Amino acid dipepetide frequency for Roseitalea porphyridii

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	17.533AlaAla: 17.533 ± 0.198	1.064AlaCys: 1.064 ± 0.033	8.343AlaAsp: 8.343 ± 0.123	8.643AlaGlu: 8.643 ± 0.104	4.976AlaPhe: 4.976 ± 0.08	12.305AlaGly: 12.305 ± 0.141	2.604AlaHis: 2.604 ± 0.059	7.34AlaIle: 7.34 ± 0.099	2.831AlaLys: 2.831 ± 0.067	14.099AlaLeu: 14.099 ± 0.152	4.028AlaMet: 4.028 ± 0.079	2.94AlaAsn: 2.94 ± 0.062	5.937AlaPro: 5.937 ± 0.089	3.611AlaGln: 3.611 ± 0.065	10.193AlaArg: 10.193 ± 0.118	5.954AlaSer: 5.954 ± 0.079	6.186AlaThr: 6.186 ± 0.098	9.209AlaVal: 9.209 ± 0.095	1.452AlaTrp: 1.452 ± 0.036	2.521AlaTyr: 2.521 ± 0.054	0.0AlaXaa: 0.0 ± 0.0
Cys	1.081CysAla: 1.081 ± 0.03	0.094CysCys: 0.094 ± 0.009	0.553CysAsp: 0.553 ± 0.024	0.473CysGlu: 0.473 ± 0.021	0.319CysPhe: 0.319 ± 0.018	0.916CysGly: 0.916 ± 0.031	0.243CysHis: 0.243 ± 0.014	0.355CysIle: 0.355 ± 0.02	0.122CysLys: 0.122 ± 0.011	0.712CysLeu: 0.712 ± 0.027	0.154CysMet: 0.154 ± 0.011	0.178CysAsn: 0.178 ± 0.014	0.429CysPro: 0.429 ± 0.021	0.189CysGln: 0.189 ± 0.014	0.578CysArg: 0.578 ± 0.027	0.394CysSer: 0.394 ± 0.022	0.416CysThr: 0.416 ± 0.02	0.612CysVal: 0.612 ± 0.026	0.096CysTrp: 0.096 ± 0.011	0.196CysTyr: 0.196 ± 0.014	0.0CysXaa: 0.0 ± 0.0
Asp	8.29AspAla: 8.29 ± 0.114	0.532AspCys: 0.532 ± 0.024	4.09AspAsp: 4.09 ± 0.073	4.173AspGlu: 4.173 ± 0.079	2.218AspPhe: 2.218 ± 0.042	5.919AspGly: 5.919 ± 0.099	1.517AspHis: 1.517 ± 0.044	3.317AspIle: 3.317 ± 0.072	1.564AspLys: 1.564 ± 0.04	6.093AspLeu: 6.093 ± 0.092	1.63AspMet: 1.63 ± 0.039	1.47AspAsn: 1.47 ± 0.042	3.835AspPro: 3.835 ± 0.063	1.76AspGln: 1.76 ± 0.042	5.202AspArg: 5.202 ± 0.08	1.82AspSer: 1.82 ± 0.042	2.892AspThr: 2.892 ± 0.067	4.364AspVal: 4.364 ± 0.08	1.051AspTrp: 1.051 ± 0.032	1.469AspTyr: 1.469 ± 0.039	0.0AspXaa: 0.0 ± 0.0
Glu	8.53GluAla: 8.53 ± 0.109	0.321GluCys: 0.321 ± 0.018	3.244GluAsp: 3.244 ± 0.062	3.381GluGlu: 3.381 ± 0.073	1.701GluPhe: 1.701 ± 0.042	4.745GluGly: 4.745 ± 0.086	1.198GluHis: 1.198 ± 0.039	3.481GluIle: 3.481 ± 0.059	1.996GluLys: 1.996 ± 0.064	5.091GluLeu: 5.091 ± 0.078	1.67GluMet: 1.67 ± 0.049	1.569GluAsn: 1.569 ± 0.042	3.324GluPro: 3.324 ± 0.064	2.1GluGln: 2.1 ± 0.047	5.501GluArg: 5.501 ± 0.086	2.108GluSer: 2.108 ± 0.04	4.355GluThr: 4.355 ± 0.078	3.67GluVal: 3.67 ± 0.062	0.64GluTrp: 0.64 ± 0.025	0.94GluTyr: 0.94 ± 0.033	0.0GluXaa: 0.0 ± 0.0
Phe	5.16PheAla: 5.16 ± 0.082	0.385PheCys: 0.385 ± 0.022	2.971PheAsp: 2.971 ± 0.052	2.383PheGlu: 2.383 ± 0.042	1.543PhePhe: 1.543 ± 0.048	4.002PheGly: 4.002 ± 0.06	0.73PheHis: 0.73 ± 0.024	1.817PheIle: 1.817 ± 0.038	0.774PheLys: 0.774 ± 0.029	3.284PheLeu: 3.284 ± 0.066	0.907PheMet: 0.907 ± 0.03	0.949PheAsn: 0.949 ± 0.03	1.523PhePro: 1.523 ± 0.04	0.867PheGln: 0.867 ± 0.03	2.247PheArg: 2.247 ± 0.052	2.071PheSer: 2.071 ± 0.046	2.014PheThr: 2.014 ± 0.039	3.081PheVal: 3.081 ± 0.062	0.56PheTrp: 0.56 ± 0.023	0.818PheTyr: 0.818 ± 0.03	0.0PheXaa: 0.0 ± 0.0
Gly	10.81GlyAla: 10.81 ± 0.144	0.778GlyCys: 0.778 ± 0.03	5.138GlyAsp: 5.138 ± 0.1	5.388GlyGlu: 5.388 ± 0.084	3.801GlyPhe: 3.801 ± 0.056	7.851GlyGly: 7.851 ± 0.196	2.095GlyHis: 2.095 ± 0.047	4.574GlyIle: 4.574 ± 0.076	2.717GlyLys: 2.717 ± 0.055	8.884GlyLeu: 8.884 ± 0.104	2.415GlyMet: 2.415 ± 0.051	2.131GlyAsn: 2.131 ± 0.065	3.828GlyPro: 3.828 ± 0.062	2.864GlyGln: 2.864 ± 0.052	6.7GlyArg: 6.7 ± 0.087	4.231GlySer: 4.231 ± 0.081	5.066GlyThr: 5.066 ± 0.109	6.3GlyVal: 6.3 ± 0.075	1.335GlyTrp: 1.335 ± 0.039	2.255GlyTyr: 2.255 ± 0.047	0.0GlyXaa: 0.0 ± 0.0
His	2.613HisAla: 2.613 ± 0.061	0.246HisCys: 0.246 ± 0.014	1.421HisAsp: 1.421 ± 0.042	1.173HisGlu: 1.173 ± 0.033	0.839HisPhe: 0.839 ± 0.027	2.132HisGly: 2.132 ± 0.044	0.609HisHis: 0.609 ± 0.031	0.941HisIle: 0.941 ± 0.029	0.472HisLys: 0.472 ± 0.022	1.981HisLeu: 1.981 ± 0.048	0.559HisMet: 0.559 ± 0.026	0.456HisAsn: 0.456 ± 0.02	1.242HisPro: 1.242 ± 0.036	0.528HisGln: 0.528 ± 0.023	1.538HisArg: 1.538 ± 0.039	0.785HisSer: 0.785 ± 0.029	0.92HisThr: 0.92 ± 0.031	1.743HisVal: 1.743 ± 0.038	0.297HisTrp: 0.297 ± 0.015	0.543HisTyr: 0.543 ± 0.023	0.0HisXaa: 0.0 ± 0.0
Ile	8.514IleAla: 8.514 ± 0.096	0.523IleCys: 0.523 ± 0.025	4.044IleAsp: 4.044 ± 0.065	3.848IleGlu: 3.848 ± 0.069	1.693IlePhe: 1.693 ± 0.043	5.42IleGly: 5.42 ± 0.087	0.892IleHis: 0.892 ± 0.027	2.432IleIle: 2.432 ± 0.048	1.173IleLys: 1.173 ± 0.038	3.959IleLeu: 3.959 ± 0.065	1.075IleMet: 1.075 ± 0.033	1.407IleAsn: 1.407 ± 0.044	2.07IlePro: 2.07 ± 0.057	0.972IleGln: 0.972 ± 0.036	3.158IleArg: 3.158 ± 0.057	2.441IleSer: 2.441 ± 0.053	2.66IleThr: 2.66 ± 0.069	5.028IleVal: 5.028 ± 0.079	0.577IleTrp: 0.577 ± 0.024	1.034IleTyr: 1.034 ± 0.034	0.0IleXaa: 0.0 ± 0.0
Lys	3.635LysAla: 3.635 ± 0.077	0.142LysCys: 0.142 ± 0.012	1.316LysAsp: 1.316 ± 0.041	1.06LysGlu: 1.06 ± 0.04	0.672LysPhe: 0.672 ± 0.027	2.205LysGly: 2.205 ± 0.052	0.515LysHis: 0.515 ± 0.024	1.255LysIle: 1.255 ± 0.039	0.994LysLys: 0.994 ± 0.04	2.439LysLeu: 2.439 ± 0.058	0.643LysMet: 0.643 ± 0.027	0.645LysAsn: 0.645 ± 0.027	1.679LysPro: 1.679 ± 0.046	0.781LysGln: 0.781 ± 0.027	2.207LysArg: 2.207 ± 0.049	1.407LysSer: 1.407 ± 0.043	1.64LysThr: 1.64 ± 0.047	1.886LysVal: 1.886 ± 0.046	0.314LysTrp: 0.314 ± 0.019	0.456LysTyr: 0.456 ± 0.018	0.0LysXaa: 0.0 ± 0.0
Leu	13.314LeuAla: 13.314 ± 0.15	0.813LeuCys: 0.813 ± 0.028	6.236LeuAsp: 6.236 ± 0.081	5.457LeuGlu: 5.457 ± 0.083	3.742LeuPhe: 3.742 ± 0.071	7.957LeuGly: 7.957 ± 0.097	1.697LeuHis: 1.697 ± 0.046	5.138LeuIle: 5.138 ± 0.083	2.756LeuLys: 2.756 ± 0.065	7.961LeuLeu: 7.961 ± 0.128	2.291LeuMet: 2.291 ± 0.051	2.282LeuAsn: 2.282 ± 0.042	4.966LeuPro: 4.966 ± 0.085	2.255LeuGln: 2.255 ± 0.051	6.322LeuArg: 6.322 ± 0.082	5.677LeuSer: 5.677 ± 0.084	5.531LeuThr: 5.531 ± 0.07	7.557LeuVal: 7.557 ± 0.09	1.058LeuTrp: 1.058 ± 0.035	2.003LeuTyr: 2.003 ± 0.048	0.0LeuXaa: 0.0 ± 0.0
Met	3.726MetAla: 3.726 ± 0.067	0.158MetCys: 0.158 ± 0.013	1.35MetAsp: 1.35 ± 0.04	1.249MetGlu: 1.249 ± 0.036	0.791MetPhe: 0.791 ± 0.029	1.944MetGly: 1.944 ± 0.045	0.5MetHis: 0.5 ± 0.023	1.506MetIle: 1.506 ± 0.043	0.911MetLys: 0.911 ± 0.031	2.498MetLeu: 2.498 ± 0.06	0.718MetMet: 0.718 ± 0.032	0.827MetAsn: 0.827 ± 0.029	1.56MetPro: 1.56 ± 0.039	0.797MetGln: 0.797 ± 0.026	2.013MetArg: 2.013 ± 0.049	1.64MetSer: 1.64 ± 0.036	1.916MetThr: 1.916 ± 0.04	1.919MetVal: 1.919 ± 0.045	0.2MetTrp: 0.2 ± 0.015	0.286MetTyr: 0.286 ± 0.018	0.0MetXaa: 0.0 ± 0.0
Asn	3.309AsnAla: 3.309 ± 0.064	0.201AsnCys: 0.201 ± 0.014	1.4AsnAsp: 1.4 ± 0.034	1.295AsnGlu: 1.295 ± 0.037	0.86AsnPhe: 0.86 ± 0.03	2.346AsnGly: 2.346 ± 0.058	0.502AsnHis: 0.502 ± 0.022	1.239AsnIle: 1.239 ± 0.039	0.556AsnLys: 0.556 ± 0.024	2.189AsnLeu: 2.189 ± 0.048	0.604AsnMet: 0.604 ± 0.025	0.627AsnAsn: 0.627 ± 0.03	1.7AsnPro: 1.7 ± 0.039	0.733AsnGln: 0.733 ± 0.024	1.819AsnArg: 1.819 ± 0.038	0.998AsnSer: 0.998 ± 0.033	1.18AsnThr: 1.18 ± 0.04	1.934AsnVal: 1.934 ± 0.049	0.419AsnTrp: 0.419 ± 0.021	0.548AsnTyr: 0.548 ± 0.023	0.0AsnXaa: 0.0 ± 0.0
Pro	6.554ProAla: 6.554 ± 0.109	0.315ProCys: 0.315 ± 0.019	4.316ProAsp: 4.316 ± 0.07	3.652ProGlu: 3.652 ± 0.066	2.152ProPhe: 2.152 ± 0.05	4.685ProGly: 4.685 ± 0.067	1.102ProHis: 1.102 ± 0.033	2.245ProIle: 2.245 ± 0.049	1.267ProLys: 1.267 ± 0.035	4.566ProLeu: 4.566 ± 0.074	1.166ProMet: 1.166 ± 0.034	1.186ProAsn: 1.186 ± 0.039	2.488ProPro: 2.488 ± 0.068	1.53ProGln: 1.53 ± 0.038	2.897ProArg: 2.897 ± 0.065	2.487ProSer: 2.487 ± 0.048	2.25ProThr: 2.25 ± 0.043	4.647ProVal: 4.647 ± 0.071	0.691ProTrp: 0.691 ± 0.029	1.12ProTyr: 1.12 ± 0.029	0.0ProXaa: 0.0 ± 0.0
Gln	3.774GlnAla: 3.774 ± 0.061	0.212GlnCys: 0.212 ± 0.013	1.349GlnAsp: 1.349 ± 0.04	1.24GlnGlu: 1.24 ± 0.04	1.04GlnPhe: 1.04 ± 0.031	2.185GlnGly: 2.185 ± 0.047	0.518GlnHis: 0.518 ± 0.018	1.828GlnIle: 1.828 ± 0.044	0.806GlnLys: 0.806 ± 0.029	2.38GlnLeu: 2.38 ± 0.052	1.002GlnMet: 1.002 ± 0.035	0.766GlnAsn: 0.766 ± 0.029	1.535GlnPro: 1.535 ± 0.044	0.96GlnGln: 0.96 ± 0.038	2.193GlnArg: 2.193 ± 0.043	1.572GlnSer: 1.572 ± 0.039	1.765GlnThr: 1.765 ± 0.039	2.069GlnVal: 2.069 ± 0.048	0.425GlnTrp: 0.425 ± 0.02	0.485GlnTyr: 0.485 ± 0.024	0.0GlnXaa: 0.0 ± 0.0
Arg	9.183ArgAla: 9.183 ± 0.114	0.565ArgCys: 0.565 ± 0.024	4.491ArgAsp: 4.491 ± 0.07	4.076ArgGlu: 4.076 ± 0.065	3.321ArgPhe: 3.321 ± 0.056	4.926ArgGly: 4.926 ± 0.073	1.869ArgHis: 1.869 ± 0.05	4.207ArgIle: 4.207 ± 0.06	2.123ArgLys: 2.123 ± 0.051	7.69ArgLeu: 7.69 ± 0.101	2.108ArgMet: 2.108 ± 0.049	1.815ArgAsn: 1.815 ± 0.043	3.859ArgPro: 3.859 ± 0.057	2.632ArgGln: 2.632 ± 0.049	6.099ArgArg: 6.099 ± 0.098	3.527ArgSer: 3.527 ± 0.063	3.99ArgThr: 3.99 ± 0.066	4.736ArgVal: 4.736 ± 0.064	0.939ArgTrp: 0.939 ± 0.031	1.714ArgTyr: 1.714 ± 0.04	0.0ArgXaa: 0.0 ± 0.0
Ser	5.928SerAla: 5.928 ± 0.092	0.325SerCys: 0.325 ± 0.022	2.865SerAsp: 2.865 ± 0.055	2.679SerGlu: 2.679 ± 0.049	1.967SerPhe: 1.967 ± 0.042	5.21SerGly: 5.21 ± 0.097	1.025SerHis: 1.025 ± 0.033	2.435SerIle: 2.435 ± 0.059	1.16SerLys: 1.16 ± 0.034	4.427SerLeu: 4.427 ± 0.072	1.258SerMet: 1.258 ± 0.04	1.161SerAsn: 1.161 ± 0.036	2.392SerPro: 2.392 ± 0.047	1.334SerGln: 1.334 ± 0.037	3.28SerArg: 3.28 ± 0.067	2.186SerSer: 2.186 ± 0.052	2.411SerThr: 2.411 ± 0.055	3.837SerVal: 3.837 ± 0.077	0.622SerTrp: 0.622 ± 0.027	1.076SerTyr: 1.076 ± 0.033	0.0SerXaa: 0.0 ± 0.0
Thr	6.556ThrAla: 6.556 ± 0.112	0.411ThrCys: 0.411 ± 0.021	3.348ThrAsp: 3.348 ± 0.069	3.019ThrGlu: 3.019 ± 0.051	2.031ThrPhe: 2.031 ± 0.052	5.902ThrGly: 5.902 ± 0.1	1.05ThrHis: 1.05 ± 0.032	3.218ThrIle: 3.218 ± 0.064	1.08ThrLys: 1.08 ± 0.035	5.758ThrLeu: 5.758 ± 0.075	1.439ThrMet: 1.439 ± 0.035	1.217ThrAsn: 1.217 ± 0.044	3.074ThrPro: 3.074 ± 0.051	1.237ThrGln: 1.237 ± 0.038	3.564ThrArg: 3.564 ± 0.061	2.378ThrSer: 2.378 ± 0.055	2.804ThrThr: 2.804 ± 0.069	4.815ThrVal: 4.815 ± 0.074	0.604ThrTrp: 0.604 ± 0.029	1.122ThrTyr: 1.122 ± 0.032	0.0ThrXaa: 0.0 ± 0.0
Val	9.625ValAla: 9.625 ± 0.1	0.687ValCys: 0.687 ± 0.026	4.665ValAsp: 4.665 ± 0.082	4.555ValGlu: 4.555 ± 0.077	3.017ValPhe: 3.017 ± 0.058	5.697ValGly: 5.697 ± 0.082	1.531ValHis: 1.531 ± 0.037	4.177ValIle: 4.177 ± 0.069	1.768ValLys: 1.768 ± 0.044	7.302ValLeu: 7.302 ± 0.098	1.991ValMet: 1.991 ± 0.051	1.903ValAsn: 1.903 ± 0.045	4.104ValPro: 4.104 ± 0.059	1.776ValGln: 1.776 ± 0.043	5.494ValArg: 5.494 ± 0.077	4.254ValSer: 4.254 ± 0.088	4.819ValThr: 4.819 ± 0.086	5.404ValVal: 5.404 ± 0.08	0.941ValTrp: 0.941 ± 0.035	1.452ValTyr: 1.452 ± 0.037	0.0ValXaa: 0.0 ± 0.0
Trp	1.267TrpAla: 1.267 ± 0.044	0.132TrpCys: 0.132 ± 0.012	0.651TrpAsp: 0.651 ± 0.024	0.535TrpGlu: 0.535 ± 0.02	0.558TrpPhe: 0.558 ± 0.025	0.805TrpGly: 0.805 ± 0.029	0.345TrpHis: 0.345 ± 0.018	0.6TrpIle: 0.6 ± 0.025	0.337TrpLys: 0.337 ± 0.018	1.603TrpLeu: 1.603 ± 0.043	0.359TrpMet: 0.359 ± 0.02	0.413TrpAsn: 0.413 ± 0.02	0.735TrpPro: 0.735 ± 0.026	0.56TrpGln: 0.56 ± 0.023	1.143TrpArg: 1.143 ± 0.028	0.721TrpSer: 0.721 ± 0.026	0.784TrpThr: 0.784 ± 0.025	0.713TrpVal: 0.713 ± 0.03	0.237TrpTrp: 0.237 ± 0.015	0.29TrpTyr: 0.29 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.366TyrAla: 2.366 ± 0.051	0.206TyrCys: 0.206 ± 0.013	1.415TyrAsp: 1.415 ± 0.035	1.287TyrGlu: 1.287 ± 0.037	0.844TyrPhe: 0.844 ± 0.03	2.01TyrGly: 2.01 ± 0.044	0.497TyrHis: 0.497 ± 0.024	0.816TyrIle: 0.816 ± 0.025	0.487TyrLys: 0.487 ± 0.023	2.098TyrLeu: 2.098 ± 0.051	0.492TyrMet: 0.492 ± 0.024	0.518TyrAsn: 0.518 ± 0.021	1.033TyrPro: 1.033 ± 0.03	0.618TyrGln: 0.618 ± 0.025	1.722TyrArg: 1.722 ± 0.039	0.927TyrSer: 0.927 ± 0.035	1.026TyrThr: 1.026 ± 0.028	1.641TyrVal: 1.641 ± 0.046	0.326TyrTrp: 0.326 ± 0.017	0.495TyrTyr: 0.495 ± 0.024	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3369 proteins (1063347 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---