Amino acid dipepetide frequency for Cellulophaga phage phi12:1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.69AlaAla: 4.69 ± 1.33
0.636AlaCys: 0.636 ± 0.255
3.1AlaAsp: 3.1 ± 0.449
3.736AlaGlu: 3.736 ± 0.604
2.146AlaPhe: 2.146 ± 0.446
3.498AlaGly: 3.498 ± 0.544
0.715AlaHis: 0.715 ± 0.252
4.452AlaIle: 4.452 ± 0.67
5.724AlaLys: 5.724 ± 0.871
5.008AlaLeu: 5.008 ± 0.671
1.431AlaMet: 1.431 ± 0.381
2.385AlaAsn: 2.385 ± 0.384
2.067AlaPro: 2.067 ± 0.453
2.941AlaGln: 2.941 ± 0.459
2.782AlaArg: 2.782 ± 0.444
4.77AlaSer: 4.77 ± 0.71
3.577AlaThr: 3.577 ± 0.591
4.054AlaVal: 4.054 ± 0.687
1.192AlaTrp: 1.192 ± 0.281
2.703AlaTyr: 2.703 ± 0.431
0.0AlaXaa: 0.0 ± 0.0
Cys
0.477CysAla: 0.477 ± 0.181
0.159CysCys: 0.159 ± 0.12
0.874CysAsp: 0.874 ± 0.257
0.795CysGlu: 0.795 ± 0.231
0.715CysPhe: 0.715 ± 0.242
0.795CysGly: 0.795 ± 0.302
0.079CysHis: 0.079 ± 0.082
0.636CysIle: 0.636 ± 0.222
1.192CysLys: 1.192 ± 0.306
0.795CysLeu: 0.795 ± 0.329
0.159CysMet: 0.159 ± 0.117
0.397CysAsn: 0.397 ± 0.157
0.715CysPro: 0.715 ± 0.254
0.397CysGln: 0.397 ± 0.173
0.874CysArg: 0.874 ± 0.281
0.874CysSer: 0.874 ± 0.313
0.238CysThr: 0.238 ± 0.119
0.238CysVal: 0.238 ± 0.152
0.079CysTrp: 0.079 ± 0.085
0.318CysTyr: 0.318 ± 0.159
0.0CysXaa: 0.0 ± 0.0
Asp
4.372AspAla: 4.372 ± 0.574
0.795AspCys: 0.795 ± 0.269
3.418AspAsp: 3.418 ± 0.561
3.736AspGlu: 3.736 ± 0.601
3.895AspPhe: 3.895 ± 0.56
4.929AspGly: 4.929 ± 0.763
1.033AspHis: 1.033 ± 0.264
5.724AspIle: 5.724 ± 0.681
5.008AspLys: 5.008 ± 0.633
6.678AspLeu: 6.678 ± 0.61
1.51AspMet: 1.51 ± 0.345
3.498AspAsn: 3.498 ± 0.474
2.941AspPro: 2.941 ± 0.515
2.623AspGln: 2.623 ± 0.414
2.544AspArg: 2.544 ± 0.49
4.134AspSer: 4.134 ± 0.615
3.18AspThr: 3.18 ± 0.609
3.259AspVal: 3.259 ± 0.54
1.113AspTrp: 1.113 ± 0.264
2.226AspTyr: 2.226 ± 0.392
0.0AspXaa: 0.0 ± 0.0
Glu
5.167GluAla: 5.167 ± 0.615
0.318GluCys: 0.318 ± 0.147
4.054GluAsp: 4.054 ± 0.649
4.77GluGlu: 4.77 ± 0.835
2.703GluPhe: 2.703 ± 0.471
3.259GluGly: 3.259 ± 0.629
0.715GluHis: 0.715 ± 0.245
6.28GluIle: 6.28 ± 0.599
5.008GluLys: 5.008 ± 0.75
6.598GluLeu: 6.598 ± 0.718
1.987GluMet: 1.987 ± 0.341
3.418GluAsn: 3.418 ± 0.439
1.749GluPro: 1.749 ± 0.437
2.862GluGln: 2.862 ± 0.649
2.305GluArg: 2.305 ± 0.389
3.1GluSer: 3.1 ± 0.592
3.1GluThr: 3.1 ± 0.463
4.69GluVal: 4.69 ± 0.511
0.874GluTrp: 0.874 ± 0.255
2.464GluTyr: 2.464 ± 0.415
0.0GluXaa: 0.0 ± 0.0
Phe
2.226PheAla: 2.226 ± 0.368
0.238PheCys: 0.238 ± 0.136
4.611PheAsp: 4.611 ± 0.624
2.782PheGlu: 2.782 ± 0.433
2.941PhePhe: 2.941 ± 0.492
2.941PheGly: 2.941 ± 0.529
0.636PheHis: 0.636 ± 0.201
3.577PheIle: 3.577 ± 0.603
4.452PheLys: 4.452 ± 0.481
3.736PheLeu: 3.736 ± 0.506
1.113PheMet: 1.113 ± 0.311
4.054PheAsn: 4.054 ± 0.479
1.272PhePro: 1.272 ± 0.325
0.954PheGln: 0.954 ± 0.294
1.113PheArg: 1.113 ± 0.371
2.623PheSer: 2.623 ± 0.466
2.544PheThr: 2.544 ± 0.366
2.464PheVal: 2.464 ± 0.441
0.715PheTrp: 0.715 ± 0.218
1.828PheTyr: 1.828 ± 0.366
0.0PheXaa: 0.0 ± 0.0
Gly
4.452GlyAla: 4.452 ± 0.831
0.715GlyCys: 0.715 ± 0.278
4.213GlyAsp: 4.213 ± 0.545
3.657GlyGlu: 3.657 ± 1.039
4.452GlyPhe: 4.452 ± 0.581
4.054GlyGly: 4.054 ± 0.692
0.636GlyHis: 0.636 ± 0.184
4.213GlyIle: 4.213 ± 0.566
4.054GlyLys: 4.054 ± 0.557
5.883GlyLeu: 5.883 ± 0.911
1.272GlyMet: 1.272 ± 0.334
2.782GlyAsn: 2.782 ± 0.475
1.749GlyPro: 1.749 ± 0.493
2.226GlyGln: 2.226 ± 0.375
1.669GlyArg: 1.669 ± 0.329
4.849GlySer: 4.849 ± 0.624
4.531GlyThr: 4.531 ± 0.9
4.134GlyVal: 4.134 ± 0.562
0.874GlyTrp: 0.874 ± 0.226
3.18GlyTyr: 3.18 ± 0.576
0.0GlyXaa: 0.0 ± 0.0
His
0.874HisAla: 0.874 ± 0.262
0.318HisCys: 0.318 ± 0.151
0.477HisAsp: 0.477 ± 0.2
0.477HisGlu: 0.477 ± 0.175
0.715HisPhe: 0.715 ± 0.248
0.795HisGly: 0.795 ± 0.24
0.079HisHis: 0.079 ± 0.079
1.272HisIle: 1.272 ± 0.358
1.351HisLys: 1.351 ± 0.368
1.192HisLeu: 1.192 ± 0.322
0.477HisMet: 0.477 ± 0.206
0.715HisAsn: 0.715 ± 0.179
0.715HisPro: 0.715 ± 0.264
0.318HisGln: 0.318 ± 0.159
0.954HisArg: 0.954 ± 0.32
0.795HisSer: 0.795 ± 0.204
0.318HisThr: 0.318 ± 0.169
0.556HisVal: 0.556 ± 0.199
0.238HisTrp: 0.238 ± 0.141
0.636HisTyr: 0.636 ± 0.233
0.0HisXaa: 0.0 ± 0.0
Ile
4.77IleAla: 4.77 ± 0.72
0.874IleCys: 0.874 ± 0.266
6.439IleAsp: 6.439 ± 0.546
7.632IleGlu: 7.632 ± 0.752
3.021IlePhe: 3.021 ± 0.58
4.134IleGly: 4.134 ± 0.531
0.795IleHis: 0.795 ± 0.237
5.167IleIle: 5.167 ± 0.592
7.075IleLys: 7.075 ± 0.894
7.314IleLeu: 7.314 ± 0.78
1.351IleMet: 1.351 ± 0.351
5.326IleAsn: 5.326 ± 0.622
2.305IlePro: 2.305 ± 0.496
2.146IleGln: 2.146 ± 0.576
2.544IleArg: 2.544 ± 0.447
6.042IleSer: 6.042 ± 0.611
3.259IleThr: 3.259 ± 0.506
4.452IleVal: 4.452 ± 0.657
0.954IleTrp: 0.954 ± 0.257
2.464IleTyr: 2.464 ± 0.531
0.0IleXaa: 0.0 ± 0.0
Lys
5.406LysAla: 5.406 ± 0.796
0.477LysCys: 0.477 ± 0.218
5.962LysAsp: 5.962 ± 0.734
6.996LysGlu: 6.996 ± 0.809
3.021LysPhe: 3.021 ± 0.578
5.326LysGly: 5.326 ± 0.746
1.431LysHis: 1.431 ± 0.409
6.916LysIle: 6.916 ± 0.937
9.142LysLys: 9.142 ± 1.096
6.996LysLeu: 6.996 ± 1.066
2.862LysMet: 2.862 ± 0.562
5.485LysAsn: 5.485 ± 0.692
3.259LysPro: 3.259 ± 0.585
2.623LysGln: 2.623 ± 0.474
3.895LysArg: 3.895 ± 0.587
5.803LysSer: 5.803 ± 0.651
4.213LysThr: 4.213 ± 0.622
4.372LysVal: 4.372 ± 0.63
1.272LysTrp: 1.272 ± 0.313
4.134LysTyr: 4.134 ± 0.716
0.0LysXaa: 0.0 ± 0.0
Leu
3.339LeuAla: 3.339 ± 0.572
1.192LeuCys: 1.192 ± 0.282
6.439LeuAsp: 6.439 ± 0.843
5.167LeuGlu: 5.167 ± 0.685
3.975LeuPhe: 3.975 ± 0.679
4.054LeuGly: 4.054 ± 0.546
1.113LeuHis: 1.113 ± 0.307
6.837LeuIle: 6.837 ± 0.866
6.837LeuLys: 6.837 ± 0.962
6.042LeuLeu: 6.042 ± 0.601
2.782LeuMet: 2.782 ± 0.551
5.485LeuAsn: 5.485 ± 0.565
3.1LeuPro: 3.1 ± 0.466
3.18LeuGln: 3.18 ± 0.505
3.18LeuArg: 3.18 ± 0.566
7.393LeuSer: 7.393 ± 0.689
5.088LeuThr: 5.088 ± 0.653
3.895LeuVal: 3.895 ± 0.63
0.874LeuTrp: 0.874 ± 0.273
2.385LeuTyr: 2.385 ± 0.454
0.0LeuXaa: 0.0 ± 0.0
Met
1.749MetAla: 1.749 ± 0.395
0.238MetCys: 0.238 ± 0.119
1.192MetAsp: 1.192 ± 0.287
1.351MetGlu: 1.351 ± 0.346
0.795MetPhe: 0.795 ± 0.198
1.192MetGly: 1.192 ± 0.277
0.477MetHis: 0.477 ± 0.21
2.067MetIle: 2.067 ± 0.392
2.464MetLys: 2.464 ± 0.399
1.272MetLeu: 1.272 ± 0.285
0.556MetMet: 0.556 ± 0.285
2.464MetAsn: 2.464 ± 0.402
1.192MetPro: 1.192 ± 0.305
1.431MetGln: 1.431 ± 0.344
1.113MetArg: 1.113 ± 0.264
2.385MetSer: 2.385 ± 0.462
1.351MetThr: 1.351 ± 0.32
1.749MetVal: 1.749 ± 0.31
0.079MetTrp: 0.079 ± 0.068
0.715MetTyr: 0.715 ± 0.228
0.0MetXaa: 0.0 ± 0.0
Asn
3.816AsnAla: 3.816 ± 0.494
1.033AsnCys: 1.033 ± 0.285
3.498AsnAsp: 3.498 ± 0.421
3.1AsnGlu: 3.1 ± 0.49
2.464AsnPhe: 2.464 ± 0.477
3.418AsnGly: 3.418 ± 0.541
1.113AsnHis: 1.113 ± 0.303
4.293AsnIle: 4.293 ± 0.398
6.916AsnLys: 6.916 ± 0.611
3.498AsnLeu: 3.498 ± 0.492
1.828AsnMet: 1.828 ± 0.363
3.577AsnAsn: 3.577 ± 0.651
2.146AsnPro: 2.146 ± 0.359
1.828AsnGln: 1.828 ± 0.339
2.782AsnArg: 2.782 ± 0.442
3.498AsnSer: 3.498 ± 0.507
3.816AsnThr: 3.816 ± 0.66
2.146AsnVal: 2.146 ± 0.371
0.397AsnTrp: 0.397 ± 0.161
3.1AsnTyr: 3.1 ± 0.608
0.0AsnXaa: 0.0 ± 0.0
Pro
2.544ProAla: 2.544 ± 0.519
0.477ProCys: 0.477 ± 0.172
1.351ProAsp: 1.351 ± 0.356
2.146ProGlu: 2.146 ± 0.452
1.908ProPhe: 1.908 ± 0.403
2.862ProGly: 2.862 ± 0.442
0.636ProHis: 0.636 ± 0.224
2.305ProIle: 2.305 ± 0.427
3.577ProLys: 3.577 ± 0.648
2.385ProLeu: 2.385 ± 0.424
0.715ProMet: 0.715 ± 0.255
1.908ProAsn: 1.908 ± 0.529
1.192ProPro: 1.192 ± 0.306
1.749ProGln: 1.749 ± 0.503
0.795ProArg: 0.795 ± 0.245
2.067ProSer: 2.067 ± 0.386
1.272ProThr: 1.272 ± 0.295
1.749ProVal: 1.749 ± 0.355
0.318ProTrp: 0.318 ± 0.154
1.51ProTyr: 1.51 ± 0.306
0.0ProXaa: 0.0 ± 0.0
Gln
2.067GlnAla: 2.067 ± 0.537
0.159GlnCys: 0.159 ± 0.107
2.464GlnAsp: 2.464 ± 0.418
2.226GlnGlu: 2.226 ± 0.47
1.51GlnPhe: 1.51 ± 0.314
3.498GlnGly: 3.498 ± 1.738
0.238GlnHis: 0.238 ± 0.169
3.18GlnIle: 3.18 ± 0.449
2.782GlnLys: 2.782 ± 0.403
4.134GlnLeu: 4.134 ± 0.514
1.192GlnMet: 1.192 ± 0.251
2.226GlnAsn: 2.226 ± 0.354
0.318GlnPro: 0.318 ± 0.179
0.795GlnGln: 0.795 ± 0.349
1.828GlnArg: 1.828 ± 0.327
1.51GlnSer: 1.51 ± 0.335
2.146GlnThr: 2.146 ± 0.314
1.51GlnVal: 1.51 ± 0.379
0.477GlnTrp: 0.477 ± 0.186
1.033GlnTyr: 1.033 ± 0.274
0.0GlnXaa: 0.0 ± 0.0
Arg
1.908ArgAla: 1.908 ± 0.343
0.715ArgCys: 0.715 ± 0.224
2.464ArgAsp: 2.464 ± 0.354
2.782ArgGlu: 2.782 ± 0.409
0.795ArgPhe: 0.795 ± 0.254
2.305ArgGly: 2.305 ± 0.484
0.318ArgHis: 0.318 ± 0.152
3.816ArgIle: 3.816 ± 0.546
4.134ArgLys: 4.134 ± 0.504
3.418ArgLeu: 3.418 ± 0.453
1.59ArgMet: 1.59 ± 0.355
1.431ArgAsn: 1.431 ± 0.317
0.795ArgPro: 0.795 ± 0.223
1.828ArgGln: 1.828 ± 0.283
0.874ArgArg: 0.874 ± 0.264
1.908ArgSer: 1.908 ± 0.324
1.749ArgThr: 1.749 ± 0.468
2.146ArgVal: 2.146 ± 0.399
0.636ArgTrp: 0.636 ± 0.195
1.749ArgTyr: 1.749 ± 0.42
0.0ArgXaa: 0.0 ± 0.0
Ser
3.339SerAla: 3.339 ± 0.513
1.033SerCys: 1.033 ± 0.329
5.167SerAsp: 5.167 ± 0.64
3.736SerGlu: 3.736 ± 0.439
3.657SerPhe: 3.657 ± 0.387
5.088SerGly: 5.088 ± 0.629
1.192SerHis: 1.192 ± 0.363
5.644SerIle: 5.644 ± 0.8
5.962SerLys: 5.962 ± 0.842
5.565SerLeu: 5.565 ± 0.566
1.51SerMet: 1.51 ± 0.334
3.736SerAsn: 3.736 ± 0.617
1.987SerPro: 1.987 ± 0.334
2.623SerGln: 2.623 ± 0.381
2.385SerArg: 2.385 ± 0.396
5.326SerSer: 5.326 ± 0.84
4.531SerThr: 4.531 ± 0.8
3.021SerVal: 3.021 ± 0.482
0.636SerTrp: 0.636 ± 0.204
3.1SerTyr: 3.1 ± 0.517
0.0SerXaa: 0.0 ± 0.0
Thr
4.054ThrAla: 4.054 ± 0.489
0.238ThrCys: 0.238 ± 0.143
3.339ThrAsp: 3.339 ± 0.562
2.782ThrGlu: 2.782 ± 0.411
2.703ThrPhe: 2.703 ± 0.511
4.77ThrGly: 4.77 ± 0.633
0.715ThrHis: 0.715 ± 0.205
3.816ThrIle: 3.816 ± 0.59
4.134ThrLys: 4.134 ± 0.813
3.736ThrLeu: 3.736 ± 0.519
0.954ThrMet: 0.954 ± 0.308
3.18ThrAsn: 3.18 ± 0.637
2.146ThrPro: 2.146 ± 0.467
1.828ThrGln: 1.828 ± 0.344
1.749ThrArg: 1.749 ± 0.36
4.134ThrSer: 4.134 ± 0.989
3.1ThrThr: 3.1 ± 0.637
2.941ThrVal: 2.941 ± 0.426
0.954ThrTrp: 0.954 ± 0.308
1.749ThrTyr: 1.749 ± 0.354
0.0ThrXaa: 0.0 ± 0.0
Val
2.226ValAla: 2.226 ± 0.381
0.318ValCys: 0.318 ± 0.138
4.69ValAsp: 4.69 ± 0.541
3.895ValGlu: 3.895 ± 0.42
2.305ValPhe: 2.305 ± 0.416
3.259ValGly: 3.259 ± 0.563
0.556ValHis: 0.556 ± 0.19
3.736ValIle: 3.736 ± 0.428
5.167ValLys: 5.167 ± 0.68
3.736ValLeu: 3.736 ± 0.667
1.033ValMet: 1.033 ± 0.29
3.259ValAsn: 3.259 ± 0.53
2.385ValPro: 2.385 ± 0.453
1.272ValGln: 1.272 ± 0.417
2.226ValArg: 2.226 ± 0.429
4.929ValSer: 4.929 ± 0.609
2.385ValThr: 2.385 ± 0.405
3.1ValVal: 3.1 ± 0.599
1.113ValTrp: 1.113 ± 0.238
2.782ValTyr: 2.782 ± 0.664
0.0ValXaa: 0.0 ± 0.0
Trp
1.59TrpAla: 1.59 ± 0.358
0.159TrpCys: 0.159 ± 0.13
0.874TrpAsp: 0.874 ± 0.208
1.51TrpGlu: 1.51 ± 0.315
0.715TrpPhe: 0.715 ± 0.219
0.874TrpGly: 0.874 ± 0.247
0.159TrpHis: 0.159 ± 0.11
1.272TrpIle: 1.272 ± 0.302
0.477TrpLys: 0.477 ± 0.23
0.795TrpLeu: 0.795 ± 0.263
0.318TrpMet: 0.318 ± 0.14
0.397TrpAsn: 0.397 ± 0.21
0.0TrpPro: 0.0 ± 0.0
0.397TrpGln: 0.397 ± 0.189
0.556TrpArg: 0.556 ± 0.233
0.874TrpSer: 0.874 ± 0.239
1.033TrpThr: 1.033 ± 0.32
1.192TrpVal: 1.192 ± 0.322
0.159TrpTrp: 0.159 ± 0.114
0.556TrpTyr: 0.556 ± 0.251
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.544TyrAla: 2.544 ± 0.424
0.715TyrCys: 0.715 ± 0.254
1.987TyrAsp: 1.987 ± 0.337
2.226TyrGlu: 2.226 ± 0.43
2.385TyrPhe: 2.385 ± 0.49
2.544TyrGly: 2.544 ± 0.485
0.636TyrHis: 0.636 ± 0.214
2.862TyrIle: 2.862 ± 0.43
4.134TyrLys: 4.134 ± 0.713
3.577TyrLeu: 3.577 ± 0.588
1.113TyrMet: 1.113 ± 0.263
2.544TyrAsn: 2.544 ± 0.343
1.431TyrPro: 1.431 ± 0.231
1.272TyrGln: 1.272 ± 0.323
1.192TyrArg: 1.192 ± 0.306
2.226TyrSer: 2.226 ± 0.4
1.59TyrThr: 1.59 ± 0.243
2.703TyrVal: 2.703 ± 0.618
0.954TyrTrp: 0.954 ± 0.341
2.385TyrTyr: 2.385 ± 0.531
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 64 proteins (12580 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski