Amino acid dipepetide frequency for Mangrovibacter sp. MFB070

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
10.073AlaAla: 10.073 ± 0.11
1.267AlaCys: 1.267 ± 0.033
4.758AlaAsp: 4.758 ± 0.069
5.424AlaGlu: 5.424 ± 0.066
3.689AlaPhe: 3.689 ± 0.063
8.168AlaGly: 8.168 ± 0.088
2.043AlaHis: 2.043 ± 0.04
5.824AlaIle: 5.824 ± 0.066
3.455AlaLys: 3.455 ± 0.053
11.885AlaLeu: 11.885 ± 0.119
2.994AlaMet: 2.994 ± 0.047
2.995AlaAsn: 2.995 ± 0.045
3.766AlaPro: 3.766 ± 0.057
4.785AlaGln: 4.785 ± 0.067
5.69AlaArg: 5.69 ± 0.078
6.047AlaSer: 6.047 ± 0.086
5.058AlaThr: 5.058 ± 0.068
7.091AlaVal: 7.091 ± 0.071
1.806AlaTrp: 1.806 ± 0.04
1.83AlaTyr: 1.83 ± 0.04
0.0AlaXaa: 0.0 ± 0.0
Cys
1.074CysAla: 1.074 ± 0.027
0.202CysCys: 0.202 ± 0.013
0.604CysAsp: 0.604 ± 0.022
0.643CysGlu: 0.643 ± 0.019
0.48CysPhe: 0.48 ± 0.017
1.096CysGly: 1.096 ± 0.031
0.339CysHis: 0.339 ± 0.014
0.586CysIle: 0.586 ± 0.024
0.316CysLys: 0.316 ± 0.016
1.129CysLeu: 1.129 ± 0.03
0.268CysMet: 0.268 ± 0.012
0.355CysAsn: 0.355 ± 0.015
0.537CysPro: 0.537 ± 0.02
0.553CysGln: 0.553 ± 0.023
0.631CysArg: 0.631 ± 0.019
0.719CysSer: 0.719 ± 0.021
0.517CysThr: 0.517 ± 0.018
0.826CysVal: 0.826 ± 0.023
0.198CysTrp: 0.198 ± 0.012
0.339CysTyr: 0.339 ± 0.014
0.0CysXaa: 0.0 ± 0.0
Asp
5.011AspAla: 5.011 ± 0.066
0.519AspCys: 0.519 ± 0.018
2.805AspAsp: 2.805 ± 0.048
3.245AspGlu: 3.245 ± 0.053
2.12AspPhe: 2.12 ± 0.04
3.778AspGly: 3.778 ± 0.061
0.933AspHis: 0.933 ± 0.027
3.489AspIle: 3.489 ± 0.045
2.439AspLys: 2.439 ± 0.047
4.388AspLeu: 4.388 ± 0.052
1.363AspMet: 1.363 ± 0.03
2.398AspAsn: 2.398 ± 0.043
2.194AspPro: 2.194 ± 0.045
1.701AspGln: 1.701 ± 0.034
2.219AspArg: 2.219 ± 0.043
2.926AspSer: 2.926 ± 0.053
2.918AspThr: 2.918 ± 0.064
3.719AspVal: 3.719 ± 0.053
0.819AspTrp: 0.819 ± 0.022
1.804AspTyr: 1.804 ± 0.04
0.0AspXaa: 0.0 ± 0.0
Glu
5.044GluAla: 5.044 ± 0.065
0.472GluCys: 0.472 ± 0.016
2.368GluAsp: 2.368 ± 0.046
3.001GluGlu: 3.001 ± 0.054
1.75GluPhe: 1.75 ± 0.036
3.407GluGly: 3.407 ± 0.05
1.528GluHis: 1.528 ± 0.035
3.071GluIle: 3.071 ± 0.053
2.999GluLys: 2.999 ± 0.048
5.584GluLeu: 5.584 ± 0.068
1.652GluMet: 1.652 ± 0.036
2.412GluAsn: 2.412 ± 0.041
2.059GluPro: 2.059 ± 0.035
3.573GluGln: 3.573 ± 0.063
3.293GluArg: 3.293 ± 0.054
2.962GluSer: 2.962 ± 0.046
2.902GluThr: 2.902 ± 0.047
3.577GluVal: 3.577 ± 0.057
0.761GluTrp: 0.761 ± 0.023
1.396GluTyr: 1.396 ± 0.03
0.0GluXaa: 0.0 ± 0.0
Phe
3.693PheAla: 3.693 ± 0.055
0.582PheCys: 0.582 ± 0.019
2.257PheAsp: 2.257 ± 0.042
1.657PheGlu: 1.657 ± 0.037
1.719PhePhe: 1.719 ± 0.039
3.179PheGly: 3.179 ± 0.047
0.869PheHis: 0.869 ± 0.026
2.574PheIle: 2.574 ± 0.043
1.141PheLys: 1.141 ± 0.024
3.415PheLeu: 3.415 ± 0.054
0.996PheMet: 0.996 ± 0.028
1.716PheAsn: 1.716 ± 0.034
1.629PhePro: 1.629 ± 0.029
1.2PheGln: 1.2 ± 0.03
1.952PheArg: 1.952 ± 0.035
3.159PheSer: 3.159 ± 0.051
2.538PheThr: 2.538 ± 0.041
2.477PheVal: 2.477 ± 0.043
0.647PheTrp: 0.647 ± 0.023
1.238PheTyr: 1.238 ± 0.028
0.0PheXaa: 0.0 ± 0.0
Gly
6.367GlyAla: 6.367 ± 0.084
1.047GlyCys: 1.047 ± 0.026
3.681GlyAsp: 3.681 ± 0.057
4.528GlyGlu: 4.528 ± 0.057
3.317GlyPhe: 3.317 ± 0.052
5.437GlyGly: 5.437 ± 0.089
1.747GlyHis: 1.747 ± 0.039
5.024GlyIle: 5.024 ± 0.059
3.938GlyLys: 3.938 ± 0.053
7.702GlyLeu: 7.702 ± 0.082
2.431GlyMet: 2.431 ± 0.043
2.877GlyAsn: 2.877 ± 0.057
2.199GlyPro: 2.199 ± 0.043
3.104GlyGln: 3.104 ± 0.053
3.811GlyArg: 3.811 ± 0.057
4.412GlySer: 4.412 ± 0.06
3.874GlyThr: 3.874 ± 0.078
5.862GlyVal: 5.862 ± 0.063
1.292GlyTrp: 1.292 ± 0.034
2.649GlyTyr: 2.649 ± 0.044
0.0GlyXaa: 0.0 ± 0.0
His
1.977HisAla: 1.977 ± 0.037
0.349HisCys: 0.349 ± 0.016
1.207HisAsp: 1.207 ± 0.029
1.163HisGlu: 1.163 ± 0.03
1.092HisPhe: 1.092 ± 0.028
1.808HisGly: 1.808 ± 0.039
0.865HisHis: 0.865 ± 0.027
1.445HisIle: 1.445 ± 0.031
0.822HisLys: 0.822 ± 0.025
2.422HisLeu: 2.422 ± 0.045
0.587HisMet: 0.587 ± 0.021
0.948HisAsn: 0.948 ± 0.025
1.415HisPro: 1.415 ± 0.034
1.3HisGln: 1.3 ± 0.031
1.222HisArg: 1.222 ± 0.03
1.45HisSer: 1.45 ± 0.032
1.206HisThr: 1.206 ± 0.032
1.371HisVal: 1.371 ± 0.034
0.465HisTrp: 0.465 ± 0.02
0.956HisTyr: 0.956 ± 0.026
0.0HisXaa: 0.0 ± 0.0
Ile
6.151IleAla: 6.151 ± 0.072
0.665IleCys: 0.665 ± 0.025
3.312IleAsp: 3.312 ± 0.047
3.071IleGlu: 3.071 ± 0.048
1.946IlePhe: 1.946 ± 0.042
4.403IleGly: 4.403 ± 0.061
1.252IleHis: 1.252 ± 0.032
3.253IleIle: 3.253 ± 0.055
2.197IleLys: 2.197 ± 0.044
4.881IleLeu: 4.881 ± 0.074
1.294IleMet: 1.294 ± 0.034
2.632IleAsn: 2.632 ± 0.04
2.719IlePro: 2.719 ± 0.04
1.967IleGln: 1.967 ± 0.038
2.965IleArg: 2.965 ± 0.045
3.911IleSer: 3.911 ± 0.058
3.808IleThr: 3.808 ± 0.061
3.615IleVal: 3.615 ± 0.055
0.679IleTrp: 0.679 ± 0.024
1.459IleTyr: 1.459 ± 0.031
0.0IleXaa: 0.0 ± 0.0
Lys
3.964LysAla: 3.964 ± 0.06
0.271LysCys: 0.271 ± 0.015
1.992LysAsp: 1.992 ± 0.036
2.098LysGlu: 2.098 ± 0.036
1.067LysPhe: 1.067 ± 0.03
2.74LysGly: 2.74 ± 0.047
0.897LysHis: 0.897 ± 0.027
2.191LysIle: 2.191 ± 0.04
2.075LysLys: 2.075 ± 0.045
3.977LysLeu: 3.977 ± 0.054
1.151LysMet: 1.151 ± 0.025
1.634LysAsn: 1.634 ± 0.035
2.067LysPro: 2.067 ± 0.031
2.006LysGln: 2.006 ± 0.037
2.261LysArg: 2.261 ± 0.042
2.191LysSer: 2.191 ± 0.04
2.502LysThr: 2.502 ± 0.036
2.826LysVal: 2.826 ± 0.05
0.421LysTrp: 0.421 ± 0.017
1.082LysTyr: 1.082 ± 0.028
0.0LysXaa: 0.0 ± 0.0
Leu
11.948LeuAla: 11.948 ± 0.113
1.364LeuCys: 1.364 ± 0.027
5.321LeuAsp: 5.321 ± 0.065
5.267LeuGlu: 5.267 ± 0.063
4.279LeuPhe: 4.279 ± 0.062
7.309LeuGly: 7.309 ± 0.087
2.446LeuHis: 2.446 ± 0.043
5.325LeuIle: 5.325 ± 0.064
4.178LeuLys: 4.178 ± 0.052
11.551LeuLeu: 11.551 ± 0.125
2.832LeuMet: 2.832 ± 0.05
4.204LeuAsn: 4.204 ± 0.062
5.781LeuPro: 5.781 ± 0.074
4.106LeuGln: 4.106 ± 0.058
5.893LeuArg: 5.893 ± 0.075
7.683LeuSer: 7.683 ± 0.074
6.092LeuThr: 6.092 ± 0.066
7.826LeuVal: 7.826 ± 0.077
1.439LeuTrp: 1.439 ± 0.032
2.586LeuTyr: 2.586 ± 0.04
0.0LeuXaa: 0.0 ± 0.0
Met
3.032MetAla: 3.032 ± 0.046
0.215MetCys: 0.215 ± 0.011
1.178MetAsp: 1.178 ± 0.028
1.199MetGlu: 1.199 ± 0.029
0.857MetPhe: 0.857 ± 0.023
1.957MetGly: 1.957 ± 0.037
0.541MetHis: 0.541 ± 0.019
1.317MetIle: 1.317 ± 0.033
1.35MetLys: 1.35 ± 0.027
3.027MetLeu: 3.027 ± 0.05
0.814MetMet: 0.814 ± 0.023
1.089MetAsn: 1.089 ± 0.027
1.342MetPro: 1.342 ± 0.027
1.263MetGln: 1.263 ± 0.03
1.397MetArg: 1.397 ± 0.034
1.884MetSer: 1.884 ± 0.033
1.625MetThr: 1.625 ± 0.033
2.017MetVal: 2.017 ± 0.037
0.253MetTrp: 0.253 ± 0.013
0.525MetTyr: 0.525 ± 0.018
0.0MetXaa: 0.0 ± 0.0
Asn
3.488AsnAla: 3.488 ± 0.058
0.36AsnCys: 0.36 ± 0.017
1.994AsnAsp: 1.994 ± 0.048
1.821AsnGlu: 1.821 ± 0.039
1.283AsnPhe: 1.283 ± 0.028
2.922AsnGly: 2.922 ± 0.063
0.885AsnHis: 0.885 ± 0.026
2.383AsnIle: 2.383 ± 0.045
1.561AsnLys: 1.561 ± 0.035
3.652AsnLeu: 3.652 ± 0.058
0.944AsnMet: 0.944 ± 0.025
1.672AsnAsn: 1.672 ± 0.042
2.224AsnPro: 2.224 ± 0.041
1.88AsnGln: 1.88 ± 0.04
1.961AsnArg: 1.961 ± 0.035
2.158AsnSer: 2.158 ± 0.045
2.272AsnThr: 2.272 ± 0.044
2.392AsnVal: 2.392 ± 0.044
0.616AsnTrp: 0.616 ± 0.02
1.196AsnTyr: 1.196 ± 0.031
0.0AsnXaa: 0.0 ± 0.0
Pro
4.937ProAla: 4.937 ± 0.061
0.438ProCys: 0.438 ± 0.016
2.906ProAsp: 2.906 ± 0.045
3.633ProGlu: 3.633 ± 0.055
1.868ProPhe: 1.868 ± 0.036
4.178ProGly: 4.178 ± 0.065
1.097ProHis: 1.097 ± 0.028
1.638ProIle: 1.638 ± 0.036
1.305ProLys: 1.305 ± 0.032
5.002ProLeu: 5.002 ± 0.063
1.012ProMet: 1.012 ± 0.023
1.23ProAsn: 1.23 ± 0.031
1.661ProPro: 1.661 ± 0.04
2.226ProGln: 2.226 ± 0.043
1.963ProArg: 1.963 ± 0.039
2.167ProSer: 2.167 ± 0.036
1.903ProThr: 1.903 ± 0.035
4.549ProVal: 4.549 ± 0.054
0.838ProTrp: 0.838 ± 0.025
1.136ProTyr: 1.136 ± 0.027
0.0ProXaa: 0.0 ± 0.0
Gln
5.218GlnAla: 5.218 ± 0.081
0.458GlnCys: 0.458 ± 0.018
1.929GlnAsp: 1.929 ± 0.039
2.217GlnGlu: 2.217 ± 0.04
1.642GlnPhe: 1.642 ± 0.033
3.43GlnGly: 3.43 ± 0.056
1.42GlnHis: 1.42 ± 0.027
2.222GlnIle: 2.222 ± 0.039
1.705GlnLys: 1.705 ± 0.03
5.17GlnLeu: 5.17 ± 0.076
1.172GlnMet: 1.172 ± 0.028
1.536GlnAsn: 1.536 ± 0.038
2.265GlnPro: 2.265 ± 0.044
3.525GlnGln: 3.525 ± 0.071
2.972GlnArg: 2.972 ± 0.053
2.508GlnSer: 2.508 ± 0.04
2.233GlnThr: 2.233 ± 0.043
3.491GlnVal: 3.491 ± 0.05
0.768GlnTrp: 0.768 ± 0.021
1.308GlnTyr: 1.308 ± 0.026
0.0GlnXaa: 0.0 ± 0.0
Arg
4.556ArgAla: 4.556 ± 0.059
0.594ArgCys: 0.594 ± 0.021
2.737ArgAsp: 2.737 ± 0.045
3.496ArgGlu: 3.496 ± 0.053
2.454ArgPhe: 2.454 ± 0.046
3.267ArgGly: 3.267 ± 0.053
1.671ArgHis: 1.671 ± 0.035
3.262ArgIle: 3.262 ± 0.049
2.259ArgLys: 2.259 ± 0.043
6.259ArgLeu: 6.259 ± 0.077
1.456ArgMet: 1.456 ± 0.037
2.037ArgAsn: 2.037 ± 0.041
2.213ArgPro: 2.213 ± 0.035
3.156ArgGln: 3.156 ± 0.053
3.299ArgArg: 3.299 ± 0.065
2.651ArgSer: 2.651 ± 0.042
2.57ArgThr: 2.57 ± 0.045
3.746ArgVal: 3.746 ± 0.057
0.903ArgTrp: 0.903 ± 0.025
2.118ArgTyr: 2.118 ± 0.042
0.0ArgXaa: 0.0 ± 0.0
Ser
6.131SerAla: 6.131 ± 0.075
0.614SerCys: 0.614 ± 0.022
3.17SerAsp: 3.17 ± 0.054
3.202SerGlu: 3.202 ± 0.042
2.346SerPhe: 2.346 ± 0.037
5.549SerGly: 5.549 ± 0.072
1.557SerHis: 1.557 ± 0.032
2.941SerIle: 2.941 ± 0.051
1.967SerLys: 1.967 ± 0.046
7.018SerLeu: 7.018 ± 0.08
1.58SerMet: 1.58 ± 0.028
1.928SerAsn: 1.928 ± 0.043
2.899SerPro: 2.899 ± 0.043
2.841SerGln: 2.841 ± 0.049
3.497SerArg: 3.497 ± 0.05
3.846SerSer: 3.846 ± 0.077
3.146SerThr: 3.146 ± 0.054
4.554SerVal: 4.554 ± 0.063
0.99SerTrp: 0.99 ± 0.028
1.578SerTyr: 1.578 ± 0.036
0.0SerXaa: 0.0 ± 0.0
Thr
5.135ThrAla: 5.135 ± 0.084
0.523ThrCys: 0.523 ± 0.02
2.703ThrAsp: 2.703 ± 0.046
