Amino acid dipepetide frequency for Cellulophaga phage phi14:2

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
2.407AlaAla: 2.407 ± 0.373
0.375AlaCys: 0.375 ± 0.106
2.813AlaAsp: 2.813 ± 0.29
2.688AlaGlu: 2.688 ± 0.232
2.219AlaPhe: 2.219 ± 0.316
2.625AlaGly: 2.625 ± 0.364
0.469AlaHis: 0.469 ± 0.157
3.563AlaIle: 3.563 ± 0.321
3.344AlaLys: 3.344 ± 0.258
4.126AlaLeu: 4.126 ± 0.489
1.281AlaMet: 1.281 ± 0.244
3.313AlaAsn: 3.313 ± 0.353
1.438AlaPro: 1.438 ± 0.178
1.813AlaGln: 1.813 ± 0.275
1.719AlaArg: 1.719 ± 0.231
2.876AlaSer: 2.876 ± 0.338
3.251AlaThr: 3.251 ± 0.327
3.157AlaVal: 3.157 ± 0.251
0.375AlaTrp: 0.375 ± 0.1
2.032AlaTyr: 2.032 ± 0.232
0.0AlaXaa: 0.0 ± 0.0
Cys
0.469CysAla: 0.469 ± 0.173
0.094CysCys: 0.094 ± 0.048
0.281CysAsp: 0.281 ± 0.095
0.563CysGlu: 0.563 ± 0.143
0.344CysPhe: 0.344 ± 0.125
0.656CysGly: 0.656 ± 0.165
0.219CysHis: 0.219 ± 0.084
0.625CysIle: 0.625 ± 0.166
1.0CysLys: 1.0 ± 0.164
0.594CysLeu: 0.594 ± 0.158
0.281CysMet: 0.281 ± 0.103
0.656CysAsn: 0.656 ± 0.172
0.313CysPro: 0.313 ± 0.11
0.156CysGln: 0.156 ± 0.083
0.406CysArg: 0.406 ± 0.129
0.344CysSer: 0.344 ± 0.102
0.594CysThr: 0.594 ± 0.143
0.281CysVal: 0.281 ± 0.106
0.031CysTrp: 0.031 ± 0.032
0.563CysTyr: 0.563 ± 0.129
0.0CysXaa: 0.0 ± 0.0
Asp
3.126AspAla: 3.126 ± 0.3
0.656AspCys: 0.656 ± 0.168
4.188AspAsp: 4.188 ± 0.437
4.845AspGlu: 4.845 ± 0.42
3.251AspPhe: 3.251 ± 0.312
4.032AspGly: 4.032 ± 0.408
1.0AspHis: 1.0 ± 0.189
6.564AspIle: 6.564 ± 0.519
5.345AspLys: 5.345 ± 0.37
5.564AspLeu: 5.564 ± 0.433
1.188AspMet: 1.188 ± 0.179
4.438AspAsn: 4.438 ± 0.389
2.157AspPro: 2.157 ± 0.305
1.594AspGln: 1.594 ± 0.201
2.032AspArg: 2.032 ± 0.241
5.188AspSer: 5.188 ± 0.379
3.438AspThr: 3.438 ± 0.282
3.532AspVal: 3.532 ± 0.263
0.75AspTrp: 0.75 ± 0.153
3.344AspTyr: 3.344 ± 0.356
0.0AspXaa: 0.0 ± 0.0
Glu
3.813GluAla: 3.813 ± 0.457
0.688GluCys: 0.688 ± 0.157
4.501GluAsp: 4.501 ± 0.369
5.345GluGlu: 5.345 ± 0.565
3.657GluPhe: 3.657 ± 0.35
4.251GluGly: 4.251 ± 0.399
0.875GluHis: 0.875 ± 0.192
6.189GluIle: 6.189 ± 0.55
5.001GluLys: 5.001 ± 0.399
6.345GluLeu: 6.345 ± 0.418
1.782GluMet: 1.782 ± 0.253
5.313GluAsn: 5.313 ± 0.443
1.688GluPro: 1.688 ± 0.275
2.219GluGln: 2.219 ± 0.284
2.282GluArg: 2.282 ± 0.307
4.595GluSer: 4.595 ± 0.42
3.501GluThr: 3.501 ± 0.33
4.532GluVal: 4.532 ± 0.489
0.438GluTrp: 0.438 ± 0.123
3.626GluTyr: 3.626 ± 0.315
0.0GluXaa: 0.0 ± 0.0
Phe
1.375PheAla: 1.375 ± 0.211
0.25PheCys: 0.25 ± 0.094
2.844PheAsp: 2.844 ± 0.323
3.282PheGlu: 3.282 ± 0.305
1.594PhePhe: 1.594 ± 0.266
2.594PheGly: 2.594 ± 0.253
0.688PheHis: 0.688 ± 0.179
3.657PheIle: 3.657 ± 0.343
5.251PheLys: 5.251 ± 0.409
3.313PheLeu: 3.313 ± 0.296
1.219PheMet: 1.219 ± 0.183
3.626PheAsn: 3.626 ± 0.281
1.407PhePro: 1.407 ± 0.234
1.125PheGln: 1.125 ± 0.19
1.875PheArg: 1.875 ± 0.262
3.313PheSer: 3.313 ± 0.362
3.626PheThr: 3.626 ± 0.464
2.532PheVal: 2.532 ± 0.255
0.563PheTrp: 0.563 ± 0.145
1.938PheTyr: 1.938 ± 0.292
0.0PheXaa: 0.0 ± 0.0
Gly
3.094GlyAla: 3.094 ± 0.42
0.5GlyCys: 0.5 ± 0.16
4.001GlyAsp: 4.001 ± 0.373
3.563GlyGlu: 3.563 ± 0.416
2.469GlyPhe: 2.469 ± 0.228
3.719GlyGly: 3.719 ± 0.363
0.75GlyHis: 0.75 ± 0.15
5.063GlyIle: 5.063 ± 0.411
5.407GlyLys: 5.407 ± 0.513
4.188GlyLeu: 4.188 ± 0.305
1.375GlyMet: 1.375 ± 0.184
4.376GlyAsn: 4.376 ± 0.419
0.5GlyPro: 0.5 ± 0.139
1.407GlyGln: 1.407 ± 0.292
1.875GlyArg: 1.875 ± 0.276
5.251GlySer: 5.251 ± 0.599
4.282GlyThr: 4.282 ± 0.541
3.407GlyVal: 3.407 ± 0.374
0.688GlyTrp: 0.688 ± 0.131
2.063GlyTyr: 2.063 ± 0.225
0.0GlyXaa: 0.0 ± 0.0
His
0.5HisAla: 0.5 ± 0.126
0.25HisCys: 0.25 ± 0.091
0.75HisAsp: 0.75 ± 0.158
0.906HisGlu: 0.906 ± 0.2
0.688HisPhe: 0.688 ± 0.157
0.625HisGly: 0.625 ± 0.136
0.281HisHis: 0.281 ± 0.11
1.156HisIle: 1.156 ± 0.225
1.063HisLys: 1.063 ± 0.165
1.438HisLeu: 1.438 ± 0.191
0.344HisMet: 0.344 ± 0.12
1.25HisAsn: 1.25 ± 0.226
0.719HisPro: 0.719 ± 0.14
0.313HisGln: 0.313 ± 0.115
0.625HisArg: 0.625 ± 0.17
1.25HisSer: 1.25 ± 0.175
0.938HisThr: 0.938 ± 0.169
0.969HisVal: 0.969 ± 0.21
0.25HisTrp: 0.25 ± 0.086
0.813HisTyr: 0.813 ± 0.147
0.0HisXaa: 0.0 ± 0.0
Ile
3.751IleAla: 3.751 ± 0.324
0.688IleCys: 0.688 ± 0.163
5.751IleAsp: 5.751 ± 0.364
6.626IleGlu: 6.626 ± 0.572
3.344IlePhe: 3.344 ± 0.285
3.469IleGly: 3.469 ± 0.332
1.0IleHis: 1.0 ± 0.21
7.126IleIle: 7.126 ± 0.685
8.033IleLys: 8.033 ± 0.614
6.376IleLeu: 6.376 ± 0.501
1.188IleMet: 1.188 ± 0.15
6.314IleAsn: 6.314 ± 0.448
2.782IlePro: 2.782 ± 0.33
2.688IleGln: 2.688 ± 0.244
3.094IleArg: 3.094 ± 0.281
5.595IleSer: 5.595 ± 0.45
5.095IleThr: 5.095 ± 0.395
3.969IleVal: 3.969 ± 0.372
0.75IleTrp: 0.75 ± 0.145
2.876IleTyr: 2.876 ± 0.308
0.0IleXaa: 0.0 ± 0.0
Lys
4.407LysAla: 4.407 ± 0.427
0.594LysCys: 0.594 ± 0.183
6.095LysAsp: 6.095 ± 0.526
6.751LysGlu: 6.751 ± 0.584
3.313LysPhe: 3.313 ± 0.315
5.001LysGly: 5.001 ± 0.626
1.625LysHis: 1.625 ± 0.203
6.407LysIle: 6.407 ± 0.475
6.157LysLys: 6.157 ± 0.581
8.314LysLeu: 8.314 ± 0.545
2.344LysMet: 2.344 ± 0.25
6.314LysAsn: 6.314 ± 0.411
2.469LysPro: 2.469 ± 0.279
2.938LysGln: 2.938 ± 0.342
3.532LysArg: 3.532 ± 0.376
5.532LysSer: 5.532 ± 0.358
5.345LysThr: 5.345 ± 0.445
4.407LysVal: 4.407 ± 0.472
0.906LysTrp: 0.906 ± 0.149
4.188LysTyr: 4.188 ± 0.4
0.0LysXaa: 0.0 ± 0.0
Leu
4.345LeuAla: 4.345 ± 0.374
0.469LeuCys: 0.469 ± 0.13
5.157LeuAsp: 5.157 ± 0.363
6.376LeuGlu: 6.376 ± 0.369
3.438LeuPhe: 3.438 ± 0.366
4.907LeuGly: 4.907 ± 0.447
1.594LeuHis: 1.594 ± 0.23
5.22LeuIle: 5.22 ± 0.332
7.283LeuLys: 7.283 ± 0.413
6.345LeuLeu: 6.345 ± 0.554
1.907LeuMet: 1.907 ± 0.241
7.095LeuAsn: 7.095 ± 0.498
2.5LeuPro: 2.5 ± 0.305
2.438LeuGln: 2.438 ± 0.255
3.094LeuArg: 3.094 ± 0.306
6.532LeuSer: 6.532 ± 0.472
4.845LeuThr: 4.845 ± 0.399
4.251LeuVal: 4.251 ± 0.387
0.531LeuTrp: 0.531 ± 0.14
3.594LeuTyr: 3.594 ± 0.407
0.0LeuXaa: 0.0 ± 0.0
Met
1.094MetAla: 1.094 ± 0.163
0.313MetCys: 0.313 ± 0.101
1.281MetAsp: 1.281 ± 0.234
1.156MetGlu: 1.156 ± 0.204
1.063MetPhe: 1.063 ± 0.194
1.188MetGly: 1.188 ± 0.189
0.25MetHis: 0.25 ± 0.085
1.469MetIle: 1.469 ± 0.236
1.907MetLys: 1.907 ± 0.259
1.688MetLeu: 1.688 ± 0.184
0.5MetMet: 0.5 ± 0.096
1.407MetAsn: 1.407 ± 0.217
0.531MetPro: 0.531 ± 0.172
0.844MetGln: 0.844 ± 0.185
0.531MetArg: 0.531 ± 0.125
1.938MetSer: 1.938 ± 0.242
1.532MetThr: 1.532 ± 0.236
1.281MetVal: 1.281 ± 0.19
0.125MetTrp: 0.125 ± 0.065
0.781MetTyr: 0.781 ± 0.141
0.0MetXaa: 0.0 ± 0.0
Asn
3.188AsnAla: 3.188 ± 0.416
0.781AsnCys: 0.781 ± 0.178
4.813AsnAsp: 4.813 ± 0.314
4.438AsnGlu: 4.438 ± 0.377
3.782AsnPhe: 3.782 ± 0.367
4.72AsnGly: 4.72 ± 0.402
1.188AsnHis: 1.188 ± 0.209
6.251AsnIle: 6.251 ± 0.447
6.783AsnLys: 6.783 ± 0.523
5.345AsnLeu: 5.345 ± 0.443
1.063AsnMet: 1.063 ± 0.168
5.376AsnAsn: 5.376 ± 0.46
2.938AsnPro: 2.938 ± 0.287
2.063AsnGln: 2.063 ± 0.218
2.844AsnArg: 2.844 ± 0.311
6.157AsnSer: 6.157 ± 0.499
5.626AsnThr: 5.626 ± 0.538
3.907AsnVal: 3.907 ± 0.405
0.781AsnTrp: 0.781 ± 0.16
3.501AsnTyr: 3.501 ± 0.368
0.0AsnXaa: 0.0 ± 0.0
Pro
1.125ProAla: 1.125 ± 0.202
0.219ProCys: 0.219 ± 0.088
2.094ProAsp: 2.094 ± 0.225
2.438ProGlu: 2.438 ± 0.307
1.625ProPhe: 1.625 ± 0.195
1.594ProGly: 1.594 ± 0.28
0.438ProHis: 0.438 ± 0.104
2.344ProIle: 2.344 ± 0.265
2.344ProLys: 2.344 ± 0.325
2.751ProLeu: 2.751 ± 0.285
0.406ProMet: 0.406 ± 0.11
1.938ProAsn: 1.938 ± 0.262
0.594ProPro: 0.594 ± 0.177
0.656ProGln: 0.656 ± 0.146
0.813ProArg: 0.813 ± 0.132
2.719ProSer: 2.719 ± 0.333
1.782ProThr: 1.782 ± 0.271
1.813ProVal: 1.813 ± 0.236
0.156ProTrp: 0.156 ± 0.073
1.25ProTyr: 1.25 ± 0.206
0.0ProXaa: 0.0 ± 0.0
Gln
2.032GlnAla: 2.032 ± 0.261
0.125GlnCys: 0.125 ± 0.064
1.938GlnAsp: 1.938 ± 0.258
2.532GlnGlu: 2.532 ± 0.266
1.938GlnPhe: 1.938 ± 0.272
1.875GlnGly: 1.875 ± 0.254
0.469GlnHis: 0.469 ± 0.109
2.188GlnIle: 2.188 ± 0.189
2.375GlnLys: 2.375 ± 0.364
2.719GlnLeu: 2.719 ± 0.288
0.656GlnMet: 0.656 ± 0.161
1.969GlnAsn: 1.969 ± 0.273
0.875GlnPro: 0.875 ± 0.175
1.375GlnGln: 1.375 ± 0.209
1.281GlnArg: 1.281 ± 0.191
1.969GlnSer: 1.969 ± 0.222
1.75GlnThr: 1.75 ± 0.248
1.407GlnVal: 1.407 ± 0.224
0.219GlnTrp: 0.219 ± 0.086
1.344GlnTyr: 1.344 ± 0.25
0.0GlnXaa: 0.0 ± 0.0
Arg
1.469ArgAla: 1.469 ± 0.186
0.469ArgCys: 0.469 ± 0.127
2.657ArgAsp: 2.657 ± 0.336
2.344ArgGlu: 2.344 ± 0.241
2.0ArgPhe: 2.0 ± 0.206
2.219ArgGly: 2.219 ± 0.278
0.5ArgHis: 0.5 ± 0.131
2.563ArgIle: 2.563 ± 0.341
3.032ArgLys: 3.032 ± 0.398
3.126ArgLeu: 3.126 ± 0.3
0.875ArgMet: 0.875 ± 0.164
2.688ArgAsn: 2.688 ± 0.394
0.813ArgPro: 0.813 ± 0.166
1.5ArgGln: 1.5 ± 0.219
1.219ArgArg: 1.219 ± 0.23
2.469ArgSer: 2.469 ± 0.283
2.188ArgThr: 2.188 ± 0.226
2.532ArgVal: 2.532 ± 0.269
0.219ArgTrp: 0.219 ± 0.078
2.032ArgTyr: 2.032 ± 0.26
0.0ArgXaa: 0.0 ± 0.0
Ser
3.188SerAla: 3.188 ± 0.37
0.5SerCys: 0.5 ± 0.143
4.813SerAsp: 4.813 ± 0.411
5.032SerGlu: 5.032 ± 0.415
4.032SerPhe: 4.032 ± 0.405
4.657SerGly: 4.657 ± 0.657
1.0SerHis: 1.0 ± 0.165
5.782SerIle: 5.782 ± 0.552
7.595SerLys: 7.595 ± 0.428
5.657SerLeu: 5.657 ± 0.401
1.25SerMet: 1.25 ± 0.172
5.439SerAsn: 5.439 ± 0.424
2.063SerPro: 2.063 ± 0.242
2.344SerGln: 2.344 ± 0.248
2.844SerArg: 2.844 ± 0.335
6.126SerSer: 6.126 ± 0.482
4.657SerThr: 4.657 ± 0.569
4.095SerVal: 4.095 ± 0.304
0.438SerTrp: 0.438 ± 0.14
3.063SerTyr: 3.063 ± 0.322
0.0SerXaa: 0.0 ± 0.0
Thr
2.938ThrAla: 2.938 ± 0.378
0.563ThrCys: 0.563 ± 0.129
4.22ThrAsp: 4.22 ± 0.416
4.282ThrGlu: 4.282 ± 0.31
2.813ThrPhe: 2.813 ± 0.33
4.032ThrGly: 4.032 ± 0.509
0.688ThrHis: 0.688 ± 0.12
5.282ThrIle: 5.282 ± 0.386
4.876ThrLys: 4.876 ± 0.413
5.032ThrLeu: 5.032 ± 0.389
1.125ThrMet: 1.125 ± 0.18
4.845ThrAsn: 4.845 ± 0.428
2.375ThrPro: 2.375 ± 0.256
1.657ThrGln: 1.657 ± 0.251
2.125ThrArg: 2.125 ± 0.26
4.782ThrSer: 4.782 ± 0.547
4.376ThrThr: 4.376 ± 0.424
3.938ThrVal: 3.938 ± 0.412
0.594ThrTrp: 0.594 ± 0.119
3.001ThrTyr: 3.001 ± 0.389
0.0ThrXaa: 0.0 ± 0.0
Val
2.032ValAla: 2.032 ± 0.23
0.469ValCys: 0.469 ± 0.152
4.126ValAsp: 4.126 ± 0.42
3.844ValGlu: 3.844 ± 0.304
2.407ValPhe: 2.407 ± 0.263
3.438ValGly: 3.438 ± 0.303
0.844ValHis: 0.844 ± 0.156
4.032ValIle: 4.032 ± 0.449
5.001ValLys: 5.001 ± 0.49
4.813ValLeu: 4.813 ± 0.449
1.219ValMet: 1.219 ± 0.179
4.095ValAsn: 4.095 ± 0.31
1.875ValPro: 1.875 ± 0.251
2.282ValGln: 2.282 ± 0.289
2.25ValArg: 2.25 ± 0.288
3.626ValSer: 3.626 ± 0.305
3.563ValThr: 3.563 ± 0.418
2.751ValVal: 2.751 ± 0.342
0.375ValTrp: 0.375 ± 0.105
2.125ValTyr: 2.125 ± 0.265
0.0ValXaa: 0.0 ± 0.0
Trp
0.438TrpAla: 0.438 ± 0.11
0.063TrpCys: 0.063 ± 0.042
0.5TrpAsp: 0.5 ± 0.129
0.594TrpGlu: 0.594 ± 0.122
0.531TrpPhe: 0.531 ± 0.145
0.25TrpGly: 0.25 ± 0.091
0.188TrpHis: 0.188 ± 0.082
1.031TrpIle: 1.031 ± 0.16
0.719TrpLys: 0.719 ± 0.142
0.875TrpLeu: 0.875 ± 0.145
0.219TrpMet: 0.219 ± 0.096
0.938TrpAsn: 0.938 ± 0.17
0.0TrpPro: 0.0 ± 0.0
0.219TrpGln: 0.219 ± 0.086
0.406TrpArg: 0.406 ± 0.113
0.75TrpSer: 0.75 ± 0.154
0.531TrpThr: 0.531 ± 0.136
0.313TrpVal: 0.313 ± 0.081
0.125TrpTrp: 0.125 ± 0.079
0.438TrpTyr: 0.438 ± 0.122
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.094TyrAla: 1.094 ± 0.183
0.438TyrCys: 0.438 ± 0.119
3.407TyrAsp: 3.407 ± 0.333
3.032TyrGlu: 3.032 ± 0.272
1.563TyrPhe: 1.563 ± 0.188
2.125TyrGly: 2.125 ± 0.253
1.063TyrHis: 1.063 ± 0.172
4.001TyrIle: 4.001 ± 0.335
4.126TyrLys: 4.126 ± 0.426
3.313TyrLeu: 3.313 ± 0.286
0.625TyrMet: 0.625 ± 0.162
4.157TyrAsn: 4.157 ± 0.443
1.063TyrPro: 1.063 ± 0.221
1.407TyrGln: 1.407 ± 0.223
2.063TyrArg: 2.063 ± 0.266
3.563TyrSer: 3.563 ± 0.307
2.625TyrThr: 2.625 ± 0.355
2.094TyrVal: 2.094 ± 0.275
0.813TyrTrp: 0.813 ± 0.155
2.063TyrTyr: 2.063 ± 0.319
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 133 proteins (31995 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski