Amino acid dipepetide frequency for Cellulophaga phage phi38:1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.408AlaAla: 4.408 ± 0.814
0.5AlaCys: 0.5 ± 0.161
3.727AlaAsp: 3.727 ± 0.421
3.817AlaGlu: 3.817 ± 0.408
2.727AlaPhe: 2.727 ± 0.31
3.363AlaGly: 3.363 ± 0.479
0.863AlaHis: 0.863 ± 0.261
4.317AlaIle: 4.317 ± 0.438
5.772AlaLys: 5.772 ± 0.745
4.499AlaLeu: 4.499 ± 0.389
1.136AlaMet: 1.136 ± 0.229
3.227AlaAsn: 3.227 ± 0.381
1.863AlaPro: 1.863 ± 0.319
1.682AlaGln: 1.682 ± 0.296
2.545AlaArg: 2.545 ± 0.403
3.954AlaSer: 3.954 ± 0.503
3.545AlaThr: 3.545 ± 0.373
2.545AlaVal: 2.545 ± 0.37
0.545AlaTrp: 0.545 ± 0.131
3.136AlaTyr: 3.136 ± 0.412
0.0AlaXaa: 0.0 ± 0.0
Cys
0.318CysAla: 0.318 ± 0.121
0.227CysCys: 0.227 ± 0.106
0.454CysAsp: 0.454 ± 0.204
0.545CysGlu: 0.545 ± 0.177
0.545CysPhe: 0.545 ± 0.152
0.682CysGly: 0.682 ± 0.2
0.364CysHis: 0.364 ± 0.15
0.954CysIle: 0.954 ± 0.253
0.5CysLys: 0.5 ± 0.179
0.727CysLeu: 0.727 ± 0.227
0.227CysMet: 0.227 ± 0.104
0.454CysAsn: 0.454 ± 0.131
0.227CysPro: 0.227 ± 0.1
0.364CysGln: 0.364 ± 0.137
0.318CysArg: 0.318 ± 0.117
0.818CysSer: 0.818 ± 0.23
0.454CysThr: 0.454 ± 0.135
0.773CysVal: 0.773 ± 0.178
0.091CysTrp: 0.091 ± 0.06
0.318CysTyr: 0.318 ± 0.12
0.0CysXaa: 0.0 ± 0.0
Asp
3.863AspAla: 3.863 ± 0.385
0.5AspCys: 0.5 ± 0.173
4.545AspAsp: 4.545 ± 0.488
4.999AspGlu: 4.999 ± 0.574
3.09AspPhe: 3.09 ± 0.388
5.499AspGly: 5.499 ± 0.555
0.773AspHis: 0.773 ± 0.197
6.044AspIle: 6.044 ± 0.691
5.408AspLys: 5.408 ± 0.487
5.499AspLeu: 5.499 ± 0.581
1.545AspMet: 1.545 ± 0.297
3.545AspAsn: 3.545 ± 0.388
2.181AspPro: 2.181 ± 0.394
1.5AspGln: 1.5 ± 0.249
2.909AspArg: 2.909 ± 0.365
4.636AspSer: 4.636 ± 0.617
3.227AspThr: 3.227 ± 0.364
4.408AspVal: 4.408 ± 0.447
1.182AspTrp: 1.182 ± 0.259
3.772AspTyr: 3.772 ± 0.426
0.0AspXaa: 0.0 ± 0.0
Glu
5.544GluAla: 5.544 ± 0.508
0.682GluCys: 0.682 ± 0.195
6.044GluAsp: 6.044 ± 0.622
6.408GluGlu: 6.408 ± 0.613
2.409GluPhe: 2.409 ± 0.291
5.681GluGly: 5.681 ± 0.457
0.954GluHis: 0.954 ± 0.197
4.545GluIle: 4.545 ± 0.45
5.408GluLys: 5.408 ± 0.438
7.044GluLeu: 7.044 ± 0.681
1.409GluMet: 1.409 ± 0.267
3.545GluAsn: 3.545 ± 0.371
1.772GluPro: 1.772 ± 0.535
2.0GluGln: 2.0 ± 0.304
3.227GluArg: 3.227 ± 0.345
5.272GluSer: 5.272 ± 0.432
3.272GluThr: 3.272 ± 0.289
6.499GluVal: 6.499 ± 0.62
0.682GluTrp: 0.682 ± 0.177
3.272GluTyr: 3.272 ± 0.407
0.0GluXaa: 0.0 ± 0.0
Phe
2.227PheAla: 2.227 ± 0.397
0.364PheCys: 0.364 ± 0.143
2.772PheAsp: 2.772 ± 0.362
2.727PheGlu: 2.727 ± 0.339
1.454PhePhe: 1.454 ± 0.292
2.727PheGly: 2.727 ± 0.367
0.591PheHis: 0.591 ± 0.161
2.272PheIle: 2.272 ± 0.384
4.454PheLys: 4.454 ± 0.423
3.499PheLeu: 3.499 ± 0.343
1.272PheMet: 1.272 ± 0.3
2.272PheAsn: 2.272 ± 0.376
1.0PhePro: 1.0 ± 0.226
1.045PheGln: 1.045 ± 0.187
1.545PheArg: 1.545 ± 0.27
3.636PheSer: 3.636 ± 0.372
2.181PheThr: 2.181 ± 0.397
2.136PheVal: 2.136 ± 0.393
0.454PheTrp: 0.454 ± 0.169
1.727PheTyr: 1.727 ± 0.31
0.0PheXaa: 0.0 ± 0.0
Gly
3.908GlyAla: 3.908 ± 0.55
0.454GlyCys: 0.454 ± 0.151
5.544GlyAsp: 5.544 ± 0.631
5.272GlyGlu: 5.272 ± 0.444
2.954GlyPhe: 2.954 ± 0.443
4.817GlyGly: 4.817 ± 0.478
0.682GlyHis: 0.682 ± 0.184
4.954GlyIle: 4.954 ± 0.502
5.681GlyLys: 5.681 ± 0.62
6.09GlyLeu: 6.09 ± 0.501
1.591GlyMet: 1.591 ± 0.234
3.272GlyAsn: 3.272 ± 0.503
0.591GlyPro: 0.591 ± 0.168
1.863GlyGln: 1.863 ± 0.255
3.908GlyArg: 3.908 ± 0.376
6.362GlySer: 6.362 ± 0.841
3.727GlyThr: 3.727 ± 0.585
5.272GlyVal: 5.272 ± 0.511
0.954GlyTrp: 0.954 ± 0.271
3.227GlyTyr: 3.227 ± 0.381
0.0GlyXaa: 0.0 ± 0.0
His
0.5HisAla: 0.5 ± 0.156
0.273HisCys: 0.273 ± 0.104
1.0HisAsp: 1.0 ± 0.235
0.909HisGlu: 0.909 ± 0.172
0.545HisPhe: 0.545 ± 0.176
1.091HisGly: 1.091 ± 0.235
0.5HisHis: 0.5 ± 0.152
0.863HisIle: 0.863 ± 0.192
1.182HisLys: 1.182 ± 0.273
1.318HisLeu: 1.318 ± 0.251
0.454HisMet: 0.454 ± 0.13
0.818HisAsn: 0.818 ± 0.211
0.5HisPro: 0.5 ± 0.185
0.318HisGln: 0.318 ± 0.125
0.591HisArg: 0.591 ± 0.172
0.818HisSer: 0.818 ± 0.202
0.727HisThr: 0.727 ± 0.225
0.591HisVal: 0.591 ± 0.166
0.227HisTrp: 0.227 ± 0.089
0.545HisTyr: 0.545 ± 0.161
0.0HisXaa: 0.0 ± 0.0
Ile
3.727IleAla: 3.727 ± 0.492
0.727IleCys: 0.727 ± 0.208
4.499IleAsp: 4.499 ± 0.426
6.635IleGlu: 6.635 ± 0.643
2.136IlePhe: 2.136 ± 0.373
4.181IleGly: 4.181 ± 0.416
0.773IleHis: 0.773 ± 0.182
3.772IleIle: 3.772 ± 0.52
6.408IleLys: 6.408 ± 0.644
5.59IleLeu: 5.59 ± 0.457
1.591IleMet: 1.591 ± 0.274
3.863IleAsn: 3.863 ± 0.423
2.272IlePro: 2.272 ± 0.369
2.181IleGln: 2.181 ± 0.422
2.999IleArg: 2.999 ± 0.376
6.135IleSer: 6.135 ± 0.603
4.181IleThr: 4.181 ± 0.403
3.363IleVal: 3.363 ± 0.368
0.545IleTrp: 0.545 ± 0.187
2.909IleTyr: 2.909 ± 0.403
0.0IleXaa: 0.0 ± 0.0
Lys
5.635LysAla: 5.635 ± 0.786
0.409LysCys: 0.409 ± 0.163
6.362LysAsp: 6.362 ± 0.563
7.226LysGlu: 7.226 ± 0.679
2.772LysPhe: 2.772 ± 0.349
7.68LysGly: 7.68 ± 0.695
0.318LysHis: 0.318 ± 0.125
5.59LysIle: 5.59 ± 0.468
7.59LysLys: 7.59 ± 0.95
6.317LysLeu: 6.317 ± 0.603
2.636LysMet: 2.636 ± 0.362
4.227LysAsn: 4.227 ± 0.408
2.636LysPro: 2.636 ± 0.355
2.318LysGln: 2.318 ± 0.33
3.09LysArg: 3.09 ± 0.404
5.272LysSer: 5.272 ± 0.537
4.59LysThr: 4.59 ± 0.637
5.681LysVal: 5.681 ± 0.623
0.909LysTrp: 0.909 ± 0.218
3.363LysTyr: 3.363 ± 0.328
0.0LysXaa: 0.0 ± 0.0
Leu
3.954LeuAla: 3.954 ± 0.694
0.727LeuCys: 0.727 ± 0.226
6.59LeuAsp: 6.59 ± 0.684
6.726LeuGlu: 6.726 ± 0.63
2.999LeuPhe: 2.999 ± 0.457
5.635LeuGly: 5.635 ± 0.532
1.409LeuHis: 1.409 ± 0.257
5.272LeuIle: 5.272 ± 0.577
6.953LeuLys: 6.953 ± 0.63
5.726LeuLeu: 5.726 ± 0.486
1.636LeuMet: 1.636 ± 0.285
5.045LeuAsn: 5.045 ± 0.46
2.59LeuPro: 2.59 ± 0.272
2.272LeuGln: 2.272 ± 0.306
4.227LeuArg: 4.227 ± 0.408
6.544LeuSer: 6.544 ± 0.435
4.499LeuThr: 4.499 ± 0.564
4.272LeuVal: 4.272 ± 0.445
0.318LeuTrp: 0.318 ± 0.138
3.318LeuTyr: 3.318 ± 0.362
0.0LeuXaa: 0.0 ± 0.0
Met
2.59MetAla: 2.59 ± 0.328
0.409MetCys: 0.409 ± 0.157
1.136MetAsp: 1.136 ± 0.236
1.591MetGlu: 1.591 ± 0.246
0.818MetPhe: 0.818 ± 0.236
1.636MetGly: 1.636 ± 0.264
0.364MetHis: 0.364 ± 0.148
1.409MetIle: 1.409 ± 0.268
1.636MetLys: 1.636 ± 0.272
1.409MetLeu: 1.409 ± 0.346
0.5MetMet: 0.5 ± 0.156
1.318MetAsn: 1.318 ± 0.211
0.727MetPro: 0.727 ± 0.15
0.545MetGln: 0.545 ± 0.16
1.0MetArg: 1.0 ± 0.234
2.0MetSer: 2.0 ± 0.278
1.227MetThr: 1.227 ± 0.261
1.318MetVal: 1.318 ± 0.238
0.227MetTrp: 0.227 ± 0.126
1.272MetTyr: 1.272 ± 0.235
0.0MetXaa: 0.0 ± 0.0
Asn
2.545AsnAla: 2.545 ± 0.364
0.636AsnCys: 0.636 ± 0.193
2.636AsnAsp: 2.636 ± 0.324
2.954AsnGlu: 2.954 ± 0.429
2.727AsnPhe: 2.727 ± 0.308
4.181AsnGly: 4.181 ± 0.638
0.954AsnHis: 0.954 ± 0.215
3.863AsnIle: 3.863 ± 0.507
4.136AsnLys: 4.136 ± 0.507
4.772AsnLeu: 4.772 ± 0.477
1.318AsnMet: 1.318 ± 0.27
3.09AsnAsn: 3.09 ± 0.399
2.136AsnPro: 2.136 ± 0.272
1.5AsnGln: 1.5 ± 0.263
2.454AsnArg: 2.454 ± 0.302
3.59AsnSer: 3.59 ± 0.461
3.636AsnThr: 3.636 ± 0.538
2.681AsnVal: 2.681 ± 0.365
0.863AsnTrp: 0.863 ± 0.193
2.181AsnTyr: 2.181 ± 0.342
0.0AsnXaa: 0.0 ± 0.0
Pro
1.091ProAla: 1.091 ± 0.198
0.409ProCys: 0.409 ± 0.184
2.091ProAsp: 2.091 ± 0.389
1.909ProGlu: 1.909 ± 0.307
1.636ProPhe: 1.636 ± 0.294
0.364ProGly: 0.364 ± 0.141
0.591ProHis: 0.591 ± 0.175
1.863ProIle: 1.863 ± 0.258
2.681ProLys: 2.681 ± 0.4
2.59ProLeu: 2.59 ± 0.356
0.636ProMet: 0.636 ± 0.166
1.318ProAsn: 1.318 ± 0.306
0.818ProPro: 0.818 ± 0.277
0.818ProGln: 0.818 ± 0.198
1.091ProArg: 1.091 ± 0.225
2.409ProSer: 2.409 ± 0.377
2.863ProThr: 2.863 ± 0.579
2.363ProVal: 2.363 ± 0.364
0.364ProTrp: 0.364 ± 0.125
1.136ProTyr: 1.136 ± 0.264
0.0ProXaa: 0.0 ± 0.0
Gln
1.727GlnAla: 1.727 ± 0.389
0.5GlnCys: 0.5 ± 0.179
2.091GlnAsp: 2.091 ± 0.228
2.272GlnGlu: 2.272 ± 0.376
1.182GlnPhe: 1.182 ± 0.217
1.863GlnGly: 1.863 ± 0.358
0.273GlnHis: 0.273 ± 0.137
2.136GlnIle: 2.136 ± 0.304
1.863GlnLys: 1.863 ± 0.381
1.863GlnLeu: 1.863 ± 0.295
0.954GlnMet: 0.954 ± 0.177
1.136GlnAsn: 1.136 ± 0.213
0.545GlnPro: 0.545 ± 0.142
0.773GlnGln: 0.773 ± 0.244
0.954GlnArg: 0.954 ± 0.253
1.954GlnSer: 1.954 ± 0.398
1.636GlnThr: 1.636 ± 0.293
1.545GlnVal: 1.545 ± 0.312
0.136GlnTrp: 0.136 ± 0.085
1.409GlnTyr: 1.409 ± 0.215
0.0GlnXaa: 0.0 ± 0.0
Arg
2.636ArgAla: 2.636 ± 0.436
0.545ArgCys: 0.545 ± 0.156
2.59ArgAsp: 2.59 ± 0.269
3.09ArgGlu: 3.09 ± 0.409
1.5ArgPhe: 1.5 ± 0.285
3.59ArgGly: 3.59 ± 0.434
0.863ArgHis: 0.863 ± 0.223
3.045ArgIle: 3.045 ± 0.484
2.818ArgLys: 2.818 ± 0.384
3.817ArgLeu: 3.817 ± 0.394
1.0ArgMet: 1.0 ± 0.21
2.363ArgAsn: 2.363 ± 0.289
1.591ArgPro: 1.591 ± 0.335
1.636ArgGln: 1.636 ± 0.326
2.5ArgArg: 2.5 ± 0.29
3.181ArgSer: 3.181 ± 0.331
2.409ArgThr: 2.409 ± 0.397
3.499ArgVal: 3.499 ± 0.377
0.364ArgTrp: 0.364 ± 0.122
1.818ArgTyr: 1.818 ± 0.273
0.0ArgXaa: 0.0 ± 0.0
Ser
3.954SerAla: 3.954 ± 0.37
0.454SerCys: 0.454 ± 0.159
4.817SerAsp: 4.817 ± 0.536
5.499SerGlu: 5.499 ± 0.617
3.181SerPhe: 3.181 ± 0.389
6.135SerGly: 6.135 ± 0.743
1.091SerHis: 1.091 ± 0.212
4.999SerIle: 4.999 ± 0.495
7.09SerLys: 7.09 ± 0.733
5.454SerLeu: 5.454 ± 0.556
1.909SerMet: 1.909 ± 0.32
4.817SerAsn: 4.817 ± 0.766
2.409SerPro: 2.409 ± 0.334
1.727SerGln: 1.727 ± 0.276
3.045SerArg: 3.045 ± 0.324
6.453SerSer: 6.453 ± 0.797
4.227SerThr: 4.227 ± 0.733
5.226SerVal: 5.226 ± 0.588
0.682SerTrp: 0.682 ± 0.145
3.318SerTyr: 3.318 ± 0.423
0.0SerXaa: 0.0 ± 0.0
Thr
3.59ThrAla: 3.59 ± 0.463
0.409ThrCys: 0.409 ± 0.145
3.59ThrAsp: 3.59 ± 0.411
4.363ThrGlu: 4.363 ± 0.476
2.363ThrPhe: 2.363 ± 0.342
4.499ThrGly: 4.499 ± 0.601
0.636ThrHis: 0.636 ± 0.187
4.681ThrIle: 4.681 ± 0.558
4.499ThrLys: 4.499 ± 0.379
4.363ThrLeu: 4.363 ± 0.425
0.773ThrMet: 0.773 ± 0.169
2.681ThrAsn: 2.681 ± 0.313
2.091ThrPro: 2.091 ± 0.343
1.636ThrGln: 1.636 ± 0.347
2.681ThrArg: 2.681 ± 0.322
3.772ThrSer: 3.772 ± 0.519
3.772ThrThr: 3.772 ± 0.523
3.863ThrVal: 3.863 ± 0.423
0.454ThrTrp: 0.454 ± 0.14
1.954ThrTyr: 1.954 ± 0.333
0.0ThrXaa: 0.0 ± 0.0
Val
3.545ValAla: 3.545 ± 0.403
0.454ValCys: 0.454 ± 0.155
5.135ValAsp: 5.135 ± 0.444
4.817ValGlu: 4.817 ± 0.695
3.136ValPhe: 3.136 ± 0.398
3.954ValGly: 3.954 ± 0.489
0.863ValHis: 0.863 ± 0.174
3.227ValIle: 3.227 ± 0.423
5.59ValLys: 5.59 ± 0.659
5.817ValLeu: 5.817 ± 0.521
1.045ValMet: 1.045 ± 0.183
3.045ValAsn: 3.045 ± 0.395
1.727ValPro: 1.727 ± 0.312
1.545ValGln: 1.545 ± 0.276
2.863ValArg: 2.863 ± 0.391
4.863ValSer: 4.863 ± 0.544
3.454ValThr: 3.454 ± 0.548
4.272ValVal: 4.272 ± 0.426
0.954ValTrp: 0.954 ± 0.2
3.136ValTyr: 3.136 ± 0.392
0.0ValXaa: 0.0 ± 0.0
Trp
0.636TrpAla: 0.636 ± 0.167
0.227TrpCys: 0.227 ± 0.115
0.545TrpAsp: 0.545 ± 0.198
1.136TrpGlu: 1.136 ± 0.258
0.727TrpPhe: 0.727 ± 0.185
0.682TrpGly: 0.682 ± 0.202
0.182TrpHis: 0.182 ± 0.108
0.773TrpIle: 0.773 ± 0.197
0.682TrpLys: 0.682 ± 0.192
0.682TrpLeu: 0.682 ± 0.222
0.5TrpMet: 0.5 ± 0.152
0.364TrpAsn: 0.364 ± 0.133
0.136TrpPro: 0.136 ± 0.074
0.091TrpGln: 0.091 ± 0.069
0.364TrpArg: 0.364 ± 0.146
0.818TrpSer: 0.818 ± 0.205
0.545TrpThr: 0.545 ± 0.164
0.682TrpVal: 0.682 ± 0.18
0.136TrpTrp: 0.136 ± 0.1
0.636TrpTyr: 0.636 ± 0.153
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.772TyrAla: 1.772 ± 0.291
0.454TyrCys: 0.454 ± 0.17
2.954TyrAsp: 2.954 ± 0.339
2.772TyrGlu: 2.772 ± 0.347
1.454TyrPhe: 1.454 ± 0.221
2.863TyrGly: 2.863 ± 0.386
0.727TyrHis: 0.727 ± 0.204
3.908TyrIle: 3.908 ± 0.479
4.317TyrLys: 4.317 ± 0.426
3.636TyrLeu: 3.636 ± 0.43
0.954TyrMet: 0.954 ± 0.228
2.454TyrAsn: 2.454 ± 0.426
1.227TyrPro: 1.227 ± 0.26
1.0TyrGln: 1.0 ± 0.231
2.545TyrArg: 2.545 ± 0.37
3.999TyrSer: 3.999 ± 0.444
2.5TyrThr: 2.5 ± 0.287
2.454TyrVal: 2.454 ± 0.347
0.454TyrTrp: 0.454 ± 0.132
2.318TyrTyr: 2.318 ± 0.311
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 101 proteins (22005 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski