Amino acid dipepetide frequency for Beijerinckiaceae bacterium RH AL1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	21.813AlaAla: 21.813 ± 0.241	1.283AlaCys: 1.283 ± 0.036	7.576AlaAsp: 7.576 ± 0.092	7.662AlaGlu: 7.662 ± 0.087	4.997AlaPhe: 4.997 ± 0.075	11.263AlaGly: 11.263 ± 0.118	2.769AlaHis: 2.769 ± 0.049	6.733AlaIle: 6.733 ± 0.086	4.571AlaLys: 4.571 ± 0.074	14.848AlaLeu: 14.848 ± 0.124	3.677AlaMet: 3.677 ± 0.064	2.713AlaAsn: 2.713 ± 0.056	7.444AlaPro: 7.444 ± 0.127	4.091AlaGln: 4.091 ± 0.067	10.244AlaArg: 10.244 ± 0.115	7.001AlaSer: 7.001 ± 0.078	7.519AlaThr: 7.519 ± 0.094	9.127AlaVal: 9.127 ± 0.093	1.668AlaTrp: 1.668 ± 0.038	2.706AlaTyr: 2.706 ± 0.045	0.0AlaXaa: 0.0 ± 0.0
Cys	1.138CysAla: 1.138 ± 0.039	0.126CysCys: 0.126 ± 0.011	0.556CysAsp: 0.556 ± 0.021	0.477CysGlu: 0.477 ± 0.021	0.362CysPhe: 0.362 ± 0.015	0.966CysGly: 0.966 ± 0.03	0.225CysHis: 0.225 ± 0.013	0.349CysIle: 0.349 ± 0.017	0.212CysLys: 0.212 ± 0.013	0.876CysLeu: 0.876 ± 0.025	0.159CysMet: 0.159 ± 0.012	0.17CysAsn: 0.17 ± 0.01	0.466CysPro: 0.466 ± 0.021	0.215CysGln: 0.215 ± 0.013	0.756CysArg: 0.756 ± 0.028	0.443CysSer: 0.443 ± 0.018	0.428CysThr: 0.428 ± 0.018	0.692CysVal: 0.692 ± 0.024	0.112CysTrp: 0.112 ± 0.008	0.19CysTyr: 0.19 ± 0.012	0.0CysXaa: 0.0 ± 0.0
Asp	8.176AspAla: 8.176 ± 0.096	0.506AspCys: 0.506 ± 0.022	3.469AspAsp: 3.469 ± 0.065	3.49AspGlu: 3.49 ± 0.06	2.04AspPhe: 2.04 ± 0.045	5.408AspGly: 5.408 ± 0.077	1.286AspHis: 1.286 ± 0.027	2.772AspIle: 2.772 ± 0.046	1.912AspLys: 1.912 ± 0.047	6.068AspLeu: 6.068 ± 0.081	1.155AspMet: 1.155 ± 0.029	1.09AspAsn: 1.09 ± 0.031	3.71AspPro: 3.71 ± 0.063	1.459AspGln: 1.459 ± 0.038	4.304AspArg: 4.304 ± 0.063	1.967AspSer: 1.967 ± 0.043	2.646AspThr: 2.646 ± 0.048	4.449AspVal: 4.449 ± 0.062	0.877AspTrp: 0.877 ± 0.027	1.412AspTyr: 1.412 ± 0.034	0.0AspXaa: 0.0 ± 0.0
Glu	8.288GluAla: 8.288 ± 0.112	0.309GluCys: 0.309 ± 0.017	2.614GluAsp: 2.614 ± 0.055	2.518GluGlu: 2.518 ± 0.062	1.311GluPhe: 1.311 ± 0.031	3.977GluGly: 3.977 ± 0.062	1.216GluHis: 1.216 ± 0.034	3.011GluIle: 3.011 ± 0.05	2.024GluLys: 2.024 ± 0.049	4.611GluLeu: 4.611 ± 0.061	1.417GluMet: 1.417 ± 0.033	1.158GluAsn: 1.158 ± 0.031	3.016GluPro: 3.016 ± 0.056	1.669GluGln: 1.669 ± 0.041	4.927GluArg: 4.927 ± 0.073	2.207GluSer: 2.207 ± 0.041	3.436GluThr: 3.436 ± 0.051	3.789GluVal: 3.789 ± 0.058	0.542GluTrp: 0.542 ± 0.022	0.741GluTyr: 0.741 ± 0.026	0.0GluXaa: 0.0 ± 0.0
Phe	5.17PheAla: 5.17 ± 0.062	0.421PheCys: 0.421 ± 0.019	2.595PheAsp: 2.595 ± 0.049	2.118PheGlu: 2.118 ± 0.038	1.388PhePhe: 1.388 ± 0.039	3.592PheGly: 3.592 ± 0.057	0.768PheHis: 0.768 ± 0.024	1.387PheIle: 1.387 ± 0.035	1.074PheLys: 1.074 ± 0.033	3.221PheLeu: 3.221 ± 0.068	0.705PheMet: 0.705 ± 0.028	0.931PheAsn: 0.931 ± 0.029	1.546PhePro: 1.546 ± 0.034	0.887PheGln: 0.887 ± 0.027	2.105PheArg: 2.105 ± 0.042	1.995PheSer: 1.995 ± 0.041	1.933PheThr: 1.933 ± 0.034	3.004PheVal: 3.004 ± 0.056	0.466PheTrp: 0.466 ± 0.021	0.876PheTyr: 0.876 ± 0.027	0.0PheXaa: 0.0 ± 0.0
Gly	10.264GlyAla: 10.264 ± 0.106	0.908GlyCys: 0.908 ± 0.023	4.566GlyAsp: 4.566 ± 0.066	4.271GlyGlu: 4.271 ± 0.065	3.67GlyPhe: 3.67 ± 0.064	7.554GlyGly: 7.554 ± 0.123	1.974GlyHis: 1.974 ± 0.046	4.168GlyIle: 4.168 ± 0.064	3.089GlyLys: 3.089 ± 0.062	9.022GlyLeu: 9.022 ± 0.092	2.076GlyMet: 2.076 ± 0.041	1.817GlyAsn: 1.817 ± 0.041	3.833GlyPro: 3.833 ± 0.065	2.482GlyGln: 2.482 ± 0.049	6.442GlyArg: 6.442 ± 0.075	4.432GlySer: 4.432 ± 0.068	4.796GlyThr: 4.796 ± 0.078	5.949GlyVal: 5.949 ± 0.079	1.293GlyTrp: 1.293 ± 0.034	2.259GlyTyr: 2.259 ± 0.045	0.0GlyXaa: 0.0 ± 0.0
His	2.781HisAla: 2.781 ± 0.059	0.214HisCys: 0.214 ± 0.014	1.418HisAsp: 1.418 ± 0.036	1.172HisGlu: 1.172 ± 0.035	0.818HisPhe: 0.818 ± 0.03	2.116HisGly: 2.116 ± 0.044	0.651HisHis: 0.651 ± 0.032	0.86HisIle: 0.86 ± 0.029	0.51HisLys: 0.51 ± 0.017	2.118HisLeu: 2.118 ± 0.04	0.473HisMet: 0.473 ± 0.018	0.412HisAsn: 0.412 ± 0.02	1.403HisPro: 1.403 ± 0.037	0.527HisGln: 0.527 ± 0.019	1.577HisArg: 1.577 ± 0.037	0.825HisSer: 0.825 ± 0.027	0.801HisThr: 0.801 ± 0.023	1.72HisVal: 1.72 ± 0.038	0.323HisTrp: 0.323 ± 0.016	0.576HisTyr: 0.576 ± 0.019	0.0HisXaa: 0.0 ± 0.0
Ile	7.481IleAla: 7.481 ± 0.074	0.474IleCys: 0.474 ± 0.022	3.48IleAsp: 3.48 ± 0.056	3.394IleGlu: 3.394 ± 0.059	1.615IlePhe: 1.615 ± 0.044	4.643IleGly: 4.643 ± 0.063	0.81IleHis: 0.81 ± 0.025	1.851IleIle: 1.851 ± 0.04	1.381IleLys: 1.381 ± 0.034	3.968IleLeu: 3.968 ± 0.058	0.849IleMet: 0.849 ± 0.027	1.132IleAsn: 1.132 ± 0.03	2.083IlePro: 2.083 ± 0.046	1.003IleGln: 1.003 ± 0.034	2.719IleArg: 2.719 ± 0.054	2.259IleSer: 2.259 ± 0.054	2.29IleThr: 2.29 ± 0.049	4.63IleVal: 4.63 ± 0.075	0.518IleTrp: 0.518 ± 0.02	1.032IleTyr: 1.032 ± 0.028	0.0IleXaa: 0.0 ± 0.0
Lys	4.561LysAla: 4.561 ± 0.074	0.161LysCys: 0.161 ± 0.011	1.698LysAsp: 1.698 ± 0.042	1.296LysGlu: 1.296 ± 0.035	0.812LysPhe: 0.812 ± 0.025	2.633LysGly: 2.633 ± 0.058	0.591LysHis: 0.591 ± 0.021	1.728LysIle: 1.728 ± 0.04	1.187LysLys: 1.187 ± 0.041	3.547LysLeu: 3.547 ± 0.054	0.739LysMet: 0.739 ± 0.028	0.719LysAsn: 0.719 ± 0.025	2.39LysPro: 2.39 ± 0.05	0.927LysGln: 0.927 ± 0.028	2.338LysArg: 2.338 ± 0.042	1.68LysSer: 1.68 ± 0.039	1.96LysThr: 1.96 ± 0.047	2.584LysVal: 2.584 ± 0.051	0.291LysTrp: 0.291 ± 0.014	0.532LysTyr: 0.532 ± 0.023	0.0LysXaa: 0.0 ± 0.0
Leu	15.531LeuAla: 15.531 ± 0.152	0.923LeuCys: 0.923 ± 0.028	6.336LeuAsp: 6.336 ± 0.08	5.077LeuGlu: 5.077 ± 0.081	3.513LeuPhe: 3.513 ± 0.068	8.309LeuGly: 8.309 ± 0.106	1.892LeuHis: 1.892 ± 0.045	4.387LeuIle: 4.387 ± 0.067	3.276LeuLys: 3.276 ± 0.056	8.957LeuLeu: 8.957 ± 0.099	2.116LeuMet: 2.116 ± 0.044	2.054LeuAsn: 2.054 ± 0.041	5.671LeuPro: 5.671 ± 0.073	2.549LeuGln: 2.549 ± 0.048	7.059LeuArg: 7.059 ± 0.078	5.518LeuSer: 5.518 ± 0.07	5.254LeuThr: 5.254 ± 0.067	8.567LeuVal: 8.567 ± 0.086	1.113LeuTrp: 1.113 ± 0.032	2.029LeuTyr: 2.029 ± 0.037	0.001LeuXaa: 0.001 ± 0.001
Met	2.829MetAla: 2.829 ± 0.049	0.158MetCys: 0.158 ± 0.012	1.025MetAsp: 1.025 ± 0.03	0.854MetGlu: 0.854 ± 0.025	0.65MetPhe: 0.65 ± 0.022	1.512MetGly: 1.512 ± 0.038	0.441MetHis: 0.441 ± 0.016	1.261MetIle: 1.261 ± 0.035	0.864MetLys: 0.864 ± 0.028	2.338MetLeu: 2.338 ± 0.045	0.598MetMet: 0.598 ± 0.026	0.656MetAsn: 0.656 ± 0.026	1.609MetPro: 1.609 ± 0.036	0.752MetGln: 0.752 ± 0.024	1.969MetArg: 1.969 ± 0.037	1.581MetSer: 1.581 ± 0.037	1.812MetThr: 1.812 ± 0.036	1.497MetVal: 1.497 ± 0.029	0.168MetTrp: 0.168 ± 0.011	0.306MetTyr: 0.306 ± 0.014	0.0MetXaa: 0.0 ± 0.0
Asn	2.891AsnAla: 2.891 ± 0.052	0.207AsnCys: 0.207 ± 0.013	1.261AsnAsp: 1.261 ± 0.034	1.118AsnGlu: 1.118 ± 0.031	0.831AsnPhe: 0.831 ± 0.027	2.115AsnGly: 2.115 ± 0.055	0.459AsnHis: 0.459 ± 0.022	1.098AsnIle: 1.098 ± 0.032	0.624AsnLys: 0.624 ± 0.024	2.194AsnLeu: 2.194 ± 0.042	0.475AsnMet: 0.475 ± 0.02	0.575AsnAsn: 0.575 ± 0.031	1.517AsnPro: 1.517 ± 0.039	0.614AsnGln: 0.614 ± 0.025	1.366AsnArg: 1.366 ± 0.03	0.912AsnSer: 0.912 ± 0.03	1.051AsnThr: 1.051 ± 0.036	1.845AsnVal: 1.845 ± 0.042	0.302AsnTrp: 0.302 ± 0.016	0.56AsnTyr: 0.56 ± 0.026	0.0AsnXaa: 0.0 ± 0.0
Pro	7.735ProAla: 7.735 ± 0.097	0.393ProCys: 0.393 ± 0.019	3.812ProAsp: 3.812 ± 0.063	3.33ProGlu: 3.33 ± 0.051	2.064ProPhe: 2.064 ± 0.042	4.88ProGly: 4.88 ± 0.071	1.226ProHis: 1.226 ± 0.033	2.517ProIle: 2.517 ± 0.045	1.929ProLys: 1.929 ± 0.047	5.029ProLeu: 5.029 ± 0.069	1.254ProMet: 1.254 ± 0.03	1.24ProAsn: 1.24 ± 0.036	3.509ProPro: 3.509 ± 0.075	1.789ProGln: 1.789 ± 0.038	3.717ProArg: 3.717 ± 0.073	3.159ProSer: 3.159 ± 0.056	2.975ProThr: 2.975 ± 0.059	4.208ProVal: 4.208 ± 0.064	0.671ProTrp: 0.671 ± 0.024	1.194ProTyr: 1.194 ± 0.031	0.0ProXaa: 0.0 ± 0.0
Gln	4.128GlnAla: 4.128 ± 0.058	0.188GlnCys: 0.188 ± 0.011	1.362GlnAsp: 1.362 ± 0.034	1.198GlnGlu: 1.198 ± 0.029	0.805GlnPhe: 0.805 ± 0.027	2.268GlnGly: 2.268 ± 0.039	0.646GlnHis: 0.646 ± 0.024	1.521GlnIle: 1.521 ± 0.033	1.019GlnLys: 1.019 ± 0.03	2.576GlnLeu: 2.576 ± 0.045	0.671GlnMet: 0.671 ± 0.023	0.717GlnAsn: 0.717 ± 0.026	1.668GlnPro: 1.668 ± 0.04	1.022GlnGln: 1.022 ± 0.037	2.247GlnArg: 2.247 ± 0.041	1.59GlnSer: 1.59 ± 0.034	1.648GlnThr: 1.648 ± 0.033	2.039GlnVal: 2.039 ± 0.043	0.303GlnTrp: 0.303 ± 0.019	0.514GlnTyr: 0.514 ± 0.021	0.0GlnXaa: 0.0 ± 0.0
Arg	9.189ArgAla: 9.189 ± 0.099	0.613ArgCys: 0.613 ± 0.021	4.479ArgAsp: 4.479 ± 0.062	4.207ArgGlu: 4.207 ± 0.064	3.061ArgPhe: 3.061 ± 0.051	5.091ArgGly: 5.091 ± 0.067	1.846ArgHis: 1.846 ± 0.042	3.547ArgIle: 3.547 ± 0.059	2.278ArgLys: 2.278 ± 0.045	8.163ArgLeu: 8.163 ± 0.081	1.717ArgMet: 1.717 ± 0.036	1.594ArgAsn: 1.594 ± 0.034	4.074ArgPro: 4.074 ± 0.063	2.3ArgGln: 2.3 ± 0.046	6.727ArgArg: 6.727 ± 0.096	3.571ArgSer: 3.571 ± 0.053	3.523ArgThr: 3.523 ± 0.051	4.934ArgVal: 4.934 ± 0.067	1.03ArgTrp: 1.03 ± 0.031	1.758ArgTyr: 1.758 ± 0.038	0.0ArgXaa: 0.0 ± 0.0
Ser	5.984SerAla: 5.984 ± 0.068	0.463SerCys: 0.463 ± 0.019	2.849SerAsp: 2.849 ± 0.047	2.401SerGlu: 2.401 ± 0.045	2.19SerPhe: 2.19 ± 0.042	4.813SerGly: 4.813 ± 0.073	1.068SerHis: 1.068 ± 0.026	2.534SerIle: 2.534 ± 0.049	1.526SerLys: 1.526 ± 0.037	5.359SerLeu: 5.359 ± 0.068	1.241SerMet: 1.241 ± 0.034	1.238SerAsn: 1.238 ± 0.038	2.982SerPro: 2.982 ± 0.052	1.464SerGln: 1.464 ± 0.038	3.646SerArg: 3.646 ± 0.06	2.968SerSer: 2.968 ± 0.062	2.66SerThr: 2.66 ± 0.062	3.628SerVal: 3.628 ± 0.053	0.668SerTrp: 0.668 ± 0.022	1.245SerTyr: 1.245 ± 0.032	0.001SerXaa: 0.001 ± 0.001
Thr	6.474ThrAla: 6.474 ± 0.092	0.473ThrCys: 0.473 ± 0.017	2.632ThrAsp: 2.632 ± 0.054	2.18ThrGlu: 2.18 ± 0.05	2.14ThrPhe: 2.14 ± 0.044	4.782ThrGly: 4.782 ± 0.075	1.14ThrHis: 1.14 ± 0.031	3.204ThrIle: 3.204 ± 0.053	1.673ThrLys: 1.673 ± 0.043	6.069ThrLeu: 6.069 ± 0.071	1.186ThrMet: 1.186 ± 0.031	1.238ThrAsn: 1.238 ± 0.033	3.739ThrPro: 3.739 ± 0.059	1.49ThrGln: 1.49 ± 0.041	3.668ThrArg: 3.668 ± 0.055	3.012ThrSer: 3.012 ± 0.065	3.149ThrThr: 3.149 ± 0.06	3.97ThrVal: 3.97 ± 0.067	0.682ThrTrp: 0.682 ± 0.023	1.289ThrTyr: 1.289 ± 0.034	0.0ThrXaa: 0.0 ± 0.0
Val	11.327ValAla: 11.327 ± 0.101	0.707ValCys: 0.707 ± 0.023	4.402ValAsp: 4.402 ± 0.063	4.342ValGlu: 4.342 ± 0.056	2.678ValPhe: 2.678 ± 0.046	6.101ValGly: 6.101 ± 0.076	1.441ValHis: 1.441 ± 0.034	3.325ValIle: 3.325 ± 0.059	2.196ValLys: 2.196 ± 0.049	7.407ValLeu: 7.407 ± 0.075	1.67ValMet: 1.67 ± 0.037	1.622ValAsn: 1.622 ± 0.045	4.181ValPro: 4.181 ± 0.054	1.81ValGln: 1.81 ± 0.04	4.985ValArg: 4.985 ± 0.06	3.974ValSer: 3.974 ± 0.063	4.464ValThr: 4.464 ± 0.078	6.508ValVal: 6.508 ± 0.084	0.853ValTrp: 0.853 ± 0.025	1.49ValTyr: 1.49 ± 0.036	0.001ValXaa: 0.001 ± 0.001
Trp	1.212TrpAla: 1.212 ± 0.032	0.136TrpCys: 0.136 ± 0.01	0.56TrpAsp: 0.56 ± 0.022	0.45TrpGlu: 0.45 ± 0.021	0.469TrpPhe: 0.469 ± 0.02	0.788TrpGly: 0.788 ± 0.025	0.4TrpHis: 0.4 ± 0.02	0.561TrpIle: 0.561 ± 0.022	0.372TrpLys: 0.372 ± 0.016	1.573TrpLeu: 1.573 ± 0.037	0.305TrpMet: 0.305 ± 0.016	0.375TrpAsn: 0.375 ± 0.018	0.678TrpPro: 0.678 ± 0.021	0.455TrpGln: 0.455 ± 0.017	1.219TrpArg: 1.219 ± 0.033	0.802TrpSer: 0.802 ± 0.027	0.797TrpThr: 0.797 ± 0.027	0.755TrpVal: 0.755 ± 0.024	0.208TrpTrp: 0.208 ± 0.015	0.287TrpTyr: 0.287 ± 0.016	0.001TrpXaa: 0.001 ± 0.001
Tyr	2.737TyrAla: 2.737 ± 0.051	0.253TyrCys: 0.253 ± 0.015	1.507TyrAsp: 1.507 ± 0.032	1.225TyrGlu: 1.225 ± 0.03	0.769TyrPhe: 0.769 ± 0.029	2.054TyrGly: 2.054 ± 0.044	0.449TyrHis: 0.449 ± 0.02	0.795TyrIle: 0.795 ± 0.027	0.656TyrLys: 0.656 ± 0.025	2.188TyrLeu: 2.188 ± 0.048	0.393TyrMet: 0.393 ± 0.019	0.561TyrAsn: 0.561 ± 0.022	1.111TyrPro: 1.111 ± 0.032	0.625TyrGln: 0.625 ± 0.022	1.688TyrArg: 1.688 ± 0.041	1.03TyrSer: 1.03 ± 0.032	1.049TyrThr: 1.049 ± 0.032	1.59TyrVal: 1.59 ± 0.034	0.315TyrTrp: 0.315 ± 0.018	0.581TyrTyr: 0.581 ± 0.024	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.001XaaAla: 0.001 ± 0.001	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.001XaaGly: 0.001 ± 0.001	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.002XaaLeu: 0.002 ± 0.001	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4238 proteins (1273430 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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