Amino acid dipepetide frequency for Streptococcus phage Javan370

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.949AlaAla: 3.949 ± 1.104
0.088AlaCys: 0.088 ± 0.097
5.704AlaAsp: 5.704 ± 0.602
5.177AlaGlu: 5.177 ± 0.8
2.633AlaPhe: 2.633 ± 0.596
4.914AlaGly: 4.914 ± 0.835
1.229AlaHis: 1.229 ± 0.3
5.177AlaIle: 5.177 ± 0.874
5.792AlaLys: 5.792 ± 1.127
6.318AlaLeu: 6.318 ± 0.846
2.457AlaMet: 2.457 ± 0.598
3.773AlaAsn: 3.773 ± 0.47
0.965AlaPro: 0.965 ± 0.301
3.51AlaGln: 3.51 ± 0.588
2.633AlaArg: 2.633 ± 0.462
4.124AlaSer: 4.124 ± 0.669
4.212AlaThr: 4.212 ± 0.758
4.212AlaVal: 4.212 ± 0.758
1.141AlaTrp: 1.141 ± 0.406
1.755AlaTyr: 1.755 ± 0.423
0.0AlaXaa: 0.0 ± 0.0
Cys
0.176CysAla: 0.176 ± 0.132
0.0CysCys: 0.0 ± 0.0
0.176CysAsp: 0.176 ± 0.11
0.527CysGlu: 0.527 ± 0.331
0.263CysPhe: 0.263 ± 0.156
0.439CysGly: 0.439 ± 0.194
0.0CysHis: 0.0 ± 0.0
0.0CysIle: 0.0 ± 0.0
0.527CysLys: 0.527 ± 0.24
0.351CysLeu: 0.351 ± 0.152
0.088CysMet: 0.088 ± 0.105
0.439CysAsn: 0.439 ± 0.264
0.176CysPro: 0.176 ± 0.139
0.088CysGln: 0.088 ± 0.111
0.263CysArg: 0.263 ± 0.144
0.088CysSer: 0.088 ± 0.082
0.176CysThr: 0.176 ± 0.124
0.439CysVal: 0.439 ± 0.237
0.0CysTrp: 0.0 ± 0.0
0.176CysTyr: 0.176 ± 0.145
0.0CysXaa: 0.0 ± 0.0
Asp
3.159AspAla: 3.159 ± 0.555
0.439AspCys: 0.439 ± 0.199
3.598AspAsp: 3.598 ± 0.667
4.563AspGlu: 4.563 ± 0.869
4.124AspPhe: 4.124 ± 0.611
5.09AspGly: 5.09 ± 0.75
0.527AspHis: 0.527 ± 0.279
5.09AspIle: 5.09 ± 0.699
6.143AspLys: 6.143 ± 0.547
7.283AspLeu: 7.283 ± 0.926
1.404AspMet: 1.404 ± 0.412
3.335AspAsn: 3.335 ± 0.557
2.106AspPro: 2.106 ± 0.389
2.369AspGln: 2.369 ± 0.557
2.369AspArg: 2.369 ± 0.585
3.598AspSer: 3.598 ± 0.563
2.72AspThr: 2.72 ± 0.482
4.475AspVal: 4.475 ± 0.639
1.316AspTrp: 1.316 ± 0.417
2.896AspTyr: 2.896 ± 0.469
0.0AspXaa: 0.0 ± 0.0
Glu
5.353GluAla: 5.353 ± 0.632
0.965GluCys: 0.965 ± 0.405
4.826GluAsp: 4.826 ± 0.888
6.757GluGlu: 6.757 ± 0.959
3.773GluPhe: 3.773 ± 0.651
3.422GluGly: 3.422 ± 0.429
0.965GluHis: 0.965 ± 0.286
5.879GluIle: 5.879 ± 0.647
6.406GluLys: 6.406 ± 0.907
8.249GluLeu: 8.249 ± 1.106
2.369GluMet: 2.369 ± 0.493
5.616GluAsn: 5.616 ± 0.769
1.843GluPro: 1.843 ± 0.374
3.51GluGln: 3.51 ± 0.76
3.071GluArg: 3.071 ± 0.504
5.09GluSer: 5.09 ± 0.755
3.861GluThr: 3.861 ± 0.482
5.528GluVal: 5.528 ± 0.847
1.053GluTrp: 1.053 ± 0.27
3.247GluTyr: 3.247 ± 0.456
0.0GluXaa: 0.0 ± 0.0
Phe
3.686PheAla: 3.686 ± 0.54
0.176PheCys: 0.176 ± 0.146
3.51PheAsp: 3.51 ± 0.56
3.861PheGlu: 3.861 ± 0.718
1.58PhePhe: 1.58 ± 0.405
3.598PheGly: 3.598 ± 0.622
0.439PheHis: 0.439 ± 0.197
2.545PheIle: 2.545 ± 0.569
4.388PheLys: 4.388 ± 0.754
2.984PheLeu: 2.984 ± 0.508
0.79PheMet: 0.79 ± 0.304
2.984PheAsn: 2.984 ± 0.66
1.667PhePro: 1.667 ± 0.39
1.404PheGln: 1.404 ± 0.36
2.018PheArg: 2.018 ± 0.608
2.282PheSer: 2.282 ± 0.43
2.369PheThr: 2.369 ± 0.517
2.194PheVal: 2.194 ± 0.625
0.351PheTrp: 0.351 ± 0.187
1.404PheTyr: 1.404 ± 0.404
0.0PheXaa: 0.0 ± 0.0
Gly
3.861GlyAla: 3.861 ± 0.682
0.176GlyCys: 0.176 ± 0.102
4.124GlyAsp: 4.124 ± 0.4
3.949GlyGlu: 3.949 ± 0.492
4.037GlyPhe: 4.037 ± 0.673
4.475GlyGly: 4.475 ± 0.684
0.702GlyHis: 0.702 ± 0.267
5.002GlyIle: 5.002 ± 0.795
5.967GlyLys: 5.967 ± 0.651
5.528GlyLeu: 5.528 ± 0.687
2.018GlyMet: 2.018 ± 0.417
3.422GlyAsn: 3.422 ± 0.616
1.316GlyPro: 1.316 ± 0.294
2.633GlyGln: 2.633 ± 0.464
2.457GlyArg: 2.457 ± 0.386
4.739GlySer: 4.739 ± 0.649
3.51GlyThr: 3.51 ± 0.493
2.457GlyVal: 2.457 ± 0.405
0.965GlyTrp: 0.965 ± 0.314
2.106GlyTyr: 2.106 ± 0.559
0.0GlyXaa: 0.0 ± 0.0
His
0.79HisAla: 0.79 ± 0.225
0.088HisCys: 0.088 ± 0.082
1.141HisAsp: 1.141 ± 0.396
0.965HisGlu: 0.965 ± 0.242
0.614HisPhe: 0.614 ± 0.268
1.053HisGly: 1.053 ± 0.477
0.351HisHis: 0.351 ± 0.163
0.965HisIle: 0.965 ± 0.405
0.614HisLys: 0.614 ± 0.205
0.79HisLeu: 0.79 ± 0.368
0.176HisMet: 0.176 ± 0.156
0.351HisAsn: 0.351 ± 0.223
0.878HisPro: 0.878 ± 0.312
0.351HisGln: 0.351 ± 0.183
0.614HisArg: 0.614 ± 0.285
0.878HisSer: 0.878 ± 0.335
0.965HisThr: 0.965 ± 0.271
0.878HisVal: 0.878 ± 0.297
0.088HisTrp: 0.088 ± 0.072
0.527HisTyr: 0.527 ± 0.25
0.0HisXaa: 0.0 ± 0.0
Ile
5.967IleAla: 5.967 ± 0.719
0.527IleCys: 0.527 ± 0.263
5.792IleAsp: 5.792 ± 0.882
6.143IleGlu: 6.143 ± 0.77
2.633IlePhe: 2.633 ± 0.618
3.949IleGly: 3.949 ± 0.783
0.79IleHis: 0.79 ± 0.252
3.335IleIle: 3.335 ± 0.58
6.581IleLys: 6.581 ± 0.742
4.914IleLeu: 4.914 ± 0.748
0.878IleMet: 0.878 ± 0.258
5.09IleAsn: 5.09 ± 0.689
2.106IlePro: 2.106 ± 0.393
2.984IleGln: 2.984 ± 0.527
3.071IleArg: 3.071 ± 0.567
3.861IleSer: 3.861 ± 0.766
4.563IleThr: 4.563 ± 0.559
3.247IleVal: 3.247 ± 0.404
0.176IleTrp: 0.176 ± 0.132
2.633IleTyr: 2.633 ± 0.525
0.0IleXaa: 0.0 ± 0.0
Lys
6.494LysAla: 6.494 ± 0.738
0.088LysCys: 0.088 ± 0.084
4.563LysAsp: 4.563 ± 0.681
8.512LysGlu: 8.512 ± 1.295
3.071LysPhe: 3.071 ± 0.503
3.335LysGly: 3.335 ± 0.409
1.316LysHis: 1.316 ± 0.436
6.406LysIle: 6.406 ± 0.636
6.318LysLys: 6.318 ± 0.796
7.108LysLeu: 7.108 ± 0.825
3.422LysMet: 3.422 ± 0.533
5.879LysAsn: 5.879 ± 0.643
2.018LysPro: 2.018 ± 0.392
4.3LysGln: 4.3 ± 0.483
3.773LysArg: 3.773 ± 0.578
5.09LysSer: 5.09 ± 0.556
5.09LysThr: 5.09 ± 0.773
4.475LysVal: 4.475 ± 0.604
1.316LysTrp: 1.316 ± 0.433
2.72LysTyr: 2.72 ± 0.432
0.0LysXaa: 0.0 ± 0.0
Leu
6.669LeuAla: 6.669 ± 0.903
0.527LeuCys: 0.527 ± 0.232
5.002LeuAsp: 5.002 ± 0.863
8.073LeuGlu: 8.073 ± 0.753
3.598LeuPhe: 3.598 ± 0.791
5.616LeuGly: 5.616 ± 0.926
1.316LeuHis: 1.316 ± 0.402
5.002LeuIle: 5.002 ± 0.94
7.459LeuLys: 7.459 ± 0.921
6.055LeuLeu: 6.055 ± 0.801
2.194LeuMet: 2.194 ± 0.355
4.914LeuAsn: 4.914 ± 0.715
2.106LeuPro: 2.106 ± 0.492
3.861LeuGln: 3.861 ± 0.717
2.984LeuArg: 2.984 ± 0.527
5.616LeuSer: 5.616 ± 0.785
5.177LeuThr: 5.177 ± 0.693
5.704LeuVal: 5.704 ± 0.757
0.439LeuTrp: 0.439 ± 0.183
2.984LeuTyr: 2.984 ± 0.49
0.0LeuXaa: 0.0 ± 0.0
Met
1.843MetAla: 1.843 ± 0.445
0.0MetCys: 0.0 ± 0.0
1.053MetAsp: 1.053 ± 0.35
2.194MetGlu: 2.194 ± 0.416
0.79MetPhe: 0.79 ± 0.269
0.527MetGly: 0.527 ± 0.223
0.351MetHis: 0.351 ± 0.212
2.282MetIle: 2.282 ± 0.36
2.633MetLys: 2.633 ± 0.416
1.404MetLeu: 1.404 ± 0.377
0.614MetMet: 0.614 ± 0.223
2.369MetAsn: 2.369 ± 0.444
0.79MetPro: 0.79 ± 0.297
0.965MetGln: 0.965 ± 0.307
0.702MetArg: 0.702 ± 0.274
2.106MetSer: 2.106 ± 0.353
1.931MetThr: 1.931 ± 0.454
1.58MetVal: 1.58 ± 0.418
0.088MetTrp: 0.088 ± 0.097
0.351MetTyr: 0.351 ± 0.177
0.0MetXaa: 0.0 ± 0.0
Asn
3.598AsnAla: 3.598 ± 0.851
0.263AsnCys: 0.263 ± 0.162
4.212AsnAsp: 4.212 ± 0.724
4.212AsnGlu: 4.212 ± 0.999
2.282AsnPhe: 2.282 ± 0.455
5.967AsnGly: 5.967 ± 0.886
0.965AsnHis: 0.965 ± 0.273
3.598AsnIle: 3.598 ± 0.661
6.143AsnLys: 6.143 ± 0.876
4.124AsnLeu: 4.124 ± 0.647
1.053AsnMet: 1.053 ± 0.313
3.598AsnAsn: 3.598 ± 0.722
1.931AsnPro: 1.931 ± 0.354
2.633AsnGln: 2.633 ± 0.452
2.018AsnArg: 2.018 ± 0.434
3.335AsnSer: 3.335 ± 0.437
3.773AsnThr: 3.773 ± 0.48
3.598AsnVal: 3.598 ± 0.553
0.614AsnTrp: 0.614 ± 0.263
1.404AsnTyr: 1.404 ± 0.42
0.0AsnXaa: 0.0 ± 0.0
Pro
1.492ProAla: 1.492 ± 0.394
0.088ProCys: 0.088 ± 0.078
1.141ProAsp: 1.141 ± 0.334
2.633ProGlu: 2.633 ± 0.562
1.229ProPhe: 1.229 ± 0.413
0.965ProGly: 0.965 ± 0.32
0.351ProHis: 0.351 ± 0.203
2.018ProIle: 2.018 ± 0.416
1.931ProLys: 1.931 ± 0.459
2.282ProLeu: 2.282 ± 0.485
0.527ProMet: 0.527 ± 0.185
1.492ProAsn: 1.492 ± 0.374
0.439ProPro: 0.439 ± 0.211
1.141ProGln: 1.141 ± 0.341
1.141ProArg: 1.141 ± 0.332
2.457ProSer: 2.457 ± 0.386
2.106ProThr: 2.106 ± 0.472
2.106ProVal: 2.106 ± 0.484
0.439ProTrp: 0.439 ± 0.157
0.614ProTyr: 0.614 ± 0.255
0.0ProXaa: 0.0 ± 0.0
Gln
3.773GlnAla: 3.773 ± 0.959
0.176GlnCys: 0.176 ± 0.136
1.404GlnAsp: 1.404 ± 0.298
3.598GlnGlu: 3.598 ± 0.575
2.369GlnPhe: 2.369 ± 0.454
3.071GlnGly: 3.071 ± 0.498
0.702GlnHis: 0.702 ± 0.193
2.457GlnIle: 2.457 ± 0.395
3.861GlnLys: 3.861 ± 0.724
4.739GlnLeu: 4.739 ± 0.667
0.614GlnMet: 0.614 ± 0.274
2.106GlnAsn: 2.106 ± 0.584
0.878GlnPro: 0.878 ± 0.355
1.755GlnGln: 1.755 ± 0.524
2.018GlnArg: 2.018 ± 0.39
2.808GlnSer: 2.808 ± 0.402
3.247GlnThr: 3.247 ± 0.604
1.58GlnVal: 1.58 ± 0.438
0.439GlnTrp: 0.439 ± 0.187
1.141GlnTyr: 1.141 ± 0.316
0.0GlnXaa: 0.0 ± 0.0
Arg
2.018ArgAla: 2.018 ± 0.416
0.0ArgCys: 0.0 ± 0.0
2.984ArgAsp: 2.984 ± 0.612
3.422ArgGlu: 3.422 ± 0.556
1.755ArgPhe: 1.755 ± 0.455
2.106ArgGly: 2.106 ± 0.417
0.79ArgHis: 0.79 ± 0.312
3.159ArgIle: 3.159 ± 0.675
3.071ArgLys: 3.071 ± 0.631
3.686ArgLeu: 3.686 ± 0.679
1.316ArgMet: 1.316 ± 0.369
1.931ArgAsn: 1.931 ± 0.338
1.229ArgPro: 1.229 ± 0.41
1.667ArgGln: 1.667 ± 0.412
1.755ArgArg: 1.755 ± 0.364
2.282ArgSer: 2.282 ± 0.479
2.545ArgThr: 2.545 ± 0.385
1.843ArgVal: 1.843 ± 0.418
0.263ArgTrp: 0.263 ± 0.133
1.843ArgTyr: 1.843 ± 0.35
0.0ArgXaa: 0.0 ± 0.0
Ser
4.212SerAla: 4.212 ± 0.763
0.263SerCys: 0.263 ± 0.153
4.739SerAsp: 4.739 ± 0.688
4.914SerGlu: 4.914 ± 0.636
2.896SerPhe: 2.896 ± 0.435
3.949SerGly: 3.949 ± 0.552
0.614SerHis: 0.614 ± 0.225
4.563SerIle: 4.563 ± 0.769
4.914SerLys: 4.914 ± 0.838
4.037SerLeu: 4.037 ± 0.632
1.316SerMet: 1.316 ± 0.413
3.773SerAsn: 3.773 ± 0.657
1.229SerPro: 1.229 ± 0.348
2.633SerGln: 2.633 ± 0.428
2.194SerArg: 2.194 ± 0.426
3.159SerSer: 3.159 ± 0.587
4.124SerThr: 4.124 ± 0.638
4.563SerVal: 4.563 ± 0.752
0.702SerTrp: 0.702 ± 0.238
2.194SerTyr: 2.194 ± 0.38
0.0SerXaa: 0.0 ± 0.0
Thr
5.441ThrAla: 5.441 ± 1.274
0.088ThrCys: 0.088 ± 0.095
3.686ThrAsp: 3.686 ± 0.559
3.686ThrGlu: 3.686 ± 0.515
2.545ThrPhe: 2.545 ± 0.445
4.124ThrGly: 4.124 ± 0.645
0.527ThrHis: 0.527 ± 0.251
4.388ThrIle: 4.388 ± 0.849
4.212ThrLys: 4.212 ± 0.461
5.616ThrLeu: 5.616 ± 0.781
1.316ThrMet: 1.316 ± 0.371
2.72ThrAsn: 2.72 ± 0.428
2.457ThrPro: 2.457 ± 0.452
2.72ThrGln: 2.72 ± 0.599
2.369ThrArg: 2.369 ± 0.465
3.51ThrSer: 3.51 ± 0.582
3.949ThrThr: 3.949 ± 0.504
4.3ThrVal: 4.3 ± 0.68
0.702ThrTrp: 0.702 ± 0.19
1.755ThrTyr: 1.755 ± 0.489
0.0ThrXaa: 0.0 ± 0.0
Val
4.563ValAla: 4.563 ± 0.681
0.176ValCys: 0.176 ± 0.107
5.265ValAsp: 5.265 ± 0.847
5.177ValGlu: 5.177 ± 0.77
1.931ValPhe: 1.931 ± 0.378
4.037ValGly: 4.037 ± 0.52
0.702ValHis: 0.702 ± 0.318
3.51ValIle: 3.51 ± 0.645
4.739ValLys: 4.739 ± 0.781
4.739ValLeu: 4.739 ± 0.789
1.58ValMet: 1.58 ± 0.354
2.545ValAsn: 2.545 ± 0.385
1.843ValPro: 1.843 ± 0.455
2.633ValGln: 2.633 ± 0.453
2.633ValArg: 2.633 ± 0.452
3.598ValSer: 3.598 ± 0.656
3.159ValThr: 3.159 ± 0.554
3.861ValVal: 3.861 ± 0.662
0.878ValTrp: 0.878 ± 0.248
1.755ValTyr: 1.755 ± 0.3
0.0ValXaa: 0.0 ± 0.0
Trp
0.351TrpAla: 0.351 ± 0.143
0.0TrpCys: 0.0 ± 0.0
0.527TrpAsp: 0.527 ± 0.197
0.878TrpGlu: 0.878 ± 0.289
0.439TrpPhe: 0.439 ± 0.225
1.229TrpGly: 1.229 ± 0.278
0.0TrpHis: 0.0 ± 0.0
0.965TrpIle: 0.965 ± 0.327
0.527TrpLys: 0.527 ± 0.222
1.755TrpLeu: 1.755 ± 0.412
0.088TrpMet: 0.088 ± 0.084
0.702TrpAsn: 0.702 ± 0.319
0.176TrpPro: 0.176 ± 0.11
0.351TrpGln: 0.351 ± 0.181
0.702TrpArg: 0.702 ± 0.227
0.614TrpSer: 0.614 ± 0.245
0.702TrpThr: 0.702 ± 0.28
0.79TrpVal: 0.79 ± 0.216
0.0TrpTrp: 0.0 ± 0.0
0.439TrpTyr: 0.439 ± 0.199
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.457TyrAla: 2.457 ± 0.329
0.263TyrCys: 0.263 ± 0.175
3.159TyrAsp: 3.159 ± 0.48
2.545TyrGlu: 2.545 ± 0.469
1.667TyrPhe: 1.667 ± 0.341
1.58TyrGly: 1.58 ± 0.479
0.439TyrHis: 0.439 ± 0.184
2.896TyrIle: 2.896 ± 0.599
3.071TyrLys: 3.071 ± 0.37
3.335TyrLeu: 3.335 ± 0.625
0.263TyrMet: 0.263 ± 0.153
2.282TyrAsn: 2.282 ± 0.409
0.439TyrPro: 0.439 ± 0.221
1.229TyrGln: 1.229 ± 0.337
0.878TyrArg: 0.878 ± 0.262
1.755TyrSer: 1.755 ± 0.491
1.931TyrThr: 1.931 ± 0.561
1.492TyrVal: 1.492 ± 0.381
0.263TyrTrp: 0.263 ± 0.171
0.439TyrTyr: 0.439 ± 0.191
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 55 proteins (11397 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski