspAsn: 2.004 ± 0.059
2.126AspPro: 2.126 ± 0.056
2.511AspGln: 2.511 ± 0.062
2.439AspArg: 2.439 ± 0.067
3.094AspSer: 3.094 ± 0.075
2.745AspThr: 2.745 ± 0.071
4.039AspVal: 4.039 ± 0.084
0.969AspTrp: 0.969 ± 0.04
2.123AspTyr: 2.123 ± 0.045
0.0AspXaa: 0.0 ± 0.0
Glu
6.12GluAla: 6.12 ± 0.121
0.404GluCys: 0.404 ± 0.027
3.339GluAsp: 3.339 ± 0.082
4.313GluGlu: 4.313 ± 0.093
2.378GluPhe: 2.378 ± 0.057
3.825GluGly: 3.825 ± 0.073
1.496GluHis: 1.496 ± 0.044
4.292GluIle: 4.292 ± 0.082
4.861GluLys: 4.861 ± 0.091
6.347GluLeu: 6.347 ± 0.109
2.069GluMet: 2.069 ± 0.058
2.954GluAsn: 2.954 ± 0.062
2.204GluPro: 2.204 ± 0.088
3.403GluGln: 3.403 ± 0.065
3.015GluArg: 3.015 ± 0.072
3.886GluSer: 3.886 ± 0.079
4.108GluThr: 4.108 ± 0.083
4.749GluVal: 4.749 ± 0.086
0.762GluTrp: 0.762 ± 0.036
1.71GluTyr: 1.71 ± 0.05
0.0GluXaa: 0.0 ± 0.0
Phe
3.003PheAla: 3.003 ± 0.074
0.418PheCys: 0.418 ± 0.025
2.753PheAsp: 2.753 ± 0.061
2.903PheGlu: 2.903 ± 0.072
1.99PhePhe: 1.99 ± 0.057
3.035PheGly: 3.035 ± 0.072
0.961PheHis: 0.961 ± 0.04
2.89PheIle: 2.89 ± 0.073
2.489PheLys: 2.489 ± 0.058
3.965PheLeu: 3.965 ± 0.076
1.104PheMet: 1.104 ± 0.043
1.964PheAsn: 1.964 ± 0.048
1.489PhePro: 1.489 ± 0.044
1.652PheGln: 1.652 ± 0.052
1.399PheArg: 1.399 ± 0.04
3.119PheSer: 3.119 ± 0.083
1.933PheThr: 1.933 ± 0.052
2.555PheVal: 2.555 ± 0.064
0.616PheTrp: 0.616 ± 0.03
1.496PheTyr: 1.496 ± 0.048
0.0PheXaa: 0.0 ± 0.0
Gly
4.864GlyAla: 4.864 ± 0.105
0.72GlyCys: 0.72 ± 0.037
3.469GlyAsp: 3.469 ± 0.081
3.946GlyGlu: 3.946 ± 0.076
3.224GlyPhe: 3.224 ± 0.076
4.446GlyGly: 4.446 ± 0.105
1.691GlyHis: 1.691 ± 0.051
4.544GlyIle: 4.544 ± 0.096
3.875GlyLys: 3.875 ± 0.08
7.195GlyLeu: 7.195 ± 0.123
2.152GlyMet: 2.152 ± 0.061
2.328GlyAsn: 2.328 ± 0.064
1.674GlyPro: 1.674 ± 0.052
3.071GlyGln: 3.071 ± 0.068
2.922GlyArg: 2.922 ± 0.076
3.638GlySer: 3.638 ± 0.076
3.31GlyThr: 3.31 ± 0.088
5.026GlyVal: 5.026 ± 0.095
0.953GlyTrp: 0.953 ± 0.035
2.474GlyTyr: 2.474 ± 0.06
0.0GlyXaa: 0.0 ± 0.0
His
1.766HisAla: 1.766 ± 0.049
0.256HisCys: 0.256 ± 0.017
1.116HisAsp: 1.116 ± 0.041
1.215HisGlu: 1.215 ± 0.04
1.184HisPhe: 1.184 ± 0.048
1.468HisGly: 1.468 ± 0.045
0.776HisHis: 0.776 ± 0.032
1.414HisIle: 1.414 ± 0.042
1.137HisLys: 1.137 ± 0.038
2.582HisLeu: 2.582 ± 0.063
0.533HisMet: 0.533 ± 0.028
0.92HisAsn: 0.92 ± 0.037
1.393HisPro: 1.393 ± 0.048
1.309HisGln: 1.309 ± 0.046
1.065HisArg: 1.065 ± 0.037
1.464HisSer: 1.464 ± 0.043
1.127HisThr: 1.127 ± 0.04
1.15HisVal: 1.15 ± 0.038
0.374HisTrp: 0.374 ± 0.024
0.932HisTyr: 0.932 ± 0.037
0.0HisXaa: 0.0 ± 0.0
Ile
5.615IleAla: 5.615 ± 0.087
0.492IleCys: 0.492 ± 0.027
4.306IleAsp: 4.306 ± 0.071
5.309IleGlu: 5.309 ± 0.107
2.282IlePhe: 2.282 ± 0.068
4.738IleGly: 4.738 ± 0.086
1.564IleHis: 1.564 ± 0.048
3.69IleIle: 3.69 ± 0.077
3.932IleLys: 3.932 ± 0.089
5.868IleLeu: 5.868 ± 0.116
1.532IleMet: 1.532 ± 0.046
2.766IleAsn: 2.766 ± 0.067
2.762IlePro: 2.762 ± 0.058
3.248IleGln: 3.248 ± 0.072
2.766IleArg: 2.766 ± 0.068
4.162IleSer: 4.162 ± 0.079
3.354IleThr: 3.354 ± 0.068
4.158IleVal: 4.158 ± 0.082
0.674IleTrp: 0.674 ± 0.032
1.65IleTyr: 1.65 ± 0.05
0.0IleXaa: 0.0 ± 0.0
Lys
5.424LysAla: 5.424 ± 0.103
0.296LysCys: 0.296 ± 0.023
3.036LysAsp: 3.036 ± 0.074
4.065LysGlu: 4.065 ± 0.086
1.59LysPhe: 1.59 ± 0.04
3.785LysGly: 3.785 ± 0.077
1.385LysHis: 1.385 ± 0.045
3.812LysIle: 3.812 ± 0.089
4.0LysLys: 4.0 ± 0.1
5.428LysLeu: 5.428 ± 0.092
1.82LysMet: 1.82 ± 0.05
2.69LysAsn: 2.69 ± 0.067
2.619LysPro: 2.619 ± 0.069
3.425LysGln: 3.425 ± 0.081
2.902LysArg: 2.902 ± 0.063
3.535LysSer: 3.535 ± 0.077
3.861LysThr: 3.861 ± 0.075
4.122LysVal: 4.122 ± 0.089
0.614LysTrp: 0.614 ± 0.027
1.357LysTyr: 1.357 ± 0.043
0.0LysXaa: 0.0 ± 0.0
Leu
8.678LeuAla: 8.678 ± 0.109
0.652LeuCys: 0.652 ± 0.033
5.759LeuAsp: 5.759 ± 0.086
6.539LeuGlu: 6.539 ± 0.109
4.242LeuPhe: 4.242 ± 0.106
6.665LeuGly: 6.665 ± 0.124
1.943LeuHis: 1.943 ± 0.054
6.878LeuIle: 6.878 ± 0.111
7.091LeuLys: 7.091 ± 0.112
9.978LeuLeu: 9.978 ± 0.167
3.021LeuMet: 3.021 ± 0.066
5.13LeuAsn: 5.13 ± 0.083
4.78LeuPro: 4.78 ± 0.085
4.115LeuGln: 4.115 ± 0.076
3.881LeuArg: 3.881 ± 0.069
7.932LeuSer: 7.932 ± 0.115
5.899LeuThr: 5.899 ± 0.092
6.699LeuVal: 6.699 ± 0.113
1.055LeuTrp: 1.055 ± 0.045
2.688LeuTyr: 2.688 ± 0.057
0.0LeuXaa: 0.0 ± 0.0
Met
2.683MetAla: 2.683 ± 0.056
0.13MetCys: 0.13 ± 0.014
1.562MetAsp: 1.562 ± 0.051
1.503MetGlu: 1.503 ± 0.05
0.832MetPhe: 0.832 ± 0.035
1.924MetGly: 1.924 ± 0.057
0.615MetHis: 0.615 ± 0.03
1.784MetIle: 1.784 ± 0.062
1.686MetLys: 1.686 ± 0.045
2.553MetLeu: 2.553 ± 0.058
0.96MetMet: 0.96 ± 0.042
1.251MetAsn: 1.251 ± 0.045
1.382MetPro: 1.382 ± 0.043
1.325MetGln: 1.325 ± 0.041
1.227MetArg: 1.227 ± 0.047
2.039MetSer: 2.039 ± 0.057
1.893MetThr: 1.893 ± 0.049
1.932MetVal: 1.932 ± 0.049
0.19MetTrp: 0.19 ± 0.017
0.485MetTyr: 0.485 ± 0.027
0.0MetXaa: 0.0 ± 0.0
Asn
3.55AsnAla: 3.55 ± 0.082
0.312AsnCys: 0.312 ± 0.023
2.313AsnAsp: 2.313 ± 0.061
2.6AsnGlu: 2.6 ± 0.069
1.555AsnPhe: 1.555 ± 0.051
2.848AsnGly: 2.848 ± 0.079
1.044AsnHis: 1.044 ± 0.042
2.647AsnIle: 2.647 ± 0.061
2.205AsnLys: 2.205 ± 0.063
4.291AsnLeu: 4.291 ± 0.086
1.012AsnMet: 1.012 ± 0.039
1.791AsnAsn: 1.791 ± 0.052
2.162AsnPro: 2.162 ± 0.046
2.512AsnGln: 2.512 ± 0.058
2.133AsnArg: 2.133 ± 0.054
2.21AsnSer: 2.21 ± 0.063
2.231AsnThr: 2.231 ± 0.058
2.655AsnVal: 2.655 ± 0.064
0.644AsnTrp: 0.644 ± 0.03
1.208AsnTyr: 1.208 ± 0.046
0.0AsnXaa: 0.0 ± 0.0
Pro
2.864ProAla: 2.864 ± 0.063
0.284ProCys: 0.284 ± 0.022
2.666ProAsp: 2.666 ± 0.065
3.602ProGlu: 3.602 ± 0.09
1.795ProPhe: 1.795 ± 0.061
2.608ProGly: 2.608 ± 0.075
0.907ProHis: 0.907 ± 0.036
2.816ProIle: 2.816 ± 0.066
2.5ProLys: 2.5 ± 0.065
3.785ProLeu: 3.785 ± 0.071
1.126ProMet: 1.126 ± 0.043
1.9ProAsn: 1.9 ± 0.051
1.238ProPro: 1.238 ± 0.042
1.58ProGln: 1.58 ± 0.055
1.238ProArg: 1.238 ± 0.042
2.438ProSer: 2.438 ± 0.063
2.069ProThr: 2.069 ± 0.058
3.249ProVal: 3.249 ± 0.074
0.465ProTrp: 0.465 ± 0.025
1.31ProTyr: 1.31 ± 0.049
0.0ProXaa: 0.0 ± 0.0
Gln
4.947GlnAla: 4.947 ± 0.087
0.258GlnCys: 0.258 ± 0.018
2.226GlnAsp: 2.226 ± 0.061
2.674GlnGlu: 2.674 ± 0.068
1.855GlnPhe: 1.855 ± 0.057
2.781GlnGly: 2.781 ± 0.07
1.166GlnHis: 1.166 ± 0.037
2.841GlnIle: 2.841 ± 0.067
3.389GlnLys: 3.389 ± 0.072
5.155GlnLeu: 5.155 ± 0.099
1.231GlnMet: 1.231 ± 0.038
2.159GlnAsn: 2.159 ± 0.058
2.026GlnPro: 2.026 ± 0.053
3.112GlnGln: 3.112 ± 0.101
2.065GlnArg: 2.065 ± 0.054
3.119GlnSer: 3.119 ± 0.072
2.999GlnThr: 2.999 ± 0.071
3.325GlnVal: 3.325 ± 0.077
0.618GlnTrp: 0.618 ± 0.033
1.341GlnTyr: 1.341 ± 0.043
0.0GlnXaa: 0.0 ± 0.0
Arg
3.116ArgAla: 3.116 ± 0.067
0.285ArgCys: 0.285 ± 0.02
2.108ArgAsp: 2.108 ± 0.061
2.569ArgGlu: 2.569 ± 0.069
2.166ArgPhe: 2.166 ± 0.057
2.258ArgGly: 2.258 ± 0.063
1.102ArgHis: 1.102 ± 0.044
2.958ArgIle: 2.958 ± 0.067
2.438ArgLys: 2.438 ± 0.066
4.931ArgLeu: 4.931 ± 0.079
1.24ArgMet: 1.24 ± 0.037
1.748ArgAsn: 1.748 ± 0.053
1.749ArgPro: 1.749 ± 0.049
2.242ArgGln: 2.242 ± 0.052
1.978ArgArg: 1.978 ± 0.058
2.367ArgSer: 2.367 ± 0.06
1.907ArgThr: 1.907 ± 0.048
2.893ArgVal: 2.893 ± 0.071
0.614ArgTrp: 0.614 ± 0.026
1.691ArgTyr: 1.691 ± 0.045
0.0ArgXaa: 0.0 ± 0.0
Ser
4.992SerAla: 4.992 ± 0.088
0.464SerCys: 0.464 ± 0.028
3.672SerAsp: 3.672 ± 0.083
4.392SerGlu: 4.392 ± 0.084
2.841SerPhe: 2.841 ± 0.065
4.726SerGly: 4.726 ± 0.088
1.54SerHis: 1.54 ± 0.043
3.933SerIle: 3.933 ± 0.08
3.255SerLys: 3.255 ± 0.072
6.694SerLeu: 6.694 ± 0.102
1.807SerMet: 1.807 ± 0.048
2.582SerAsn: 2.582 ± 0.067
2.41SerPro: 2.41 ± 0.053
3.107SerGln: 3.107 ± 0.074
2.519SerArg: 2.519 ± 0.059
4.112SerSer: 4.112 ± 0.087
3.107SerThr: 3.107 ± 0.067
4.399SerVal: 4.399 ± 0.087
0.738SerTrp: 0.738 ± 0.034
1.87SerTyr: 1.87 ± 0.062
0.0SerXaa: 0.0 ± 0.0
Thr
4.264ThrAla: 4.264 ± 0.093
0.438ThrCys: 0.438 ± 0.029
2.985ThrAsp: 2.985 ± 0.072
3.397ThrGlu: 3.397 ± 0.069
2.267ThrPhe: 2.267 ± 0.059
3.957ThrGly: 3.957 ± 0.075
1.355ThrHis: 1.355 ± 0.043
3.212ThrIle: 3.212 ± 0.076
2.356ThrLys: 2.356 ± 0.058
6.507ThrLeu: 6.507 ± 0.102
1.152ThrMet: 1.152 ± 0.041
1.899ThrAsn: 1.899 ± 0.057
2.922ThrPro: 2.922 ± 0.067
2.834ThrGln: 2.834 ± 0.07
2.032ThrArg: 2.032 ± 0.048
3.098ThrSer: 3.098 ± 0.078
2.777ThrThr: 2.777 ± 0.067
3.81ThrVal: 3.81 ± 0.075
0.586ThrTrp: 0.586 ± 0.028
1.622ThrTyr: 1.622 ± 0.049
0.0ThrXaa: 0.0 ± 0.0
Val
5.666ValAla: 5.666 ± 0.101
0.616ValCys: 0.616 ± 0.031
3.835ValAsp: 3.835 ± 0.076
4.622ValGlu: 4.622 ± 0.082
2.94ValPhe: 2.94 ± 0.068
4.321ValGly: 4.321 ± 0.085
1.316ValHis: 1.316 ± 0.038
4.817ValIle: 4.817 ± 0.091
4.039ValLys: 4.039 ± 0.092
7.1ValLeu: 7.1 ± 0.127
2.089ValMet: 2.089 ± 0.055
2.885ValAsn: 2.885 ± 0.059
2.631ValPro: 2.631 ± 0.068
2.536ValGln: 2.536 ± 0.064
2.816ValArg: 2.816 ± 0.071
4.875ValSer: 4.875 ± 0.089
3.91ValThr: 3.91 ± 0.078
5.145ValVal: 5.145 ± 0.101
0.738ValTrp: 0.738 ± 0.033
1.884ValTyr: 1.884 ± 0.052
0.0ValXaa: 0.0 ± 0.0
Trp
0.774TrpAla: 0.774 ± 0.037
0.122TrpCys: 0.122 ± 0.013
0.532TrpAsp: 0.532 ± 0.03
0.594TrpGlu: 0.594 ± 0.03
0.607TrpPhe: 0.607 ± 0.034
0.695TrpGly: 0.695 ± 0.033
0.388TrpHis: 0.388 ± 0.023
0.76TrpIle: 0.76 ± 0.033
0.597TrpLys: 0.597 ± 0.033
1.702TrpLeu: 1.702 ± 0.063
0.379TrpMet: 0.379 ± 0.022
0.449TrpAsn: 0.449 ± 0.024
0.483TrpPro: 0.483 ± 0.024
0.938TrpGln: 0.938 ± 0.039
0.589TrpArg: 0.589 ± 0.03
0.727TrpSer: 0.727 ± 0.039
0.504TrpThr: 0.504 ± 0.03
1.101TrpVal: 1.101 ± 0.047
0.172TrpTrp: 0.172 ± 0.016
0.307TrpTyr: 0.307 ± 0.022
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.323TyrAla: 2.323 ± 0.051
0.291TyrCys: 0.291 ± 0.022
1.92TyrAsp: 1.92 ± 0.05
1.938TyrGlu: 1.938 ± 0.053
1.4TyrPhe: 1.4 ± 0.051
1.994TyrGly: 1.994 ± 0.055
0.785TyrHis: 0.785 ± 0.034
1.626TyrIle: 1.626 ± 0.048
1.359TyrLys: 1.359 ± 0.047
3.294TyrLeu: 3.294 ± 0.074
0.584TyrMet: 0.584 ± 0.031
1.091TyrAsn: 1.091 ± 0.047
1.277TyrPro: 1.277 ± 0.042
2.091TyrGln: 2.091 ± 0.049
1.655TyrArg: 1.655 ± 0.051
1.796TyrSer: 1.796 ± 0.053
1.356TyrThr: 1.356 ± 0.053
1.715TyrVal: 1.715 ± 0.049
0.443TyrTrp: 0.443 ± 0.027
0.957TyrTyr: 0.957 ± 0.044
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2187 proteins (722023 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski