Amino acid dipepetide frequency for Cellulophaga phage phi3ST:2

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.237AlaAla: 5.237 ± 0.812
0.691AlaCys: 0.691 ± 0.196
3.165AlaAsp: 3.165 ± 0.368
3.511AlaGlu: 3.511 ± 0.604
2.072AlaPhe: 2.072 ± 0.444
3.856AlaGly: 3.856 ± 0.531
0.748AlaHis: 0.748 ± 0.202
5.007AlaIle: 5.007 ± 0.479
6.446AlaLys: 6.446 ± 1.258
5.525AlaLeu: 5.525 ± 0.615
0.921AlaMet: 0.921 ± 0.222
3.28AlaAsn: 3.28 ± 0.381
1.381AlaPro: 1.381 ± 0.429
1.842AlaGln: 1.842 ± 0.273
1.957AlaArg: 1.957 ± 0.308
4.719AlaSer: 4.719 ± 0.467
4.777AlaThr: 4.777 ± 0.721
4.604AlaVal: 4.604 ± 0.604
0.403AlaTrp: 0.403 ± 0.133
1.324AlaTyr: 1.324 ± 0.299
0.0AlaXaa: 0.0 ± 0.0
Cys
0.173CysAla: 0.173 ± 0.094
0.403CysCys: 0.403 ± 0.133
0.518CysAsp: 0.518 ± 0.143
0.748CysGlu: 0.748 ± 0.241
0.46CysPhe: 0.46 ± 0.188
0.691CysGly: 0.691 ± 0.273
0.0CysHis: 0.0 ± 0.0
0.921CysIle: 0.921 ± 0.281
0.863CysLys: 0.863 ± 0.209
0.863CysLeu: 0.863 ± 0.267
0.0CysMet: 0.0 ± 0.0
0.345CysAsn: 0.345 ± 0.125
0.576CysPro: 0.576 ± 0.23
0.288CysGln: 0.288 ± 0.123
0.576CysArg: 0.576 ± 0.2
0.806CysSer: 0.806 ± 0.247
0.403CysThr: 0.403 ± 0.128
0.863CysVal: 0.863 ± 0.221
0.058CysTrp: 0.058 ± 0.054
0.403CysTyr: 0.403 ± 0.148
0.0CysXaa: 0.0 ± 0.0
Asp
2.762AspAla: 2.762 ± 0.318
0.633AspCys: 0.633 ± 0.168
3.511AspAsp: 3.511 ± 0.471
4.144AspGlu: 4.144 ± 0.472
3.453AspPhe: 3.453 ± 0.388
4.086AspGly: 4.086 ± 0.492
0.691AspHis: 0.691 ± 0.191
4.086AspIle: 4.086 ± 0.42
4.604AspLys: 4.604 ± 0.52
5.122AspLeu: 5.122 ± 0.667
0.921AspMet: 0.921 ± 0.196
3.683AspAsn: 3.683 ± 0.423
1.324AspPro: 1.324 ± 0.239
1.036AspGln: 1.036 ± 0.209
2.014AspArg: 2.014 ± 0.369
5.698AspSer: 5.698 ± 0.578
2.935AspThr: 2.935 ± 0.394
4.259AspVal: 4.259 ± 0.549
1.266AspTrp: 1.266 ± 0.296
2.935AspTyr: 2.935 ± 0.423
0.058AspXaa: 0.058 ± 0.059
Glu
5.122GluAla: 5.122 ± 0.86
0.518GluCys: 0.518 ± 0.21
4.259GluAsp: 4.259 ± 0.5
5.87GluGlu: 5.87 ± 1.383
2.532GluPhe: 2.532 ± 0.323
3.05GluGly: 3.05 ± 0.48
1.266GluHis: 1.266 ± 0.269
6.388GluIle: 6.388 ± 0.593
6.503GluLys: 6.503 ± 0.745
5.698GluLeu: 5.698 ± 0.565
1.209GluMet: 1.209 ± 0.293
4.489GluAsn: 4.489 ± 0.598
1.151GluPro: 1.151 ± 0.278
2.532GluGln: 2.532 ± 0.469
1.842GluArg: 1.842 ± 0.333
5.295GluSer: 5.295 ± 0.582
4.374GluThr: 4.374 ± 0.366
5.122GluVal: 5.122 ± 0.481
0.691GluTrp: 0.691 ± 0.189
1.554GluTyr: 1.554 ± 0.288
0.0GluXaa: 0.0 ± 0.0
Phe
2.532PheAla: 2.532 ± 0.373
0.403PheCys: 0.403 ± 0.177
3.626PheAsp: 3.626 ± 0.443
2.82PheGlu: 2.82 ± 0.377
1.842PhePhe: 1.842 ± 0.271
1.899PheGly: 1.899 ± 0.297
0.863PheHis: 0.863 ± 0.215
3.741PheIle: 3.741 ± 0.405
4.949PheLys: 4.949 ± 0.6
3.741PheLeu: 3.741 ± 0.601
1.324PheMet: 1.324 ± 0.259
3.28PheAsn: 3.28 ± 0.447
1.496PhePro: 1.496 ± 0.29
1.209PheGln: 1.209 ± 0.274
1.727PheArg: 1.727 ± 0.314
4.777PheSer: 4.777 ± 0.455
2.475PheThr: 2.475 ± 0.339
2.878PheVal: 2.878 ± 0.35
0.403PheTrp: 0.403 ± 0.122
1.496PheTyr: 1.496 ± 0.282
0.0PheXaa: 0.0 ± 0.0
Gly
3.626GlyAla: 3.626 ± 0.457
0.46GlyCys: 0.46 ± 0.153
3.683GlyAsp: 3.683 ± 0.453
3.568GlyGlu: 3.568 ± 0.474
3.223GlyPhe: 3.223 ± 0.489
4.316GlyGly: 4.316 ± 0.755
0.576GlyHis: 0.576 ± 0.197
3.683GlyIle: 3.683 ± 0.57
4.777GlyLys: 4.777 ± 0.596
3.683GlyLeu: 3.683 ± 0.429
1.036GlyMet: 1.036 ± 0.228
3.568GlyAsn: 3.568 ± 0.586
0.23GlyPro: 0.23 ± 0.104
1.727GlyGln: 1.727 ± 0.316
2.475GlyArg: 2.475 ± 0.329
4.144GlySer: 4.144 ± 0.621
3.913GlyThr: 3.913 ± 0.483
4.086GlyVal: 4.086 ± 0.721
0.576GlyTrp: 0.576 ± 0.182
2.187GlyTyr: 2.187 ± 0.365
0.0GlyXaa: 0.0 ± 0.0
His
0.748HisAla: 0.748 ± 0.189
0.23HisCys: 0.23 ± 0.099
0.576HisAsp: 0.576 ± 0.155
0.978HisGlu: 0.978 ± 0.265
0.863HisPhe: 0.863 ± 0.236
1.151HisGly: 1.151 ± 0.301
0.23HisHis: 0.23 ± 0.137
1.036HisIle: 1.036 ± 0.26
1.381HisLys: 1.381 ± 0.319
1.554HisLeu: 1.554 ± 0.297
0.288HisMet: 0.288 ± 0.117
0.863HisAsn: 0.863 ± 0.224
0.46HisPro: 0.46 ± 0.151
0.633HisGln: 0.633 ± 0.21
0.748HisArg: 0.748 ± 0.225
0.921HisSer: 0.921 ± 0.205
0.46HisThr: 0.46 ± 0.149
0.633HisVal: 0.633 ± 0.175
0.345HisTrp: 0.345 ± 0.129
0.633HisTyr: 0.633 ± 0.168
0.0HisXaa: 0.0 ± 0.0
Ile
4.086IleAla: 4.086 ± 0.405
0.576IleCys: 0.576 ± 0.172
5.582IleAsp: 5.582 ± 0.522
6.043IleGlu: 6.043 ± 0.669
2.417IlePhe: 2.417 ± 0.339
3.05IleGly: 3.05 ± 0.489
1.036IleHis: 1.036 ± 0.258
4.316IleIle: 4.316 ± 0.563
7.079IleLys: 7.079 ± 0.664
5.122IleLeu: 5.122 ± 0.516
1.554IleMet: 1.554 ± 0.249
5.582IleAsn: 5.582 ± 0.571
2.417IlePro: 2.417 ± 0.319
1.957IleGln: 1.957 ± 0.3
2.532IleArg: 2.532 ± 0.42
5.928IleSer: 5.928 ± 0.524
5.064IleThr: 5.064 ± 0.566
4.892IleVal: 4.892 ± 0.546
0.806IleTrp: 0.806 ± 0.171
2.993IleTyr: 2.993 ± 0.423
0.0IleXaa: 0.0 ± 0.0
Lys
6.215LysAla: 6.215 ± 0.687
0.863LysCys: 0.863 ± 0.21
4.719LysAsp: 4.719 ± 0.71
7.079LysGlu: 7.079 ± 1.039
4.547LysPhe: 4.547 ± 0.555
5.237LysGly: 5.237 ± 0.77
2.014LysHis: 2.014 ± 0.443
6.215LysIle: 6.215 ± 0.642
11.798LysLys: 11.798 ± 1.824
7.654LysLeu: 7.654 ± 0.985
2.762LysMet: 2.762 ± 0.461
5.755LysAsn: 5.755 ± 0.624
1.496LysPro: 1.496 ± 0.217
3.05LysGln: 3.05 ± 0.415
2.993LysArg: 2.993 ± 0.621
6.446LysSer: 6.446 ± 0.625
6.331LysThr: 6.331 ± 0.618
5.352LysVal: 5.352 ± 0.602
1.093LysTrp: 1.093 ± 0.297
3.223LysTyr: 3.223 ± 0.349
0.23LysXaa: 0.23 ± 0.168
Leu
4.777LeuAla: 4.777 ± 0.55
1.381LeuCys: 1.381 ± 0.271
5.41LeuAsp: 5.41 ± 0.534
5.698LeuGlu: 5.698 ± 0.694
3.108LeuPhe: 3.108 ± 0.443
4.547LeuGly: 4.547 ± 0.526
1.093LeuHis: 1.093 ± 0.255
6.561LeuIle: 6.561 ± 0.664
8.805LeuLys: 8.805 ± 0.744
5.813LeuLeu: 5.813 ± 0.63
2.244LeuMet: 2.244 ± 0.372
5.928LeuAsn: 5.928 ± 0.64
2.705LeuPro: 2.705 ± 0.413
2.475LeuGln: 2.475 ± 0.27
3.338LeuArg: 3.338 ± 0.425
7.712LeuSer: 7.712 ± 0.699
4.029LeuThr: 4.029 ± 0.466
5.18LeuVal: 5.18 ± 0.459
1.093LeuTrp: 1.093 ± 0.283
2.878LeuTyr: 2.878 ± 0.455
0.0LeuXaa: 0.0 ± 0.0
Met
1.266MetAla: 1.266 ± 0.295
0.115MetCys: 0.115 ± 0.094
0.691MetAsp: 0.691 ± 0.202
1.496MetGlu: 1.496 ± 0.316
0.691MetPhe: 0.691 ± 0.206
0.748MetGly: 0.748 ± 0.274
0.403MetHis: 0.403 ± 0.162
0.863MetIle: 0.863 ± 0.209
2.417MetLys: 2.417 ± 0.37
1.036MetLeu: 1.036 ± 0.226
0.518MetMet: 0.518 ± 0.17
1.784MetAsn: 1.784 ± 0.341
0.633MetPro: 0.633 ± 0.239
1.439MetGln: 1.439 ± 0.263
1.209MetArg: 1.209 ± 0.256
2.072MetSer: 2.072 ± 0.288
1.209MetThr: 1.209 ± 0.291
0.806MetVal: 0.806 ± 0.249
0.058MetTrp: 0.058 ± 0.05
0.518MetTyr: 0.518 ± 0.15
0.0MetXaa: 0.0 ± 0.0
Asn
3.511AsnAla: 3.511 ± 0.61
0.633AsnCys: 0.633 ± 0.228
3.453AsnAsp: 3.453 ± 0.488
4.949AsnGlu: 4.949 ± 0.511
3.28AsnPhe: 3.28 ± 0.51
3.798AsnGly: 3.798 ± 0.503
0.518AsnHis: 0.518 ± 0.168
4.316AsnIle: 4.316 ± 0.469
6.503AsnLys: 6.503 ± 0.619
6.446AsnLeu: 6.446 ± 0.484
1.324AsnMet: 1.324 ± 0.286
4.029AsnAsn: 4.029 ± 0.466
1.957AsnPro: 1.957 ± 0.292
2.475AsnGln: 2.475 ± 0.401
2.244AsnArg: 2.244 ± 0.355
5.007AsnSer: 5.007 ± 0.616
3.108AsnThr: 3.108 ± 0.446
4.259AsnVal: 4.259 ± 0.488
0.748AsnTrp: 0.748 ± 0.223
2.762AsnTyr: 2.762 ± 0.338
0.0AsnXaa: 0.0 ± 0.0
Pro
1.611ProAla: 1.611 ± 0.326
0.288ProCys: 0.288 ± 0.131
1.899ProAsp: 1.899 ± 0.372
2.072ProGlu: 2.072 ± 0.339
1.554ProPhe: 1.554 ± 0.303
0.806ProGly: 0.806 ± 0.209
0.403ProHis: 0.403 ± 0.161
1.324ProIle: 1.324 ± 0.246
1.784ProLys: 1.784 ± 0.308
2.475ProLeu: 2.475 ± 0.397
0.345ProMet: 0.345 ± 0.149
1.496ProAsn: 1.496 ± 0.31
0.633ProPro: 0.633 ± 0.243
0.921ProGln: 0.921 ± 0.201
0.403ProArg: 0.403 ± 0.151
2.187ProSer: 2.187 ± 0.362
1.784ProThr: 1.784 ± 0.336
2.072ProVal: 2.072 ± 0.439
0.115ProTrp: 0.115 ± 0.078
0.921ProTyr: 0.921 ± 0.246
0.0ProXaa: 0.0 ± 0.0
Gln
2.475GlnAla: 2.475 ± 0.379
0.173GlnCys: 0.173 ± 0.09
1.669GlnAsp: 1.669 ± 0.282
1.957GlnGlu: 1.957 ± 0.329
1.669GlnPhe: 1.669 ± 0.295
1.669GlnGly: 1.669 ± 0.241
0.633GlnHis: 0.633 ± 0.254
2.532GlnIle: 2.532 ± 0.399
2.187GlnLys: 2.187 ± 0.36
3.453GlnLeu: 3.453 ± 0.461
0.633GlnMet: 0.633 ± 0.182
2.072GlnAsn: 2.072 ± 0.36
0.576GlnPro: 0.576 ± 0.17
1.266GlnGln: 1.266 ± 0.255
1.266GlnArg: 1.266 ± 0.243
2.129GlnSer: 2.129 ± 0.298
1.784GlnThr: 1.784 ± 0.289
1.842GlnVal: 1.842 ± 0.407
0.288GlnTrp: 0.288 ± 0.121
1.324GlnTyr: 1.324 ± 0.28
0.0GlnXaa: 0.0 ± 0.0
Arg
2.475ArgAla: 2.475 ± 0.389
0.288ArgCys: 0.288 ± 0.13
2.014ArgAsp: 2.014 ± 0.317
1.324ArgGlu: 1.324 ± 0.271
2.072ArgPhe: 2.072 ± 0.295
1.554ArgGly: 1.554 ± 0.225
0.46ArgHis: 0.46 ± 0.148
3.165ArgIle: 3.165 ± 0.437
3.568ArgLys: 3.568 ± 0.555
3.28ArgLeu: 3.28 ± 0.465
0.806ArgMet: 0.806 ± 0.252
2.647ArgAsn: 2.647 ± 0.404
0.748ArgPro: 0.748 ± 0.187
1.324ArgGln: 1.324 ± 0.289
1.899ArgArg: 1.899 ± 0.327
2.244ArgSer: 2.244 ± 0.391
2.129ArgThr: 2.129 ± 0.333
2.014ArgVal: 2.014 ± 0.357
0.633ArgTrp: 0.633 ± 0.201
1.439ArgTyr: 1.439 ± 0.259
0.0ArgXaa: 0.0 ± 0.0
Ser
4.604SerAla: 4.604 ± 0.647
0.518SerCys: 0.518 ± 0.203
4.547SerAsp: 4.547 ± 0.494
5.064SerGlu: 5.064 ± 0.454
5.237SerPhe: 5.237 ± 0.564
5.525SerGly: 5.525 ± 0.678
1.496SerHis: 1.496 ± 0.282
5.295SerIle: 5.295 ± 0.549
6.791SerLys: 6.791 ± 0.802
6.676SerLeu: 6.676 ± 0.559
1.324SerMet: 1.324 ± 0.262
5.41SerAsn: 5.41 ± 0.598
1.784SerPro: 1.784 ± 0.302
2.417SerGln: 2.417 ± 0.345
2.82SerArg: 2.82 ± 0.37
6.964SerSer: 6.964 ± 0.743
5.064SerThr: 5.064 ± 0.516
5.064SerVal: 5.064 ± 0.457
0.806SerTrp: 0.806 ± 0.238
2.647SerTyr: 2.647 ± 0.399
0.0SerXaa: 0.0 ± 0.0
Thr
3.338ThrAla: 3.338 ± 0.525
0.518ThrCys: 0.518 ± 0.182
3.338ThrAsp: 3.338 ± 0.471
3.913ThrGlu: 3.913 ± 0.403
2.82ThrPhe: 2.82 ± 0.432
3.856ThrGly: 3.856 ± 0.566
0.863ThrHis: 0.863 ± 0.214
5.467ThrIle: 5.467 ± 0.457
4.834ThrLys: 4.834 ± 0.513
6.158ThrLeu: 6.158 ± 0.714
0.576ThrMet: 0.576 ± 0.176
3.108ThrAsn: 3.108 ± 0.466
2.475ThrPro: 2.475 ± 0.354
1.611ThrGln: 1.611 ± 0.324
2.014ThrArg: 2.014 ± 0.379
4.489ThrSer: 4.489 ± 0.47
2.993ThrThr: 2.993 ± 0.421
3.741ThrVal: 3.741 ± 0.472
0.576ThrTrp: 0.576 ± 0.201
2.244ThrTyr: 2.244 ± 0.38
0.0ThrXaa: 0.0 ± 0.0
Val
4.719ValAla: 4.719 ± 0.937
0.633ValCys: 0.633 ± 0.183
4.029ValAsp: 4.029 ± 0.554
5.18ValGlu: 5.18 ± 0.737
3.223ValPhe: 3.223 ± 0.341
3.165ValGly: 3.165 ± 0.466
0.863ValHis: 0.863 ± 0.253
4.892ValIle: 4.892 ± 0.533
5.928ValLys: 5.928 ± 0.511
5.582ValLeu: 5.582 ± 0.664
1.151ValMet: 1.151 ± 0.266
4.834ValAsn: 4.834 ± 0.528
1.496ValPro: 1.496 ± 0.242
1.669ValGln: 1.669 ± 0.302
2.072ValArg: 2.072 ± 0.339
5.18ValSer: 5.18 ± 0.574
3.626ValThr: 3.626 ± 0.427
4.316ValVal: 4.316 ± 0.585
0.576ValTrp: 0.576 ± 0.178
2.129ValTyr: 2.129 ± 0.395
0.0ValXaa: 0.0 ± 0.0
Trp
0.806TrpAla: 0.806 ± 0.182
0.173TrpCys: 0.173 ± 0.101
0.633TrpAsp: 0.633 ± 0.186
0.806TrpGlu: 0.806 ± 0.171
0.691TrpPhe: 0.691 ± 0.197
0.576TrpGly: 0.576 ± 0.184
0.173TrpHis: 0.173 ± 0.096
0.518TrpIle: 0.518 ± 0.153
0.518TrpLys: 0.518 ± 0.18
1.151TrpLeu: 1.151 ± 0.268
0.173TrpMet: 0.173 ± 0.089
0.633TrpAsn: 0.633 ± 0.217
0.173TrpPro: 0.173 ± 0.109
0.46TrpGln: 0.46 ± 0.162
0.518TrpArg: 0.518 ± 0.176
1.036TrpSer: 1.036 ± 0.286
0.633TrpThr: 0.633 ± 0.166
1.036TrpVal: 1.036 ± 0.22
0.173TrpTrp: 0.173 ± 0.105
0.288TrpTyr: 0.288 ± 0.12
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.381TyrAla: 1.381 ± 0.293
0.46TyrCys: 0.46 ± 0.182
1.784TyrAsp: 1.784 ± 0.313
2.244TyrGlu: 2.244 ± 0.333
1.727TyrPhe: 1.727 ± 0.334
1.957TyrGly: 1.957 ± 0.364
0.403TyrHis: 0.403 ± 0.157
2.705TyrIle: 2.705 ± 0.44
3.28TyrLys: 3.28 ± 0.447
3.798TyrLeu: 3.798 ± 0.446
0.806TyrMet: 0.806 ± 0.24
2.532TyrAsn: 2.532 ± 0.309
1.381TyrPro: 1.381 ± 0.32
1.266TyrGln: 1.266 ± 0.237
1.439TyrArg: 1.439 ± 0.256
2.302TyrSer: 2.302 ± 0.37
1.727TyrThr: 1.727 ± 0.375
2.244TyrVal: 2.244 ± 0.428
0.46TyrTrp: 0.46 ± 0.164
1.611TyrTyr: 1.611 ± 0.261
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.115XaaAsp: 0.115 ± 0.118
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.058XaaLys: 0.058 ± 0.059
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.115XaaThr: 0.115 ± 0.104
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 80 proteins (17377 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski