Amino acid dipepetide frequency for Rathayibacter tanaceti

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
19.345AlaAla: 19.345 ± 0.233
0.666AlaCys: 0.666 ± 0.03
7.493AlaAsp: 7.493 ± 0.104
8.31AlaGlu: 8.31 ± 0.125
3.675AlaPhe: 3.675 ± 0.072
12.168AlaGly: 12.168 ± 0.158
2.462AlaHis: 2.462 ± 0.056
5.271AlaIle: 5.271 ± 0.082
2.283AlaLys: 2.283 ± 0.064
14.707AlaLeu: 14.707 ± 0.177
2.429AlaMet: 2.429 ± 0.052
2.026AlaAsn: 2.026 ± 0.053
6.763AlaPro: 6.763 ± 0.101
3.542AlaGln: 3.542 ± 0.068
9.881AlaArg: 9.881 ± 0.12
8.489AlaSer: 8.489 ± 0.117
7.315AlaThr: 7.315 ± 0.107
12.414AlaVal: 12.414 ± 0.145
1.661AlaTrp: 1.661 ± 0.044
2.138AlaTyr: 2.138 ± 0.052
0.0AlaXaa: 0.0 ± 0.0
Cys
0.747CysAla: 0.747 ± 0.034
0.092CysCys: 0.092 ± 0.012
0.28CysAsp: 0.28 ± 0.017
0.252CysGlu: 0.252 ± 0.017
0.151CysPhe: 0.151 ± 0.013
0.638CysGly: 0.638 ± 0.031
0.099CysHis: 0.099 ± 0.012
0.171CysIle: 0.171 ± 0.014
0.046CysLys: 0.046 ± 0.008
0.455CysLeu: 0.455 ± 0.022
0.107CysMet: 0.107 ± 0.011
0.088CysAsn: 0.088 ± 0.011
0.34CysPro: 0.34 ± 0.022
0.099CysGln: 0.099 ± 0.012
0.483CysArg: 0.483 ± 0.025
0.522CysSer: 0.522 ± 0.029
0.412CysThr: 0.412 ± 0.023
0.458CysVal: 0.458 ± 0.023
0.095CysTrp: 0.095 ± 0.013
0.099CysTyr: 0.099 ± 0.011
0.0CysXaa: 0.0 ± 0.0
Asp
7.841AspAla: 7.841 ± 0.113
0.278AspCys: 0.278 ± 0.016
3.91AspAsp: 3.91 ± 0.081
4.354AspGlu: 4.354 ± 0.081
1.599AspPhe: 1.599 ± 0.044
6.042AspGly: 6.042 ± 0.103
1.192AspHis: 1.192 ± 0.036
2.053AspIle: 2.053 ± 0.057
0.78AspLys: 0.78 ± 0.039
5.926AspLeu: 5.926 ± 0.073
0.625AspMet: 0.625 ± 0.026
0.778AspAsn: 0.778 ± 0.032
4.196AspPro: 4.196 ± 0.066
1.44AspGln: 1.44 ± 0.045
4.748AspArg: 4.748 ± 0.095
3.285AspSer: 3.285 ± 0.061
2.712AspThr: 2.712 ± 0.062
5.293AspVal: 5.293 ± 0.09
0.873AspTrp: 0.873 ± 0.031
1.25AspTyr: 1.25 ± 0.039
0.0AspXaa: 0.0 ± 0.0
Glu
7.316GluAla: 7.316 ± 0.104
0.235GluCys: 0.235 ± 0.016
2.864GluAsp: 2.864 ± 0.06
3.562GluGlu: 3.562 ± 0.084
1.615GluPhe: 1.615 ± 0.047
4.417GluGly: 4.417 ± 0.083
1.571GluHis: 1.571 ± 0.041
2.663GluIle: 2.663 ± 0.052
1.314GluLys: 1.314 ± 0.043
6.487GluLeu: 6.487 ± 0.109
0.876GluMet: 0.876 ± 0.031
1.238GluAsn: 1.238 ± 0.041
3.219GluPro: 3.219 ± 0.065
2.248GluGln: 2.248 ± 0.058
5.976GluArg: 5.976 ± 0.106
3.203GluSer: 3.203 ± 0.067
3.072GluThr: 3.072 ± 0.057
4.654GluVal: 4.654 ± 0.078
0.853GluTrp: 0.853 ± 0.033
1.094GluTyr: 1.094 ± 0.043
0.0GluXaa: 0.0 ± 0.0
Phe
3.977PheAla: 3.977 ± 0.073
0.192PheCys: 0.192 ± 0.015
2.233PheAsp: 2.233 ± 0.046
1.74PheGlu: 1.74 ± 0.052
0.995PhePhe: 0.995 ± 0.035
3.154PheGly: 3.154 ± 0.064
0.535PheHis: 0.535 ± 0.026
0.868PheIle: 0.868 ± 0.032
0.397PheLys: 0.397 ± 0.023
2.81PheLeu: 2.81 ± 0.068
0.356PheMet: 0.356 ± 0.025
0.491PheAsn: 0.491 ± 0.024
1.322PhePro: 1.322 ± 0.035
0.691PheGln: 0.691 ± 0.032
1.814PheArg: 1.814 ± 0.048
1.891PheSer: 1.891 ± 0.048
2.004PheThr: 2.004 ± 0.053
2.76PheVal: 2.76 ± 0.073
0.433PheTrp: 0.433 ± 0.021
0.599PheTyr: 0.599 ± 0.031
0.0PheXaa: 0.0 ± 0.0
Gly
11.264GlyAla: 11.264 ± 0.136
0.619GlyCys: 0.619 ± 0.03
4.945GlyAsp: 4.945 ± 0.086
5.117GlyGlu: 5.117 ± 0.078
3.154GlyPhe: 3.154 ± 0.062
8.185GlyGly: 8.185 ± 0.107
1.74GlyHis: 1.74 ± 0.051
4.196GlyIle: 4.196 ± 0.079
1.718GlyLys: 1.718 ± 0.05
9.032GlyLeu: 9.032 ± 0.121
1.717GlyMet: 1.717 ± 0.043
1.522GlyAsn: 1.522 ± 0.05
3.997GlyPro: 3.997 ± 0.083
2.219GlyGln: 2.219 ± 0.055
7.496GlyArg: 7.496 ± 0.116
6.315GlySer: 6.315 ± 0.093
5.893GlyThr: 5.893 ± 0.099
8.402GlyVal: 8.402 ± 0.109
1.489GlyTrp: 1.489 ± 0.04
2.082GlyTyr: 2.082 ± 0.048
0.0GlyXaa: 0.0 ± 0.0
His
2.21HisAla: 2.21 ± 0.055
0.133HisCys: 0.133 ± 0.012
1.282HisAsp: 1.282 ± 0.041
1.202HisGlu: 1.202 ± 0.04
0.551HisPhe: 0.551 ± 0.024
1.916HisGly: 1.916 ± 0.044
0.52HisHis: 0.52 ± 0.028
0.584HisIle: 0.584 ± 0.023
0.224HisLys: 0.224 ± 0.014
2.047HisLeu: 2.047 ± 0.051
0.263HisMet: 0.263 ± 0.017
0.31HisAsn: 0.31 ± 0.019
1.488HisPro: 1.488 ± 0.044
0.478HisGln: 0.478 ± 0.026
1.896HisArg: 1.896 ± 0.053
1.091HisSer: 1.091 ± 0.038
0.868HisThr: 0.868 ± 0.033
1.595HisVal: 1.595 ± 0.051
0.296HisTrp: 0.296 ± 0.021
0.42HisTyr: 0.42 ± 0.024
0.0HisXaa: 0.0 ± 0.0
Ile
6.356IleAla: 6.356 ± 0.095
0.231IleCys: 0.231 ± 0.016
3.171IleAsp: 3.171 ± 0.055
2.756IleGlu: 2.756 ± 0.054
0.88IlePhe: 0.88 ± 0.031
4.414IleGly: 4.414 ± 0.087
0.582IleHis: 0.582 ± 0.028
1.35IleIle: 1.35 ± 0.049
0.63IleLys: 0.63 ± 0.028
3.407IleLeu: 3.407 ± 0.069
0.482IleMet: 0.482 ± 0.022
0.72IleAsn: 0.72 ± 0.031
2.076IlePro: 2.076 ± 0.05
0.856IleGln: 0.856 ± 0.034
2.666IleArg: 2.666 ± 0.056
2.019IleSer: 2.019 ± 0.059
2.587IleThr: 2.587 ± 0.051
4.201IleVal: 4.201 ± 0.079
0.414IleTrp: 0.414 ± 0.026
0.648IleTyr: 0.648 ± 0.03
0.0IleXaa: 0.0 ± 0.0
Lys
2.015LysAla: 2.015 ± 0.051
0.06LysCys: 0.06 ± 0.007
0.911LysAsp: 0.911 ± 0.035
0.881LysGlu: 0.881 ± 0.035
0.361LysPhe: 0.361 ± 0.021
1.391LysGly: 1.391 ± 0.049
0.37LysHis: 0.37 ± 0.019
0.775LysIle: 0.775 ± 0.029
0.666LysLys: 0.666 ± 0.033
1.547LysLeu: 1.547 ± 0.046
0.307LysMet: 0.307 ± 0.018
0.506LysAsn: 0.506 ± 0.031
0.96LysPro: 0.96 ± 0.036
0.575LysGln: 0.575 ± 0.028
1.387LysArg: 1.387 ± 0.05
0.942LysSer: 0.942 ± 0.031
1.173LysThr: 1.173 ± 0.041
1.385LysVal: 1.385 ± 0.048
0.198LysTrp: 0.198 ± 0.016
0.375LysTyr: 0.375 ± 0.019
0.0LysXaa: 0.0 ± 0.0
Leu
15.145LeuAla: 15.145 ± 0.146
0.543LeuCys: 0.543 ± 0.027
6.942LeuAsp: 6.942 ± 0.09
5.689LeuGlu: 5.689 ± 0.098
2.717LeuPhe: 2.717 ± 0.069
9.68LeuGly: 9.68 ± 0.129
2.061LeuHis: 2.061 ± 0.056
3.957LeuIle: 3.957 ± 0.082
1.524LeuLys: 1.524 ± 0.047
11.42LeuLeu: 11.42 ± 0.168
1.36LeuMet: 1.36 ± 0.041
1.543LeuAsn: 1.543 ± 0.049
5.698LeuPro: 5.698 ± 0.095
2.407LeuGln: 2.407 ± 0.064
8.166LeuArg: 8.166 ± 0.124
6.05LeuSer: 6.05 ± 0.077
5.988LeuThr: 5.988 ± 0.078
9.912LeuVal: 9.912 ± 0.151
1.138LeuTrp: 1.138 ± 0.034
1.658LeuTyr: 1.658 ± 0.037
0.0LeuXaa: 0.0 ± 0.0
Met
1.82MetAla: 1.82 ± 0.053
0.087MetCys: 0.087 ± 0.01
0.708MetAsp: 0.708 ± 0.025
0.578MetGlu: 0.578 ± 0.029
0.411MetPhe: 0.411 ± 0.021
1.082MetGly: 1.082 ± 0.035
0.294MetHis: 0.294 ± 0.018
0.78MetIle: 0.78 ± 0.031
0.344MetLys: 0.344 ± 0.021
1.711MetLeu: 1.711 ± 0.047
0.256MetMet: 0.256 ± 0.02
0.393MetAsn: 0.393 ± 0.021
0.992MetPro: 0.992 ± 0.035
0.49MetGln: 0.49 ± 0.024
1.302MetArg: 1.302 ± 0.041
1.411MetSer: 1.411 ± 0.044
1.623MetThr: 1.623 ± 0.045
1.207MetVal: 1.207 ± 0.047
0.155MetTrp: 0.155 ± 0.012
0.219MetTyr: 0.219 ± 0.016
0.0MetXaa: 0.0 ± 0.0
Asn
2.158AsnAla: 2.158 ± 0.05
0.1AsnCys: 0.1 ± 0.012
1.027AsnAsp: 1.027 ± 0.037
0.895AsnGlu: 0.895 ± 0.03
0.525AsnPhe: 0.525 ± 0.026
1.826AsnGly: 1.826 ± 0.049
0.329AsnHis: 0.329 ± 0.021
0.72AsnIle: 0.72 ± 0.032
0.338AsnLys: 0.338 ± 0.02
1.697AsnLeu: 1.697 ± 0.045
0.239AsnMet: 0.239 ± 0.018
0.399AsnAsn: 0.399 ± 0.024
1.257AsnPro: 1.257 ± 0.044
0.476AsnGln: 0.476 ± 0.026
1.259AsnArg: 1.259 ± 0.041
0.912AsnSer: 0.912 ± 0.039
1.0AsnThr: 1.0 ± 0.035
1.518AsnVal: 1.518 ± 0.042
0.248AsnTrp: 0.248 ± 0.018
0.436AsnTyr: 0.436 ± 0.024
0.0AsnXaa: 0.0 ± 0.0
Pro
7.203ProAla: 7.203 ± 0.103
0.252ProCys: 0.252 ± 0.018
3.67ProAsp: 3.67 ± 0.072
4.088ProGlu: 4.088 ± 0.072
1.673ProPhe: 1.673 ± 0.048
5.194ProGly: 5.194 ± 0.076
1.078ProHis: 1.078 ± 0.035
1.913ProIle: 1.913 ± 0.045
0.773ProLys: 0.773 ± 0.035
5.251ProLeu: 5.251 ± 0.086
0.904ProMet: 0.904 ± 0.033
0.864ProAsn: 0.864 ± 0.034
2.66ProPro: 2.66 ± 0.075
1.477ProGln: 1.477 ± 0.043
4.174ProArg: 4.174 ± 0.081
3.739ProSer: 3.739 ± 0.073
3.459ProThr: 3.459 ± 0.075
5.091ProVal: 5.091 ± 0.086
0.805ProTrp: 0.805 ± 0.03
0.974ProTyr: 0.974 ± 0.036
0.0ProXaa: 0.0 ± 0.0
Gln
3.032GlnAla: 3.032 ± 0.061
0.137GlnCys: 0.137 ± 0.012
1.164GlnAsp: 1.164 ± 0.039
1.438GlnGlu: 1.438 ± 0.043
0.772GlnPhe: 0.772 ± 0.027
1.908GlnGly: 1.908 ± 0.05
0.57GlnHis: 0.57 ± 0.034
1.247GlnIle: 1.247 ± 0.043
0.681GlnLys: 0.681 ± 0.03
2.964GlnLeu: 2.964 ± 0.064
0.405GlnMet: 0.405 ± 0.022
0.654GlnAsn: 0.654 ± 0.03
1.444GlnPro: 1.444 ± 0.044
1.068GlnGln: 1.068 ± 0.04
2.362GlnArg: 2.362 ± 0.071
1.48GlnSer: 1.48 ± 0.046
1.347GlnThr: 1.347 ± 0.037
2.181GlnVal: 2.181 ± 0.047
0.401GlnTrp: 0.401 ± 0.021
0.632GlnTyr: 0.632 ± 0.025
0.0GlnXaa: 0.0 ± 0.0
Arg
9.957ArgAla: 9.957 ± 0.136
0.553ArgCys: 0.553 ± 0.026
4.231ArgAsp: 4.231 ± 0.075
4.711ArgGlu: 4.711 ± 0.081
2.514ArgPhe: 2.514 ± 0.048
6.162ArgGly: 6.162 ± 0.094
1.7ArgHis: 1.7 ± 0.053
3.7ArgIle: 3.7 ± 0.067
1.086ArgLys: 1.086 ± 0.037
8.352ArgLeu: 8.352 ± 0.111
1.709ArgMet: 1.709 ± 0.042
1.19ArgAsn: 1.19 ± 0.039
4.444ArgPro: 4.444 ± 0.074
1.88ArgGln: 1.88 ± 0.049
8.202ArgArg: 8.202 ± 0.145
5.787ArgSer: 5.787 ± 0.098
4.876ArgThr: 4.876 ± 0.077
6.419ArgVal: 6.419 ± 0.09
1.247ArgTrp: 1.247 ± 0.041
1.543ArgTyr: 1.543 ± 0.036
0.0ArgXaa: 0.0 ± 0.0
Ser
8.721SerAla: 8.721 ± 0.12
0.418SerCys: 0.418 ± 0.025
3.316SerAsp: 3.316 ± 0.076
2.973SerGlu: 2.973 ± 0.063
1.952SerPhe: 1.952 ± 0.048
6.82SerGly: 6.82 ± 0.113
0.95SerHis: 0.95 ± 0.034
2.673SerIle: 2.673 ± 0.06
0.975SerLys: 0.975 ± 0.034
5.799SerLeu: 5.799 ± 0.08
1.177SerMet: 1.177 ± 0.036
1.072SerAsn: 1.072 ± 0.036
3.73SerPro: 3.73 ± 0.078
1.328SerGln: 1.328 ± 0.044
4.865SerArg: 4.865 ± 0.084
4.87SerSer: 4.87 ± 0.113
4.594SerThr: 4.594 ± 0.081
5.411SerVal: 5.411 ± 0.087
1.011SerTrp: 1.011 ± 0.031
1.286SerTyr: 1.286 ± 0.04
0.0SerXaa: 0.0 ± 0.0
Thr
8.315ThrAla: 8.315 ± 0.125
0.323ThrCys: 0.323 ± 0.019
3.23ThrAsp: 3.23 ± 0.067
3.018ThrGlu: 3.018 ± 0.057
1.713ThrPhe: 1.713 ± 0.051
5.938ThrGly: 5.938 ± 0.083
0.929ThrHis: 0.929 ± 0.034
2.515ThrIle: 2.515 ± 0.064
1.018ThrLys: 1.018 ± 0.034
5.978ThrLeu: 5.978 ± 0.088
0.841ThrMet: 0.841 ± 0.034
1.095ThrAsn: 1.095 ± 0.043
4.067ThrPro: 4.067 ± 0.073
1.317ThrGln: 1.317 ± 0.038
4.185ThrArg: 4.185 ± 0.082
4.024ThrSer: 4.024 ± 0.071
4.315ThrThr: 4.315 ± 0.091
6.06ThrVal: 6.06 ± 0.086
0.843ThrTrp: 0.843 ± 0.034
1.0ThrTyr: 1.0 ± 0.037
0.0ThrXaa: 0.0 ± 0.0
Val
11.909ValAla: 11.909 ± 0.144
0.485ValCys: 0.485 ± 0.026
5.856ValAsp: 5.856 ± 0.089
5.263ValGlu: 5.263 ± 0.089
2.85ValPhe: 2.85 ± 0.065
7.367ValGly: 7.367 ± 0.107
1.83ValHis: 1.83 ± 0.054
3.802ValIle: 3.802 ± 0.083
1.417ValLys: 1.417 ± 0.039
10.383ValLeu: 10.383 ± 0.146
1.282ValMet: 1.282 ± 0.039
1.651ValAsn: 1.651 ± 0.049
4.921ValPro: 4.921 ± 0.078
2.31ValGln: 2.31 ± 0.059
6.495ValArg: 6.495 ± 0.108
5.522ValSer: 5.522 ± 0.085
5.508ValThr: 5.508 ± 0.093
9.81ValVal: 9.81 ± 0.131
1.028ValTrp: 1.028 ± 0.034
1.568ValTyr: 1.568 ± 0.041
0.0ValXaa: 0.0 ± 0.0
Trp
1.478TrpAla: 1.478 ± 0.044
0.11TrpCys: 0.11 ± 0.012
0.668TrpAsp: 0.668 ± 0.028
0.619TrpGlu: 0.619 ± 0.025
0.514TrpPhe: 0.514 ± 0.023
0.939TrpGly: 0.939 ± 0.034
0.28TrpHis: 0.28 ± 0.018
0.639TrpIle: 0.639 ± 0.026
0.268TrpLys: 0.268 ± 0.019
1.566TrpLeu: 1.566 ± 0.046
0.307TrpMet: 0.307 ± 0.018
0.389TrpAsn: 0.389 ± 0.022
0.688TrpPro: 0.688 ± 0.028
0.461TrpGln: 0.461 ± 0.025
1.261TrpArg: 1.261 ± 0.041
1.092TrpSer: 1.092 ± 0.037
0.92TrpThr: 0.92 ± 0.03
1.018TrpVal: 1.018 ± 0.041
0.301TrpTrp: 0.301 ± 0.019
0.266TrpTyr: 0.266 ± 0.018
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.228TyrAla: 2.228 ± 0.05
0.117TyrCys: 0.117 ± 0.012
1.274TyrAsp: 1.274 ± 0.048
1.029TyrGlu: 1.029 ± 0.039
0.643TyrPhe: 0.643 ± 0.029
1.863TyrGly: 1.863 ± 0.047
0.284TyrHis: 0.284 ± 0.017
0.568TyrIle: 0.568 ± 0.027
0.305TyrLys: 0.305 ± 0.021
2.055TyrLeu: 2.055 ± 0.053
0.215TyrMet: 0.215 ± 0.014
0.433TyrAsn: 0.433 ± 0.024
0.979TyrPro: 0.979 ± 0.035
0.523TyrGln: 0.523 ± 0.027
1.649TyrArg: 1.649 ± 0.043
1.295TyrSer: 1.295 ± 0.04
1.06TyrThr: 1.06 ± 0.036
1.469TyrVal: 1.469 ± 0.043
0.296TyrTrp: 0.296 ± 0.017
0.49TyrTyr: 0.49 ± 0.024
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3209 proteins (878195 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski