Amino acid dipepetide frequency for Mycobacterium virus Che8

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
15.29AlaAla: 15.29 ± 2.33
0.849AlaCys: 0.849 ± 0.227
7.433AlaAsp: 7.433 ± 0.771
7.167AlaGlu: 7.167 ± 0.654
2.814AlaPhe: 2.814 ± 0.435
9.397AlaGly: 9.397 ± 1.267
2.708AlaHis: 2.708 ± 0.575
3.929AlaIle: 3.929 ± 0.509
4.194AlaLys: 4.194 ± 0.37
9.131AlaLeu: 9.131 ± 0.645
2.389AlaMet: 2.389 ± 0.387
2.814AlaAsn: 2.814 ± 0.453
4.672AlaPro: 4.672 ± 0.545
3.876AlaGln: 3.876 ± 0.536
7.592AlaArg: 7.592 ± 0.762
5.203AlaSer: 5.203 ± 0.786
6.636AlaThr: 6.636 ± 0.584
7.061AlaVal: 7.061 ± 0.627
3.398AlaTrp: 3.398 ± 0.933
2.336AlaTyr: 2.336 ± 0.372
0.0AlaXaa: 0.0 ± 0.0
Cys
0.849CysAla: 0.849 ± 0.245
0.159CysCys: 0.159 ± 0.1
1.168CysAsp: 1.168 ± 0.321
0.956CysGlu: 0.956 ± 0.234
0.159CysPhe: 0.159 ± 0.088
1.805CysGly: 1.805 ± 0.391
0.212CysHis: 0.212 ± 0.11
0.159CysIle: 0.159 ± 0.09
0.531CysLys: 0.531 ± 0.187
0.531CysLeu: 0.531 ± 0.196
0.0CysMet: 0.0 ± 0.0
0.265CysAsn: 0.265 ± 0.111
0.903CysPro: 0.903 ± 0.247
0.265CysGln: 0.265 ± 0.145
0.796CysArg: 0.796 ± 0.296
0.956CysSer: 0.956 ± 0.35
0.425CysThr: 0.425 ± 0.195
0.743CysVal: 0.743 ± 0.21
0.212CysTrp: 0.212 ± 0.1
0.212CysTyr: 0.212 ± 0.118
0.0CysXaa: 0.0 ± 0.0
Asp
6.371AspAla: 6.371 ± 0.661
0.69AspCys: 0.69 ± 0.212
4.937AspAsp: 4.937 ± 0.644
3.663AspGlu: 3.663 ± 0.467
1.699AspPhe: 1.699 ± 0.279
6.212AspGly: 6.212 ± 0.765
1.54AspHis: 1.54 ± 0.246
2.177AspIle: 2.177 ± 0.291
1.593AspLys: 1.593 ± 0.255
5.468AspLeu: 5.468 ± 0.53
1.274AspMet: 1.274 ± 0.297
1.752AspAsn: 1.752 ± 0.331
4.406AspPro: 4.406 ± 0.474
2.92AspGln: 2.92 ± 0.388
5.309AspArg: 5.309 ± 0.63
3.451AspSer: 3.451 ± 0.49
4.3AspThr: 4.3 ± 0.484
4.725AspVal: 4.725 ± 0.486
1.487AspTrp: 1.487 ± 0.244
2.177AspTyr: 2.177 ± 0.368
0.0AspXaa: 0.0 ± 0.0
Glu
6.742GluAla: 6.742 ± 0.598
1.115GluCys: 1.115 ± 0.283
3.716GluAsp: 3.716 ± 0.465
2.654GluGlu: 2.654 ± 0.48
2.708GluPhe: 2.708 ± 0.397
3.398GluGly: 3.398 ± 0.44
1.38GluHis: 1.38 ± 0.314
1.805GluIle: 1.805 ± 0.319
2.23GluLys: 2.23 ± 0.317
6.212GluLeu: 6.212 ± 0.561
1.38GluMet: 1.38 ± 0.255
1.858GluAsn: 1.858 ± 0.29
3.026GluPro: 3.026 ± 0.452
2.601GluGln: 2.601 ± 0.347
5.362GluArg: 5.362 ± 0.636
3.238GluSer: 3.238 ± 0.528
3.504GluThr: 3.504 ± 0.435
4.353GluVal: 4.353 ± 0.477
1.327GluTrp: 1.327 ± 0.323
2.124GluTyr: 2.124 ± 0.378
0.0GluXaa: 0.0 ± 0.0
Phe
3.026PheAla: 3.026 ± 0.375
0.265PheCys: 0.265 ± 0.124
2.389PheAsp: 2.389 ± 0.437
1.752PheGlu: 1.752 ± 0.335
1.009PhePhe: 1.009 ± 0.244
2.442PheGly: 2.442 ± 0.572
0.478PheHis: 0.478 ± 0.149
1.38PheIle: 1.38 ± 0.34
1.009PheLys: 1.009 ± 0.222
2.071PheLeu: 2.071 ± 0.275
0.903PheMet: 0.903 ± 0.206
1.062PheAsn: 1.062 ± 0.256
1.699PhePro: 1.699 ± 0.335
1.221PheGln: 1.221 ± 0.308
1.858PheArg: 1.858 ± 0.278
1.487PheSer: 1.487 ± 0.248
2.548PheThr: 2.548 ± 0.419
2.017PheVal: 2.017 ± 0.353
0.743PheTrp: 0.743 ± 0.149
0.903PheTyr: 0.903 ± 0.229
0.0PheXaa: 0.0 ± 0.0
Gly
8.972GlyAla: 8.972 ± 1.311
1.274GlyCys: 1.274 ± 0.284
5.734GlyAsp: 5.734 ± 0.531
4.672GlyGlu: 4.672 ± 0.523
2.867GlyPhe: 2.867 ± 0.467
10.353GlyGly: 10.353 ± 2.064
1.646GlyHis: 1.646 ± 0.264
3.876GlyIle: 3.876 ± 0.616
2.814GlyLys: 2.814 ± 0.381
5.734GlyLeu: 5.734 ± 0.587
1.964GlyMet: 1.964 ± 0.353
3.079GlyAsn: 3.079 ± 0.392
4.46GlyPro: 4.46 ± 0.489
2.283GlyGln: 2.283 ± 0.443
4.884GlyArg: 4.884 ± 0.579
7.539GlySer: 7.539 ± 1.05
5.468GlyThr: 5.468 ± 0.736
6.158GlyVal: 6.158 ± 0.711
2.23GlyTrp: 2.23 ± 0.323
1.593GlyTyr: 1.593 ± 0.275
0.0GlyXaa: 0.0 ± 0.0
His
1.858HisAla: 1.858 ± 0.325
0.319HisCys: 0.319 ± 0.163
1.221HisAsp: 1.221 ± 0.258
1.062HisGlu: 1.062 ± 0.249
0.584HisPhe: 0.584 ± 0.157
1.805HisGly: 1.805 ± 0.364
0.849HisHis: 0.849 ± 0.26
1.168HisIle: 1.168 ± 0.264
0.584HisLys: 0.584 ± 0.15
1.805HisLeu: 1.805 ± 0.37
0.372HisMet: 0.372 ± 0.141
0.849HisAsn: 0.849 ± 0.226
1.221HisPro: 1.221 ± 0.237
0.956HisGln: 0.956 ± 0.229
1.911HisArg: 1.911 ± 0.391
1.38HisSer: 1.38 ± 0.231
1.433HisThr: 1.433 ± 0.267
1.911HisVal: 1.911 ± 0.597
0.531HisTrp: 0.531 ± 0.157
0.849HisTyr: 0.849 ± 0.177
0.0HisXaa: 0.0 ± 0.0
Ile
5.203IleAla: 5.203 ± 0.569
0.425IleCys: 0.425 ± 0.225
3.079IleAsp: 3.079 ± 0.45
3.345IleGlu: 3.345 ± 0.345
0.796IlePhe: 0.796 ± 0.24
3.716IleGly: 3.716 ± 0.508
1.38IleHis: 1.38 ± 0.328
1.274IleIle: 1.274 ± 0.279
1.168IleLys: 1.168 ± 0.258
2.283IleLeu: 2.283 ± 0.371
0.425IleMet: 0.425 ± 0.125
1.54IleAsn: 1.54 ± 0.256
2.495IlePro: 2.495 ± 0.345
1.327IleGln: 1.327 ± 0.259
2.654IleArg: 2.654 ± 0.381
2.124IleSer: 2.124 ± 0.348
3.398IleThr: 3.398 ± 0.438
3.079IleVal: 3.079 ± 0.436
0.903IleTrp: 0.903 ± 0.229
0.849IleTyr: 0.849 ± 0.164
0.0IleXaa: 0.0 ± 0.0
Lys
3.716LysAla: 3.716 ± 0.473
0.319LysCys: 0.319 ± 0.118
1.38LysAsp: 1.38 ± 0.276
1.54LysGlu: 1.54 ± 0.257
1.433LysPhe: 1.433 ± 0.227
2.23LysGly: 2.23 ± 0.349
0.903LysHis: 0.903 ± 0.288
0.956LysIle: 0.956 ± 0.195
1.168LysLys: 1.168 ± 0.318
2.283LysLeu: 2.283 ± 0.329
0.584LysMet: 0.584 ± 0.188
0.743LysAsn: 0.743 ± 0.211
2.177LysPro: 2.177 ± 0.357
1.858LysGln: 1.858 ± 0.255
2.442LysArg: 2.442 ± 0.38
1.911LysSer: 1.911 ± 0.268
2.389LysThr: 2.389 ± 0.356
2.654LysVal: 2.654 ± 0.351
1.009LysTrp: 1.009 ± 0.286
0.903LysTyr: 0.903 ± 0.199
0.0LysXaa: 0.0 ± 0.0
Leu
7.91LeuAla: 7.91 ± 0.64
0.584LeuCys: 0.584 ± 0.181
4.831LeuAsp: 4.831 ± 0.506
4.088LeuGlu: 4.088 ± 0.396
2.177LeuPhe: 2.177 ± 0.374
5.309LeuGly: 5.309 ± 0.605
1.433LeuHis: 1.433 ± 0.32
3.398LeuIle: 3.398 ± 0.341
2.283LeuLys: 2.283 ± 0.313
4.353LeuLeu: 4.353 ± 0.508
1.487LeuMet: 1.487 ± 0.283
2.708LeuAsn: 2.708 ± 0.369
5.203LeuPro: 5.203 ± 0.705
2.761LeuGln: 2.761 ± 0.465
5.203LeuArg: 5.203 ± 0.561
5.203LeuSer: 5.203 ± 0.527
4.99LeuThr: 4.99 ± 0.602
5.628LeuVal: 5.628 ± 0.499
1.221LeuTrp: 1.221 ± 0.243
2.336LeuTyr: 2.336 ± 0.375
0.0LeuXaa: 0.0 ± 0.0
Met
1.699MetAla: 1.699 ± 0.29
0.212MetCys: 0.212 ± 0.106
0.956MetAsp: 0.956 ± 0.235
1.062MetGlu: 1.062 ± 0.196
0.69MetPhe: 0.69 ± 0.198
1.858MetGly: 1.858 ± 0.308
0.159MetHis: 0.159 ± 0.086
0.743MetIle: 0.743 ± 0.177
0.956MetLys: 0.956 ± 0.217
1.646MetLeu: 1.646 ± 0.233
0.637MetMet: 0.637 ± 0.202
0.849MetAsn: 0.849 ± 0.182
1.38MetPro: 1.38 ± 0.234
0.531MetGln: 0.531 ± 0.174
1.487MetArg: 1.487 ± 0.302
2.336MetSer: 2.336 ± 0.377
2.389MetThr: 2.389 ± 0.293
1.168MetVal: 1.168 ± 0.254
0.425MetTrp: 0.425 ± 0.148
0.319MetTyr: 0.319 ± 0.135
0.0MetXaa: 0.0 ± 0.0
Asn
3.61AsnAla: 3.61 ± 0.397
0.159AsnCys: 0.159 ± 0.093
1.858AsnAsp: 1.858 ± 0.255
1.593AsnGlu: 1.593 ± 0.33
1.009AsnPhe: 1.009 ± 0.301
3.716AsnGly: 3.716 ± 0.527
1.009AsnHis: 1.009 ± 0.216
1.433AsnIle: 1.433 ± 0.36
0.796AsnLys: 0.796 ± 0.185
2.017AsnLeu: 2.017 ± 0.322
0.531AsnMet: 0.531 ± 0.143
1.487AsnAsn: 1.487 ± 0.341
2.124AsnPro: 2.124 ± 0.323
1.009AsnGln: 1.009 ± 0.274
2.017AsnArg: 2.017 ± 0.384
1.327AsnSer: 1.327 ± 0.253
2.336AsnThr: 2.336 ± 0.371
2.177AsnVal: 2.177 ± 0.413
0.743AsnTrp: 0.743 ± 0.19
0.796AsnTyr: 0.796 ± 0.173
0.0AsnXaa: 0.0 ± 0.0
Pro
4.566ProAla: 4.566 ± 0.604
0.637ProCys: 0.637 ± 0.176
3.769ProAsp: 3.769 ± 0.404
5.362ProGlu: 5.362 ± 0.533
1.433ProPhe: 1.433 ± 0.303
6.53ProGly: 6.53 ± 0.694
1.593ProHis: 1.593 ± 0.315
2.017ProIle: 2.017 ± 0.341
1.858ProLys: 1.858 ± 0.286
4.406ProLeu: 4.406 ± 0.493
1.168ProMet: 1.168 ± 0.304
2.23ProAsn: 2.23 ± 0.326
3.876ProPro: 3.876 ± 0.6
2.017ProGln: 2.017 ± 0.307
2.867ProArg: 2.867 ± 0.418
3.504ProSer: 3.504 ± 0.403
3.451ProThr: 3.451 ± 0.427
4.778ProVal: 4.778 ± 0.574
0.956ProTrp: 0.956 ± 0.212
1.009ProTyr: 1.009 ± 0.262
0.0ProXaa: 0.0 ± 0.0
Gln
4.566GlnAla: 4.566 ± 0.477
0.425GlnCys: 0.425 ± 0.193
1.646GlnAsp: 1.646 ± 0.277
1.752GlnGlu: 1.752 ± 0.398
0.903GlnPhe: 0.903 ± 0.262
2.548GlnGly: 2.548 ± 0.367
0.956GlnHis: 0.956 ± 0.201
1.752GlnIle: 1.752 ± 0.319
1.168GlnLys: 1.168 ± 0.232
2.601GlnLeu: 2.601 ± 0.378
0.956GlnMet: 0.956 ± 0.197
0.849GlnAsn: 0.849 ± 0.221
2.708GlnPro: 2.708 ± 0.413
1.487GlnGln: 1.487 ± 0.322
2.654GlnArg: 2.654 ± 0.385
2.389GlnSer: 2.389 ± 0.382
1.858GlnThr: 1.858 ± 0.374
2.389GlnVal: 2.389 ± 0.36
0.637GlnTrp: 0.637 ± 0.179
0.903GlnTyr: 0.903 ± 0.293
0.0GlnXaa: 0.0 ± 0.0
Arg
7.008ArgAla: 7.008 ± 0.716
1.009ArgCys: 1.009 ± 0.308
4.778ArgAsp: 4.778 ± 0.49
5.468ArgGlu: 5.468 ± 0.68
2.283ArgPhe: 2.283 ± 0.376
4.247ArgGly: 4.247 ± 0.432
1.699ArgHis: 1.699 ± 0.308
4.247ArgIle: 4.247 ± 0.577
2.601ArgLys: 2.601 ± 0.432
5.15ArgLeu: 5.15 ± 0.579
2.814ArgMet: 2.814 ± 0.432
1.964ArgAsn: 1.964 ± 0.373
3.079ArgPro: 3.079 ± 0.321
1.858ArgGln: 1.858 ± 0.329
6.158ArgArg: 6.158 ± 0.925
3.982ArgSer: 3.982 ± 0.5
3.451ArgThr: 3.451 ± 0.504
5.415ArgVal: 5.415 ± 0.696
1.858ArgTrp: 1.858 ± 0.275
1.593ArgTyr: 1.593 ± 0.296
0.0ArgXaa: 0.0 ± 0.0
Ser
7.326SerAla: 7.326 ± 1.718
0.425SerCys: 0.425 ± 0.181
4.513SerAsp: 4.513 ± 0.534
2.867SerGlu: 2.867 ± 0.457
1.805SerPhe: 1.805 ± 0.36
6.424SerGly: 6.424 ± 0.786
1.009SerHis: 1.009 ± 0.194
3.026SerIle: 3.026 ± 0.473
2.177SerLys: 2.177 ± 0.386
3.982SerLeu: 3.982 ± 0.464
1.274SerMet: 1.274 ± 0.294
1.911SerAsn: 1.911 ± 0.381
3.451SerPro: 3.451 ± 0.364
1.858SerGln: 1.858 ± 0.285
3.929SerArg: 3.929 ± 0.528
3.982SerSer: 3.982 ± 0.696
3.451SerThr: 3.451 ± 0.522
4.513SerVal: 4.513 ± 0.538
1.274SerTrp: 1.274 ± 0.26
1.593SerTyr: 1.593 ± 0.251
0.0SerXaa: 0.0 ± 0.0
Thr
6.849ThrAla: 6.849 ± 0.537
0.584ThrCys: 0.584 ± 0.247
3.929ThrAsp: 3.929 ± 0.549
4.247ThrGlu: 4.247 ± 0.435
2.283ThrPhe: 2.283 ± 0.363
6.583ThrGly: 6.583 ± 0.708
1.327ThrHis: 1.327 ± 0.304
3.345ThrIle: 3.345 ± 0.451
1.805ThrLys: 1.805 ± 0.293
4.406ThrLeu: 4.406 ± 0.534
1.221ThrMet: 1.221 ± 0.214
2.017ThrAsn: 2.017 ± 0.362
4.035ThrPro: 4.035 ± 0.533
1.858ThrGln: 1.858 ± 0.28
4.566ThrArg: 4.566 ± 0.639
3.451ThrSer: 3.451 ± 0.477
4.088ThrThr: 4.088 ± 0.632
5.84ThrVal: 5.84 ± 0.566
1.168ThrTrp: 1.168 ± 0.32
1.487ThrTyr: 1.487 ± 0.293
0.0ThrXaa: 0.0 ± 0.0
Val
8.813ValAla: 8.813 ± 0.815
1.168ValCys: 1.168 ± 0.288
5.628ValAsp: 5.628 ± 0.569
4.937ValGlu: 4.937 ± 0.547
2.124ValPhe: 2.124 ± 0.336
5.893ValGly: 5.893 ± 0.593
1.433ValHis: 1.433 ± 0.24
2.867ValIle: 2.867 ± 0.438
1.964ValLys: 1.964 ± 0.343
5.309ValLeu: 5.309 ± 0.531
1.115ValMet: 1.115 ± 0.218
2.177ValAsn: 2.177 ± 0.389
4.778ValPro: 4.778 ± 0.415
2.761ValGln: 2.761 ± 0.36
4.725ValArg: 4.725 ± 0.576
4.619ValSer: 4.619 ± 0.506
5.362ValThr: 5.362 ± 0.612
7.008ValVal: 7.008 ± 0.932
1.38ValTrp: 1.38 ± 0.261
1.274ValTyr: 1.274 ± 0.246
0.0ValXaa: 0.0 ± 0.0
Trp
1.964TrpAla: 1.964 ± 0.295
0.265TrpCys: 0.265 ± 0.131
1.327TrpAsp: 1.327 ± 0.3
1.062TrpGlu: 1.062 ± 0.318
0.743TrpPhe: 0.743 ± 0.223
1.327TrpGly: 1.327 ± 0.478
0.531TrpHis: 0.531 ± 0.164
0.903TrpIle: 0.903 ± 0.223
0.849TrpLys: 0.849 ± 0.183
1.858TrpLeu: 1.858 ± 0.328
0.796TrpMet: 0.796 ± 0.265
0.849TrpAsn: 0.849 ± 0.242
1.062TrpPro: 1.062 ± 0.251
0.956TrpGln: 0.956 ± 0.253
2.336TrpArg: 2.336 ± 0.416
1.54TrpSer: 1.54 ± 0.648
1.858TrpThr: 1.858 ± 0.36
1.38TrpVal: 1.38 ± 0.279
0.903TrpTrp: 0.903 ± 0.263
0.372TrpTyr: 0.372 ± 0.149
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.548TyrAla: 2.548 ± 0.43
0.425TyrCys: 0.425 ± 0.184
1.858TyrAsp: 1.858 ± 0.34
1.487TyrGlu: 1.487 ± 0.27
0.743TyrPhe: 0.743 ± 0.22
1.858TyrGly: 1.858 ± 0.345
0.425TyrHis: 0.425 ± 0.129
1.009TyrIle: 1.009 ± 0.218
0.849TyrLys: 0.849 ± 0.252
1.858TyrLeu: 1.858 ± 0.268
0.159TyrMet: 0.159 ± 0.086
0.743TyrAsn: 0.743 ± 0.191
1.274TyrPro: 1.274 ± 0.21
0.743TyrGln: 0.743 ± 0.203
1.911TyrArg: 1.911 ± 0.346
1.168TyrSer: 1.168 ± 0.246
1.752TyrThr: 1.752 ± 0.274
2.336TyrVal: 2.336 ± 0.302
0.478TyrTrp: 0.478 ± 0.146
0.425TyrTyr: 0.425 ± 0.172
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 112 proteins (18837 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski