Amino acid dipepetide frequency for Cryptosporidium parvum (strain Iowa II)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	1.769AlaAla: 1.769 ± 0.063	0.658AlaCys: 0.658 ± 0.019	1.449AlaAsp: 1.449 ± 0.032	2.026AlaGlu: 2.026 ± 0.038	1.683AlaPhe: 1.683 ± 0.028	1.573AlaGly: 1.573 ± 0.037	0.605AlaHis: 0.605 ± 0.018	3.084AlaIle: 3.084 ± 0.049	2.423AlaLys: 2.423 ± 0.061	3.713AlaLeu: 3.713 ± 0.056	0.715AlaMet: 0.715 ± 0.017	2.171AlaAsn: 2.171 ± 0.042	1.378AlaPro: 1.378 ± 0.094	1.2AlaGln: 1.2 ± 0.029	1.397AlaArg: 1.397 ± 0.031	3.346AlaSer: 3.346 ± 0.051	1.785AlaThr: 1.785 ± 0.037	1.761AlaVal: 1.761 ± 0.036	0.296AlaTrp: 0.296 ± 0.013	1.112AlaTyr: 1.112 ± 0.025	0.004AlaXaa: 0.004 ± 0.001
Cys	0.483CysAla: 0.483 ± 0.017	0.393CysCys: 0.393 ± 0.015	0.869CysAsp: 0.869 ± 0.02	1.025CysGlu: 1.025 ± 0.024	0.886CysPhe: 0.886 ± 0.021	0.902CysGly: 0.902 ± 0.025	0.327CysHis: 0.327 ± 0.013	1.749CysIle: 1.749 ± 0.031	1.282CysLys: 1.282 ± 0.029	1.621CysLeu: 1.621 ± 0.029	0.361CysMet: 0.361 ± 0.012	1.317CysAsn: 1.317 ± 0.032	0.681CysPro: 0.681 ± 0.039	0.545CysGln: 0.545 ± 0.018	0.722CysArg: 0.722 ± 0.019	1.66CysSer: 1.66 ± 0.043	0.762CysThr: 0.762 ± 0.022	0.775CysVal: 0.775 ± 0.024	0.154CysTrp: 0.154 ± 0.008	0.594CysTyr: 0.594 ± 0.018	0.001CysXaa: 0.001 ± 0.001
Asp	1.598AspAla: 1.598 ± 0.047	0.825AspCys: 0.825 ± 0.021	3.305AspAsp: 3.305 ± 0.074	4.464AspGlu: 4.464 ± 0.059	2.843AspPhe: 2.843 ± 0.036	2.305AspGly: 2.305 ± 0.045	1.093AspHis: 1.093 ± 0.026	4.749AspIle: 4.749 ± 0.045	3.478AspLys: 3.478 ± 0.049	5.271AspLeu: 5.271 ± 0.055	0.862AspMet: 0.862 ± 0.021	3.563AspAsn: 3.563 ± 0.041	1.825AspPro: 1.825 ± 0.033	1.975AspGln: 1.975 ± 0.034	1.62AspArg: 1.62 ± 0.035	5.124AspSer: 5.124 ± 0.058	2.137AspThr: 2.137 ± 0.037	2.152AspVal: 2.152 ± 0.039	0.494AspTrp: 0.494 ± 0.018	2.07AspTyr: 2.07 ± 0.031	0.005AspXaa: 0.005 ± 0.003
Glu	2.434GluAla: 2.434 ± 0.047	1.076GluCys: 1.076 ± 0.028	3.911GluAsp: 3.911 ± 0.058	6.299GluGlu: 6.299 ± 0.152	3.402GluPhe: 3.402 ± 0.044	2.527GluGly: 2.527 ± 0.044	1.078GluHis: 1.078 ± 0.026	6.591GluIle: 6.591 ± 0.066	6.392GluLys: 6.392 ± 0.092	6.845GluLeu: 6.845 ± 0.07	1.541GluMet: 1.541 ± 0.026	6.094GluAsn: 6.094 ± 0.063	1.403GluPro: 1.403 ± 0.028	2.276GluGln: 2.276 ± 0.038	2.948GluArg: 2.948 ± 0.062	5.983GluSer: 5.983 ± 0.064	3.281GluThr: 3.281 ± 0.045	3.053GluVal: 3.053 ± 0.045	0.618GluTrp: 0.618 ± 0.021	2.776GluTyr: 2.776 ± 0.036	0.007GluXaa: 0.007 ± 0.003
Phe	1.503PheAla: 1.503 ± 0.029	0.927PheCys: 0.927 ± 0.021	2.892PheAsp: 2.892 ± 0.04	3.612PheGlu: 3.612 ± 0.048	2.385PhePhe: 2.385 ± 0.042	2.875PheGly: 2.875 ± 0.041	0.94PheHis: 0.94 ± 0.022	4.033PheIle: 4.033 ± 0.057	3.311PheLys: 3.311 ± 0.045	4.559PheLeu: 4.559 ± 0.065	0.833PheMet: 0.833 ± 0.018	3.548PheAsn: 3.548 ± 0.056	1.874PhePro: 1.874 ± 0.032	1.867PheGln: 1.867 ± 0.034	1.687PheArg: 1.687 ± 0.03	5.166PheSer: 5.166 ± 0.059	2.21PheThr: 2.21 ± 0.033	2.454PheVal: 2.454 ± 0.039	0.499PheTrp: 0.499 ± 0.018	1.706PheTyr: 1.706 ± 0.029	0.002PheXaa: 0.002 ± 0.001
Gly	1.86GlyAla: 1.86 ± 0.045	0.774GlyCys: 0.774 ± 0.021	2.274GlyAsp: 2.274 ± 0.049	2.864GlyGlu: 2.864 ± 0.047	2.414GlyPhe: 2.414 ± 0.038	3.282GlyGly: 3.282 ± 0.099	0.813GlyHis: 0.813 ± 0.022	4.562GlyIle: 4.562 ± 0.056	3.356GlyLys: 3.356 ± 0.047	3.996GlyLeu: 3.996 ± 0.046	0.963GlyMet: 0.963 ± 0.028	3.552GlyAsn: 3.552 ± 0.054	1.228GlyPro: 1.228 ± 0.037	1.4GlyGln: 1.4 ± 0.031	2.02GlyArg: 2.02 ± 0.036	4.365GlySer: 4.365 ± 0.078	2.403GlyThr: 2.403 ± 0.051	2.676GlyVal: 2.676 ± 0.054	0.402GlyTrp: 0.402 ± 0.016	1.743GlyTyr: 1.743 ± 0.044	0.007GlyXaa: 0.007 ± 0.004
His	0.629HisAla: 0.629 ± 0.015	0.365HisCys: 0.365 ± 0.013	0.792HisAsp: 0.792 ± 0.019	1.127HisGlu: 1.127 ± 0.023	1.087HisPhe: 1.087 ± 0.022	0.895HisGly: 0.895 ± 0.023	0.576HisHis: 0.576 ± 0.028	1.669HisIle: 1.669 ± 0.032	1.173HisLys: 1.173 ± 0.023	1.882HisLeu: 1.882 ± 0.029	0.293HisMet: 0.293 ± 0.01	1.242HisAsn: 1.242 ± 0.03	0.905HisPro: 0.905 ± 0.025	0.722HisGln: 0.722 ± 0.025	0.723HisArg: 0.723 ± 0.02	1.874HisSer: 1.874 ± 0.028	0.744HisThr: 0.744 ± 0.021	0.776HisVal: 0.776 ± 0.019	0.177HisTrp: 0.177 ± 0.01	0.763HisTyr: 0.763 ± 0.022	0.001HisXaa: 0.001 ± 0.001
Ile	2.821IleAla: 2.821 ± 0.04	1.65IleCys: 1.65 ± 0.038	4.555IleAsp: 4.555 ± 0.049	5.97IleGlu: 5.97 ± 0.073	4.515IlePhe: 4.515 ± 0.072	3.946IleGly: 3.946 ± 0.055	1.752IleHis: 1.752 ± 0.03	7.353IleIle: 7.353 ± 0.111	6.678IleLys: 6.678 ± 0.07	8.932IleLeu: 8.932 ± 0.1	1.525IleMet: 1.525 ± 0.028	6.876IleAsn: 6.876 ± 0.092	3.845IlePro: 3.845 ± 0.047	3.699IleGln: 3.699 ± 0.049	3.362IleArg: 3.362 ± 0.048	9.371IleSer: 9.371 ± 0.087	3.887IleThr: 3.887 ± 0.042	3.839IleVal: 3.839 ± 0.049	0.872IleTrp: 0.872 ± 0.025	3.267IleTyr: 3.267 ± 0.054	0.007IleXaa: 0.007 ± 0.002
Lys	2.609LysAla: 2.609 ± 0.045	1.227LysCys: 1.227 ± 0.027	4.303LysAsp: 4.303 ± 0.077	6.062LysGlu: 6.062 ± 0.103	3.279LysPhe: 3.279 ± 0.046	3.017LysGly: 3.017 ± 0.046	1.404LysHis: 1.404 ± 0.024	6.477LysIle: 6.477 ± 0.085	7.106LysLys: 7.106 ± 0.111	7.565LysLeu: 7.565 ± 0.068	1.719LysMet: 1.719 ± 0.029	6.338LysAsn: 6.338 ± 0.067	2.119LysPro: 2.119 ± 0.04	2.71LysGln: 2.71 ± 0.038	3.33LysArg: 3.33 ± 0.05	7.084LysSer: 7.084 ± 0.075	3.637LysThr: 3.637 ± 0.044	3.79LysVal: 3.79 ± 0.049	0.62LysTrp: 0.62 ± 0.019	3.285LysTyr: 3.285 ± 0.05	0.006LysXaa: 0.006 ± 0.003
Leu	3.46LeuAla: 3.46 ± 0.051	1.618LeuCys: 1.618 ± 0.03	5.174LeuAsp: 5.174 ± 0.05	7.079LeuGlu: 7.079 ± 0.072	5.035LeuPhe: 5.035 ± 0.073	4.247LeuGly: 4.247 ± 0.053	1.653LeuHis: 1.653 ± 0.031	8.02LeuIle: 8.02 ± 0.094	7.719LeuLys: 7.719 ± 0.08	9.91LeuLeu: 9.91 ± 0.101	1.712LeuMet: 1.712 ± 0.026	7.532LeuAsn: 7.532 ± 0.077	3.514LeuPro: 3.514 ± 0.044	3.282LeuGln: 3.282 ± 0.049	4.081LeuArg: 4.081 ± 0.061	9.233LeuSer: 9.233 ± 0.076	4.179LeuThr: 4.179 ± 0.042	4.565LeuVal: 4.565 ± 0.049	0.782LeuTrp: 0.782 ± 0.02	3.276LeuTyr: 3.276 ± 0.045	0.009LeuXaa: 0.009 ± 0.004
Met	0.833MetAla: 0.833 ± 0.017	0.251MetCys: 0.251 ± 0.01	1.25MetAsp: 1.25 ± 0.024	1.503MetGlu: 1.503 ± 0.027	0.783MetPhe: 0.783 ± 0.022	1.018MetGly: 1.018 ± 0.026	0.337MetHis: 0.337 ± 0.013	1.65MetIle: 1.65 ± 0.029	1.569MetLys: 1.569 ± 0.026	1.684MetLeu: 1.684 ± 0.027	0.465MetMet: 0.465 ± 0.016	1.747MetAsn: 1.747 ± 0.03	0.594MetPro: 0.594 ± 0.023	0.602MetGln: 0.602 ± 0.018	0.762MetArg: 0.762 ± 0.019	1.51MetSer: 1.51 ± 0.026	0.81MetThr: 0.81 ± 0.021	1.0MetVal: 1.0 ± 0.02	0.134MetTrp: 0.134 ± 0.008	0.583MetTyr: 0.583 ± 0.015	0.0MetXaa: 0.0 ± 0.0
Asn	2.227AsnAla: 2.227 ± 0.04	1.267AsnCys: 1.267 ± 0.031	4.034AsnAsp: 4.034 ± 0.043	5.46AsnGlu: 5.46 ± 0.065	3.522AsnPhe: 3.522 ± 0.048	3.413AsnGly: 3.413 ± 0.05	1.626AsnHis: 1.626 ± 0.032	7.593AsnIle: 7.593 ± 0.093	6.371AsnLys: 6.371 ± 0.075	7.07AsnLeu: 7.07 ± 0.069	1.553AsnMet: 1.553 ± 0.03	8.8AsnAsn: 8.8 ± 0.181	2.527AsnPro: 2.527 ± 0.035	3.2AsnGln: 3.2 ± 0.049	2.628AsnArg: 2.628 ± 0.034	9.087AsnSer: 9.087 ± 0.092	3.993AsnThr: 3.993 ± 0.052	3.102AsnVal: 3.102 ± 0.038	0.645AsnTrp: 0.645 ± 0.018	3.122AsnTyr: 3.122 ± 0.044	0.009AsnXaa: 0.009 ± 0.003
Pro	1.2ProAla: 1.2 ± 0.086	0.533ProCys: 0.533 ± 0.018	1.504ProAsp: 1.504 ± 0.03	2.406ProGlu: 2.406 ± 0.045	1.699ProPhe: 1.699 ± 0.03	1.581ProGly: 1.581 ± 0.04	0.612ProHis: 0.612 ± 0.023	3.288ProIle: 3.288 ± 0.044	2.605ProLys: 2.605 ± 0.046	3.12ProLeu: 3.12 ± 0.044	0.586ProMet: 0.586 ± 0.019	2.735ProAsn: 2.735 ± 0.042	1.876ProPro: 1.876 ± 0.092	1.197ProGln: 1.197 ± 0.028	1.263ProArg: 1.263 ± 0.029	3.259ProSer: 3.259 ± 0.053	1.834ProThr: 1.834 ± 0.043	1.662ProVal: 1.662 ± 0.034	0.351ProTrp: 0.351 ± 0.013	1.219ProTyr: 1.219 ± 0.026	0.003ProXaa: 0.003 ± 0.002
Gln	1.289GlnAla: 1.289 ± 0.027	0.526GlnCys: 0.526 ± 0.019	1.916GlnAsp: 1.916 ± 0.034	2.734GlnGlu: 2.734 ± 0.049	1.664GlnPhe: 1.664 ± 0.028	1.552GlnGly: 1.552 ± 0.031	0.659GlnHis: 0.659 ± 0.025	3.415GlnIle: 3.415 ± 0.042	2.832GlnLys: 2.832 ± 0.041	3.475GlnLeu: 3.475 ± 0.047	0.755GlnMet: 0.755 ± 0.023	3.161GlnAsn: 3.161 ± 0.044	0.952GlnPro: 0.952 ± 0.026	1.664GlnGln: 1.664 ± 0.098	1.441GlnArg: 1.441 ± 0.027	3.06GlnSer: 3.06 ± 0.044	1.708GlnThr: 1.708 ± 0.034	1.872GlnVal: 1.872 ± 0.03	0.309GlnTrp: 0.309 ± 0.012	1.243GlnTyr: 1.243 ± 0.024	0.004GlnXaa: 0.004 ± 0.002
Arg	1.478ArgAla: 1.478 ± 0.032	0.645ArgCys: 0.645 ± 0.02	1.908ArgAsp: 1.908 ± 0.04	2.753ArgGlu: 2.753 ± 0.042	1.944ArgPhe: 1.944 ± 0.031	1.827ArgGly: 1.827 ± 0.039	0.711ArgHis: 0.711 ± 0.016	3.665ArgIle: 3.665 ± 0.046	3.47ArgLys: 3.47 ± 0.049	3.697ArgLeu: 3.697 ± 0.043	0.877ArgMet: 0.877 ± 0.02	3.036ArgAsn: 3.036 ± 0.043	1.169ArgPro: 1.169 ± 0.03	1.365ArgGln: 1.365 ± 0.03	2.322ArgArg: 2.322 ± 0.048	3.392ArgSer: 3.392 ± 0.048	1.692ArgThr: 1.692 ± 0.032	1.971ArgVal: 1.971 ± 0.037	0.376ArgTrp: 0.376 ± 0.014	1.51ArgTyr: 1.51 ± 0.028	0.004ArgXaa: 0.004 ± 0.002
Ser	3.102SerAla: 3.102 ± 0.05	1.633SerCys: 1.633 ± 0.031	4.697SerAsp: 4.697 ± 0.054	6.422SerGlu: 6.422 ± 0.067	4.67SerPhe: 4.67 ± 0.047	4.847SerGly: 4.847 ± 0.072	1.714SerHis: 1.714 ± 0.033	8.923SerIle: 8.923 ± 0.083	7.97SerLys: 7.97 ± 0.074	9.124SerLeu: 9.124 ± 0.083	1.757SerMet: 1.757 ± 0.028	8.869SerAsn: 8.869 ± 0.085	3.257SerPro: 3.257 ± 0.061	3.76SerGln: 3.76 ± 0.045	3.934SerArg: 3.934 ± 0.05	12.036SerSer: 12.036 ± 0.158	4.919SerThr: 4.919 ± 0.068	4.211SerVal: 4.211 ± 0.053	0.759SerTrp: 0.759 ± 0.02	3.032SerTyr: 3.032 ± 0.041	0.007SerXaa: 0.007 ± 0.003
Thr	1.744ThrAla: 1.744 ± 0.036	0.851ThrCys: 0.851 ± 0.024	2.064ThrAsp: 2.064 ± 0.031	2.955ThrGlu: 2.955 ± 0.036	2.196ThrPhe: 2.196 ± 0.032	2.577ThrGly: 2.577 ± 0.063	0.829ThrHis: 0.829 ± 0.017	4.025ThrIle: 4.025 ± 0.043	3.375ThrLys: 3.375 ± 0.046	4.471ThrLeu: 4.471 ± 0.056	0.845ThrMet: 0.845 ± 0.018	3.811ThrAsn: 3.811 ± 0.053	1.997ThrPro: 1.997 ± 0.041	1.729ThrGln: 1.729 ± 0.028	1.853ThrArg: 1.853 ± 0.037	4.683ThrSer: 4.683 ± 0.063	3.399ThrThr: 3.399 ± 0.309	2.182ThrVal: 2.182 ± 0.034	0.392ThrTrp: 0.392 ± 0.014	1.471ThrTyr: 1.471 ± 0.03	0.008ThrXaa: 0.008 ± 0.003
Val	1.857ValAla: 1.857 ± 0.041	0.921ValCys: 0.921 ± 0.024	2.517ValAsp: 2.517 ± 0.039	3.128ValGlu: 3.128 ± 0.042	2.377ValPhe: 2.377 ± 0.038	2.438ValGly: 2.438 ± 0.047	0.832ValHis: 0.832 ± 0.019	3.795ValIle: 3.795 ± 0.05	3.21ValLys: 3.21 ± 0.044	4.395ValLeu: 4.395 ± 0.051	0.811ValMet: 0.811 ± 0.021	3.298ValAsn: 3.298 ± 0.047	1.911ValPro: 1.911 ± 0.04	1.546ValGln: 1.546 ± 0.029	1.801ValArg: 1.801 ± 0.033	4.631ValSer: 4.631 ± 0.052	2.207ValThr: 2.207 ± 0.042	2.451ValVal: 2.451 ± 0.043	0.427ValTrp: 0.427 ± 0.015	1.613ValTyr: 1.613 ± 0.031	0.002ValXaa: 0.002 ± 0.001
Trp	0.283TrpAla: 0.283 ± 0.014	0.166TrpCys: 0.166 ± 0.008	0.527TrpAsp: 0.527 ± 0.017	0.552TrpGlu: 0.552 ± 0.019	0.426TrpPhe: 0.426 ± 0.015	0.446TrpGly: 0.446 ± 0.018	0.141TrpHis: 0.141 ± 0.008	0.841TrpIle: 0.841 ± 0.023	0.76TrpLys: 0.76 ± 0.019	0.817TrpLeu: 0.817 ± 0.021	0.219TrpMet: 0.219 ± 0.01	0.69TrpAsn: 0.69 ± 0.017	0.234TrpPro: 0.234 ± 0.011	0.238TrpGln: 0.238 ± 0.011	0.453TrpArg: 0.453 ± 0.015	0.77TrpSer: 0.77 ± 0.023	0.379TrpThr: 0.379 ± 0.014	0.436TrpVal: 0.436 ± 0.014	0.116TrpTrp: 0.116 ± 0.007	0.33TrpTyr: 0.33 ± 0.013	0.0TrpXaa: 0.0 ± 0.0
Tyr	0.967TyrAla: 0.967 ± 0.023	0.801TyrCys: 0.801 ± 0.021	1.809TyrAsp: 1.809 ± 0.032	2.087TyrGlu: 2.087 ± 0.031	2.068TyrPhe: 2.068 ± 0.043	1.683TyrGly: 1.683 ± 0.029	0.711TyrHis: 0.711 ± 0.018	3.231TyrIle: 3.231 ± 0.046	2.603TyrLys: 2.603 ± 0.036	3.923TyrLeu: 3.923 ± 0.049	0.691TyrMet: 0.691 ± 0.02	2.858TyrAsn: 2.858 ± 0.043	1.239TyrPro: 1.239 ± 0.036	1.252TyrGln: 1.252 ± 0.023	1.463TyrArg: 1.463 ± 0.032	4.004TyrSer: 4.004 ± 0.051	1.488TyrThr: 1.488 ± 0.027	1.439TyrVal: 1.439 ± 0.027	0.397TyrTrp: 0.397 ± 0.015	1.841TyrTyr: 1.841 ± 0.036	0.003TyrXaa: 0.003 ± 0.001
Xaa	0.002XaaAla: 0.002 ± 0.001	0.002XaaCys: 0.002 ± 0.001	0.007XaaAsp: 0.007 ± 0.003	0.005XaaGlu: 0.005 ± 0.002	0.004XaaPhe: 0.004 ± 0.002	0.006XaaGly: 0.006 ± 0.003	0.002XaaHis: 0.002 ± 0.001	0.009XaaIle: 0.009 ± 0.003	0.005XaaLys: 0.005 ± 0.001	0.011XaaLeu: 0.011 ± 0.004	0.002XaaMet: 0.002 ± 0.001	0.01XaaAsn: 0.01 ± 0.004	0.002XaaPro: 0.002 ± 0.001	0.004XaaGln: 0.004 ± 0.002	0.002XaaArg: 0.002 ± 0.001	0.007XaaSer: 0.007 ± 0.003	0.004XaaThr: 0.004 ± 0.002	0.003XaaVal: 0.003 ± 0.001	0.0XaaTrp: 0.0 ± 0.0	0.002XaaTyr: 0.002 ± 0.001	0.064XaaXaa: 0.064 ± 0.021

Statistics based on 3805 proteins (2271432 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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