2.655ThrGlu: 2.655 ± 0.045
2.006ThrPhe: 2.006 ± 0.041
4.853ThrGly: 4.853 ± 0.07
1.321ThrHis: 1.321 ± 0.032
2.876ThrIle: 2.876 ± 0.052
1.462ThrLys: 1.462 ± 0.032
7.207ThrLeu: 7.207 ± 0.082
1.107ThrMet: 1.107 ± 0.028
1.623ThrAsn: 1.623 ± 0.04
3.42ThrPro: 3.42 ± 0.059
2.445ThrGln: 2.445 ± 0.044
3.132ThrArg: 3.132 ± 0.051
3.09ThrSer: 3.09 ± 0.045
3.092ThrThr: 3.092 ± 0.071
4.097ThrVal: 4.097 ± 0.104
1.037ThrTrp: 1.037 ± 0.028
1.132ThrTyr: 1.132 ± 0.045
0.0ThrXaa: 0.0 ± 0.0
Val
7.375ValAla: 7.375 ± 0.081
0.879ValCys: 0.879 ± 0.021
3.725ValAsp: 3.725 ± 0.055
3.732ValGlu: 3.732 ± 0.06
2.794ValPhe: 2.794 ± 0.044
4.668ValGly: 4.668 ± 0.061
1.376ValHis: 1.376 ± 0.032
4.682ValIle: 4.682 ± 0.062
2.9ValLys: 2.9 ± 0.043
7.773ValLeu: 7.773 ± 0.082
2.252ValMet: 2.252 ± 0.036
2.848ValAsn: 2.848 ± 0.052
3.211ValPro: 3.211 ± 0.05
2.536ValGln: 2.536 ± 0.037
3.717ValArg: 3.717 ± 0.05
4.94ValSer: 4.94 ± 0.06
4.616ValThr: 4.616 ± 0.1
5.993ValVal: 5.993 ± 0.08
1.062ValTrp: 1.062 ± 0.027
1.728ValTyr: 1.728 ± 0.035
0.0ValXaa: 0.0 ± 0.0
Trp
1.095TrpAla: 1.095 ± 0.029
0.198TrpCys: 0.198 ± 0.011
0.665TrpAsp: 0.665 ± 0.022
0.611TrpGlu: 0.611 ± 0.021
0.752TrpPhe: 0.752 ± 0.022
0.997TrpGly: 0.997 ± 0.029
0.536TrpHis: 0.536 ± 0.02
0.648TrpIle: 0.648 ± 0.022
0.494TrpLys: 0.494 ± 0.015
2.406TrpLeu: 2.406 ± 0.043
0.413TrpMet: 0.413 ± 0.015
0.512TrpAsn: 0.512 ± 0.019
0.734TrpPro: 0.734 ± 0.022
1.313TrpGln: 1.313 ± 0.034
1.083TrpArg: 1.083 ± 0.032
0.913TrpSer: 0.913 ± 0.026
0.536TrpThr: 0.536 ± 0.02
1.123TrpVal: 1.123 ± 0.026
0.263TrpTrp: 0.263 ± 0.014
0.419TrpTyr: 0.419 ± 0.016
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.38TyrAla: 2.38 ± 0.041
0.395TyrCys: 0.395 ± 0.017
1.476TyrAsp: 1.476 ± 0.039
1.151TyrGlu: 1.151 ± 0.028
1.176TyrPhe: 1.176 ± 0.031
2.154TyrGly: 2.154 ± 0.047
0.746TyrHis: 0.746 ± 0.023
1.429TyrIle: 1.429 ± 0.034
0.852TyrLys: 0.852 ± 0.028
2.98TyrLeu: 2.98 ± 0.045
0.564TyrMet: 0.564 ± 0.018
1.018TyrAsn: 1.018 ± 0.028
1.35TyrPro: 1.35 ± 0.036
1.71TyrGln: 1.71 ± 0.035
1.746TyrArg: 1.746 ± 0.038
1.735TyrSer: 1.735 ± 0.037
1.507TyrThr: 1.507 ± 0.044
1.654TyrVal: 1.654 ± 0.037
0.455TyrTrp: 0.455 ± 0.018
0.913TyrTyr: 0.913 ± 0.03
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4781 proteins (1517325 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski