Amino acid dipepetide frequency for Cellulophaga phage phi18:2

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.865AlaAla: 4.865 ± 1.303
0.811AlaCys: 0.811 ± 0.297
3.568AlaAsp: 3.568 ± 0.641
3.73AlaGlu: 3.73 ± 0.623
2.676AlaPhe: 2.676 ± 0.501
3.973AlaGly: 3.973 ± 0.588
0.892AlaHis: 0.892 ± 0.242
4.784AlaIle: 4.784 ± 0.756
5.433AlaLys: 5.433 ± 0.824
4.703AlaLeu: 4.703 ± 0.639
1.541AlaMet: 1.541 ± 0.397
2.595AlaAsn: 2.595 ± 0.419
2.108AlaPro: 2.108 ± 0.549
2.676AlaGln: 2.676 ± 0.595
2.433AlaArg: 2.433 ± 0.408
4.622AlaSer: 4.622 ± 0.613
3.244AlaThr: 3.244 ± 0.64
3.325AlaVal: 3.325 ± 0.853
1.216AlaTrp: 1.216 ± 0.25
2.757AlaTyr: 2.757 ± 0.475
0.0AlaXaa: 0.0 ± 0.0
Cys
0.324CysAla: 0.324 ± 0.162
0.081CysCys: 0.081 ± 0.08
0.892CysAsp: 0.892 ± 0.233
0.811CysGlu: 0.811 ± 0.268
0.811CysPhe: 0.811 ± 0.259
0.649CysGly: 0.649 ± 0.264
0.162CysHis: 0.162 ± 0.118
0.405CysIle: 0.405 ± 0.21
0.73CysLys: 0.73 ± 0.267
0.892CysLeu: 0.892 ± 0.343
0.081CysMet: 0.081 ± 0.111
0.405CysAsn: 0.405 ± 0.182
0.73CysPro: 0.73 ± 0.207
0.568CysGln: 0.568 ± 0.179
0.811CysArg: 0.811 ± 0.239
0.973CysSer: 0.973 ± 0.273
0.243CysThr: 0.243 ± 0.127
0.487CysVal: 0.487 ± 0.231
0.081CysTrp: 0.081 ± 0.099
0.405CysTyr: 0.405 ± 0.192
0.0CysXaa: 0.0 ± 0.0
Asp
4.784AspAla: 4.784 ± 0.658
0.811AspCys: 0.811 ± 0.268
2.757AspAsp: 2.757 ± 0.55
3.973AspGlu: 3.973 ± 0.547
3.811AspPhe: 3.811 ± 0.472
4.054AspGly: 4.054 ± 0.526
0.811AspHis: 0.811 ± 0.243
5.595AspIle: 5.595 ± 0.562
5.595AspLys: 5.595 ± 0.573
6.73AspLeu: 6.73 ± 0.789
1.622AspMet: 1.622 ± 0.427
3.487AspAsn: 3.487 ± 0.516
3.081AspPro: 3.081 ± 0.56
2.595AspGln: 2.595 ± 0.426
2.514AspArg: 2.514 ± 0.458
3.73AspSer: 3.73 ± 0.68
2.595AspThr: 2.595 ± 0.657
3.487AspVal: 3.487 ± 0.502
1.054AspTrp: 1.054 ± 0.244
1.865AspTyr: 1.865 ± 0.412
0.0AspXaa: 0.0 ± 0.0
Glu
4.703GluAla: 4.703 ± 0.765
0.487GluCys: 0.487 ± 0.18
3.649GluAsp: 3.649 ± 0.609
4.622GluGlu: 4.622 ± 0.963
3.163GluPhe: 3.163 ± 0.464
2.838GluGly: 2.838 ± 0.497
0.405GluHis: 0.405 ± 0.169
5.838GluIle: 5.838 ± 0.668
5.028GluLys: 5.028 ± 0.783
5.92GluLeu: 5.92 ± 0.826
1.946GluMet: 1.946 ± 0.351
3.73GluAsn: 3.73 ± 0.455
1.135GluPro: 1.135 ± 0.266
2.271GluGln: 2.271 ± 0.471
2.514GluArg: 2.514 ± 0.448
3.406GluSer: 3.406 ± 0.636
3.244GluThr: 3.244 ± 0.472
4.703GluVal: 4.703 ± 0.587
0.892GluTrp: 0.892 ± 0.228
3.0GluTyr: 3.0 ± 0.49
0.0GluXaa: 0.0 ± 0.0
Phe
3.0PheAla: 3.0 ± 0.505
0.162PheCys: 0.162 ± 0.113
5.109PheAsp: 5.109 ± 0.612
3.0PheGlu: 3.0 ± 0.491
2.676PhePhe: 2.676 ± 0.507
2.189PheGly: 2.189 ± 0.357
0.487PheHis: 0.487 ± 0.187
3.973PheIle: 3.973 ± 0.536
4.136PheLys: 4.136 ± 0.469
3.973PheLeu: 3.973 ± 0.682
1.379PheMet: 1.379 ± 0.329
3.568PheAsn: 3.568 ± 0.397
1.622PhePro: 1.622 ± 0.383
0.973PheGln: 0.973 ± 0.369
1.541PheArg: 1.541 ± 0.334
3.325PheSer: 3.325 ± 0.532
2.027PheThr: 2.027 ± 0.343
2.595PheVal: 2.595 ± 0.456
0.405PheTrp: 0.405 ± 0.207
1.946PheTyr: 1.946 ± 0.392
0.0PheXaa: 0.0 ± 0.0
Gly
4.136GlyAla: 4.136 ± 0.932
0.487GlyCys: 0.487 ± 0.219
4.46GlyAsp: 4.46 ± 0.901
3.487GlyGlu: 3.487 ± 0.609
4.136GlyPhe: 4.136 ± 0.615
4.541GlyGly: 4.541 ± 1.021
0.73GlyHis: 0.73 ± 0.276
4.541GlyIle: 4.541 ± 0.713
4.298GlyLys: 4.298 ± 0.553
5.514GlyLeu: 5.514 ± 0.56
1.379GlyMet: 1.379 ± 0.283
2.271GlyAsn: 2.271 ± 0.367
1.541GlyPro: 1.541 ± 0.327
2.514GlyGln: 2.514 ± 0.438
1.541GlyArg: 1.541 ± 0.298
5.595GlySer: 5.595 ± 0.855
4.784GlyThr: 4.784 ± 0.88
3.568GlyVal: 3.568 ± 0.497
0.73GlyTrp: 0.73 ± 0.23
2.838GlyTyr: 2.838 ± 0.56
0.0GlyXaa: 0.0 ± 0.0
His
0.811HisAla: 0.811 ± 0.248
0.324HisCys: 0.324 ± 0.164
0.405HisAsp: 0.405 ± 0.199
0.487HisGlu: 0.487 ± 0.198
0.568HisPhe: 0.568 ± 0.212
0.811HisGly: 0.811 ± 0.299
0.0HisHis: 0.0 ± 0.0
1.379HisIle: 1.379 ± 0.415
0.973HisLys: 0.973 ± 0.4
1.541HisLeu: 1.541 ± 0.365
0.405HisMet: 0.405 ± 0.184
0.649HisAsn: 0.649 ± 0.227
0.649HisPro: 0.649 ± 0.227
0.568HisGln: 0.568 ± 0.192
0.568HisArg: 0.568 ± 0.237
1.054HisSer: 1.054 ± 0.236
0.243HisThr: 0.243 ± 0.13
0.73HisVal: 0.73 ± 0.238
0.162HisTrp: 0.162 ± 0.118
0.811HisTyr: 0.811 ± 0.252
0.0HisXaa: 0.0 ± 0.0
Ile
5.271IleAla: 5.271 ± 0.748
0.73IleCys: 0.73 ± 0.246
6.244IleAsp: 6.244 ± 0.719
7.379IleGlu: 7.379 ± 0.981
3.487IlePhe: 3.487 ± 0.504
4.46IleGly: 4.46 ± 0.592
0.649IleHis: 0.649 ± 0.236
5.514IleIle: 5.514 ± 0.561
7.704IleLys: 7.704 ± 1.012
7.541IleLeu: 7.541 ± 0.886
1.703IleMet: 1.703 ± 0.34
5.352IleAsn: 5.352 ± 0.62
2.676IlePro: 2.676 ± 0.654
2.108IleGln: 2.108 ± 0.427
2.838IleArg: 2.838 ± 0.484
5.514IleSer: 5.514 ± 0.694
3.487IleThr: 3.487 ± 0.539
5.271IleVal: 5.271 ± 0.667
0.811IleTrp: 0.811 ± 0.204
2.676IleTyr: 2.676 ± 0.627
0.0IleXaa: 0.0 ± 0.0
Lys
4.946LysAla: 4.946 ± 0.936
0.73LysCys: 0.73 ± 0.261
6.001LysAsp: 6.001 ± 0.678
7.136LysGlu: 7.136 ± 0.931
2.919LysPhe: 2.919 ± 0.464
6.487LysGly: 6.487 ± 0.719
1.46LysHis: 1.46 ± 0.401
7.704LysIle: 7.704 ± 1.099
9.163LysLys: 9.163 ± 1.249
7.136LysLeu: 7.136 ± 1.057
2.757LysMet: 2.757 ± 0.544
4.298LysAsn: 4.298 ± 0.741
3.649LysPro: 3.649 ± 0.503
2.433LysGln: 2.433 ± 0.438
4.136LysArg: 4.136 ± 0.569
5.514LysSer: 5.514 ± 0.731
4.703LysThr: 4.703 ± 0.58
4.541LysVal: 4.541 ± 0.739
1.216LysTrp: 1.216 ± 0.34
3.568LysTyr: 3.568 ± 0.611
0.0LysXaa: 0.0 ± 0.0
Leu
3.487LeuAla: 3.487 ± 0.618
1.135LeuCys: 1.135 ± 0.341
6.001LeuAsp: 6.001 ± 0.769
5.595LeuGlu: 5.595 ± 0.86
3.973LeuPhe: 3.973 ± 0.809
4.054LeuGly: 4.054 ± 0.519
1.379LeuHis: 1.379 ± 0.47
6.244LeuIle: 6.244 ± 0.949
6.487LeuLys: 6.487 ± 0.939
6.812LeuLeu: 6.812 ± 0.712
2.757LeuMet: 2.757 ± 0.592
5.352LeuAsn: 5.352 ± 0.523
3.406LeuPro: 3.406 ± 0.536
2.757LeuGln: 2.757 ± 0.534
3.568LeuArg: 3.568 ± 0.715
6.893LeuSer: 6.893 ± 0.589
4.784LeuThr: 4.784 ± 0.714
3.973LeuVal: 3.973 ± 0.556
0.892LeuTrp: 0.892 ± 0.3
2.757LeuTyr: 2.757 ± 0.435
0.0LeuXaa: 0.0 ± 0.0
Met
1.46MetAla: 1.46 ± 0.4
0.243MetCys: 0.243 ± 0.13
0.973MetAsp: 0.973 ± 0.244
1.379MetGlu: 1.379 ± 0.265
0.973MetPhe: 0.973 ± 0.256
0.973MetGly: 0.973 ± 0.249
0.405MetHis: 0.405 ± 0.242
1.946MetIle: 1.946 ± 0.408
2.514MetLys: 2.514 ± 0.459
1.379MetLeu: 1.379 ± 0.353
0.649MetMet: 0.649 ± 0.352
2.352MetAsn: 2.352 ± 0.373
1.379MetPro: 1.379 ± 0.361
1.379MetGln: 1.379 ± 0.344
1.46MetArg: 1.46 ± 0.365
2.352MetSer: 2.352 ± 0.48
1.622MetThr: 1.622 ± 0.409
1.379MetVal: 1.379 ± 0.308
0.162MetTrp: 0.162 ± 0.101
0.811MetTyr: 0.811 ± 0.251
0.0MetXaa: 0.0 ± 0.0
Asn
3.163AsnAla: 3.163 ± 0.505
1.054AsnCys: 1.054 ± 0.281
3.081AsnAsp: 3.081 ± 0.476
2.433AsnGlu: 2.433 ± 0.505
2.676AsnPhe: 2.676 ± 0.5
3.811AsnGly: 3.811 ± 0.74
0.892AsnHis: 0.892 ± 0.273
4.541AsnIle: 4.541 ± 0.565
6.568AsnLys: 6.568 ± 0.857
3.73AsnLeu: 3.73 ± 0.612
1.297AsnMet: 1.297 ± 0.333
2.676AsnAsn: 2.676 ± 0.625
2.271AsnPro: 2.271 ± 0.381
2.108AsnGln: 2.108 ± 0.427
2.433AsnArg: 2.433 ± 0.426
3.487AsnSer: 3.487 ± 0.592
3.081AsnThr: 3.081 ± 0.612
2.757AsnVal: 2.757 ± 0.393
0.487AsnTrp: 0.487 ± 0.234
2.271AsnTyr: 2.271 ± 0.433
0.0AsnXaa: 0.0 ± 0.0
Pro
2.433ProAla: 2.433 ± 0.427
0.568ProCys: 0.568 ± 0.243
2.271ProAsp: 2.271 ± 0.52
1.865ProGlu: 1.865 ± 0.454
1.703ProPhe: 1.703 ± 0.362
2.757ProGly: 2.757 ± 0.488
0.811ProHis: 0.811 ± 0.21
2.676ProIle: 2.676 ± 0.374
3.244ProLys: 3.244 ± 0.597
2.514ProLeu: 2.514 ± 0.474
0.568ProMet: 0.568 ± 0.275
2.027ProAsn: 2.027 ± 0.538
1.379ProPro: 1.379 ± 0.324
1.865ProGln: 1.865 ± 0.47
0.811ProArg: 0.811 ± 0.204
2.514ProSer: 2.514 ± 0.576
2.027ProThr: 2.027 ± 0.438
1.946ProVal: 1.946 ± 0.433
0.324ProTrp: 0.324 ± 0.167
1.46ProTyr: 1.46 ± 0.277
0.0ProXaa: 0.0 ± 0.0
Gln
2.108GlnAla: 2.108 ± 0.519
0.081GlnCys: 0.081 ± 0.08
2.433GlnAsp: 2.433 ± 0.359
2.027GlnGlu: 2.027 ± 0.477
1.46GlnPhe: 1.46 ± 0.296
2.838GlnGly: 2.838 ± 0.997
0.243GlnHis: 0.243 ± 0.131
2.919GlnIle: 2.919 ± 0.364
2.595GlnLys: 2.595 ± 0.403
3.73GlnLeu: 3.73 ± 0.388
1.216GlnMet: 1.216 ± 0.296
2.027GlnAsn: 2.027 ± 0.355
0.324GlnPro: 0.324 ± 0.154
1.054GlnGln: 1.054 ± 0.34
1.946GlnArg: 1.946 ± 0.364
1.622GlnSer: 1.622 ± 0.311
2.108GlnThr: 2.108 ± 0.329
1.784GlnVal: 1.784 ± 0.43
0.568GlnTrp: 0.568 ± 0.208
1.297GlnTyr: 1.297 ± 0.232
0.0GlnXaa: 0.0 ± 0.0
Arg
2.027ArgAla: 2.027 ± 0.419
0.487ArgCys: 0.487 ± 0.175
2.352ArgAsp: 2.352 ± 0.391
2.757ArgGlu: 2.757 ± 0.394
1.135ArgPhe: 1.135 ± 0.317
1.784ArgGly: 1.784 ± 0.405
0.487ArgHis: 0.487 ± 0.167
3.811ArgIle: 3.811 ± 0.513
3.811ArgLys: 3.811 ± 0.503
3.649ArgLeu: 3.649 ± 0.596
1.379ArgMet: 1.379 ± 0.339
1.784ArgAsn: 1.784 ± 0.401
0.892ArgPro: 0.892 ± 0.257
1.379ArgGln: 1.379 ± 0.286
1.054ArgArg: 1.054 ± 0.429
2.433ArgSer: 2.433 ± 0.459
1.946ArgThr: 1.946 ± 0.365
2.108ArgVal: 2.108 ± 0.435
0.73ArgTrp: 0.73 ± 0.209
1.784ArgTyr: 1.784 ± 0.397
0.0ArgXaa: 0.0 ± 0.0
Ser
4.217SerAla: 4.217 ± 0.533
0.892SerCys: 0.892 ± 0.291
4.298SerAsp: 4.298 ± 0.527
3.487SerGlu: 3.487 ± 0.577
3.406SerPhe: 3.406 ± 0.4
5.514SerGly: 5.514 ± 0.725
1.054SerHis: 1.054 ± 0.282
6.325SerIle: 6.325 ± 0.765
6.73SerLys: 6.73 ± 0.649
5.109SerLeu: 5.109 ± 0.571
1.946SerMet: 1.946 ± 0.362
3.73SerAsn: 3.73 ± 0.668
2.027SerPro: 2.027 ± 0.335
3.163SerGln: 3.163 ± 0.554
2.108SerArg: 2.108 ± 0.393
4.46SerSer: 4.46 ± 0.678
3.811SerThr: 3.811 ± 0.645
2.919SerVal: 2.919 ± 0.554
0.973SerTrp: 0.973 ± 0.268
3.0SerTyr: 3.0 ± 0.409
0.0SerXaa: 0.0 ± 0.0
Thr
3.487ThrAla: 3.487 ± 0.397
0.487ThrCys: 0.487 ± 0.219
3.244ThrAsp: 3.244 ± 0.536
2.676ThrGlu: 2.676 ± 0.448
2.514ThrPhe: 2.514 ± 0.468
5.271ThrGly: 5.271 ± 0.764
0.649ThrHis: 0.649 ± 0.223
4.541ThrIle: 4.541 ± 0.616
4.703ThrLys: 4.703 ± 0.702
3.325ThrLeu: 3.325 ± 0.502
0.811ThrMet: 0.811 ± 0.305
2.838ThrAsn: 2.838 ± 0.353
2.595ThrPro: 2.595 ± 0.639
1.216ThrGln: 1.216 ± 0.295
1.784ThrArg: 1.784 ± 0.402
3.73ThrSer: 3.73 ± 0.759
2.838ThrThr: 2.838 ± 0.615
2.595ThrVal: 2.595 ± 0.434
1.135ThrTrp: 1.135 ± 0.281
2.352ThrTyr: 2.352 ± 0.662
0.0ThrXaa: 0.0 ± 0.0
Val
2.676ValAla: 2.676 ± 0.53
0.324ValCys: 0.324 ± 0.172
4.703ValAsp: 4.703 ± 0.635
3.649ValGlu: 3.649 ± 0.468
2.352ValPhe: 2.352 ± 0.42
2.676ValGly: 2.676 ± 0.41
0.649ValHis: 0.649 ± 0.231
4.217ValIle: 4.217 ± 0.485
5.514ValLys: 5.514 ± 0.629
4.136ValLeu: 4.136 ± 0.77
1.135ValMet: 1.135 ± 0.294
2.676ValAsn: 2.676 ± 0.472
2.757ValPro: 2.757 ± 0.469
1.297ValGln: 1.297 ± 0.34
2.027ValArg: 2.027 ± 0.377
4.379ValSer: 4.379 ± 0.562
2.757ValThr: 2.757 ± 0.485
3.73ValVal: 3.73 ± 0.527
1.054ValTrp: 1.054 ± 0.267
2.595ValTyr: 2.595 ± 0.422
0.0ValXaa: 0.0 ± 0.0
Trp
1.216TrpAla: 1.216 ± 0.371
0.081TrpCys: 0.081 ± 0.089
1.054TrpAsp: 1.054 ± 0.22
1.135TrpGlu: 1.135 ± 0.314
0.73TrpPhe: 0.73 ± 0.209
0.892TrpGly: 0.892 ± 0.256
0.324TrpHis: 0.324 ± 0.155
1.135TrpIle: 1.135 ± 0.284
0.973TrpLys: 0.973 ± 0.327
0.973TrpLeu: 0.973 ± 0.281
0.324TrpMet: 0.324 ± 0.16
0.487TrpAsn: 0.487 ± 0.235
0.0TrpPro: 0.0 ± 0.0
0.405TrpGln: 0.405 ± 0.151
0.487TrpArg: 0.487 ± 0.214
0.73TrpSer: 0.73 ± 0.193
1.135TrpThr: 1.135 ± 0.349
0.973TrpVal: 0.973 ± 0.297
0.081TrpTrp: 0.081 ± 0.081
0.649TrpTyr: 0.649 ± 0.271
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.838TyrAla: 2.838 ± 0.425
0.649TyrCys: 0.649 ± 0.234
1.46TyrAsp: 1.46 ± 0.362
1.865TyrGlu: 1.865 ± 0.317
2.919TyrPhe: 2.919 ± 0.536
2.514TyrGly: 2.514 ± 0.476
0.649TyrHis: 0.649 ± 0.209
3.325TyrIle: 3.325 ± 0.525
4.298TyrLys: 4.298 ± 0.672
3.0TyrLeu: 3.0 ± 0.525
0.811TyrMet: 0.811 ± 0.227
2.514TyrAsn: 2.514 ± 0.483
1.541TyrPro: 1.541 ± 0.289
1.054TyrGln: 1.054 ± 0.331
1.216TyrArg: 1.216 ± 0.298
2.838TyrSer: 2.838 ± 0.405
2.108TyrThr: 2.108 ± 0.322
2.433TyrVal: 2.433 ± 0.531
0.811TyrTrp: 0.811 ± 0.34
2.108TyrTyr: 2.108 ± 0.478
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 63 proteins (12333 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski