Amino acid dipepetide frequency for Streptococcus satellite phage Javan232

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
0.0AlaAla: 0.0 ± 0.0
0.452AlaCys: 0.452 ± 0.57
3.617AlaAsp: 3.617 ± 1.523
3.165AlaGlu: 3.165 ± 1.215
3.165AlaPhe: 3.165 ± 0.939
4.973AlaGly: 4.973 ± 1.013
0.452AlaHis: 0.452 ± 0.343
8.137AlaIle: 8.137 ± 1.593
3.165AlaLys: 3.165 ± 0.882
3.165AlaLeu: 3.165 ± 1.495
1.356AlaMet: 1.356 ± 1.03
2.26AlaAsn: 2.26 ± 1.292
1.808AlaPro: 1.808 ± 0.742
0.904AlaGln: 0.904 ± 0.461
4.973AlaArg: 4.973 ± 0.959
4.069AlaSer: 4.069 ± 1.233
5.877AlaThr: 5.877 ± 1.539
1.356AlaVal: 1.356 ± 0.888
0.452AlaTrp: 0.452 ± 0.402
4.973AlaTyr: 4.973 ± 1.226
0.0AlaXaa: 0.0 ± 0.0
Cys
0.0CysAla: 0.0 ± 0.0
0.0CysCys: 0.0 ± 0.0
0.452CysAsp: 0.452 ± 0.468
0.452CysGlu: 0.452 ± 0.376
0.452CysPhe: 0.452 ± 0.505
0.0CysGly: 0.0 ± 0.0
0.0CysHis: 0.0 ± 0.0
0.0CysIle: 0.0 ± 0.0
0.904CysLys: 0.904 ± 0.678
1.356CysLeu: 1.356 ± 0.766
0.0CysMet: 0.0 ± 0.0
0.0CysAsn: 0.0 ± 0.0
0.452CysPro: 0.452 ± 0.402
0.452CysGln: 0.452 ± 0.499
0.904CysArg: 0.904 ± 0.561
0.0CysSer: 0.0 ± 0.0
0.0CysThr: 0.0 ± 0.0
0.0CysVal: 0.0 ± 0.0
0.452CysTrp: 0.452 ± 0.343
0.0CysTyr: 0.0 ± 0.0
0.0CysXaa: 0.0 ± 0.0
Asp
1.356AspAla: 1.356 ± 0.72
0.0AspCys: 0.0 ± 0.0
5.425AspAsp: 5.425 ± 1.559
6.329AspGlu: 6.329 ± 1.851
2.712AspPhe: 2.712 ± 1.226
1.808AspGly: 1.808 ± 0.671
0.904AspHis: 0.904 ± 0.998
4.973AspIle: 4.973 ± 1.601
5.425AspLys: 5.425 ± 1.509
6.781AspLeu: 6.781 ± 1.957
3.165AspMet: 3.165 ± 1.221
4.521AspAsn: 4.521 ± 1.331
1.356AspPro: 1.356 ± 0.906
0.0AspGln: 0.0 ± 0.0
1.356AspArg: 1.356 ± 0.772
2.26AspSer: 2.26 ± 0.919
3.165AspThr: 3.165 ± 0.868
3.165AspVal: 3.165 ± 0.905
0.452AspTrp: 0.452 ± 0.343
5.877AspTyr: 5.877 ± 0.912
0.0AspXaa: 0.0 ± 0.0
Glu
3.617GluAla: 3.617 ± 1.986
0.452GluCys: 0.452 ± 0.468
6.329GluAsp: 6.329 ± 2.154
10.398GluGlu: 10.398 ± 3.183
4.069GluPhe: 4.069 ± 1.144
1.808GluGly: 1.808 ± 0.844
1.356GluHis: 1.356 ± 0.719
3.165GluIle: 3.165 ± 1.816
6.781GluLys: 6.781 ± 2.011
14.919GluLeu: 14.919 ± 4.324
0.904GluMet: 0.904 ± 0.751
2.712GluAsn: 2.712 ± 0.988
1.808GluPro: 1.808 ± 0.767
4.521GluGln: 4.521 ± 1.383
3.617GluArg: 3.617 ± 1.128
2.26GluSer: 2.26 ± 0.92
4.069GluThr: 4.069 ± 1.188
7.685GluVal: 7.685 ± 1.792
0.904GluTrp: 0.904 ± 0.469
3.165GluTyr: 3.165 ± 1.363
0.0GluXaa: 0.0 ± 0.0
Phe
0.904PheAla: 0.904 ± 0.881
0.904PheCys: 0.904 ± 0.83
2.26PheAsp: 2.26 ± 0.987
2.26PheGlu: 2.26 ± 0.768
1.808PhePhe: 1.808 ± 0.725
0.452PheGly: 0.452 ± 0.402
0.904PheHis: 0.904 ± 0.606
4.069PheIle: 4.069 ± 0.822
4.069PheLys: 4.069 ± 1.44
4.973PheLeu: 4.973 ± 1.778
1.356PheMet: 1.356 ± 1.001
3.165PheAsn: 3.165 ± 0.847
0.452PhePro: 0.452 ± 0.343
0.904PheGln: 0.904 ± 0.64
0.904PheArg: 0.904 ± 0.686
4.521PheSer: 4.521 ± 1.026
0.904PheThr: 0.904 ± 0.686
1.808PheVal: 1.808 ± 0.6
0.904PheTrp: 0.904 ± 0.552
4.521PheTyr: 4.521 ± 1.46
0.0PheXaa: 0.0 ± 0.0
Gly
0.904GlyAla: 0.904 ± 0.597
0.452GlyCys: 0.452 ± 0.402
3.165GlyAsp: 3.165 ± 1.331
3.165GlyGlu: 3.165 ± 1.09
0.904GlyPhe: 0.904 ± 0.554
1.356GlyGly: 1.356 ± 0.727
0.904GlyHis: 0.904 ± 0.617
2.26GlyIle: 2.26 ± 0.848
5.425GlyLys: 5.425 ± 1.911
4.069GlyLeu: 4.069 ± 1.136
0.452GlyMet: 0.452 ± 0.589
1.356GlyAsn: 1.356 ± 0.96
0.0GlyPro: 0.0 ± 0.0
0.904GlyGln: 0.904 ± 0.422
1.356GlyArg: 1.356 ± 0.772
1.356GlySer: 1.356 ± 0.717
3.165GlyThr: 3.165 ± 1.253
4.521GlyVal: 4.521 ± 1.399
0.904GlyTrp: 0.904 ± 0.518
3.165GlyTyr: 3.165 ± 1.018
0.0GlyXaa: 0.0 ± 0.0
His
1.356HisAla: 1.356 ± 1.205
0.0HisCys: 0.0 ± 0.0
0.0HisAsp: 0.0 ± 0.0
2.26HisGlu: 2.26 ± 0.879
0.452HisPhe: 0.452 ± 0.343
0.904HisGly: 0.904 ± 0.606
0.0HisHis: 0.0 ± 0.0
0.0HisIle: 0.0 ± 0.0
1.356HisLys: 1.356 ± 0.763
1.808HisLeu: 1.808 ± 0.844
0.0HisMet: 0.0 ± 0.0
1.356HisAsn: 1.356 ± 1.254
0.452HisPro: 0.452 ± 0.343
0.904HisGln: 0.904 ± 0.686
0.452HisArg: 0.452 ± 0.343
0.452HisSer: 0.452 ± 0.402
0.452HisThr: 0.452 ± 0.402
0.904HisVal: 0.904 ± 0.644
0.452HisTrp: 0.452 ± 0.505
1.808HisTyr: 1.808 ± 0.963
0.0HisXaa: 0.0 ± 0.0
Ile
6.781IleAla: 6.781 ± 2.355
0.452IleCys: 0.452 ± 0.505
5.877IleAsp: 5.877 ± 1.856
5.425IleGlu: 5.425 ± 1.803
4.069IlePhe: 4.069 ± 1.521
2.26IleGly: 2.26 ± 0.643
0.904IleHis: 0.904 ± 0.461
4.973IleIle: 4.973 ± 0.981
9.042IleLys: 9.042 ± 1.787
5.425IleLeu: 5.425 ± 1.36
2.712IleMet: 2.712 ± 1.002
9.042IleAsn: 9.042 ± 1.892
3.617IlePro: 3.617 ± 1.472
3.165IleGln: 3.165 ± 1.455
1.808IleArg: 1.808 ± 0.847
1.808IleSer: 1.808 ± 1.124
5.425IleThr: 5.425 ± 1.587
1.356IleVal: 1.356 ± 0.437
0.904IleTrp: 0.904 ± 0.553
2.26IleTyr: 2.26 ± 0.898
0.0IleXaa: 0.0 ± 0.0
Lys
5.877LysAla: 5.877 ± 1.894
0.0LysCys: 0.0 ± 0.0
4.973LysAsp: 4.973 ± 1.005
10.398LysGlu: 10.398 ± 1.595
1.356LysPhe: 1.356 ± 0.656
3.165LysGly: 3.165 ± 0.999
0.904LysHis: 0.904 ± 0.803
8.137LysIle: 8.137 ± 2.15
10.85LysLys: 10.85 ± 1.796
7.233LysLeu: 7.233 ± 2.113
1.356LysMet: 1.356 ± 0.74
4.973LysAsn: 4.973 ± 1.853
2.712LysPro: 2.712 ± 1.008
6.781LysGln: 6.781 ± 1.597
4.973LysArg: 4.973 ± 1.288
5.425LysSer: 5.425 ± 1.16
6.329LysThr: 6.329 ± 1.46
4.521LysVal: 4.521 ± 1.309
0.904LysTrp: 0.904 ± 0.678
5.425LysTyr: 5.425 ± 1.187
0.0LysXaa: 0.0 ± 0.0
Leu
9.042LeuAla: 9.042 ± 1.824
0.0LeuCys: 0.0 ± 0.0
6.781LeuAsp: 6.781 ± 1.193
9.494LeuGlu: 9.494 ± 1.806
4.973LeuPhe: 4.973 ± 1.215
6.781LeuGly: 6.781 ± 2.049
1.808LeuHis: 1.808 ± 0.63
5.425LeuIle: 5.425 ± 1.575
9.494LeuLys: 9.494 ± 2.009
6.329LeuLeu: 6.329 ± 1.349
1.808LeuMet: 1.808 ± 0.763
9.494LeuAsn: 9.494 ± 2.507
3.617LeuPro: 3.617 ± 0.78
5.425LeuGln: 5.425 ± 1.837
5.425LeuArg: 5.425 ± 2.209
3.617LeuSer: 3.617 ± 1.827
4.521LeuThr: 4.521 ± 1.045
3.617LeuVal: 3.617 ± 0.986
0.904LeuTrp: 0.904 ± 0.659
5.425LeuTyr: 5.425 ± 1.467
0.0LeuXaa: 0.0 ± 0.0
Met
1.808MetAla: 1.808 ± 1.001
0.0MetCys: 0.0 ± 0.0
0.904MetAsp: 0.904 ± 0.597
1.808MetGlu: 1.808 ± 0.938
0.452MetPhe: 0.452 ± 0.343
0.452MetGly: 0.452 ± 0.468
0.0MetHis: 0.0 ± 0.0
1.356MetIle: 1.356 ± 0.954
1.356MetLys: 1.356 ± 0.88
4.069MetLeu: 4.069 ± 1.499
1.356MetMet: 1.356 ± 0.925
0.904MetAsn: 0.904 ± 0.422
0.904MetPro: 0.904 ± 0.731
1.356MetGln: 1.356 ± 0.847
0.0MetArg: 0.0 ± 0.0
1.356MetSer: 1.356 ± 0.796
3.617MetThr: 3.617 ± 0.783
0.452MetVal: 0.452 ± 0.604
0.0MetTrp: 0.0 ± 0.0
0.904MetTyr: 0.904 ± 0.631
0.0MetXaa: 0.0 ± 0.0
Asn
4.069AsnAla: 4.069 ± 0.815
0.904AsnCys: 0.904 ± 0.469
2.712AsnAsp: 2.712 ± 1.284
2.26AsnGlu: 2.26 ± 0.899
1.356AsnPhe: 1.356 ± 0.928
4.973AsnGly: 4.973 ± 1.281
0.904AsnHis: 0.904 ± 0.518
4.973AsnIle: 4.973 ± 1.337
6.781AsnLys: 6.781 ± 1.48
3.617AsnLeu: 3.617 ± 1.31
1.356AsnMet: 1.356 ± 0.686
2.26AsnAsn: 2.26 ± 0.659
3.617AsnPro: 3.617 ± 1.454
2.712AsnGln: 2.712 ± 0.682
4.973AsnArg: 4.973 ± 1.05
4.069AsnSer: 4.069 ± 1.429
4.521AsnThr: 4.521 ± 1.351
1.808AsnVal: 1.808 ± 0.789
0.0AsnTrp: 0.0 ± 0.0
1.356AsnTyr: 1.356 ± 0.762
0.0AsnXaa: 0.0 ± 0.0
Pro
2.712ProAla: 2.712 ± 1.163
0.0ProCys: 0.0 ± 0.0
1.808ProAsp: 1.808 ± 1.0
2.712ProGlu: 2.712 ± 0.945
2.26ProPhe: 2.26 ± 0.682
0.0ProGly: 0.0 ± 0.0
0.0ProHis: 0.0 ± 0.0
4.521ProIle: 4.521 ± 1.251
3.165ProLys: 3.165 ± 0.912
4.973ProLeu: 4.973 ± 1.453
0.452ProMet: 0.452 ± 0.376
1.808ProAsn: 1.808 ± 1.373
1.808ProPro: 1.808 ± 0.867
0.452ProGln: 0.452 ± 0.343
1.808ProArg: 1.808 ± 0.804
0.0ProSer: 0.0 ± 0.0
1.808ProThr: 1.808 ± 0.807
0.904ProVal: 0.904 ± 0.553
0.0ProTrp: 0.0 ± 0.0
0.904ProTyr: 0.904 ± 0.686
0.0ProXaa: 0.0 ± 0.0
Gln
3.617GlnAla: 3.617 ± 1.066
0.0GlnCys: 0.0 ± 0.0
2.26GlnAsp: 2.26 ± 0.987
4.521GlnGlu: 4.521 ± 1.635
1.808GlnPhe: 1.808 ± 0.87
1.356GlnGly: 1.356 ± 0.594
0.452GlnHis: 0.452 ± 0.402
4.521GlnIle: 4.521 ± 1.401
3.617GlnLys: 3.617 ± 1.239
4.973GlnLeu: 4.973 ± 1.035
0.0GlnMet: 0.0 ± 0.0
0.904GlnAsn: 0.904 ± 0.552
1.808GlnPro: 1.808 ± 0.897
1.808GlnGln: 1.808 ± 0.715
0.0GlnArg: 0.0 ± 0.0
2.712GlnSer: 2.712 ± 1.587
3.165GlnThr: 3.165 ± 1.221
3.165GlnVal: 3.165 ± 1.162
0.452GlnTrp: 0.452 ± 0.57
2.712GlnTyr: 2.712 ± 0.828
0.0GlnXaa: 0.0 ± 0.0
Arg
2.712ArgAla: 2.712 ± 0.939
0.0ArgCys: 0.0 ± 0.0
3.165ArgAsp: 3.165 ± 0.778
3.165ArgGlu: 3.165 ± 0.854
2.26ArgPhe: 2.26 ± 1.208
2.26ArgGly: 2.26 ± 0.839
1.808ArgHis: 1.808 ± 1.355
3.617ArgIle: 3.617 ± 0.901
3.617ArgLys: 3.617 ± 1.092
3.617ArgLeu: 3.617 ± 0.922
0.904ArgMet: 0.904 ± 0.589
0.904ArgAsn: 0.904 ± 0.752
0.904ArgPro: 0.904 ± 0.553
2.26ArgGln: 2.26 ± 1.102
2.712ArgArg: 2.712 ± 0.964
0.904ArgSer: 0.904 ± 0.597
3.617ArgThr: 3.617 ± 1.465
1.356ArgVal: 1.356 ± 0.568
0.452ArgTrp: 0.452 ± 0.559
1.356ArgTyr: 1.356 ± 0.942
0.0ArgXaa: 0.0 ± 0.0
Ser
2.712SerAla: 2.712 ± 1.223
0.904SerCys: 0.904 ± 0.597
4.069SerAsp: 4.069 ± 1.16
2.26SerGlu: 2.26 ± 0.841
2.712SerPhe: 2.712 ± 0.885
0.0SerGly: 0.0 ± 0.0
0.0SerHis: 0.0 ± 0.0
2.712SerIle: 2.712 ± 1.103
3.165SerLys: 3.165 ± 0.693
5.425SerLeu: 5.425 ± 1.536
1.356SerMet: 1.356 ± 0.637
1.808SerAsn: 1.808 ± 0.663
1.356SerPro: 1.356 ± 0.605
2.712SerGln: 2.712 ± 1.17
1.356SerArg: 1.356 ± 0.696
1.808SerSer: 1.808 ± 0.776
2.26SerThr: 2.26 ± 1.22
3.165SerVal: 3.165 ± 0.803
0.0SerTrp: 0.0 ± 0.0
3.165SerTyr: 3.165 ± 1.609
0.0SerXaa: 0.0 ± 0.0
Thr
4.069ThrAla: 4.069 ± 0.897
0.452ThrCys: 0.452 ± 0.376
2.712ThrAsp: 2.712 ± 0.932
5.877ThrGlu: 5.877 ± 1.401
2.712ThrPhe: 2.712 ± 1.275
2.712ThrGly: 2.712 ± 1.312
0.452ThrHis: 0.452 ± 0.402
7.233ThrIle: 7.233 ± 1.619
5.877ThrLys: 5.877 ± 1.64
6.329ThrLeu: 6.329 ± 1.898
0.452ThrMet: 0.452 ± 0.53
3.165ThrAsn: 3.165 ± 1.69
3.617ThrPro: 3.617 ± 1.934
0.904ThrGln: 0.904 ± 0.717
2.712ThrArg: 2.712 ± 0.778
2.26ThrSer: 2.26 ± 0.764
3.165ThrThr: 3.165 ± 0.725
3.617ThrVal: 3.617 ± 1.377
0.0ThrTrp: 0.0 ± 0.0
2.712ThrTyr: 2.712 ± 0.885
0.0ThrXaa: 0.0 ± 0.0
Val
2.712ValAla: 2.712 ± 0.992
0.0ValCys: 0.0 ± 0.0
1.356ValAsp: 1.356 ± 0.75
4.973ValGlu: 4.973 ± 1.549
2.712ValPhe: 2.712 ± 1.132
1.356ValGly: 1.356 ± 1.012
0.904ValHis: 0.904 ± 0.803
4.069ValIle: 4.069 ± 1.308
4.069ValLys: 4.069 ± 1.135
6.329ValLeu: 6.329 ± 1.013
2.26ValMet: 2.26 ± 1.233
4.069ValAsn: 4.069 ± 1.372
1.356ValPro: 1.356 ± 0.54
1.808ValGln: 1.808 ± 0.799
0.452ValArg: 0.452 ± 0.343
1.356ValSer: 1.356 ± 0.749
2.712ValThr: 2.712 ± 0.862
2.26ValVal: 2.26 ± 0.899
0.0ValTrp: 0.0 ± 0.0
2.712ValTyr: 2.712 ± 1.285
0.0ValXaa: 0.0 ± 0.0
Trp
0.452TrpAla: 0.452 ± 0.402
0.0TrpCys: 0.0 ± 0.0
0.452TrpAsp: 0.452 ± 0.402
0.452TrpGlu: 0.452 ± 0.559
0.452TrpPhe: 0.452 ± 0.56
0.452TrpGly: 0.452 ± 0.499
0.452TrpHis: 0.452 ± 0.604
0.452TrpIle: 0.452 ± 0.505
0.904TrpLys: 0.904 ± 0.686
0.904TrpLeu: 0.904 ± 0.686
0.0TrpMet: 0.0 ± 0.0
0.452TrpAsn: 0.452 ± 0.343
0.0TrpPro: 0.0 ± 0.0
0.904TrpGln: 0.904 ± 0.616
0.0TrpArg: 0.0 ± 0.0
0.452TrpSer: 0.452 ± 0.402
0.452TrpThr: 0.452 ± 0.57
0.904TrpVal: 0.904 ± 0.62
0.452TrpTrp: 0.452 ± 0.402
0.452TrpTyr: 0.452 ± 0.343
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.617TyrAla: 3.617 ± 0.765
0.904TyrCys: 0.904 ± 0.589
2.712TyrAsp: 2.712 ± 1.02
3.165TyrGlu: 3.165 ± 1.554
1.356TyrPhe: 1.356 ± 0.732
3.165TyrGly: 3.165 ± 1.07
2.26TyrHis: 2.26 ± 0.711
2.712TyrIle: 2.712 ± 0.753
7.233TyrLys: 7.233 ± 1.514
7.685TyrLeu: 7.685 ± 2.951
1.356TyrMet: 1.356 ± 0.767
4.069TyrAsn: 4.069 ± 0.955
0.452TyrPro: 0.452 ± 0.343
4.973TyrGln: 4.973 ± 1.742
1.808TyrArg: 1.808 ± 1.271
2.26TyrSer: 2.26 ± 0.772
1.808TyrThr: 1.808 ± 0.72
0.904TyrVal: 0.904 ± 0.803
0.452TyrTrp: 0.452 ± 0.343
2.26TyrTyr: 2.26 ± 0.795
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 14 proteins (2213 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski