Amino acid dipepetide frequency for Cellulophaga phage phi39:1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
6.959AlaAla: 6.959 ± 1.409
0.107AlaCys: 0.107 ± 0.103
5.567AlaAsp: 5.567 ± 1.352
3.747AlaGlu: 3.747 ± 0.863
2.998AlaPhe: 2.998 ± 0.64
4.711AlaGly: 4.711 ± 1.101
0.857AlaHis: 0.857 ± 0.387
5.996AlaIle: 5.996 ± 1.172
6.531AlaLys: 6.531 ± 1.899
5.782AlaLeu: 5.782 ± 1.124
0.749AlaMet: 0.749 ± 0.255
3.747AlaAsn: 3.747 ± 0.427
1.606AlaPro: 1.606 ± 0.413
3.105AlaGln: 3.105 ± 0.735
1.713AlaArg: 1.713 ± 0.461
2.784AlaSer: 2.784 ± 0.653
3.747AlaThr: 3.747 ± 0.992
5.782AlaVal: 5.782 ± 0.792
0.214AlaTrp: 0.214 ± 0.127
2.355AlaTyr: 2.355 ± 0.408
0.0AlaXaa: 0.0 ± 0.0
Cys
0.107CysAla: 0.107 ± 0.124
0.0CysCys: 0.0 ± 0.0
0.321CysAsp: 0.321 ± 0.162
0.107CysGlu: 0.107 ± 0.104
0.749CysPhe: 0.749 ± 0.313
0.642CysGly: 0.642 ± 0.289
0.107CysHis: 0.107 ± 0.103
1.071CysIle: 1.071 ± 0.396
0.964CysLys: 0.964 ± 0.34
0.749CysLeu: 0.749 ± 0.315
0.321CysMet: 0.321 ± 0.195
0.428CysAsn: 0.428 ± 0.219
0.214CysPro: 0.214 ± 0.14
0.535CysGln: 0.535 ± 0.211
0.214CysArg: 0.214 ± 0.157
0.749CysSer: 0.749 ± 0.297
0.214CysThr: 0.214 ± 0.155
0.535CysVal: 0.535 ± 0.234
0.214CysTrp: 0.214 ± 0.146
0.749CysTyr: 0.749 ± 0.266
0.0CysXaa: 0.0 ± 0.0
Asp
4.925AspAla: 4.925 ± 1.014
0.321AspCys: 0.321 ± 0.185
5.46AspAsp: 5.46 ± 0.982
3.533AspGlu: 3.533 ± 0.656
3.64AspPhe: 3.64 ± 0.482
5.139AspGly: 5.139 ± 1.027
1.071AspHis: 1.071 ± 0.337
3.212AspIle: 3.212 ± 0.599
4.497AspLys: 4.497 ± 0.852
5.675AspLeu: 5.675 ± 0.939
0.857AspMet: 0.857 ± 0.286
2.998AspAsn: 2.998 ± 0.464
2.141AspPro: 2.141 ± 0.361
2.463AspGln: 2.463 ± 0.799
2.141AspArg: 2.141 ± 0.555
5.246AspSer: 5.246 ± 0.794
2.355AspThr: 2.355 ± 0.47
4.283AspVal: 4.283 ± 0.664
0.535AspTrp: 0.535 ± 0.222
2.57AspTyr: 2.57 ± 0.655
0.0AspXaa: 0.0 ± 0.0
Glu
5.675GluAla: 5.675 ± 1.339
0.642GluCys: 0.642 ± 0.272
3.961GluAsp: 3.961 ± 1.031
4.176GluGlu: 4.176 ± 0.663
2.891GluPhe: 2.891 ± 0.66
4.39GluGly: 4.39 ± 0.591
0.321GluHis: 0.321 ± 0.222
4.497GluIle: 4.497 ± 0.684
5.46GluLys: 5.46 ± 0.78
5.889GluLeu: 5.889 ± 1.006
1.392GluMet: 1.392 ± 0.411
4.283GluAsn: 4.283 ± 0.706
1.178GluPro: 1.178 ± 0.34
1.606GluGln: 1.606 ± 0.387
2.248GluArg: 2.248 ± 0.487
2.784GluSer: 2.784 ± 0.528
2.784GluThr: 2.784 ± 0.529
5.46GluVal: 5.46 ± 0.986
0.749GluTrp: 0.749 ± 0.295
2.248GluTyr: 2.248 ± 0.569
0.0GluXaa: 0.0 ± 0.0
Phe
1.927PheAla: 1.927 ± 0.556
0.857PheCys: 0.857 ± 0.326
2.784PheAsp: 2.784 ± 0.507
3.854PheGlu: 3.854 ± 0.664
1.82PhePhe: 1.82 ± 0.67
2.998PheGly: 2.998 ± 0.427
0.749PheHis: 0.749 ± 0.396
4.604PheIle: 4.604 ± 0.748
3.747PheLys: 3.747 ± 0.64
4.39PheLeu: 4.39 ± 0.636
0.964PheMet: 0.964 ± 0.36
3.212PheAsn: 3.212 ± 0.814
1.071PhePro: 1.071 ± 0.359
1.071PheGln: 1.071 ± 0.297
1.82PheArg: 1.82 ± 0.35
4.925PheSer: 4.925 ± 0.658
3.105PheThr: 3.105 ± 0.617
3.212PheVal: 3.212 ± 0.723
0.535PheTrp: 0.535 ± 0.265
2.248PheTyr: 2.248 ± 0.551
0.0PheXaa: 0.0 ± 0.0
Gly
5.032GlyAla: 5.032 ± 0.95
1.071GlyCys: 1.071 ± 0.346
4.176GlyAsp: 4.176 ± 0.548
3.64GlyGlu: 3.64 ± 0.712
5.675GlyPhe: 5.675 ± 0.487
6.638GlyGly: 6.638 ± 1.152
0.428GlyHis: 0.428 ± 0.223
3.105GlyIle: 3.105 ± 0.704
5.353GlyLys: 5.353 ± 0.726
5.889GlyLeu: 5.889 ± 1.049
1.178GlyMet: 1.178 ± 0.44
4.497GlyAsn: 4.497 ± 0.972
1.392GlyPro: 1.392 ± 0.411
1.606GlyGln: 1.606 ± 0.504
2.248GlyArg: 2.248 ± 0.386
5.139GlySer: 5.139 ± 1.038
3.64GlyThr: 3.64 ± 0.878
6.317GlyVal: 6.317 ± 0.871
0.857GlyTrp: 0.857 ± 0.289
2.463GlyTyr: 2.463 ± 0.466
0.0GlyXaa: 0.0 ± 0.0
His
0.857HisAla: 0.857 ± 0.332
0.214HisCys: 0.214 ± 0.141
0.642HisAsp: 0.642 ± 0.248
0.642HisGlu: 0.642 ± 0.287
0.321HisPhe: 0.321 ± 0.235
0.857HisGly: 0.857 ± 0.246
0.321HisHis: 0.321 ± 0.236
0.642HisIle: 0.642 ± 0.3
1.285HisLys: 1.285 ± 0.443
1.071HisLeu: 1.071 ± 0.413
0.0HisMet: 0.0 ± 0.0
0.428HisAsn: 0.428 ± 0.207
0.321HisPro: 0.321 ± 0.158
0.535HisGln: 0.535 ± 0.28
0.214HisArg: 0.214 ± 0.132
0.749HisSer: 0.749 ± 0.287
0.428HisThr: 0.428 ± 0.2
0.749HisVal: 0.749 ± 0.291
0.214HisTrp: 0.214 ± 0.158
0.428HisTyr: 0.428 ± 0.174
0.0HisXaa: 0.0 ± 0.0
Ile
4.069IleAla: 4.069 ± 0.694
0.535IleCys: 0.535 ± 0.309
5.139IleAsp: 5.139 ± 0.733
5.032IleGlu: 5.032 ± 0.778
3.64IlePhe: 3.64 ± 0.464
4.283IleGly: 4.283 ± 0.895
0.535IleHis: 0.535 ± 0.21
5.353IleIle: 5.353 ± 0.907
6.852IleLys: 6.852 ± 1.134
6.959IleLeu: 6.959 ± 1.039
1.713IleMet: 1.713 ± 0.408
4.925IleAsn: 4.925 ± 0.699
2.355IlePro: 2.355 ± 0.405
2.034IleGln: 2.034 ± 0.476
2.891IleArg: 2.891 ± 0.501
6.852IleSer: 6.852 ± 0.831
4.925IleThr: 4.925 ± 0.725
4.283IleVal: 4.283 ± 0.493
0.642IleTrp: 0.642 ± 0.31
2.998IleTyr: 2.998 ± 0.663
0.0IleXaa: 0.0 ± 0.0
Lys
7.495LysAla: 7.495 ± 2.582
0.857LysCys: 0.857 ± 0.379
4.818LysAsp: 4.818 ± 0.825
5.675LysGlu: 5.675 ± 0.989
3.212LysPhe: 3.212 ± 0.513
4.176LysGly: 4.176 ± 0.615
1.071LysHis: 1.071 ± 0.346
6.959LysIle: 6.959 ± 0.88
6.959LysLys: 6.959 ± 1.253
6.745LysLeu: 6.745 ± 1.018
2.034LysMet: 2.034 ± 0.451
5.889LysAsn: 5.889 ± 0.744
1.713LysPro: 1.713 ± 0.469
2.463LysGln: 2.463 ± 0.491
3.426LysArg: 3.426 ± 0.721
4.818LysSer: 4.818 ± 0.613
5.675LysThr: 5.675 ± 0.994
4.176LysVal: 4.176 ± 0.574
1.178LysTrp: 1.178 ± 0.254
2.784LysTyr: 2.784 ± 0.644
0.0LysXaa: 0.0 ± 0.0
Leu
4.711LeuAla: 4.711 ± 1.115
1.071LeuCys: 1.071 ± 0.363
6.531LeuAsp: 6.531 ± 0.832
6.424LeuGlu: 6.424 ± 0.749
3.105LeuPhe: 3.105 ± 0.46
6.21LeuGly: 6.21 ± 0.616
1.178LeuHis: 1.178 ± 0.42
8.137LeuIle: 8.137 ± 0.885
8.672LeuLys: 8.672 ± 1.117
8.137LeuLeu: 8.137 ± 1.24
2.355LeuMet: 2.355 ± 0.593
5.139LeuAsn: 5.139 ± 0.627
3.105LeuPro: 3.105 ± 0.667
3.105LeuGln: 3.105 ± 0.539
2.248LeuArg: 2.248 ± 0.59
7.495LeuSer: 7.495 ± 0.957
5.46LeuThr: 5.46 ± 1.077
6.21LeuVal: 6.21 ± 1.167
0.428LeuTrp: 0.428 ± 0.184
2.034LeuTyr: 2.034 ± 0.462
0.0LeuXaa: 0.0 ± 0.0
Met
2.034MetAla: 2.034 ± 0.494
0.0MetCys: 0.0 ± 0.0
0.321MetAsp: 0.321 ± 0.191
1.285MetGlu: 1.285 ± 0.347
0.749MetPhe: 0.749 ± 0.353
1.071MetGly: 1.071 ± 0.232
0.321MetHis: 0.321 ± 0.241
1.178MetIle: 1.178 ± 0.296
2.034MetLys: 2.034 ± 0.409
1.392MetLeu: 1.392 ± 0.404
0.107MetMet: 0.107 ± 0.109
2.355MetAsn: 2.355 ± 0.481
0.749MetPro: 0.749 ± 0.254
0.642MetGln: 0.642 ± 0.305
0.428MetArg: 0.428 ± 0.177
1.285MetSer: 1.285 ± 0.378
1.071MetThr: 1.071 ± 0.379
1.178MetVal: 1.178 ± 0.352
0.214MetTrp: 0.214 ± 0.158
0.749MetTyr: 0.749 ± 0.266
0.0MetXaa: 0.0 ± 0.0
Asn
2.355AsnAla: 2.355 ± 0.477
0.642AsnCys: 0.642 ± 0.239
3.64AsnAsp: 3.64 ± 0.662
4.925AsnGlu: 4.925 ± 0.822
3.533AsnPhe: 3.533 ± 0.507
4.604AsnGly: 4.604 ± 0.564
0.321AsnHis: 0.321 ± 0.172
4.818AsnIle: 4.818 ± 0.916
4.711AsnLys: 4.711 ± 0.813
6.317AsnLeu: 6.317 ± 0.863
1.606AsnMet: 1.606 ± 0.315
3.105AsnAsn: 3.105 ± 0.563
2.248AsnPro: 2.248 ± 0.622
1.499AsnGln: 1.499 ± 0.336
1.499AsnArg: 1.499 ± 0.406
5.996AsnSer: 5.996 ± 0.869
2.57AsnThr: 2.57 ± 0.49
3.961AsnVal: 3.961 ± 0.687
0.428AsnTrp: 0.428 ± 0.153
3.105AsnTyr: 3.105 ± 0.709
0.0AsnXaa: 0.0 ± 0.0
Pro
1.713ProAla: 1.713 ± 0.422
0.107ProCys: 0.107 ± 0.124
1.178ProAsp: 1.178 ± 0.409
1.927ProGlu: 1.927 ± 0.582
1.285ProPhe: 1.285 ± 0.435
2.784ProGly: 2.784 ± 0.455
0.214ProHis: 0.214 ± 0.144
3.105ProIle: 3.105 ± 0.594
1.285ProLys: 1.285 ± 0.474
2.784ProLeu: 2.784 ± 0.472
0.214ProMet: 0.214 ± 0.212
1.606ProAsn: 1.606 ± 0.467
0.642ProPro: 0.642 ± 0.223
0.642ProGln: 0.642 ± 0.233
0.642ProArg: 0.642 ± 0.239
2.034ProSer: 2.034 ± 0.522
1.927ProThr: 1.927 ± 0.391
2.677ProVal: 2.677 ± 0.501
0.214ProTrp: 0.214 ± 0.156
1.285ProTyr: 1.285 ± 0.298
0.0ProXaa: 0.0 ± 0.0
Gln
1.606GlnAla: 1.606 ± 0.738
0.107GlnCys: 0.107 ± 0.1
0.857GlnAsp: 0.857 ± 0.346
1.927GlnGlu: 1.927 ± 0.794
1.606GlnPhe: 1.606 ± 0.571
0.857GlnGly: 0.857 ± 0.322
0.214GlnHis: 0.214 ± 0.14
2.355GlnIle: 2.355 ± 0.383
2.141GlnLys: 2.141 ± 0.556
3.212GlnLeu: 3.212 ± 0.67
1.285GlnMet: 1.285 ± 0.363
1.927GlnAsn: 1.927 ± 0.349
0.857GlnPro: 0.857 ± 0.276
0.857GlnGln: 0.857 ± 0.286
1.178GlnArg: 1.178 ± 0.346
2.034GlnSer: 2.034 ± 0.385
1.606GlnThr: 1.606 ± 0.452
2.355GlnVal: 2.355 ± 0.453
0.321GlnTrp: 0.321 ± 0.211
1.285GlnTyr: 1.285 ± 0.4
0.0GlnXaa: 0.0 ± 0.0
Arg
2.677ArgAla: 2.677 ± 0.816
0.107ArgCys: 0.107 ± 0.134
1.392ArgAsp: 1.392 ± 0.425
1.713ArgGlu: 1.713 ± 0.521
1.927ArgPhe: 1.927 ± 0.406
1.927ArgGly: 1.927 ± 0.487
0.535ArgHis: 0.535 ± 0.291
1.82ArgIle: 1.82 ± 0.432
2.141ArgLys: 2.141 ± 0.424
3.426ArgLeu: 3.426 ± 0.649
0.749ArgMet: 0.749 ± 0.257
1.82ArgAsn: 1.82 ± 0.324
1.071ArgPro: 1.071 ± 0.505
0.428ArgGln: 0.428 ± 0.225
1.713ArgArg: 1.713 ± 0.492
3.533ArgSer: 3.533 ± 0.552
1.713ArgThr: 1.713 ± 0.412
2.355ArgVal: 2.355 ± 0.454
0.749ArgTrp: 0.749 ± 0.307
1.071ArgTyr: 1.071 ± 0.313
0.0ArgXaa: 0.0 ± 0.0
Ser
4.818SerAla: 4.818 ± 0.749
0.321SerCys: 0.321 ± 0.181
4.604SerAsp: 4.604 ± 0.844
3.64SerGlu: 3.64 ± 0.679
3.961SerPhe: 3.961 ± 0.532
7.281SerGly: 7.281 ± 1.143
0.857SerHis: 0.857 ± 0.266
6.745SerIle: 6.745 ± 0.807
5.996SerLys: 5.996 ± 0.911
7.709SerLeu: 7.709 ± 0.977
1.285SerMet: 1.285 ± 0.356
4.069SerAsn: 4.069 ± 0.82
1.82SerPro: 1.82 ± 0.487
1.285SerGln: 1.285 ± 0.377
2.891SerArg: 2.891 ± 0.653
5.032SerSer: 5.032 ± 0.685
4.283SerThr: 4.283 ± 0.687
4.176SerVal: 4.176 ± 0.591
0.535SerTrp: 0.535 ± 0.318
2.355SerTyr: 2.355 ± 0.364
0.0SerXaa: 0.0 ± 0.0
Thr
5.675ThrAla: 5.675 ± 0.977
0.107ThrCys: 0.107 ± 0.108
2.57ThrAsp: 2.57 ± 0.581
2.677ThrGlu: 2.677 ± 0.559
2.463ThrPhe: 2.463 ± 0.4
4.818ThrGly: 4.818 ± 0.968
0.428ThrHis: 0.428 ± 0.21
4.604ThrIle: 4.604 ± 0.742
4.818ThrLys: 4.818 ± 0.788
5.139ThrLeu: 5.139 ± 0.97
0.749ThrMet: 0.749 ± 0.265
2.891ThrAsn: 2.891 ± 0.727
2.784ThrPro: 2.784 ± 0.673
1.178ThrGln: 1.178 ± 0.37
1.178ThrArg: 1.178 ± 0.371
3.212ThrSer: 3.212 ± 0.767
2.355ThrThr: 2.355 ± 0.54
3.854ThrVal: 3.854 ± 0.505
0.749ThrTrp: 0.749 ± 0.271
1.927ThrTyr: 1.927 ± 0.514
0.0ThrXaa: 0.0 ± 0.0
Val
4.176ValAla: 4.176 ± 0.804
0.749ValCys: 0.749 ± 0.225
6.21ValAsp: 6.21 ± 0.886
5.032ValGlu: 5.032 ± 0.662
2.891ValPhe: 2.891 ± 0.542
4.39ValGly: 4.39 ± 0.711
0.535ValHis: 0.535 ± 0.213
4.497ValIle: 4.497 ± 0.851
4.818ValLys: 4.818 ± 0.826
5.996ValLeu: 5.996 ± 0.663
0.964ValMet: 0.964 ± 0.237
5.353ValAsn: 5.353 ± 0.883
1.499ValPro: 1.499 ± 0.409
2.248ValGln: 2.248 ± 0.417
2.141ValArg: 2.141 ± 0.464
5.782ValSer: 5.782 ± 0.734
4.283ValThr: 4.283 ± 0.92
6.317ValVal: 6.317 ± 1.06
0.535ValTrp: 0.535 ± 0.232
1.927ValTyr: 1.927 ± 0.479
0.0ValXaa: 0.0 ± 0.0
Trp
0.535TrpAla: 0.535 ± 0.215
0.321TrpCys: 0.321 ± 0.159
0.964TrpAsp: 0.964 ± 0.297
0.749TrpGlu: 0.749 ± 0.24
0.964TrpPhe: 0.964 ± 0.317
0.535TrpGly: 0.535 ± 0.199
0.107TrpHis: 0.107 ± 0.108
0.642TrpIle: 0.642 ± 0.284
0.214TrpLys: 0.214 ± 0.144
1.071TrpLeu: 1.071 ± 0.337
0.214TrpMet: 0.214 ± 0.193
0.749TrpAsn: 0.749 ± 0.192
0.0TrpPro: 0.0 ± 0.0
0.428TrpGln: 0.428 ± 0.2
0.321TrpArg: 0.321 ± 0.198
0.857TrpSer: 0.857 ± 0.292
0.107TrpThr: 0.107 ± 0.1
0.964TrpVal: 0.964 ± 0.318
0.214TrpTrp: 0.214 ± 0.179
0.321TrpTyr: 0.321 ± 0.167
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.713TyrAla: 1.713 ± 0.334
0.857TyrCys: 0.857 ± 0.374
1.927TyrAsp: 1.927 ± 0.557
1.927TyrGlu: 1.927 ± 0.401
2.463TyrPhe: 2.463 ± 0.571
2.034TyrGly: 2.034 ± 0.514
0.749TyrHis: 0.749 ± 0.321
2.677TyrIle: 2.677 ± 0.52
3.747TyrLys: 3.747 ± 0.823
3.426TyrLeu: 3.426 ± 0.628
0.321TyrMet: 0.321 ± 0.17
2.463TyrAsn: 2.463 ± 0.718
1.499TyrPro: 1.499 ± 0.487
0.857TyrGln: 0.857 ± 0.427
1.713TyrArg: 1.713 ± 0.536
2.355TyrSer: 2.355 ± 0.468
1.927TyrThr: 1.927 ± 0.572
1.499TyrVal: 1.499 ± 0.399
0.749TyrTrp: 0.749 ± 0.237
1.071TyrTyr: 1.071 ± 0.265
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 48 proteins (9341 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski