Amino acid dipepetide frequency for Piromyces finnis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	2.123AlaAla: 2.123 ± 0.037	0.669AlaCys: 0.669 ± 0.022	1.76AlaAsp: 1.76 ± 0.024	2.273AlaGlu: 2.273 ± 0.031	1.621AlaPhe: 1.621 ± 0.018	1.584AlaGly: 1.584 ± 0.026	0.561AlaHis: 0.561 ± 0.01	3.286AlaIle: 3.286 ± 0.035	3.048AlaLys: 3.048 ± 0.031	3.586AlaLeu: 3.586 ± 0.035	0.81AlaMet: 0.81 ± 0.014	2.644AlaAsn: 2.644 ± 0.026	1.291AlaPro: 1.291 ± 0.034	1.26AlaGln: 1.26 ± 0.018	1.225AlaArg: 1.225 ± 0.018	3.089AlaSer: 3.089 ± 0.03	2.232AlaThr: 2.232 ± 0.029	1.974AlaVal: 1.974 ± 0.024	0.292AlaTrp: 0.292 ± 0.009	1.441AlaTyr: 1.441 ± 0.019	0.0AlaXaa: 0.0 ± 0.0
Cys	0.486CysAla: 0.486 ± 0.013	0.476CysCys: 0.476 ± 0.013	0.768CysAsp: 0.768 ± 0.015	0.862CysGlu: 0.862 ± 0.018	0.632CysPhe: 0.632 ± 0.012	0.908CysGly: 0.908 ± 0.025	0.312CysHis: 0.312 ± 0.009	1.267CysIle: 1.267 ± 0.018	1.21CysLys: 1.21 ± 0.019	1.21CysLeu: 1.21 ± 0.019	0.268CysMet: 0.268 ± 0.01	1.088CysAsn: 1.088 ± 0.018	0.578CysPro: 0.578 ± 0.021	0.591CysGln: 0.591 ± 0.014	0.483CysArg: 0.483 ± 0.011	1.284CysSer: 1.284 ± 0.029	0.72CysThr: 0.72 ± 0.016	0.674CysVal: 0.674 ± 0.013	0.16CysTrp: 0.16 ± 0.006	0.664CysTyr: 0.664 ± 0.014	0.0CysXaa: 0.0 ± 0.0
Asp	2.008AspAla: 2.008 ± 0.032	0.745AspCys: 0.745 ± 0.013	4.685AspAsp: 4.685 ± 0.059	5.049AspGlu: 5.049 ± 0.051	2.569AspPhe: 2.569 ± 0.024	2.332AspGly: 2.332 ± 0.028	0.869AspHis: 0.869 ± 0.014	5.888AspIle: 5.888 ± 0.047	4.542AspLys: 4.542 ± 0.037	4.367AspLeu: 4.367 ± 0.031	1.055AspMet: 1.055 ± 0.014	5.629AspAsn: 5.629 ± 0.051	1.68AspPro: 1.68 ± 0.021	1.524AspGln: 1.524 ± 0.019	1.591AspArg: 1.591 ± 0.031	4.561AspSer: 4.561 ± 0.043	2.746AspThr: 2.746 ± 0.024	2.68AspVal: 2.68 ± 0.026	0.478AspTrp: 0.478 ± 0.011	2.738AspTyr: 2.738 ± 0.027	0.0AspXaa: 0.0 ± 0.0
Glu	2.698GluAla: 2.698 ± 0.028	0.962GluCys: 0.962 ± 0.017	4.523GluAsp: 4.523 ± 0.044	7.923GluGlu: 7.923 ± 0.103	2.703GluPhe: 2.703 ± 0.025	2.327GluGly: 2.327 ± 0.027	0.96GluHis: 0.96 ± 0.016	6.704GluIle: 6.704 ± 0.056	8.209GluLys: 8.209 ± 0.086	5.962GluLeu: 5.962 ± 0.055	1.553GluMet: 1.553 ± 0.02	7.822GluAsn: 7.822 ± 0.082	1.689GluPro: 1.689 ± 0.025	2.412GluGln: 2.412 ± 0.04	2.467GluArg: 2.467 ± 0.033	5.021GluSer: 5.021 ± 0.046	3.48GluThr: 3.48 ± 0.035	3.143GluVal: 3.143 ± 0.032	0.63GluTrp: 0.63 ± 0.012	3.063GluTyr: 3.063 ± 0.033	0.0GluXaa: 0.0 ± 0.0
Phe	1.39PheAla: 1.39 ± 0.018	0.623PheCys: 0.623 ± 0.012	2.658PheAsp: 2.658 ± 0.026	2.689PheGlu: 2.689 ± 0.023	1.887PhePhe: 1.887 ± 0.021	2.083PheGly: 2.083 ± 0.034	0.762PheHis: 0.762 ± 0.012	3.899PheIle: 3.899 ± 0.039	3.334PheLys: 3.334 ± 0.029	3.46PheLeu: 3.46 ± 0.032	0.852PheMet: 0.852 ± 0.015	3.785PheAsn: 3.785 ± 0.029	1.342PhePro: 1.342 ± 0.02	1.327PheGln: 1.327 ± 0.017	1.19PheArg: 1.19 ± 0.015	3.734PheSer: 3.734 ± 0.035	2.051PheThr: 2.051 ± 0.023	1.938PheVal: 1.938 ± 0.02	0.33PheTrp: 0.33 ± 0.008	1.871PheTyr: 1.871 ± 0.023	0.0PheXaa: 0.0 ± 0.0
Gly	1.699GlyAla: 1.699 ± 0.029	0.681GlyCys: 0.681 ± 0.021	2.073GlyAsp: 2.073 ± 0.026	2.371GlyGlu: 2.371 ± 0.027	1.82GlyPhe: 1.82 ± 0.022	2.218GlyGly: 2.218 ± 0.04	0.826GlyHis: 0.826 ± 0.022	3.408GlyIle: 3.408 ± 0.032	3.502GlyLys: 3.502 ± 0.039	2.988GlyLeu: 2.988 ± 0.033	0.877GlyMet: 0.877 ± 0.018	3.481GlyAsn: 3.481 ± 0.035	1.019GlyPro: 1.019 ± 0.019	1.226GlyGln: 1.226 ± 0.018	1.44GlyArg: 1.44 ± 0.024	3.273GlySer: 3.273 ± 0.036	1.999GlyThr: 1.999 ± 0.026	2.065GlyVal: 2.065 ± 0.026	0.468GlyTrp: 0.468 ± 0.012	2.069GlyTyr: 2.069 ± 0.03	0.0GlyXaa: 0.0 ± 0.0
His	0.566HisAla: 0.566 ± 0.011	0.324HisCys: 0.324 ± 0.01	0.861HisAsp: 0.861 ± 0.012	1.018HisGlu: 1.018 ± 0.015	0.819HisPhe: 0.819 ± 0.012	0.76HisGly: 0.76 ± 0.017	0.658HisHis: 0.658 ± 0.023	1.369HisIle: 1.369 ± 0.016	1.182HisLys: 1.182 ± 0.015	1.558HisLeu: 1.558 ± 0.02	0.311HisMet: 0.311 ± 0.008	1.272HisAsn: 1.272 ± 0.016	0.793HisPro: 0.793 ± 0.014	0.71HisGln: 0.71 ± 0.014	0.643HisArg: 0.643 ± 0.013	1.619HisSer: 1.619 ± 0.024	0.756HisThr: 0.756 ± 0.013	0.683HisVal: 0.683 ± 0.012	0.17HisTrp: 0.17 ± 0.005	0.873HisTyr: 0.873 ± 0.013	0.0HisXaa: 0.0 ± 0.0
Ile	3.089IleAla: 3.089 ± 0.029	1.236IleCys: 1.236 ± 0.018	5.35IleAsp: 5.35 ± 0.049	6.407IleGlu: 6.407 ± 0.066	3.668IlePhe: 3.668 ± 0.04	3.115IleGly: 3.115 ± 0.034	1.585IleHis: 1.585 ± 0.02	7.921IleIle: 7.921 ± 0.069	8.104IleLys: 8.104 ± 0.052	7.095IleLeu: 7.095 ± 0.054	1.606IleMet: 1.606 ± 0.018	9.098IleAsn: 9.098 ± 0.077	3.764IlePro: 3.764 ± 0.036	3.156IleGln: 3.156 ± 0.028	2.556IleArg: 2.556 ± 0.024	7.326IleSer: 7.326 ± 0.045	4.467IleThr: 4.467 ± 0.032	3.833IleVal: 3.833 ± 0.032	0.58IleTrp: 0.58 ± 0.011	3.71IleTyr: 3.71 ± 0.037	0.0IleXaa: 0.0 ± 0.0
Lys	3.306LysAla: 3.306 ± 0.033	1.322LysCys: 1.322 ± 0.026	5.31LysAsp: 5.31 ± 0.036	8.334LysGlu: 8.334 ± 0.062	3.117LysPhe: 3.117 ± 0.025	2.9LysGly: 2.9 ± 0.029	1.429LysHis: 1.429 ± 0.015	7.425LysIle: 7.425 ± 0.049	10.132LysLys: 10.132 ± 0.071	7.305LysLeu: 7.305 ± 0.051	1.775LysMet: 1.775 ± 0.019	8.842LysAsn: 8.842 ± 0.068	2.636LysPro: 2.636 ± 0.028	3.067LysGln: 3.067 ± 0.045	3.465LysArg: 3.465 ± 0.031	7.002LysSer: 7.002 ± 0.052	4.707LysThr: 4.707 ± 0.045	3.759LysVal: 3.759 ± 0.029	0.639LysTrp: 0.639 ± 0.011	4.344LysTyr: 4.344 ± 0.039	0.0LysXaa: 0.0 ± 0.0
Leu	3.13LeuAla: 3.13 ± 0.032	1.271LeuCys: 1.271 ± 0.016	4.217LeuAsp: 4.217 ± 0.029	5.501LeuGlu: 5.501 ± 0.056	3.818LeuPhe: 3.818 ± 0.034	2.968LeuGly: 2.968 ± 0.032	1.371LeuHis: 1.371 ± 0.019	6.946LeuIle: 6.946 ± 0.06	7.985LeuLys: 7.985 ± 0.06	7.735LeuLeu: 7.735 ± 0.067	1.75LeuMet: 1.75 ± 0.024	7.538LeuAsn: 7.538 ± 0.059	3.28LeuPro: 3.28 ± 0.044	2.901LeuGln: 2.901 ± 0.031	2.733LeuArg: 2.733 ± 0.026	7.337LeuSer: 7.337 ± 0.055	4.227LeuThr: 4.227 ± 0.032	3.517LeuVal: 3.517 ± 0.03	0.643LeuTrp: 0.643 ± 0.012	3.598LeuTyr: 3.598 ± 0.034	0.0LeuXaa: 0.0 ± 0.0
Met	0.954MetAla: 0.954 ± 0.015	0.212MetCys: 0.212 ± 0.007	1.368MetAsp: 1.368 ± 0.015	1.638MetGlu: 1.638 ± 0.022	0.732MetPhe: 0.732 ± 0.012	0.811MetGly: 0.811 ± 0.014	0.263MetHis: 0.263 ± 0.008	1.494MetIle: 1.494 ± 0.017	2.042MetLys: 2.042 ± 0.019	1.392MetLeu: 1.392 ± 0.018	0.501MetMet: 0.501 ± 0.01	2.354MetAsn: 2.354 ± 0.047	0.665MetPro: 0.665 ± 0.014	0.56MetGln: 0.56 ± 0.012	0.573MetArg: 0.573 ± 0.012	1.508MetSer: 1.508 ± 0.016	1.013MetThr: 1.013 ± 0.015	0.964MetVal: 0.964 ± 0.013	0.118MetTrp: 0.118 ± 0.005	0.771MetTyr: 0.771 ± 0.013	0.0MetXaa: 0.0 ± 0.0
Asn	2.971AsnAla: 2.971 ± 0.028	1.119AsnCys: 1.119 ± 0.018	6.303AsnAsp: 6.303 ± 0.057	7.767AsnGlu: 7.767 ± 0.1	3.212AsnPhe: 3.212 ± 0.031	3.884AsnGly: 3.884 ± 0.037	1.488AsnHis: 1.488 ± 0.021	9.01AsnIle: 9.01 ± 0.076	8.702AsnLys: 8.702 ± 0.072	6.681AsnLeu: 6.681 ± 0.061	1.915AsnMet: 1.915 ± 0.041	15.286AsnAsn: 15.286 ± 0.23	2.776AsnPro: 2.776 ± 0.03	3.35AsnGln: 3.35 ± 0.041	2.438AsnArg: 2.438 ± 0.03	8.815AsnSer: 8.815 ± 0.085	5.264AsnThr: 5.264 ± 0.043	3.931AsnVal: 3.931 ± 0.029	0.569AsnTrp: 0.569 ± 0.012	4.167AsnTyr: 4.167 ± 0.044	0.0AsnXaa: 0.0 ± 0.0
Pro	1.257ProAla: 1.257 ± 0.025	0.392ProCys: 0.392 ± 0.012	1.592ProAsp: 1.592 ± 0.02	2.566ProGlu: 2.566 ± 0.038	1.47ProPhe: 1.47 ± 0.02	1.226ProGly: 1.226 ± 0.02	0.518ProHis: 0.518 ± 0.01	2.971ProIle: 2.971 ± 0.03	2.785ProLys: 2.785 ± 0.027	3.048ProLeu: 3.048 ± 0.033	0.68ProMet: 0.68 ± 0.017	2.637ProAsn: 2.637 ± 0.03	1.967ProPro: 1.967 ± 0.066	1.302ProGln: 1.302 ± 0.025	0.987ProArg: 0.987 ± 0.023	3.331ProSer: 3.331 ± 0.042	2.27ProThr: 2.27 ± 0.034	1.938ProVal: 1.938 ± 0.037	0.249ProTrp: 0.249 ± 0.008	1.456ProTyr: 1.456 ± 0.021	0.0ProXaa: 0.0 ± 0.0
Gln	1.271GlnAla: 1.271 ± 0.019	0.552GlnCys: 0.552 ± 0.014	1.571GlnAsp: 1.571 ± 0.018	2.468GlnGlu: 2.468 ± 0.033	1.402GlnPhe: 1.402 ± 0.018	1.193GlnGly: 1.193 ± 0.026	0.612GlnHis: 0.612 ± 0.012	2.614GlnIle: 2.614 ± 0.025	3.139GlnLys: 3.139 ± 0.028	3.167GlnLeu: 3.167 ± 0.038	0.787GlnMet: 0.787 ± 0.013	3.37GlnAsn: 3.37 ± 0.044	1.299GlnPro: 1.299 ± 0.029	2.455GlnGln: 2.455 ± 0.073	1.219GlnArg: 1.219 ± 0.018	2.658GlnSer: 2.658 ± 0.028	1.69GlnThr: 1.69 ± 0.019	1.395GlnVal: 1.395 ± 0.018	0.372GlnTrp: 0.372 ± 0.011	1.718GlnTyr: 1.718 ± 0.021	0.0GlnXaa: 0.0 ± 0.0
Arg	1.213ArgAla: 1.213 ± 0.02	0.483ArgCys: 0.483 ± 0.012	1.738ArgAsp: 1.738 ± 0.047	2.155ArgGlu: 2.155 ± 0.034	1.313ArgPhe: 1.313 ± 0.016	1.245ArgGly: 1.245 ± 0.021	0.632ArgHis: 0.632 ± 0.013	2.661ArgIle: 2.661 ± 0.024	3.285ArgLys: 3.285 ± 0.032	2.6ArgLeu: 2.6 ± 0.029	0.685ArgMet: 0.685 ± 0.012	2.844ArgAsn: 2.844 ± 0.031	0.964ArgPro: 0.964 ± 0.018	1.101ArgGln: 1.101 ± 0.016	1.687ArgArg: 1.687 ± 0.028	2.516ArgSer: 2.516 ± 0.034	1.479ArgThr: 1.479 ± 0.018	1.472ArgVal: 1.472 ± 0.02	0.263ArgTrp: 0.263 ± 0.007	1.414ArgTyr: 1.414 ± 0.018	0.0ArgXaa: 0.0 ± 0.0
Ser	2.712SerAla: 2.712 ± 0.031	1.089SerCys: 1.089 ± 0.021	4.386SerAsp: 4.386 ± 0.032	5.176SerGlu: 5.176 ± 0.047	3.918SerPhe: 3.918 ± 0.036	3.3SerGly: 3.3 ± 0.038	1.454SerHis: 1.454 ± 0.022	7.624SerIle: 7.624 ± 0.054	7.218SerLys: 7.218 ± 0.055	7.469SerLeu: 7.469 ± 0.057	1.617SerMet: 1.617 ± 0.021	8.626SerAsn: 8.626 ± 0.082	3.039SerPro: 3.039 ± 0.045	2.958SerGln: 2.958 ± 0.032	2.621SerArg: 2.621 ± 0.037	10.159SerSer: 10.159 ± 0.129	5.148SerThr: 5.148 ± 0.051	3.685SerVal: 3.685 ± 0.031	0.58SerTrp: 0.58 ± 0.013	3.475SerTyr: 3.475 ± 0.032	0.0SerXaa: 0.0 ± 0.0
Thr	2.054ThrAla: 2.054 ± 0.024	0.706ThrCys: 0.706 ± 0.013	2.536ThrAsp: 2.536 ± 0.025	3.497ThrGlu: 3.497 ± 0.03	2.283ThrPhe: 2.283 ± 0.023	2.21ThrGly: 2.21 ± 0.034	0.83ThrHis: 0.83 ± 0.013	4.857ThrIle: 4.857 ± 0.038	4.414ThrLys: 4.414 ± 0.036	4.581ThrLeu: 4.581 ± 0.042	0.944ThrMet: 0.944 ± 0.014	4.652ThrAsn: 4.652 ± 0.041	2.479ThrPro: 2.479 ± 0.039	1.674ThrGln: 1.674 ± 0.022	1.424ThrArg: 1.424 ± 0.02	5.084ThrSer: 5.084 ± 0.057	5.174ThrThr: 5.174 ± 0.13	2.54ThrVal: 2.54 ± 0.025	0.382ThrTrp: 0.382 ± 0.008	1.966ThrTyr: 1.966 ± 0.022	0.0ThrXaa: 0.0 ± 0.0
Val	1.966ValAla: 1.966 ± 0.031	0.706ValCys: 0.706 ± 0.013	2.785ValAsp: 2.785 ± 0.027	3.303ValGlu: 3.303 ± 0.039	1.936ValPhe: 1.936 ± 0.024	1.909ValGly: 1.909 ± 0.023	0.748ValHis: 0.748 ± 0.011	3.868ValIle: 3.868 ± 0.032	3.955ValLys: 3.955 ± 0.031	3.749ValLeu: 3.749 ± 0.032	0.894ValMet: 0.894 ± 0.014	3.872ValAsn: 3.872 ± 0.03	1.698ValPro: 1.698 ± 0.025	1.477ValGln: 1.477 ± 0.019	1.354ValArg: 1.354 ± 0.018	3.533ValSer: 3.533 ± 0.029	2.392ValThr: 2.392 ± 0.03	2.484ValVal: 2.484 ± 0.031	0.339ValTrp: 0.339 ± 0.008	1.865ValTyr: 1.865 ± 0.02	0.0ValXaa: 0.0 ± 0.0
Trp	0.34TrpAla: 0.34 ± 0.008	0.232TrpCys: 0.232 ± 0.008	0.545TrpAsp: 0.545 ± 0.012	0.484TrpGlu: 0.484 ± 0.011	0.316TrpPhe: 0.316 ± 0.008	0.425TrpGly: 0.425 ± 0.012	0.12TrpHis: 0.12 ± 0.004	0.64TrpIle: 0.64 ± 0.013	0.702TrpLys: 0.702 ± 0.014	0.627TrpLeu: 0.627 ± 0.012	0.189TrpMet: 0.189 ± 0.007	0.704TrpAsn: 0.704 ± 0.015	0.184TrpPro: 0.184 ± 0.006	0.186TrpGln: 0.186 ± 0.006	0.273TrpArg: 0.273 ± 0.007	0.556TrpSer: 0.556 ± 0.013	0.366TrpThr: 0.366 ± 0.009	0.383TrpVal: 0.383 ± 0.009	0.104TrpTrp: 0.104 ± 0.005	0.339TrpTyr: 0.339 ± 0.009	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.536TyrAla: 1.536 ± 0.02	0.843TyrCys: 0.843 ± 0.018	2.705TyrAsp: 2.705 ± 0.03	2.772TyrGlu: 2.772 ± 0.026	1.969TyrPhe: 1.969 ± 0.021	2.106TyrGly: 2.106 ± 0.028	0.946TyrHis: 0.946 ± 0.016	3.816TyrIle: 3.816 ± 0.039	3.326TyrLys: 3.326 ± 0.033	3.889TyrLeu: 3.889 ± 0.036	0.863TyrMet: 0.863 ± 0.015	4.1TyrAsn: 4.1 ± 0.039	1.501TyrPro: 1.501 ± 0.021	1.716TyrGln: 1.716 ± 0.021	1.383TyrArg: 1.383 ± 0.019	3.846TyrSer: 3.846 ± 0.04	2.105TyrThr: 2.105 ± 0.025	1.771TyrVal: 1.771 ± 0.022	0.348TyrTrp: 0.348 ± 0.008	2.461TyrTyr: 2.461 ± 0.038	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 10787 proteins (5648188 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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