Amino acid dipepetide frequency for Sulfurimonas denitrificans (strain ATCC 33889 / DSM 1251) (Thiomicrospira denitrificans (strain ATCC 33889 / DSM 1251))

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.349AlaAla: 4.349 ± 0.138
0.584AlaCys: 0.584 ± 0.034
3.322AlaAsp: 3.322 ± 0.082
3.36AlaGlu: 3.36 ± 0.068
3.005AlaPhe: 3.005 ± 0.076
3.912AlaGly: 3.912 ± 0.091
1.392AlaHis: 1.392 ± 0.053
6.341AlaIle: 6.341 ± 0.101
6.402AlaLys: 6.402 ± 0.104
8.111AlaLeu: 8.111 ± 0.116
2.011AlaMet: 2.011 ± 0.052
3.353AlaAsn: 3.353 ± 0.069
1.915AlaPro: 1.915 ± 0.056
2.671AlaGln: 2.671 ± 0.067
2.223AlaArg: 2.223 ± 0.066
4.932AlaSer: 4.932 ± 0.095
4.038AlaThr: 4.038 ± 0.114
3.727AlaVal: 3.727 ± 0.1
0.414AlaTrp: 0.414 ± 0.026
2.508AlaTyr: 2.508 ± 0.059
0.0AlaXaa: 0.0 ± 0.0
Cys
0.624CysAla: 0.624 ± 0.029
0.068CysCys: 0.068 ± 0.01
0.599CysAsp: 0.599 ± 0.028
0.686CysGlu: 0.686 ± 0.034
0.335CysPhe: 0.335 ± 0.023
0.744CysGly: 0.744 ± 0.031
0.251CysHis: 0.251 ± 0.023
0.503CysIle: 0.503 ± 0.027
0.683CysLys: 0.683 ± 0.033
0.495CysLeu: 0.495 ± 0.028
0.176CysMet: 0.176 ± 0.017
0.464CysAsn: 0.464 ± 0.029
0.348CysPro: 0.348 ± 0.025
0.213CysGln: 0.213 ± 0.018
0.338CysArg: 0.338 ± 0.022
0.726CysSer: 0.726 ± 0.036
0.378CysThr: 0.378 ± 0.023
0.504CysVal: 0.504 ± 0.029
0.043CysTrp: 0.043 ± 0.008
0.302CysTyr: 0.302 ± 0.023
0.0CysXaa: 0.0 ± 0.0
Asp
4.351AspAla: 4.351 ± 0.097
0.372AspCys: 0.372 ± 0.025
3.177AspAsp: 3.177 ± 0.08
5.699AspGlu: 5.699 ± 0.098
3.172AspPhe: 3.172 ± 0.065
3.813AspGly: 3.813 ± 0.092
0.52AspHis: 0.52 ± 0.03
5.954AspIle: 5.954 ± 0.095
4.989AspLys: 4.989 ± 0.097
4.568AspLeu: 4.568 ± 0.079
1.614AspMet: 1.614 ± 0.046
2.597AspAsn: 2.597 ± 0.068
1.155AspPro: 1.155 ± 0.044
0.762AspGln: 0.762 ± 0.032
1.835AspArg: 1.835 ± 0.053
3.684AspSer: 3.684 ± 0.076
2.839AspThr: 2.839 ± 0.073
3.617AspVal: 3.617 ± 0.077
0.388AspTrp: 0.388 ± 0.025
2.142AspTyr: 2.142 ± 0.057
0.0AspXaa: 0.0 ± 0.0
Glu
5.185GluAla: 5.185 ± 0.092
0.683GluCys: 0.683 ± 0.034
3.854GluAsp: 3.854 ± 0.081
5.029GluGlu: 5.029 ± 0.095
3.678GluPhe: 3.678 ± 0.074
3.055GluGly: 3.055 ± 0.081
1.611GluHis: 1.611 ± 0.054
7.007GluIle: 7.007 ± 0.117
5.87GluLys: 5.87 ± 0.103
8.074GluLeu: 8.074 ± 0.128
2.102GluMet: 2.102 ± 0.05
3.99GluAsn: 3.99 ± 0.091
1.608GluPro: 1.608 ± 0.05
2.332GluGln: 2.332 ± 0.068
2.539GluArg: 2.539 ± 0.072
4.561GluSer: 4.561 ± 0.099
2.679GluThr: 2.679 ± 0.06
4.586GluVal: 4.586 ± 0.086
0.514GluTrp: 0.514 ± 0.03
2.865GluTyr: 2.865 ± 0.068
0.0GluXaa: 0.0 ± 0.0
Phe
3.331PheAla: 3.331 ± 0.072
0.514PheCys: 0.514 ± 0.029
3.224PheAsp: 3.224 ± 0.083
3.593PheGlu: 3.593 ± 0.08
2.667PhePhe: 2.667 ± 0.07
3.249PheGly: 3.249 ± 0.071
0.753PheHis: 0.753 ± 0.03
4.287PheIle: 4.287 ± 0.091
3.826PheLys: 3.826 ± 0.077
4.966PheLeu: 4.966 ± 0.103
1.313PheMet: 1.313 ± 0.046
2.501PheAsn: 2.501 ± 0.057
1.091PhePro: 1.091 ± 0.05
0.937PheGln: 0.937 ± 0.036
1.45PheArg: 1.45 ± 0.048
4.069PheSer: 4.069 ± 0.086
2.483PheThr: 2.483 ± 0.067
3.043PheVal: 3.043 ± 0.069
0.437PheTrp: 0.437 ± 0.027
2.112PheTyr: 2.112 ± 0.06
0.0PheXaa: 0.0 ± 0.0
Gly
4.493GlyAla: 4.493 ± 0.103
0.735GlyCys: 0.735 ± 0.039
3.257GlyAsp: 3.257 ± 0.078
3.725GlyGlu: 3.725 ± 0.066
3.337GlyPhe: 3.337 ± 0.085
4.067GlyGly: 4.067 ± 0.114
1.138GlyHis: 1.138 ± 0.045
4.883GlyIle: 4.883 ± 0.091
3.907GlyLys: 3.907 ± 0.09
4.779GlyLeu: 4.779 ± 0.098
1.596GlyMet: 1.596 ± 0.054
2.318GlyAsn: 2.318 ± 0.073
0.846GlyPro: 0.846 ± 0.041
1.205GlyGln: 1.205 ± 0.048
1.969GlyArg: 1.969 ± 0.061
3.802GlySer: 3.802 ± 0.099
2.873GlyThr: 2.873 ± 0.108
4.975GlyVal: 4.975 ± 0.104
0.483GlyTrp: 0.483 ± 0.031
2.653GlyTyr: 2.653 ± 0.069
0.0GlyXaa: 0.0 ± 0.0
His
1.113HisAla: 1.113 ± 0.042
0.163HisCys: 0.163 ± 0.016
0.934HisAsp: 0.934 ± 0.039
1.138HisGlu: 1.138 ± 0.046
0.992HisPhe: 0.992 ± 0.038
1.127HisGly: 1.127 ± 0.046
0.451HisHis: 0.451 ± 0.03
1.499HisIle: 1.499 ± 0.045
1.508HisLys: 1.508 ± 0.052
1.708HisLeu: 1.708 ± 0.055
0.425HisMet: 0.425 ± 0.027
1.03HisAsn: 1.03 ± 0.039
0.777HisPro: 0.777 ± 0.034
0.629HisGln: 0.629 ± 0.034
0.636HisArg: 0.636 ± 0.03
1.238HisSer: 1.238 ± 0.04
0.995HisThr: 0.995 ± 0.037
1.465HisVal: 1.465 ± 0.049
0.142HisTrp: 0.142 ± 0.016
0.766HisTyr: 0.766 ± 0.034
0.0HisXaa: 0.0 ± 0.0
Ile
6.59IleAla: 6.59 ± 0.113
0.694IleCys: 0.694 ± 0.038
5.717IleAsp: 5.717 ± 0.087
6.644IleGlu: 6.644 ± 0.091
4.315IlePhe: 4.315 ± 0.088
5.083IleGly: 5.083 ± 0.089
1.361IleHis: 1.361 ± 0.042
6.804IleIle: 6.804 ± 0.116
7.683IleLys: 7.683 ± 0.125
8.193IleLeu: 8.193 ± 0.139
1.905IleMet: 1.905 ± 0.055
4.613IleAsn: 4.613 ± 0.073
2.472IlePro: 2.472 ± 0.065
2.103IleGln: 2.103 ± 0.061
2.716IleArg: 2.716 ± 0.074
6.636IleSer: 6.636 ± 0.106
4.594IleThr: 4.594 ± 0.08
5.501IleVal: 5.501 ± 0.085
0.526IleTrp: 0.526 ± 0.031
3.266IleTyr: 3.266 ± 0.071
0.0IleXaa: 0.0 ± 0.0
Lys
5.155LysAla: 5.155 ± 0.08
0.517LysCys: 0.517 ± 0.032
5.031LysAsp: 5.031 ± 0.095
8.231LysGlu: 8.231 ± 0.141
3.16LysPhe: 3.16 ± 0.074
3.411LysGly: 3.411 ± 0.084
1.45LysHis: 1.45 ± 0.048
7.947LysIle: 7.947 ± 0.11
7.886LysLys: 7.886 ± 0.125
7.228LysLeu: 7.228 ± 0.125
2.351LysMet: 2.351 ± 0.06
6.005LysAsn: 6.005 ± 0.121
2.292LysPro: 2.292 ± 0.064
2.229LysGln: 2.229 ± 0.063
3.122LysArg: 3.122 ± 0.074
5.894LysSer: 5.894 ± 0.101
4.14LysThr: 4.14 ± 0.081
4.404LysVal: 4.404 ± 0.096
0.486LysTrp: 0.486 ± 0.029
3.125LysTyr: 3.125 ± 0.078
0.0LysXaa: 0.0 ± 0.0
Leu
6.002LeuAla: 6.002 ± 0.099
0.839LeuCys: 0.839 ± 0.033
5.525LeuAsp: 5.525 ± 0.094
7.02LeuGlu: 7.02 ± 0.123
5.335LeuPhe: 5.335 ± 0.107
5.569LeuGly: 5.569 ± 0.103
2.146LeuHis: 2.146 ± 0.055
7.2LeuIle: 7.2 ± 0.123
8.549LeuLys: 8.549 ± 0.112
9.823LeuLeu: 9.823 ± 0.153
2.385LeuMet: 2.385 ± 0.069
5.175LeuAsn: 5.175 ± 0.094
2.945LeuPro: 2.945 ± 0.069
3.062LeuGln: 3.062 ± 0.077
3.669LeuArg: 3.669 ± 0.077
8.5LeuSer: 8.5 ± 0.139
4.437LeuThr: 4.437 ± 0.095
5.274LeuVal: 5.274 ± 0.097
0.692LeuTrp: 0.692 ± 0.032
3.546LeuTyr: 3.546 ± 0.081
0.0LeuXaa: 0.0 ± 0.0
Met
1.948MetAla: 1.948 ± 0.062
0.216MetCys: 0.216 ± 0.016
1.31MetAsp: 1.31 ± 0.052
1.297MetGlu: 1.297 ± 0.051
1.158MetPhe: 1.158 ± 0.039
1.687MetGly: 1.687 ± 0.051
0.473MetHis: 0.473 ± 0.028
2.195MetIle: 2.195 ± 0.06
2.126MetLys: 2.126 ± 0.053
2.698MetLeu: 2.698 ± 0.066
0.797MetMet: 0.797 ± 0.041
1.287MetAsn: 1.287 ± 0.047
1.075MetPro: 1.075 ± 0.037
1.22MetGln: 1.22 ± 0.039
1.1MetArg: 1.1 ± 0.037
2.127MetSer: 2.127 ± 0.06
1.03MetThr: 1.03 ± 0.043
1.533MetVal: 1.533 ± 0.05
0.182MetTrp: 0.182 ± 0.018
0.746MetTyr: 0.746 ± 0.034
0.0MetXaa: 0.0 ± 0.0
Asn
3.448AsnAla: 3.448 ± 0.09
0.331AsnCys: 0.331 ± 0.022
2.545AsnAsp: 2.545 ± 0.066
3.727AsnGlu: 3.727 ± 0.07
2.742AsnPhe: 2.742 ± 0.069
2.974AsnGly: 2.974 ± 0.073
0.885AsnHis: 0.885 ± 0.034
5.76AsnIle: 5.76 ± 0.103
3.657AsnLys: 3.657 ± 0.084
4.963AsnLeu: 4.963 ± 0.088
1.34AsnMet: 1.34 ± 0.042
2.52AsnAsn: 2.52 ± 0.069
1.967AsnPro: 1.967 ± 0.059
1.508AsnGln: 1.508 ± 0.052
2.121AsnArg: 2.121 ± 0.058
4.351AsnSer: 4.351 ± 0.085
2.407AsnThr: 2.407 ± 0.074
2.739AsnVal: 2.739 ± 0.064
0.307AsnTrp: 0.307 ± 0.023
2.152AsnTyr: 2.152 ± 0.058
0.0AsnXaa: 0.0 ± 0.0
Pro
1.448ProAla: 1.448 ± 0.047
0.227ProCys: 0.227 ± 0.016
1.324ProAsp: 1.324 ± 0.045
1.705ProGlu: 1.705 ± 0.059
1.7ProPhe: 1.7 ± 0.05
0.935ProGly: 0.935 ± 0.038
0.709ProHis: 0.709 ± 0.037
2.551ProIle: 2.551 ± 0.068
2.43ProLys: 2.43 ± 0.06
3.006ProLeu: 3.006 ± 0.06
0.747ProMet: 0.747 ± 0.038
1.479ProAsn: 1.479 ± 0.052
0.78ProPro: 0.78 ± 0.046
1.109ProGln: 1.109 ± 0.038
0.78ProArg: 0.78 ± 0.033
2.096ProSer: 2.096 ± 0.062
1.678ProThr: 1.678 ± 0.057
1.537ProVal: 1.537 ± 0.052
0.248ProTrp: 0.248 ± 0.02
1.313ProTyr: 1.313 ± 0.05
0.0ProXaa: 0.0 ± 0.0
Gln
1.682GlnAla: 1.682 ± 0.055
0.138GlnCys: 0.138 ± 0.014
1.614GlnAsp: 1.614 ± 0.051
2.487GlnGlu: 2.487 ± 0.067
0.983GlnPhe: 0.983 ± 0.042
1.318GlnGly: 1.318 ± 0.04
0.514GlnHis: 0.514 ± 0.03
2.348GlnIle: 2.348 ± 0.064
3.269GlnLys: 3.269 ± 0.064
2.246GlnLeu: 2.246 ± 0.061
0.815GlnMet: 0.815 ± 0.036
2.4GlnAsn: 2.4 ± 0.072
0.645GlnPro: 0.645 ± 0.024
0.854GlnGln: 0.854 ± 0.049
1.402GlnArg: 1.402 ± 0.047
1.991GlnSer: 1.991 ± 0.061
1.668GlnThr: 1.668 ± 0.048
1.344GlnVal: 1.344 ± 0.047
0.205GlnTrp: 0.205 ± 0.019
0.803GlnTyr: 0.803 ± 0.037
0.0GlnXaa: 0.0 ± 0.0
Arg
2.747ArgAla: 2.747 ± 0.063
0.271ArgCys: 0.271 ± 0.023
2.523ArgAsp: 2.523 ± 0.069
3.128ArgGlu: 3.128 ± 0.077
1.725ArgPhe: 1.725 ± 0.046
2.081ArgGly: 2.081 ± 0.059
0.666ArgHis: 0.666 ± 0.033
2.435ArgIle: 2.435 ± 0.062
2.17ArgLys: 2.17 ± 0.055
2.974ArgLeu: 2.974 ± 0.069
0.812ArgMet: 0.812 ± 0.032
1.473ArgAsn: 1.473 ± 0.057
0.854ArgPro: 0.854 ± 0.035
0.848ArgGln: 0.848 ± 0.041
1.349ArgArg: 1.349 ± 0.049
1.942ArgSer: 1.942 ± 0.055
1.419ArgThr: 1.419 ± 0.049
3.249ArgVal: 3.249 ± 0.068
0.27ArgTrp: 0.27 ± 0.019
1.592ArgTyr: 1.592 ± 0.048
0.0ArgXaa: 0.0 ± 0.0
Ser
5.083SerAla: 5.083 ± 0.101
0.627SerCys: 0.627 ± 0.03
4.038SerAsp: 4.038 ± 0.074
4.349SerGlu: 4.349 ± 0.083
3.847SerPhe: 3.847 ± 0.084
4.61SerGly: 4.61 ± 0.09
1.462SerHis: 1.462 ± 0.042
6.177SerIle: 6.177 ± 0.1
6.195SerLys: 6.195 ± 0.099
7.462SerLeu: 7.462 ± 0.108
1.862SerMet: 1.862 ± 0.053
3.547SerAsn: 3.547 ± 0.089
1.755SerPro: 1.755 ± 0.048
2.335SerGln: 2.335 ± 0.067
2.45SerArg: 2.45 ± 0.067
5.98SerSer: 5.98 ± 0.107
3.488SerThr: 3.488 ± 0.078
4.364SerVal: 4.364 ± 0.087
0.526SerTrp: 0.526 ± 0.03
3.037SerTyr: 3.037 ± 0.075
0.0SerXaa: 0.0 ± 0.0
Thr
3.172ThrAla: 3.172 ± 0.117
0.522ThrCys: 0.522 ± 0.033
2.301ThrAsp: 2.301 ± 0.06
2.003ThrGlu: 2.003 ± 0.051
2.515ThrPhe: 2.515 ± 0.061
2.682ThrGly: 2.682 ± 0.099
1.004ThrHis: 1.004 ± 0.042
4.696ThrIle: 4.696 ± 0.098
4.388ThrLys: 4.388 ± 0.08
6.15ThrLeu: 6.15 ± 0.12
1.035ThrMet: 1.035 ± 0.04
2.501ThrAsn: 2.501 ± 0.075
2.271ThrPro: 2.271 ± 0.064
1.912ThrGln: 1.912 ± 0.062
1.379ThrArg: 1.379 ± 0.046
3.242ThrSer: 3.242 ± 0.07
3.005ThrThr: 3.005 ± 0.094
2.523ThrVal: 2.523 ± 0.078
0.283ThrTrp: 0.283 ± 0.021
1.786ThrTyr: 1.786 ± 0.051
0.0ThrXaa: 0.0 ± 0.0
Val
4.856ValAla: 4.856 ± 0.101
0.586ValCys: 0.586 ± 0.032
4.093ValAsp: 4.093 ± 0.081
4.683ValGlu: 4.683 ± 0.104
2.572ValPhe: 2.572 ± 0.062
4.038ValGly: 4.038 ± 0.1
1.047ValHis: 1.047 ± 0.039
5.028ValIle: 5.028 ± 0.09
4.775ValLys: 4.775 ± 0.088
5.661ValLeu: 5.661 ± 0.096
1.671ValMet: 1.671 ± 0.053
2.808ValAsn: 2.808 ± 0.062
1.682ValPro: 1.682 ± 0.061
1.493ValGln: 1.493 ± 0.049
1.794ValArg: 1.794 ± 0.048
4.242ValSer: 4.242 ± 0.085
3.166ValThr: 3.166 ± 0.089
4.732ValVal: 4.732 ± 0.096
0.449ValTrp: 0.449 ± 0.025
1.991ValTyr: 1.991 ± 0.055
0.0ValXaa: 0.0 ± 0.0
Trp
0.471TrpAla: 0.471 ± 0.03
0.074TrpCys: 0.074 ± 0.01
0.391TrpAsp: 0.391 ± 0.026
0.388TrpGlu: 0.388 ± 0.027
0.424TrpPhe: 0.424 ± 0.03
0.485TrpGly: 0.485 ± 0.029
0.191TrpHis: 0.191 ± 0.018
0.637TrpIle: 0.637 ± 0.035
0.362TrpLys: 0.362 ± 0.022
0.797TrpLeu: 0.797 ± 0.037
0.245TrpMet: 0.245 ± 0.02
0.316TrpAsn: 0.316 ± 0.023
0.154TrpPro: 0.154 ± 0.015
0.296TrpGln: 0.296 ± 0.021
0.28TrpArg: 0.28 ± 0.02
0.468TrpSer: 0.468 ± 0.028
0.236TrpThr: 0.236 ± 0.022
0.403TrpVal: 0.403 ± 0.027
0.077TrpTrp: 0.077 ± 0.012
0.273TrpTyr: 0.273 ± 0.02
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.521TyrAla: 2.521 ± 0.066
0.32TyrCys: 0.32 ± 0.021
2.471TyrAsp: 2.471 ± 0.067
2.931TyrGlu: 2.931 ± 0.075
2.185TyrPhe: 2.185 ± 0.052
2.204TyrGly: 2.204 ± 0.063
0.712TyrHis: 0.712 ± 0.032
3.163TyrIle: 3.163 ± 0.069
3.392TyrLys: 3.392 ± 0.08
3.79TyrLeu: 3.79 ± 0.068
0.999TyrMet: 0.999 ± 0.04
2.066TyrAsn: 2.066 ± 0.059
1.168TyrPro: 1.168 ± 0.042
1.008TyrGln: 1.008 ± 0.037
1.377TyrArg: 1.377 ± 0.053
2.714TyrSer: 2.714 ± 0.069
1.817TyrThr: 1.817 ± 0.054
1.844TyrVal: 1.844 ± 0.052
0.296TyrTrp: 0.296 ± 0.021
1.51TyrTyr: 1.51 ± 0.059
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2084 proteins (674622 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski