Amino acid dipepetide frequency for Achromobacter phage JWF

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
10.504AlaAla: 10.504 ± 1.612
0.839AlaCys: 0.839 ± 0.158
5.631AlaAsp: 5.631 ± 0.438
5.432AlaGlu: 5.432 ± 0.562
2.836AlaPhe: 2.836 ± 0.324
6.47AlaGly: 6.47 ± 0.887
1.957AlaHis: 1.957 ± 0.297
4.633AlaIle: 4.633 ± 0.467
4.753AlaLys: 4.753 ± 0.508
7.628AlaLeu: 7.628 ± 0.54
3.275AlaMet: 3.275 ± 0.364
4.233AlaAsn: 4.233 ± 0.552
3.235AlaPro: 3.235 ± 0.403
4.912AlaGln: 4.912 ± 0.664
5.511AlaArg: 5.511 ± 0.486
5.871AlaSer: 5.871 ± 0.529
6.39AlaThr: 6.39 ± 0.659
6.55AlaVal: 6.55 ± 0.557
1.558AlaTrp: 1.558 ± 0.297
2.836AlaTyr: 2.836 ± 0.341
0.0AlaXaa: 0.0 ± 0.0
Cys
0.998CysAla: 0.998 ± 0.187
0.16CysCys: 0.16 ± 0.078
0.679CysAsp: 0.679 ± 0.172
0.639CysGlu: 0.639 ± 0.172
0.399CysPhe: 0.399 ± 0.109
0.799CysGly: 0.799 ± 0.204
0.2CysHis: 0.2 ± 0.079
0.28CysIle: 0.28 ± 0.096
0.439CysLys: 0.439 ± 0.125
0.639CysLeu: 0.639 ± 0.167
0.12CysMet: 0.12 ± 0.074
0.599CysAsn: 0.599 ± 0.178
0.359CysPro: 0.359 ± 0.114
0.32CysGln: 0.32 ± 0.12
0.32CysArg: 0.32 ± 0.112
0.359CysSer: 0.359 ± 0.112
0.399CysThr: 0.399 ± 0.136
0.679CysVal: 0.679 ± 0.149
0.12CysTrp: 0.12 ± 0.06
0.2CysTyr: 0.2 ± 0.081
0.0CysXaa: 0.0 ± 0.0
Asp
5.392AspAla: 5.392 ± 0.497
0.439AspCys: 0.439 ± 0.134
4.074AspAsp: 4.074 ± 0.416
4.633AspGlu: 4.633 ± 0.54
1.997AspPhe: 1.997 ± 0.248
5.631AspGly: 5.631 ± 0.556
1.398AspHis: 1.398 ± 0.241
2.915AspIle: 2.915 ± 0.371
2.396AspLys: 2.396 ± 0.385
5.272AspLeu: 5.272 ± 0.37
2.276AspMet: 2.276 ± 0.269
2.117AspAsn: 2.117 ± 0.333
3.235AspPro: 3.235 ± 0.404
2.955AspGln: 2.955 ± 0.348
3.115AspArg: 3.115 ± 0.318
3.395AspSer: 3.395 ± 0.333
3.035AspThr: 3.035 ± 0.298
4.114AspVal: 4.114 ± 0.419
1.158AspTrp: 1.158 ± 0.226
1.917AspTyr: 1.917 ± 0.293
0.0AspXaa: 0.0 ± 0.0
Glu
7.269GluAla: 7.269 ± 0.715
0.679GluCys: 0.679 ± 0.188
3.794GluAsp: 3.794 ± 0.408
4.034GluGlu: 4.034 ± 0.449
2.037GluPhe: 2.037 ± 0.279
3.714GluGly: 3.714 ± 0.355
1.598GluHis: 1.598 ± 0.253
3.554GluIle: 3.554 ± 0.399
4.114GluLys: 4.114 ± 0.419
6.789GluLeu: 6.789 ± 0.654
1.598GluMet: 1.598 ± 0.213
2.636GluAsn: 2.636 ± 0.326
2.356GluPro: 2.356 ± 0.358
3.035GluGln: 3.035 ± 0.319
3.475GluArg: 3.475 ± 0.347
3.554GluSer: 3.554 ± 0.409
3.475GluThr: 3.475 ± 0.413
3.515GluVal: 3.515 ± 0.343
0.799GluTrp: 0.799 ± 0.193
1.757GluTyr: 1.757 ± 0.229
0.0GluXaa: 0.0 ± 0.0
Phe
2.516PheAla: 2.516 ± 0.352
0.16PheCys: 0.16 ± 0.074
3.155PheAsp: 3.155 ± 0.404
2.596PheGlu: 2.596 ± 0.359
1.398PhePhe: 1.398 ± 0.273
2.276PheGly: 2.276 ± 0.242
0.919PheHis: 0.919 ± 0.21
1.198PheIle: 1.198 ± 0.264
1.797PheLys: 1.797 ± 0.25
2.836PheLeu: 2.836 ± 0.366
1.398PheMet: 1.398 ± 0.261
1.877PheAsn: 1.877 ± 0.262
1.158PhePro: 1.158 ± 0.207
1.558PheGln: 1.558 ± 0.272
1.797PheArg: 1.797 ± 0.263
1.917PheSer: 1.917 ± 0.294
2.077PheThr: 2.077 ± 0.337
2.596PheVal: 2.596 ± 0.42
0.439PheTrp: 0.439 ± 0.118
1.078PheTyr: 1.078 ± 0.229
0.0PheXaa: 0.0 ± 0.0
Gly
4.832GlyAla: 4.832 ± 0.678
0.599GlyCys: 0.599 ± 0.151
3.834GlyAsp: 3.834 ± 0.349
4.513GlyGlu: 4.513 ± 0.469
2.876GlyPhe: 2.876 ± 0.309
4.832GlyGly: 4.832 ± 0.613
1.238GlyHis: 1.238 ± 0.262
3.235GlyIle: 3.235 ± 0.408
4.273GlyLys: 4.273 ± 0.442
5.551GlyLeu: 5.551 ± 0.466
2.356GlyMet: 2.356 ± 0.242
2.796GlyAsn: 2.796 ± 0.32
2.556GlyPro: 2.556 ± 0.331
3.554GlyGln: 3.554 ± 0.39
4.074GlyArg: 4.074 ± 0.425
3.914GlySer: 3.914 ± 0.441
4.513GlyThr: 4.513 ± 0.463
5.152GlyVal: 5.152 ± 0.426
1.637GlyTrp: 1.637 ± 0.291
3.235GlyTyr: 3.235 ± 0.346
0.0GlyXaa: 0.0 ± 0.0
His
1.518HisAla: 1.518 ± 0.274
0.24HisCys: 0.24 ± 0.105
1.478HisAsp: 1.478 ± 0.315
1.278HisGlu: 1.278 ± 0.231
0.479HisPhe: 0.479 ± 0.147
1.637HisGly: 1.637 ± 0.31
0.799HisHis: 0.799 ± 0.208
1.518HisIle: 1.518 ± 0.265
0.839HisLys: 0.839 ± 0.196
2.436HisLeu: 2.436 ± 0.414
0.639HisMet: 0.639 ± 0.166
0.998HisAsn: 0.998 ± 0.234
1.318HisPro: 1.318 ± 0.239
1.078HisGln: 1.078 ± 0.188
1.518HisArg: 1.518 ± 0.28
1.078HisSer: 1.078 ± 0.219
1.118HisThr: 1.118 ± 0.241
1.558HisVal: 1.558 ± 0.309
0.559HisTrp: 0.559 ± 0.158
0.879HisTyr: 0.879 ± 0.21
0.0HisXaa: 0.0 ± 0.0
Ile
4.393IleAla: 4.393 ± 0.386
0.479IleCys: 0.479 ± 0.16
3.075IleAsp: 3.075 ± 0.373
4.353IleGlu: 4.353 ± 0.499
1.398IlePhe: 1.398 ± 0.257
3.515IleGly: 3.515 ± 0.371
1.198IleHis: 1.198 ± 0.241
2.876IleIle: 2.876 ± 0.308
2.836IleLys: 2.836 ± 0.36
3.594IleLeu: 3.594 ± 0.336
1.757IleMet: 1.757 ± 0.319
2.716IleAsn: 2.716 ± 0.32
2.756IlePro: 2.756 ± 0.362
2.436IleGln: 2.436 ± 0.271
2.676IleArg: 2.676 ± 0.352
2.596IleSer: 2.596 ± 0.268
3.195IleThr: 3.195 ± 0.413
2.636IleVal: 2.636 ± 0.337
0.32IleTrp: 0.32 ± 0.099
1.318IleTyr: 1.318 ± 0.286
0.0IleXaa: 0.0 ± 0.0
Lys
5.631LysAla: 5.631 ± 0.55
0.599LysCys: 0.599 ± 0.191
2.995LysAsp: 2.995 ± 0.366
3.475LysGlu: 3.475 ± 0.379
1.877LysPhe: 1.877 ± 0.293
3.435LysGly: 3.435 ± 0.398
1.078LysHis: 1.078 ± 0.257
3.115LysIle: 3.115 ± 0.406
2.676LysLys: 2.676 ± 0.464
4.633LysLeu: 4.633 ± 0.386
1.957LysMet: 1.957 ± 0.265
2.037LysAsn: 2.037 ± 0.294
2.117LysPro: 2.117 ± 0.295
1.677LysGln: 1.677 ± 0.261
2.436LysArg: 2.436 ± 0.314
2.636LysSer: 2.636 ± 0.26
3.435LysThr: 3.435 ± 0.383
3.235LysVal: 3.235 ± 0.373
1.118LysTrp: 1.118 ± 0.229
1.478LysTyr: 1.478 ± 0.261
0.0LysXaa: 0.0 ± 0.0
Leu
8.826LeuAla: 8.826 ± 0.689
0.799LeuCys: 0.799 ± 0.189
4.912LeuAsp: 4.912 ± 0.485
5.232LeuGlu: 5.232 ± 0.549
2.316LeuPhe: 2.316 ± 0.457
5.112LeuGly: 5.112 ± 0.45
2.077LeuHis: 2.077 ± 0.237
3.994LeuIle: 3.994 ± 0.336
5.112LeuLys: 5.112 ± 0.425
6.829LeuLeu: 6.829 ± 0.504
2.556LeuMet: 2.556 ± 0.316
3.475LeuAsn: 3.475 ± 0.37
3.914LeuPro: 3.914 ± 0.437
3.515LeuGln: 3.515 ± 0.477
6.35LeuArg: 6.35 ± 0.458
4.793LeuSer: 4.793 ± 0.485
5.471LeuThr: 5.471 ± 0.51
6.47LeuVal: 6.47 ± 0.62
0.759LeuTrp: 0.759 ± 0.138
2.596LeuTyr: 2.596 ± 0.25
0.0LeuXaa: 0.0 ± 0.0
Met
3.435MetAla: 3.435 ± 0.373
0.16MetCys: 0.16 ± 0.082
2.157MetAsp: 2.157 ± 0.272
1.917MetGlu: 1.917 ± 0.272
0.759MetPhe: 0.759 ± 0.196
1.598MetGly: 1.598 ± 0.239
0.439MetHis: 0.439 ± 0.122
1.877MetIle: 1.877 ± 0.193
1.917MetLys: 1.917 ± 0.309
2.476MetLeu: 2.476 ± 0.294
0.759MetMet: 0.759 ± 0.149
1.558MetAsn: 1.558 ± 0.235
1.118MetPro: 1.118 ± 0.19
0.879MetGln: 0.879 ± 0.207
2.436MetArg: 2.436 ± 0.348
1.837MetSer: 1.837 ± 0.227
2.716MetThr: 2.716 ± 0.293
2.037MetVal: 2.037 ± 0.299
0.559MetTrp: 0.559 ± 0.206
0.639MetTyr: 0.639 ± 0.219
0.0MetXaa: 0.0 ± 0.0
Asn
3.554AsnAla: 3.554 ± 0.484
0.639AsnCys: 0.639 ± 0.198
2.316AsnAsp: 2.316 ± 0.372
2.237AsnGlu: 2.237 ± 0.306
1.438AsnPhe: 1.438 ± 0.231
3.435AsnGly: 3.435 ± 0.359
1.118AsnHis: 1.118 ± 0.225
2.117AsnIle: 2.117 ± 0.322
2.276AsnLys: 2.276 ± 0.308
3.235AsnLeu: 3.235 ± 0.357
1.118AsnMet: 1.118 ± 0.234
2.077AsnAsn: 2.077 ± 0.282
2.716AsnPro: 2.716 ± 0.369
1.957AsnGln: 1.957 ± 0.373
2.796AsnArg: 2.796 ± 0.37
2.316AsnSer: 2.316 ± 0.311
3.315AsnThr: 3.315 ± 0.315
2.995AsnVal: 2.995 ± 0.419
0.679AsnTrp: 0.679 ± 0.191
1.318AsnTyr: 1.318 ± 0.25
0.0AsnXaa: 0.0 ± 0.0
Pro
3.874ProAla: 3.874 ± 0.404
0.28ProCys: 0.28 ± 0.107
3.794ProAsp: 3.794 ± 0.49
3.475ProGlu: 3.475 ± 0.337
1.757ProPhe: 1.757 ± 0.267
2.756ProGly: 2.756 ± 0.284
0.998ProHis: 0.998 ± 0.228
1.837ProIle: 1.837 ± 0.246
1.877ProLys: 1.877 ± 0.277
3.075ProLeu: 3.075 ± 0.416
1.158ProMet: 1.158 ± 0.178
1.677ProAsn: 1.677 ± 0.27
2.237ProPro: 2.237 ± 0.395
1.598ProGln: 1.598 ± 0.322
2.636ProArg: 2.636 ± 0.267
2.796ProSer: 2.796 ± 0.424
2.995ProThr: 2.995 ± 0.367
3.674ProVal: 3.674 ± 0.48
0.759ProTrp: 0.759 ± 0.198
1.198ProTyr: 1.198 ± 0.223
0.0ProXaa: 0.0 ± 0.0
Gln
5.951GlnAla: 5.951 ± 0.655
0.2GlnCys: 0.2 ± 0.095
2.556GlnAsp: 2.556 ± 0.339
2.077GlnGlu: 2.077 ± 0.285
1.677GlnPhe: 1.677 ± 0.279
2.436GlnGly: 2.436 ± 0.318
0.799GlnHis: 0.799 ± 0.193
2.077GlnIle: 2.077 ± 0.227
1.797GlnLys: 1.797 ± 0.256
3.994GlnLeu: 3.994 ± 0.459
1.438GlnMet: 1.438 ± 0.248
1.358GlnAsn: 1.358 ± 0.226
1.677GlnPro: 1.677 ± 0.26
2.237GlnGln: 2.237 ± 0.322
3.195GlnArg: 3.195 ± 0.407
2.197GlnSer: 2.197 ± 0.405
2.476GlnThr: 2.476 ± 0.268
3.035GlnVal: 3.035 ± 0.358
0.559GlnTrp: 0.559 ± 0.158
1.198GlnTyr: 1.198 ± 0.257
0.0GlnXaa: 0.0 ± 0.0
Arg
5.312ArgAla: 5.312 ± 0.424
0.599ArgCys: 0.599 ± 0.202
3.914ArgAsp: 3.914 ± 0.373
3.155ArgGlu: 3.155 ± 0.361
2.117ArgPhe: 2.117 ± 0.278
3.714ArgGly: 3.714 ± 0.335
1.518ArgHis: 1.518 ± 0.262
3.515ArgIle: 3.515 ± 0.356
2.796ArgLys: 2.796 ± 0.326
5.072ArgLeu: 5.072 ± 0.424
1.757ArgMet: 1.757 ± 0.284
2.396ArgAsn: 2.396 ± 0.267
2.676ArgPro: 2.676 ± 0.325
2.396ArgGln: 2.396 ± 0.323
4.393ArgArg: 4.393 ± 0.474
3.395ArgSer: 3.395 ± 0.37
2.756ArgThr: 2.756 ± 0.335
4.553ArgVal: 4.553 ± 0.353
0.959ArgTrp: 0.959 ± 0.203
2.237ArgTyr: 2.237 ± 0.376
0.0ArgXaa: 0.0 ± 0.0
Ser
5.312SerAla: 5.312 ± 0.631
0.599SerCys: 0.599 ± 0.227
3.155SerAsp: 3.155 ± 0.382
3.115SerGlu: 3.115 ± 0.361
2.556SerPhe: 2.556 ± 0.381
5.671SerGly: 5.671 ± 0.546
1.478SerHis: 1.478 ± 0.312
2.636SerIle: 2.636 ± 0.258
2.197SerLys: 2.197 ± 0.349
4.553SerLeu: 4.553 ± 0.426
1.837SerMet: 1.837 ± 0.287
3.035SerAsn: 3.035 ± 0.336
2.396SerPro: 2.396 ± 0.342
2.356SerGln: 2.356 ± 0.449
2.915SerArg: 2.915 ± 0.342
3.874SerSer: 3.874 ± 0.519
3.874SerThr: 3.874 ± 0.377
3.515SerVal: 3.515 ± 0.396
0.919SerTrp: 0.919 ± 0.196
1.637SerTyr: 1.637 ± 0.203
0.0SerXaa: 0.0 ± 0.0
Thr
5.951ThrAla: 5.951 ± 0.592
0.399ThrCys: 0.399 ± 0.114
2.756ThrAsp: 2.756 ± 0.33
4.114ThrGlu: 4.114 ± 0.465
2.636ThrPhe: 2.636 ± 0.301
4.872ThrGly: 4.872 ± 0.54
1.717ThrHis: 1.717 ± 0.319
3.355ThrIle: 3.355 ± 0.338
3.035ThrLys: 3.035 ± 0.357
6.27ThrLeu: 6.27 ± 0.512
1.877ThrMet: 1.877 ± 0.31
2.796ThrAsn: 2.796 ± 0.378
3.554ThrPro: 3.554 ± 0.408
2.237ThrGln: 2.237 ± 0.325
3.235ThrArg: 3.235 ± 0.39
3.155ThrSer: 3.155 ± 0.392
4.553ThrThr: 4.553 ± 0.466
3.834ThrVal: 3.834 ± 0.397
1.078ThrTrp: 1.078 ± 0.236
1.757ThrTyr: 1.757 ± 0.25
0.0ThrXaa: 0.0 ± 0.0
Val
5.911ValAla: 5.911 ± 0.439
0.359ValCys: 0.359 ± 0.133
4.193ValAsp: 4.193 ± 0.391
4.114ValGlu: 4.114 ± 0.519
2.356ValPhe: 2.356 ± 0.364
4.273ValGly: 4.273 ± 0.442
1.318ValHis: 1.318 ± 0.219
3.754ValIle: 3.754 ± 0.462
4.313ValLys: 4.313 ± 0.335
6.31ValLeu: 6.31 ± 0.476
2.037ValMet: 2.037 ± 0.252
2.836ValAsn: 2.836 ± 0.442
2.756ValPro: 2.756 ± 0.321
2.516ValGln: 2.516 ± 0.301
3.714ValArg: 3.714 ± 0.432
4.753ValSer: 4.753 ± 0.456
4.393ValThr: 4.393 ± 0.515
4.952ValVal: 4.952 ± 0.515
0.759ValTrp: 0.759 ± 0.145
2.197ValTyr: 2.197 ± 0.349
0.0ValXaa: 0.0 ± 0.0
Trp
1.398TrpAla: 1.398 ± 0.221
0.28TrpCys: 0.28 ± 0.09
0.959TrpAsp: 0.959 ± 0.203
1.118TrpGlu: 1.118 ± 0.207
0.599TrpPhe: 0.599 ± 0.143
0.998TrpGly: 0.998 ± 0.174
0.479TrpHis: 0.479 ± 0.149
0.519TrpIle: 0.519 ± 0.197
0.839TrpLys: 0.839 ± 0.162
1.318TrpLeu: 1.318 ± 0.259
0.359TrpMet: 0.359 ± 0.11
0.759TrpAsn: 0.759 ± 0.176
0.559TrpPro: 0.559 ± 0.146
0.599TrpGln: 0.599 ± 0.145
0.799TrpArg: 0.799 ± 0.188
1.038TrpSer: 1.038 ± 0.246
1.198TrpThr: 1.198 ± 0.216
1.038TrpVal: 1.038 ± 0.191
0.32TrpTrp: 0.32 ± 0.105
0.519TrpTyr: 0.519 ± 0.178
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.476TyrAla: 2.476 ± 0.296
0.2TyrCys: 0.2 ± 0.11
2.037TyrAsp: 2.037 ± 0.328
2.276TyrGlu: 2.276 ± 0.293
1.238TyrPhe: 1.238 ± 0.248
2.396TyrGly: 2.396 ± 0.249
0.639TyrHis: 0.639 ± 0.161
1.118TyrIle: 1.118 ± 0.195
1.358TyrLys: 1.358 ± 0.295
2.596TyrLeu: 2.596 ± 0.353
0.959TyrMet: 0.959 ± 0.196
1.677TyrAsn: 1.677 ± 0.296
1.757TyrPro: 1.757 ± 0.291
1.158TyrGln: 1.158 ± 0.2
1.837TyrArg: 1.837 ± 0.232
2.157TyrSer: 2.157 ± 0.374
1.797TyrThr: 1.797 ± 0.273
1.677TyrVal: 1.677 ± 0.293
0.639TyrTrp: 0.639 ± 0.17
0.998TyrTyr: 0.998 ± 0.222
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 116 proteins (25040 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski