Amino acid dipepetide frequency for Desulfofundulus thermobenzoicus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	11.802AlaAla: 11.802 ± 0.147	1.333AlaCys: 1.333 ± 0.039	3.941AlaAsp: 3.941 ± 0.065	5.875AlaGlu: 5.875 ± 0.092	3.107AlaPhe: 3.107 ± 0.053	10.79AlaGly: 10.79 ± 0.125	1.546AlaHis: 1.546 ± 0.035	4.792AlaIle: 4.792 ± 0.078	2.916AlaLys: 2.916 ± 0.056	10.564AlaLeu: 10.564 ± 0.12	2.468AlaMet: 2.468 ± 0.045	1.989AlaAsn: 1.989 ± 0.055	3.51AlaPro: 3.51 ± 0.06	2.626AlaGln: 2.626 ± 0.06	8.336AlaArg: 8.336 ± 0.114	3.883AlaSer: 3.883 ± 0.061	3.911AlaThr: 3.911 ± 0.074	8.93AlaVal: 8.93 ± 0.108	0.998AlaTrp: 0.998 ± 0.034	2.299AlaTyr: 2.299 ± 0.054	0.0AlaXaa: 0.0 ± 0.0
Cys	1.183CysAla: 1.183 ± 0.035	0.27CysCys: 0.27 ± 0.021	0.5CysAsp: 0.5 ± 0.025	0.485CysGlu: 0.485 ± 0.021	0.401CysPhe: 0.401 ± 0.021	1.407CysGly: 1.407 ± 0.037	0.338CysHis: 0.338 ± 0.022	0.541CysIle: 0.541 ± 0.021	0.372CysLys: 0.372 ± 0.019	1.315CysLeu: 1.315 ± 0.037	0.238CysMet: 0.238 ± 0.015	0.348CysAsn: 0.348 ± 0.019	0.926CysPro: 0.926 ± 0.038	0.417CysGln: 0.417 ± 0.021	1.286CysArg: 1.286 ± 0.04	0.686CysSer: 0.686 ± 0.032	0.622CysThr: 0.622 ± 0.023	0.732CysVal: 0.732 ± 0.031	0.13CysTrp: 0.13 ± 0.012	0.369CysTyr: 0.369 ± 0.02	0.0CysXaa: 0.0 ± 0.0
Asp	3.549AspAla: 3.549 ± 0.063	0.593AspCys: 0.593 ± 0.027	1.942AspAsp: 1.942 ± 0.048	3.196AspGlu: 3.196 ± 0.063	1.972AspPhe: 1.972 ± 0.044	3.768AspGly: 3.768 ± 0.066	0.902AspHis: 0.902 ± 0.029	3.113AspIle: 3.113 ± 0.058	1.783AspLys: 1.783 ± 0.047	5.611AspLeu: 5.611 ± 0.079	1.21AspMet: 1.21 ± 0.032	1.29AspAsn: 1.29 ± 0.039	2.947AspPro: 2.947 ± 0.06	1.467AspGln: 1.467 ± 0.044	3.68AspArg: 3.68 ± 0.061	1.785AspSer: 1.785 ± 0.046	2.056AspThr: 2.056 ± 0.051	3.517AspVal: 3.517 ± 0.067	0.595AspTrp: 0.595 ± 0.026	1.702AspTyr: 1.702 ± 0.041	0.0AspXaa: 0.0 ± 0.0
Glu	6.37GluAla: 6.37 ± 0.098	0.582GluCys: 0.582 ± 0.025	2.944GluAsp: 2.944 ± 0.055	6.171GluGlu: 6.171 ± 0.086	1.915GluPhe: 1.915 ± 0.049	4.755GluGly: 4.755 ± 0.074	1.263GluHis: 1.263 ± 0.037	4.813GluIle: 4.813 ± 0.079	5.11GluLys: 5.11 ± 0.079	7.095GluLeu: 7.095 ± 0.1	2.217GluMet: 2.217 ± 0.052	2.456GluAsn: 2.456 ± 0.05	2.491GluPro: 2.491 ± 0.057	2.793GluGln: 2.793 ± 0.064	4.681GluArg: 4.681 ± 0.085	2.401GluSer: 2.401 ± 0.051	2.962GluThr: 2.962 ± 0.057	5.364GluVal: 5.364 ± 0.083	0.633GluTrp: 0.633 ± 0.025	1.847GluTyr: 1.847 ± 0.043	0.0GluXaa: 0.0 ± 0.0
Phe	3.074PheAla: 3.074 ± 0.059	0.559PheCys: 0.559 ± 0.023	1.777PheAsp: 1.777 ± 0.042	1.647PheGlu: 1.647 ± 0.049	1.658PhePhe: 1.658 ± 0.043	2.766PheGly: 2.766 ± 0.052	0.877PheHis: 0.877 ± 0.03	2.17PheIle: 2.17 ± 0.052	1.539PheLys: 1.539 ± 0.039	4.046PheLeu: 4.046 ± 0.068	0.877PheMet: 0.877 ± 0.031	1.275PheAsn: 1.275 ± 0.035	1.853PhePro: 1.853 ± 0.044	1.166PheGln: 1.166 ± 0.034	2.06PheArg: 2.06 ± 0.051	2.141PheSer: 2.141 ± 0.054	2.255PheThr: 2.255 ± 0.055	2.443PheVal: 2.443 ± 0.054	0.499PheTrp: 0.499 ± 0.024	1.254PheTyr: 1.254 ± 0.03	0.0PheXaa: 0.0 ± 0.0
Gly	7.189GlyAla: 7.189 ± 0.097	1.19GlyCys: 1.19 ± 0.037	3.778GlyAsp: 3.778 ± 0.066	5.891GlyGlu: 5.891 ± 0.081	3.07GlyPhe: 3.07 ± 0.061	7.197GlyGly: 7.197 ± 0.132	1.61GlyHis: 1.61 ± 0.039	5.15GlyIle: 5.15 ± 0.072	4.393GlyLys: 4.393 ± 0.068	9.041GlyLeu: 9.041 ± 0.111	2.488GlyMet: 2.488 ± 0.061	2.536GlyAsn: 2.536 ± 0.056	3.145GlyPro: 3.145 ± 0.059	3.126GlyGln: 3.126 ± 0.058	6.684GlyArg: 6.684 ± 0.089	4.053GlySer: 4.053 ± 0.064	4.209GlyThr: 4.209 ± 0.079	6.827GlyVal: 6.827 ± 0.092	0.978GlyTrp: 0.978 ± 0.034	2.865GlyTyr: 2.865 ± 0.06	0.0GlyXaa: 0.0 ± 0.0
His	1.312HisAla: 1.312 ± 0.035	0.327HisCys: 0.327 ± 0.018	0.791HisAsp: 0.791 ± 0.028	0.917HisGlu: 0.917 ± 0.03	0.894HisPhe: 0.894 ± 0.032	1.62HisGly: 1.62 ± 0.043	0.608HisHis: 0.608 ± 0.03	1.117HisIle: 1.117 ± 0.033	0.618HisLys: 0.618 ± 0.022	2.374HisLeu: 2.374 ± 0.051	0.513HisMet: 0.513 ± 0.024	0.629HisAsn: 0.629 ± 0.024	1.407HisPro: 1.407 ± 0.038	0.656HisGln: 0.656 ± 0.028	1.708HisArg: 1.708 ± 0.041	0.886HisSer: 0.886 ± 0.031	0.971HisThr: 0.971 ± 0.032	1.235HisVal: 1.235 ± 0.033	0.279HisTrp: 0.279 ± 0.015	0.724HisTyr: 0.724 ± 0.029	0.0HisXaa: 0.0 ± 0.0
Ile	4.961IleAla: 4.961 ± 0.07	0.797IleCys: 0.797 ± 0.028	2.744IleAsp: 2.744 ± 0.057	3.18IleGlu: 3.18 ± 0.054	2.238IlePhe: 2.238 ± 0.058	4.006IleGly: 4.006 ± 0.071	1.131IleHis: 1.131 ± 0.035	3.857IleIle: 3.857 ± 0.069	2.929IleLys: 2.929 ± 0.054	5.804IleLeu: 5.804 ± 0.086	1.48IleMet: 1.48 ± 0.036	2.315IleAsn: 2.315 ± 0.053	3.201IlePro: 3.201 ± 0.054	1.775IleGln: 1.775 ± 0.043	3.716IleArg: 3.716 ± 0.069	3.185IleSer: 3.185 ± 0.061	3.413IleThr: 3.413 ± 0.063	3.607IleVal: 3.607 ± 0.065	0.574IleTrp: 0.574 ± 0.025	1.749IleTyr: 1.749 ± 0.039	0.0IleXaa: 0.0 ± 0.0
Lys	3.81LysAla: 3.81 ± 0.066	0.425LysCys: 0.425 ± 0.026	2.293LysAsp: 2.293 ± 0.047	3.858LysGlu: 3.858 ± 0.079	1.192LysPhe: 1.192 ± 0.038	3.452LysGly: 3.452 ± 0.059	0.79LysHis: 0.79 ± 0.025	2.959LysIle: 2.959 ± 0.065	2.899LysLys: 2.899 ± 0.07	3.995LysLeu: 3.995 ± 0.061	1.323LysMet: 1.323 ± 0.035	1.751LysAsn: 1.751 ± 0.05	2.032LysPro: 2.032 ± 0.049	1.627LysGln: 1.627 ± 0.044	2.557LysArg: 2.557 ± 0.05	1.931LysSer: 1.931 ± 0.044	2.375LysThr: 2.375 ± 0.048	3.436LysVal: 3.436 ± 0.072	0.462LysTrp: 0.462 ± 0.024	1.4LysTyr: 1.4 ± 0.038	0.0LysXaa: 0.0 ± 0.0
Leu	12.233LeuAla: 12.233 ± 0.125	1.217LeuCys: 1.217 ± 0.039	5.227LeuAsp: 5.227 ± 0.069	7.429LeuGlu: 7.429 ± 0.103	3.955LeuPhe: 3.955 ± 0.066	8.132LeuGly: 8.132 ± 0.107	1.97LeuHis: 1.97 ± 0.049	5.124LeuIle: 5.124 ± 0.083	5.266LeuLys: 5.266 ± 0.074	11.223LeuLeu: 11.223 ± 0.126	2.304LeuMet: 2.304 ± 0.047	3.297LeuAsn: 3.297 ± 0.06	5.704LeuPro: 5.704 ± 0.082	3.722LeuGln: 3.722 ± 0.072	6.079LeuArg: 6.079 ± 0.101	5.804LeuSer: 5.804 ± 0.077	5.428LeuThr: 5.428 ± 0.084	8.956LeuVal: 8.956 ± 0.1	1.043LeuTrp: 1.043 ± 0.031	2.749LeuTyr: 2.749 ± 0.052	0.0LeuXaa: 0.0 ± 0.0
Met	2.851MetAla: 2.851 ± 0.059	0.235MetCys: 0.235 ± 0.017	1.427MetAsp: 1.427 ± 0.042	1.968MetGlu: 1.968 ± 0.044	0.755MetPhe: 0.755 ± 0.028	2.167MetGly: 2.167 ± 0.048	0.442MetHis: 0.442 ± 0.021	1.363MetIle: 1.363 ± 0.04	1.206MetLys: 1.206 ± 0.035	2.381MetLeu: 2.381 ± 0.048	0.565MetMet: 0.565 ± 0.026	0.784MetAsn: 0.784 ± 0.027	1.267MetPro: 1.267 ± 0.038	0.817MetGln: 0.817 ± 0.027	1.435MetArg: 1.435 ± 0.035	1.2MetSer: 1.2 ± 0.033	1.227MetThr: 1.227 ± 0.033	2.273MetVal: 2.273 ± 0.052	0.196MetTrp: 0.196 ± 0.013	0.496MetTyr: 0.496 ± 0.023	0.0MetXaa: 0.0 ± 0.0
Asn	2.379AsnAla: 2.379 ± 0.048	0.417AsnCys: 0.417 ± 0.021	1.241AsnAsp: 1.241 ± 0.037	1.568AsnGlu: 1.568 ± 0.039	1.114AsnPhe: 1.114 ± 0.031	2.436AsnGly: 2.436 ± 0.055	0.62AsnHis: 0.62 ± 0.025	2.047AsnIle: 2.047 ± 0.052	1.314AsnLys: 1.314 ± 0.037	3.519AsnLeu: 3.519 ± 0.067	0.782AsnMet: 0.782 ± 0.028	1.147AsnAsn: 1.147 ± 0.044	2.15AsnPro: 2.15 ± 0.046	1.088AsnGln: 1.088 ± 0.034	2.326AsnArg: 2.326 ± 0.056	1.328AsnSer: 1.328 ± 0.039	1.473AsnThr: 1.473 ± 0.04	2.105AsnVal: 2.105 ± 0.053	0.357AsnTrp: 0.357 ± 0.018	0.992AsnTyr: 0.992 ± 0.034	0.0AsnXaa: 0.0 ± 0.0
Pro	5.536ProAla: 5.536 ± 0.079	0.515ProCys: 0.515 ± 0.026	2.837ProAsp: 2.837 ± 0.058	4.268ProGlu: 4.268 ± 0.068	1.825ProPhe: 1.825 ± 0.046	5.847ProGly: 5.847 ± 0.097	0.957ProHis: 0.957 ± 0.031	1.62ProIle: 1.62 ± 0.039	1.308ProLys: 1.308 ± 0.042	4.757ProLeu: 4.757 ± 0.076	0.884ProMet: 0.884 ± 0.029	1.107ProAsn: 1.107 ± 0.033	2.718ProPro: 2.718 ± 0.06	1.389ProGln: 1.389 ± 0.042	3.158ProArg: 3.158 ± 0.058	1.981ProSer: 1.981 ± 0.045	1.75ProThr: 1.75 ± 0.041	5.437ProVal: 5.437 ± 0.079	0.582ProTrp: 0.582 ± 0.029	1.379ProTyr: 1.379 ± 0.037	0.0ProXaa: 0.0 ± 0.0
Gln	3.45GlnAla: 3.45 ± 0.066	0.366GlnCys: 0.366 ± 0.021	1.364GlnAsp: 1.364 ± 0.035	2.854GlnGlu: 2.854 ± 0.058	1.099GlnPhe: 1.099 ± 0.034	2.467GlnGly: 2.467 ± 0.051	0.54GlnHis: 0.54 ± 0.022	1.897GlnIle: 1.897 ± 0.038	2.058GlnLys: 2.058 ± 0.047	3.39GlnLeu: 3.39 ± 0.065	0.974GlnMet: 0.974 ± 0.032	1.1GlnAsn: 1.1 ± 0.036	1.521GlnPro: 1.521 ± 0.04	1.47GlnGln: 1.47 ± 0.043	2.135GlnArg: 2.135 ± 0.052	1.354GlnSer: 1.354 ± 0.034	1.442GlnThr: 1.442 ± 0.035	3.353GlnVal: 3.353 ± 0.064	0.414GlnTrp: 0.414 ± 0.022	0.87GlnTyr: 0.87 ± 0.03	0.0GlnXaa: 0.0 ± 0.0
Arg	6.207ArgAla: 6.207 ± 0.085	0.863ArgCys: 0.863 ± 0.031	3.471ArgAsp: 3.471 ± 0.06	6.695ArgGlu: 6.695 ± 0.102	2.496ArgPhe: 2.496 ± 0.052	5.148ArgGly: 5.148 ± 0.08	1.562ArgHis: 1.562 ± 0.041	3.695ArgIle: 3.695 ± 0.056	2.861ArgLys: 2.861 ± 0.052	7.929ArgLeu: 7.929 ± 0.116	1.702ArgMet: 1.702 ± 0.037	1.84ArgAsn: 1.84 ± 0.046	3.293ArgPro: 3.293 ± 0.066	3.232ArgGln: 3.232 ± 0.071	5.744ArgArg: 5.744 ± 0.097	2.764ArgSer: 2.764 ± 0.051	2.91ArgThr: 2.91 ± 0.056	6.04ArgVal: 6.04 ± 0.093	0.847ArgTrp: 0.847 ± 0.029	2.244ArgTyr: 2.244 ± 0.048	0.0ArgXaa: 0.0 ± 0.0
Ser	3.714SerAla: 3.714 ± 0.067	0.694SerCys: 0.694 ± 0.027	1.848SerAsp: 1.848 ± 0.04	2.23SerGlu: 2.23 ± 0.053	1.948SerPhe: 1.948 ± 0.043	4.676SerGly: 4.676 ± 0.078	0.986SerHis: 0.986 ± 0.031	2.562SerIle: 2.562 ± 0.057	1.58SerLys: 1.58 ± 0.046	5.511SerLeu: 5.511 ± 0.079	1.142SerMet: 1.142 ± 0.036	1.186SerAsn: 1.186 ± 0.041	2.806SerPro: 2.806 ± 0.053	1.416SerGln: 1.416 ± 0.039	3.911SerArg: 3.911 ± 0.076	2.434SerSer: 2.434 ± 0.058	2.301SerThr: 2.301 ± 0.052	3.066SerVal: 3.066 ± 0.058	0.606SerTrp: 0.606 ± 0.027	1.39SerTyr: 1.39 ± 0.039	0.0SerXaa: 0.0 ± 0.0
Thr	4.88ThrAla: 4.88 ± 0.082	0.608ThrCys: 0.608 ± 0.025	2.113ThrAsp: 2.113 ± 0.052	2.388ThrGlu: 2.388 ± 0.052	1.818ThrPhe: 1.818 ± 0.042	5.971ThrGly: 5.971 ± 0.086	0.893ThrHis: 0.893 ± 0.028	2.842ThrIle: 2.842 ± 0.054	1.31ThrLys: 1.31 ± 0.044	4.977ThrLeu: 4.977 ± 0.076	1.136ThrMet: 1.136 ± 0.032	1.315ThrAsn: 1.315 ± 0.039	2.707ThrPro: 2.707 ± 0.056	1.013ThrGln: 1.013 ± 0.033	3.315ThrArg: 3.315 ± 0.061	2.16ThrSer: 2.16 ± 0.046	2.487ThrThr: 2.487 ± 0.063	4.518ThrVal: 4.518 ± 0.07	0.469ThrTrp: 0.469 ± 0.022	1.261ThrTyr: 1.261 ± 0.036	0.0ThrXaa: 0.0 ± 0.0
Val	7.891ValAla: 7.891 ± 0.104	1.014ValCys: 1.014 ± 0.031	4.441ValAsp: 4.441 ± 0.064	5.927ValGlu: 5.927 ± 0.092	2.888ValPhe: 2.888 ± 0.058	5.463ValGly: 5.463 ± 0.072	1.545ValHis: 1.545 ± 0.043	4.925ValIle: 4.925 ± 0.074	3.689ValLys: 3.689 ± 0.07	8.525ValLeu: 8.525 ± 0.095	1.947ValMet: 1.947 ± 0.044	2.686ValAsn: 2.686 ± 0.058	3.985ValPro: 3.985 ± 0.068	2.607ValGln: 2.607 ± 0.051	5.233ValArg: 5.233 ± 0.093	4.121ValSer: 4.121 ± 0.065	4.512ValThr: 4.512 ± 0.086	7.424ValVal: 7.424 ± 0.104	0.708ValTrp: 0.708 ± 0.027	2.356ValTyr: 2.356 ± 0.044	0.0ValXaa: 0.0 ± 0.0
Trp	0.879TrpAla: 0.879 ± 0.03	0.129TrpCys: 0.129 ± 0.013	0.504TrpAsp: 0.504 ± 0.027	0.815TrpGlu: 0.815 ± 0.029	0.395TrpPhe: 0.395 ± 0.021	0.84TrpGly: 0.84 ± 0.03	0.236TrpHis: 0.236 ± 0.015	0.536TrpIle: 0.536 ± 0.024	0.425TrpLys: 0.425 ± 0.021	1.378TrpLeu: 1.378 ± 0.045	0.268TrpMet: 0.268 ± 0.015	0.345TrpAsn: 0.345 ± 0.019	0.626TrpPro: 0.626 ± 0.028	0.575TrpGln: 0.575 ± 0.023	0.788TrpArg: 0.788 ± 0.029	0.517TrpSer: 0.517 ± 0.025	0.409TrpThr: 0.409 ± 0.021	0.737TrpVal: 0.737 ± 0.029	0.169TrpTrp: 0.169 ± 0.013	0.326TrpTyr: 0.326 ± 0.018	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.346TyrAla: 2.346 ± 0.044	0.433TyrCys: 0.433 ± 0.018	1.494TyrAsp: 1.494 ± 0.042	1.503TyrGlu: 1.503 ± 0.04	1.197TyrPhe: 1.197 ± 0.038	2.511TyrGly: 2.511 ± 0.051	0.77TyrHis: 0.77 ± 0.029	1.543TyrIle: 1.543 ± 0.042	0.989TyrLys: 0.989 ± 0.033	3.428TyrLeu: 3.428 ± 0.065	0.537TyrMet: 0.537 ± 0.024	1.007TyrAsn: 1.007 ± 0.035	1.559TyrPro: 1.559 ± 0.044	1.136TyrGln: 1.136 ± 0.035	2.711TyrArg: 2.711 ± 0.053	1.393TyrSer: 1.393 ± 0.038	1.469TyrThr: 1.469 ± 0.037	1.887TyrVal: 1.887 ± 0.044	0.358TyrTrp: 0.358 ± 0.017	1.028TyrTyr: 1.028 ± 0.029	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3512 proteins (1013857 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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