Amino acid dipepetide frequency for Thiobaca trueperi

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	13.923AlaAla: 13.923 ± 0.162	1.256AlaCys: 1.256 ± 0.037	6.804AlaAsp: 6.804 ± 0.083	7.311AlaGlu: 7.311 ± 0.094	3.718AlaPhe: 3.718 ± 0.055	9.444AlaGly: 9.444 ± 0.102	2.353AlaHis: 2.353 ± 0.047	5.896AlaIle: 5.896 ± 0.077	2.697AlaLys: 2.697 ± 0.055	13.21AlaLeu: 13.21 ± 0.145	2.899AlaMet: 2.899 ± 0.052	2.825AlaAsn: 2.825 ± 0.053	5.113AlaPro: 5.113 ± 0.089	4.263AlaGln: 4.263 ± 0.068	9.147AlaArg: 9.147 ± 0.098	5.775AlaSer: 5.775 ± 0.089	5.707AlaThr: 5.707 ± 0.094	7.913AlaVal: 7.913 ± 0.086	1.413AlaTrp: 1.413 ± 0.038	2.279AlaTyr: 2.279 ± 0.049	0.0AlaXaa: 0.0 ± 0.0
Cys	1.067CysAla: 1.067 ± 0.033	0.15CysCys: 0.15 ± 0.011	0.544CysAsp: 0.544 ± 0.023	0.578CysGlu: 0.578 ± 0.023	0.344CysPhe: 0.344 ± 0.016	1.049CysGly: 1.049 ± 0.037	0.344CysHis: 0.344 ± 0.021	0.449CysIle: 0.449 ± 0.022	0.217CysLys: 0.217 ± 0.015	1.09CysLeu: 1.09 ± 0.029	0.178CysMet: 0.178 ± 0.012	0.289CysAsn: 0.289 ± 0.015	0.602CysPro: 0.602 ± 0.023	0.41CysGln: 0.41 ± 0.018	0.788CysArg: 0.788 ± 0.028	0.504CysSer: 0.504 ± 0.022	0.491CysThr: 0.491 ± 0.022	0.678CysVal: 0.678 ± 0.026	0.121CysTrp: 0.121 ± 0.01	0.238CysTyr: 0.238 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	6.878AspAla: 6.878 ± 0.087	0.653AspCys: 0.653 ± 0.028	3.377AspAsp: 3.377 ± 0.057	3.74AspGlu: 3.74 ± 0.06	2.308AspPhe: 2.308 ± 0.047	4.806AspGly: 4.806 ± 0.075	1.334AspHis: 1.334 ± 0.034	2.81AspIle: 2.81 ± 0.044	1.31AspLys: 1.31 ± 0.038	7.32AspLeu: 7.32 ± 0.08	1.156AspMet: 1.156 ± 0.033	1.251AspAsn: 1.251 ± 0.033	3.979AspPro: 3.979 ± 0.069	2.46AspGln: 2.46 ± 0.049	4.493AspArg: 4.493 ± 0.07	2.682AspSer: 2.682 ± 0.049	2.584AspThr: 2.584 ± 0.05	3.452AspVal: 3.452 ± 0.052	1.261AspTrp: 1.261 ± 0.036	1.801AspTyr: 1.801 ± 0.038	0.0AspXaa: 0.0 ± 0.0
Glu	6.385GluAla: 6.385 ± 0.081	0.453GluCys: 0.453 ± 0.022	2.82GluAsp: 2.82 ± 0.05	2.767GluGlu: 2.767 ± 0.059	1.757GluPhe: 1.757 ± 0.037	3.747GluGly: 3.747 ± 0.061	1.447GluHis: 1.447 ± 0.038	3.665GluIle: 3.665 ± 0.063	1.616GluLys: 1.616 ± 0.044	6.132GluLeu: 6.132 ± 0.08	1.335GluMet: 1.335 ± 0.036	1.381GluAsn: 1.381 ± 0.032	3.051GluPro: 3.051 ± 0.057	3.321GluGln: 3.321 ± 0.055	5.992GluArg: 5.992 ± 0.082	3.402GluSer: 3.402 ± 0.057	3.978GluThr: 3.978 ± 0.058	3.819GluVal: 3.819 ± 0.059	0.7GluTrp: 0.7 ± 0.023	1.055GluTyr: 1.055 ± 0.031	0.0GluXaa: 0.0 ± 0.0
Phe	4.072PheAla: 4.072 ± 0.06	0.391PheCys: 0.391 ± 0.017	2.504PheAsp: 2.504 ± 0.049	2.019PheGlu: 2.019 ± 0.048	1.426PhePhe: 1.426 ± 0.045	3.133PheGly: 3.133 ± 0.061	0.783PheHis: 0.783 ± 0.03	1.701PheIle: 1.701 ± 0.041	0.979PheLys: 0.979 ± 0.03	3.469PheLeu: 3.469 ± 0.069	0.748PheMet: 0.748 ± 0.024	1.075PheAsn: 1.075 ± 0.032	1.526PhePro: 1.526 ± 0.036	1.227PheGln: 1.227 ± 0.034	2.195PheArg: 2.195 ± 0.042	2.07PheSer: 2.07 ± 0.054	1.814PheThr: 1.814 ± 0.045	2.498PheVal: 2.498 ± 0.049	0.515PheTrp: 0.515 ± 0.023	0.922PheTyr: 0.922 ± 0.033	0.0PheXaa: 0.0 ± 0.0
Gly	7.708GlyAla: 7.708 ± 0.093	1.067GlyCys: 1.067 ± 0.037	4.325GlyAsp: 4.325 ± 0.065	4.727GlyGlu: 4.727 ± 0.066	3.256GlyPhe: 3.256 ± 0.062	6.043GlyGly: 6.043 ± 0.107	1.893GlyHis: 1.893 ± 0.04	4.572GlyIle: 4.572 ± 0.067	2.461GlyLys: 2.461 ± 0.044	9.265GlyLeu: 9.265 ± 0.099	2.101GlyMet: 2.101 ± 0.042	2.0GlyAsn: 2.0 ± 0.052	2.759GlyPro: 2.759 ± 0.051	3.328GlyGln: 3.328 ± 0.062	5.937GlyArg: 5.937 ± 0.073	4.126GlySer: 4.126 ± 0.083	3.948GlyThr: 3.948 ± 0.087	5.758GlyVal: 5.758 ± 0.089	1.385GlyTrp: 1.385 ± 0.035	2.243GlyTyr: 2.243 ± 0.046	0.0GlyXaa: 0.0 ± 0.0
His	2.562HisAla: 2.562 ± 0.045	0.29HisCys: 0.29 ± 0.019	1.34HisAsp: 1.34 ± 0.034	1.197HisGlu: 1.197 ± 0.032	0.935HisPhe: 0.935 ± 0.029	1.838HisGly: 1.838 ± 0.036	0.694HisHis: 0.694 ± 0.026	0.902HisIle: 0.902 ± 0.029	0.468HisLys: 0.468 ± 0.021	2.848HisLeu: 2.848 ± 0.055	0.373HisMet: 0.373 ± 0.017	0.539HisAsn: 0.539 ± 0.022	1.665HisPro: 1.665 ± 0.045	0.912HisGln: 0.912 ± 0.027	1.797HisArg: 1.797 ± 0.035	1.004HisSer: 1.004 ± 0.029	0.965HisThr: 0.965 ± 0.03	1.304HisVal: 1.304 ± 0.032	0.449HisTrp: 0.449 ± 0.02	0.659HisTyr: 0.659 ± 0.024	0.0HisXaa: 0.0 ± 0.0
Ile	6.479IleAla: 6.479 ± 0.085	0.5IleCys: 0.5 ± 0.02	3.844IleAsp: 3.844 ± 0.06	3.823IleGlu: 3.823 ± 0.055	1.506IlePhe: 1.506 ± 0.037	4.543IleGly: 4.543 ± 0.062	1.209IleHis: 1.209 ± 0.033	2.022IleIle: 2.022 ± 0.046	1.592IleLys: 1.592 ± 0.038	5.502IleLeu: 5.502 ± 0.076	0.817IleMet: 0.817 ± 0.029	1.57IleAsn: 1.57 ± 0.04	2.678IlePro: 2.678 ± 0.046	2.038IleGln: 2.038 ± 0.042	3.862IleArg: 3.862 ± 0.061	2.433IleSer: 2.433 ± 0.056	2.38IleThr: 2.38 ± 0.044	3.305IleVal: 3.305 ± 0.06	0.626IleTrp: 0.626 ± 0.024	1.138IleTyr: 1.138 ± 0.029	0.0IleXaa: 0.0 ± 0.0
Lys	2.796LysAla: 2.796 ± 0.056	0.177LysCys: 0.177 ± 0.012	1.512LysAsp: 1.512 ± 0.038	1.442LysGlu: 1.442 ± 0.037	0.695LysPhe: 0.695 ± 0.024	2.096LysGly: 2.096 ± 0.047	0.559LysHis: 0.559 ± 0.022	1.364LysIle: 1.364 ± 0.038	1.003LysLys: 1.003 ± 0.042	2.543LysLeu: 2.543 ± 0.053	0.55LysMet: 0.55 ± 0.022	0.719LysAsn: 0.719 ± 0.023	1.656LysPro: 1.656 ± 0.039	1.067LysGln: 1.067 ± 0.03	2.078LysArg: 2.078 ± 0.046	1.493LysSer: 1.493 ± 0.042	1.784LysThr: 1.784 ± 0.041	1.772LysVal: 1.772 ± 0.039	0.298LysTrp: 0.298 ± 0.019	0.564LysTyr: 0.564 ± 0.023	0.0LysXaa: 0.0 ± 0.0
Leu	14.586LeuAla: 14.586 ± 0.141	1.095LeuCys: 1.095 ± 0.033	7.695LeuAsp: 7.695 ± 0.09	6.337LeuGlu: 6.337 ± 0.075	3.951LeuPhe: 3.951 ± 0.066	8.405LeuGly: 8.405 ± 0.101	2.441LeuHis: 2.441 ± 0.049	6.296LeuIle: 6.296 ± 0.081	3.227LeuLys: 3.227 ± 0.056	12.569LeuLeu: 12.569 ± 0.164	2.514LeuMet: 2.514 ± 0.044	3.147LeuAsn: 3.147 ± 0.053	6.127LeuPro: 6.127 ± 0.078	3.294LeuGln: 3.294 ± 0.052	8.415LeuArg: 8.415 ± 0.099	6.614LeuSer: 6.614 ± 0.087	6.742LeuThr: 6.742 ± 0.077	7.778LeuVal: 7.778 ± 0.092	1.293LeuTrp: 1.293 ± 0.043	2.421LeuTyr: 2.421 ± 0.043	0.0LeuXaa: 0.0 ± 0.0
Met	2.49MetAla: 2.49 ± 0.047	0.144MetCys: 0.144 ± 0.011	1.171MetAsp: 1.171 ± 0.034	1.097MetGlu: 1.097 ± 0.032	0.546MetPhe: 0.546 ± 0.023	1.495MetGly: 1.495 ± 0.034	0.469MetHis: 0.469 ± 0.021	1.096MetIle: 1.096 ± 0.033	0.76MetLys: 0.76 ± 0.026	2.433MetLeu: 2.433 ± 0.055	0.529MetMet: 0.529 ± 0.021	0.813MetAsn: 0.813 ± 0.026	1.348MetPro: 1.348 ± 0.036	0.963MetGln: 0.963 ± 0.03	1.649MetArg: 1.649 ± 0.044	1.498MetSer: 1.498 ± 0.036	1.575MetThr: 1.575 ± 0.035	1.369MetVal: 1.369 ± 0.032	0.15MetTrp: 0.15 ± 0.012	0.295MetTyr: 0.295 ± 0.016	0.0MetXaa: 0.0 ± 0.0
Asn	2.898AsnAla: 2.898 ± 0.063	0.271AsnCys: 0.271 ± 0.018	1.372AsnAsp: 1.372 ± 0.038	1.296AsnGlu: 1.296 ± 0.031	0.802AsnPhe: 0.802 ± 0.026	2.165AsnGly: 2.165 ± 0.05	0.63AsnHis: 0.63 ± 0.027	1.242AsnIle: 1.242 ± 0.04	0.615AsnLys: 0.615 ± 0.026	3.252AsnLeu: 3.252 ± 0.061	0.505AsnMet: 0.505 ± 0.02	0.676AsnAsn: 0.676 ± 0.026	2.021AsnPro: 2.021 ± 0.042	1.143AsnGln: 1.143 ± 0.035	2.252AsnArg: 2.252 ± 0.044	1.134AsnSer: 1.134 ± 0.035	1.237AsnThr: 1.237 ± 0.044	1.488AsnVal: 1.488 ± 0.038	0.389AsnTrp: 0.389 ± 0.019	0.601AsnTyr: 0.601 ± 0.024	0.0AsnXaa: 0.0 ± 0.0
Pro	6.141ProAla: 6.141 ± 0.093	0.443ProCys: 0.443 ± 0.02	4.151ProAsp: 4.151 ± 0.067	3.874ProGlu: 3.874 ± 0.07	1.871ProPhe: 1.871 ± 0.04	4.478ProGly: 4.478 ± 0.065	1.077ProHis: 1.077 ± 0.031	2.319ProIle: 2.319 ± 0.048	1.269ProLys: 1.269 ± 0.034	5.618ProLeu: 5.618 ± 0.083	1.101ProMet: 1.101 ± 0.028	1.301ProAsn: 1.301 ± 0.038	3.006ProPro: 3.006 ± 0.064	1.781ProGln: 1.781 ± 0.041	3.07ProArg: 3.07 ± 0.055	2.739ProSer: 2.739 ± 0.049	2.587ProThr: 2.587 ± 0.048	4.264ProVal: 4.264 ± 0.066	0.788ProTrp: 0.788 ± 0.028	1.152ProTyr: 1.152 ± 0.033	0.0ProXaa: 0.0 ± 0.0
Gln	5.091GlnAla: 5.091 ± 0.072	0.344GlnCys: 0.344 ± 0.015	2.012GlnAsp: 2.012 ± 0.045	2.0GlnGlu: 2.0 ± 0.046	1.13GlnPhe: 1.13 ± 0.038	3.127GlnGly: 3.127 ± 0.052	0.843GlnHis: 0.843 ± 0.025	2.349GlnIle: 2.349 ± 0.052	0.903GlnLys: 0.903 ± 0.027	3.653GlnLeu: 3.653 ± 0.057	0.88GlnMet: 0.88 ± 0.03	0.857GlnAsn: 0.857 ± 0.027	2.255GlnPro: 2.255 ± 0.048	1.698GlnGln: 1.698 ± 0.039	3.401GlnArg: 3.401 ± 0.06	2.295GlnSer: 2.295 ± 0.046	2.494GlnThr: 2.494 ± 0.041	3.001GlnVal: 3.001 ± 0.051	0.489GlnTrp: 0.489 ± 0.019	0.705GlnTyr: 0.705 ± 0.025	0.0GlnXaa: 0.0 ± 0.0
Arg	7.689ArgAla: 7.689 ± 0.091	0.687ArgCys: 0.687 ± 0.023	4.392ArgAsp: 4.392 ± 0.065	4.949ArgGlu: 4.949 ± 0.073	3.261ArgPhe: 3.261 ± 0.061	4.647ArgGly: 4.647 ± 0.071	2.198ArgHis: 2.198 ± 0.047	4.745ArgIle: 4.745 ± 0.064	1.801ArgLys: 1.801 ± 0.041	10.644ArgLeu: 10.644 ± 0.126	1.753ArgMet: 1.753 ± 0.038	1.878ArgAsn: 1.878 ± 0.038	3.62ArgPro: 3.62 ± 0.054	3.699ArgGln: 3.699 ± 0.066	6.196ArgArg: 6.196 ± 0.079	3.247ArgSer: 3.247 ± 0.052	3.405ArgThr: 3.405 ± 0.063	5.119ArgVal: 5.119 ± 0.071	1.193ArgTrp: 1.193 ± 0.037	2.126ArgTyr: 2.126 ± 0.045	0.0ArgXaa: 0.0 ± 0.0
Ser	5.837SerAla: 5.837 ± 0.081	0.492SerCys: 0.492 ± 0.023	2.955SerAsp: 2.955 ± 0.054	2.9SerGlu: 2.9 ± 0.047	1.915SerPhe: 1.915 ± 0.05	5.257SerGly: 5.257 ± 0.09	1.192SerHis: 1.192 ± 0.024	2.571SerIle: 2.571 ± 0.046	1.285SerLys: 1.285 ± 0.033	6.182SerLeu: 6.182 ± 0.073	1.165SerMet: 1.165 ± 0.028	1.344SerAsn: 1.344 ± 0.039	2.865SerPro: 2.865 ± 0.057	1.973SerGln: 1.973 ± 0.039	3.836SerArg: 3.836 ± 0.061	2.844SerSer: 2.844 ± 0.065	2.566SerThr: 2.566 ± 0.057	3.538SerVal: 3.538 ± 0.067	0.632SerTrp: 0.632 ± 0.022	1.133SerTyr: 1.133 ± 0.033	0.0SerXaa: 0.0 ± 0.0
Thr	6.116ThrAla: 6.116 ± 0.1	0.532ThrCys: 0.532 ± 0.025	3.127ThrAsp: 3.127 ± 0.05	2.794ThrGlu: 2.794 ± 0.048	1.695ThrPhe: 1.695 ± 0.04	4.93ThrGly: 4.93 ± 0.092	1.154ThrHis: 1.154 ± 0.03	2.398ThrIle: 2.398 ± 0.048	1.104ThrLys: 1.104 ± 0.037	6.943ThrLeu: 6.943 ± 0.09	0.856ThrMet: 0.856 ± 0.028	1.267ThrAsn: 1.267 ± 0.041	3.621ThrPro: 3.621 ± 0.059	1.942ThrGln: 1.942 ± 0.041	3.589ThrArg: 3.589 ± 0.053	2.56ThrSer: 2.56 ± 0.056	2.782ThrThr: 2.782 ± 0.075	3.62ThrVal: 3.62 ± 0.078	0.63ThrTrp: 0.63 ± 0.025	1.129ThrTyr: 1.129 ± 0.036	0.0ThrXaa: 0.0 ± 0.0
Val	7.8ValAla: 7.8 ± 0.095	0.78ValCys: 0.78 ± 0.023	3.667ValAsp: 3.667 ± 0.047	4.158ValGlu: 4.158 ± 0.061	2.494ValPhe: 2.494 ± 0.05	4.919ValGly: 4.919 ± 0.082	1.276ValHis: 1.276 ± 0.035	3.811ValIle: 3.811 ± 0.065	1.933ValLys: 1.933 ± 0.045	7.366ValLeu: 7.366 ± 0.106	1.723ValMet: 1.723 ± 0.039	2.059ValAsn: 2.059 ± 0.049	3.206ValPro: 3.206 ± 0.054	2.346ValGln: 2.346 ± 0.047	5.046ValArg: 5.046 ± 0.074	3.972ValSer: 3.972 ± 0.066	4.007ValThr: 4.007 ± 0.079	4.962ValVal: 4.962 ± 0.08	0.975ValTrp: 0.975 ± 0.029	1.491ValTyr: 1.491 ± 0.038	0.0ValXaa: 0.0 ± 0.0
Trp	1.009TrpAla: 1.009 ± 0.031	0.157TrpCys: 0.157 ± 0.012	0.688TrpAsp: 0.688 ± 0.026	0.711TrpGlu: 0.711 ± 0.027	0.575TrpPhe: 0.575 ± 0.027	0.883TrpGly: 0.883 ± 0.029	0.325TrpHis: 0.325 ± 0.017	0.792TrpIle: 0.792 ± 0.028	0.39TrpLys: 0.39 ± 0.02	2.039TrpLeu: 2.039 ± 0.053	0.364TrpMet: 0.364 ± 0.015	0.421TrpAsn: 0.421 ± 0.019	0.69TrpPro: 0.69 ± 0.025	0.653TrpGln: 0.653 ± 0.026	1.222TrpArg: 1.222 ± 0.037	0.894TrpSer: 0.894 ± 0.033	0.7TrpThr: 0.7 ± 0.024	0.876TrpVal: 0.876 ± 0.03	0.237TrpTrp: 0.237 ± 0.014	0.284TrpTyr: 0.284 ± 0.018	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.419TyrAla: 2.419 ± 0.042	0.248TyrCys: 0.248 ± 0.015	1.355TyrAsp: 1.355 ± 0.041	1.102TyrGlu: 1.102 ± 0.031	0.88TyrPhe: 0.88 ± 0.03	1.896TyrGly: 1.896 ± 0.046	0.519TyrHis: 0.519 ± 0.022	0.866TyrIle: 0.866 ± 0.025	0.54TyrLys: 0.54 ± 0.024	2.87TyrLeu: 2.87 ± 0.052	0.344TyrMet: 0.344 ± 0.015	0.578TyrAsn: 0.578 ± 0.023	1.243TyrPro: 1.243 ± 0.034	1.008TyrGln: 1.008 ± 0.032	2.284TyrArg: 2.284 ± 0.047	1.197TyrSer: 1.197 ± 0.032	1.041TyrThr: 1.041 ± 0.035	1.479TyrVal: 1.479 ± 0.032	0.366TyrTrp: 0.366 ± 0.017	0.65TyrTyr: 0.65 ± 0.023	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3588 proteins (1205061 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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