Amino acid dipepetide frequency for Physcomitrium patens (Spreading-leaved earth moss) (Physcomitrella patens)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	8.12AlaAla: 8.12 ± 0.037	1.322AlaCys: 1.322 ± 0.009	3.653AlaAsp: 3.653 ± 0.013	5.085AlaGlu: 5.085 ± 0.027	2.674AlaPhe: 2.674 ± 0.013	5.304AlaGly: 5.304 ± 0.018	1.648AlaHis: 1.648 ± 0.009	3.503AlaIle: 3.503 ± 0.013	3.903AlaLys: 3.903 ± 0.016	7.571AlaLeu: 7.571 ± 0.029	2.026AlaMet: 2.026 ± 0.011	2.651AlaAsn: 2.651 ± 0.012	3.732AlaPro: 3.732 ± 0.028	2.911AlaGln: 2.911 ± 0.015	4.196AlaArg: 4.196 ± 0.015	6.852AlaSer: 6.852 ± 0.028	4.27AlaThr: 4.27 ± 0.016	5.731AlaVal: 5.731 ± 0.029	0.9AlaTrp: 0.9 ± 0.008	1.758AlaTyr: 1.758 ± 0.01	0.0AlaXaa: 0.0 ± 0.0
Cys	1.178CysAla: 1.178 ± 0.008	0.525CysCys: 0.525 ± 0.006	0.837CysAsp: 0.837 ± 0.007	0.972CysGlu: 0.972 ± 0.007	0.741CysPhe: 0.741 ± 0.007	1.36CysGly: 1.36 ± 0.009	0.46CysHis: 0.46 ± 0.005	0.891CysIle: 0.891 ± 0.008	0.972CysLys: 0.972 ± 0.008	1.662CysLeu: 1.662 ± 0.011	0.448CysMet: 0.448 ± 0.005	0.749CysAsn: 0.749 ± 0.006	0.843CysPro: 0.843 ± 0.009	0.616CysGln: 0.616 ± 0.006	1.112CysArg: 1.112 ± 0.008	1.702CysSer: 1.702 ± 0.013	0.968CysThr: 0.968 ± 0.008	1.207CysVal: 1.207 ± 0.009	0.259CysTrp: 0.259 ± 0.004	0.46CysTyr: 0.46 ± 0.005	0.0CysXaa: 0.0 ± 0.0
Asp	4.056AspAla: 4.056 ± 0.016	0.878AspCys: 0.878 ± 0.007	3.355AspAsp: 3.355 ± 0.018	3.885AspGlu: 3.885 ± 0.019	2.082AspPhe: 2.082 ± 0.011	3.829AspGly: 3.829 ± 0.018	1.202AspHis: 1.202 ± 0.008	2.666AspIle: 2.666 ± 0.015	2.426AspLys: 2.426 ± 0.013	4.88AspLeu: 4.88 ± 0.018	1.324AspMet: 1.324 ± 0.009	1.843AspAsn: 1.843 ± 0.01	2.528AspPro: 2.528 ± 0.012	1.708AspGln: 1.708 ± 0.009	2.732AspArg: 2.732 ± 0.015	4.224AspSer: 4.224 ± 0.017	2.475AspThr: 2.475 ± 0.011	3.938AspVal: 3.938 ± 0.014	0.706AspTrp: 0.706 ± 0.007	1.431AspTyr: 1.431 ± 0.009	0.0AspXaa: 0.0 ± 0.0
Glu	5.483GluAla: 5.483 ± 0.04	0.991GluCys: 0.991 ± 0.008	4.088GluAsp: 4.088 ± 0.02	6.023GluGlu: 6.023 ± 0.035	2.138GluPhe: 2.138 ± 0.011	4.209GluGly: 4.209 ± 0.019	1.429GluHis: 1.429 ± 0.009	3.116GluIle: 3.116 ± 0.015	4.244GluLys: 4.244 ± 0.023	6.172GluLeu: 6.172 ± 0.026	1.611GluMet: 1.611 ± 0.01	2.604GluAsn: 2.604 ± 0.013	2.341GluPro: 2.341 ± 0.013	2.514GluGln: 2.514 ± 0.012	4.084GluArg: 4.084 ± 0.022	4.796GluSer: 4.796 ± 0.022	3.102GluThr: 3.102 ± 0.014	4.743GluVal: 4.743 ± 0.028	0.764GluTrp: 0.764 ± 0.007	1.561GluTyr: 1.561 ± 0.01	0.0GluXaa: 0.0 ± 0.0
Phe	2.53PheAla: 2.53 ± 0.013	0.787PheCys: 0.787 ± 0.007	2.044PheAsp: 2.044 ± 0.012	2.225PheGlu: 2.225 ± 0.011	1.586PhePhe: 1.586 ± 0.012	2.72PheGly: 2.72 ± 0.016	0.926PheHis: 0.926 ± 0.008	1.6PheIle: 1.6 ± 0.012	1.803PheLys: 1.803 ± 0.01	3.699PheLeu: 3.699 ± 0.016	0.891PheMet: 0.891 ± 0.008	1.455PheAsn: 1.455 ± 0.008	1.705PhePro: 1.705 ± 0.01	1.534PheGln: 1.534 ± 0.009	1.974PheArg: 1.974 ± 0.01	3.267PheSer: 3.267 ± 0.015	1.9PheThr: 1.9 ± 0.011	2.547PheVal: 2.547 ± 0.014	0.516PheTrp: 0.516 ± 0.006	1.023PheTyr: 1.023 ± 0.008	0.0PheXaa: 0.0 ± 0.0
Gly	5.072GlyAla: 5.072 ± 0.022	1.282GlyCys: 1.282 ± 0.011	3.612GlyAsp: 3.612 ± 0.016	3.86GlyGlu: 3.86 ± 0.016	2.69GlyPhe: 2.69 ± 0.014	6.191GlyGly: 6.191 ± 0.038	1.67GlyHis: 1.67 ± 0.01	3.2GlyIle: 3.2 ± 0.016	3.606GlyLys: 3.606 ± 0.014	6.047GlyLeu: 6.047 ± 0.021	1.677GlyMet: 1.677 ± 0.011	2.871GlyAsn: 2.871 ± 0.016	2.865GlyPro: 2.865 ± 0.017	2.381GlyGln: 2.381 ± 0.014	4.312GlyArg: 4.312 ± 0.02	6.446GlySer: 6.446 ± 0.024	3.57GlyThr: 3.57 ± 0.014	4.775GlyVal: 4.775 ± 0.019	0.934GlyTrp: 0.934 ± 0.008	1.865GlyTyr: 1.865 ± 0.013	0.001GlyXaa: 0.001 ± 0.0
His	1.651HisAla: 1.651 ± 0.01	0.516HisCys: 0.516 ± 0.005	1.183HisAsp: 1.183 ± 0.008	1.406HisGlu: 1.406 ± 0.01	0.954HisPhe: 0.954 ± 0.008	1.749HisGly: 1.749 ± 0.011	0.883HisHis: 0.883 ± 0.01	1.159HisIle: 1.159 ± 0.008	1.109HisLys: 1.109 ± 0.009	2.37HisLeu: 2.37 ± 0.011	0.593HisMet: 0.593 ± 0.006	0.898HisAsn: 0.898 ± 0.007	1.401HisPro: 1.401 ± 0.01	1.08HisGln: 1.08 ± 0.008	1.562HisArg: 1.562 ± 0.01	2.115HisSer: 2.115 ± 0.011	1.16HisThr: 1.16 ± 0.008	1.659HisVal: 1.659 ± 0.01	0.321HisTrp: 0.321 ± 0.004	0.675HisTyr: 0.675 ± 0.006	0.0HisXaa: 0.0 ± 0.0
Ile	3.568IleAla: 3.568 ± 0.015	0.928IleCys: 0.928 ± 0.007	2.432IleAsp: 2.432 ± 0.01	2.781IleGlu: 2.781 ± 0.016	1.847IlePhe: 1.847 ± 0.011	2.833IleGly: 2.833 ± 0.014	1.132IleHis: 1.132 ± 0.009	2.149IleIle: 2.149 ± 0.014	2.274IleLys: 2.274 ± 0.013	4.498IleLeu: 4.498 ± 0.019	1.04IleMet: 1.04 ± 0.008	1.694IleAsn: 1.694 ± 0.011	2.528IlePro: 2.528 ± 0.014	1.811IleGln: 1.811 ± 0.009	2.517IleArg: 2.517 ± 0.011	3.936IleSer: 3.936 ± 0.014	2.338IleThr: 2.338 ± 0.013	3.178IleVal: 3.178 ± 0.014	0.56IleTrp: 0.56 ± 0.005	1.174IleTyr: 1.174 ± 0.008	0.0IleXaa: 0.0 ± 0.0
Lys	4.121LysAla: 4.121 ± 0.017	0.816LysCys: 0.816 ± 0.007	2.973LysAsp: 2.973 ± 0.015	4.198LysGlu: 4.198 ± 0.024	1.796LysPhe: 1.796 ± 0.01	3.234LysGly: 3.234 ± 0.014	1.259LysHis: 1.259 ± 0.008	2.481LysIle: 2.481 ± 0.014	3.745LysLys: 3.745 ± 0.021	5.274LysLeu: 5.274 ± 0.021	1.252LysMet: 1.252 ± 0.009	2.106LysAsn: 2.106 ± 0.012	2.508LysPro: 2.508 ± 0.014	2.221LysGln: 2.221 ± 0.011	3.485LysArg: 3.485 ± 0.014	4.191LysSer: 4.191 ± 0.018	2.648LysThr: 2.648 ± 0.011	3.665LysVal: 3.665 ± 0.013	0.682LysTrp: 0.682 ± 0.006	1.399LysTyr: 1.399 ± 0.009	0.0LysXaa: 0.0 ± 0.0
Leu	7.262LeuAla: 7.262 ± 0.024	1.735LeuCys: 1.735 ± 0.009	4.977LeuAsp: 4.977 ± 0.016	6.583LeuGlu: 6.583 ± 0.029	3.31LeuPhe: 3.31 ± 0.016	5.945LeuGly: 5.945 ± 0.022	2.64LeuHis: 2.64 ± 0.012	3.818LeuIle: 3.818 ± 0.016	5.44LeuLys: 5.44 ± 0.024	9.711LeuLeu: 9.711 ± 0.038	2.09LeuMet: 2.09 ± 0.01	3.606LeuAsn: 3.606 ± 0.018	5.253LeuPro: 5.253 ± 0.022	5.023LeuGln: 5.023 ± 0.022	6.086LeuArg: 6.086 ± 0.021	7.843LeuSer: 7.843 ± 0.027	4.757LeuThr: 4.757 ± 0.031	6.373LeuVal: 6.373 ± 0.021	1.139LeuTrp: 1.139 ± 0.008	2.272LeuTyr: 2.272 ± 0.013	0.0LeuXaa: 0.0 ± 0.0
Met	2.279MetAla: 2.279 ± 0.012	0.385MetCys: 0.385 ± 0.005	1.391MetAsp: 1.391 ± 0.009	1.857MetGlu: 1.857 ± 0.011	0.768MetPhe: 0.768 ± 0.006	1.629MetGly: 1.629 ± 0.011	0.584MetHis: 0.584 ± 0.005	0.962MetIle: 0.962 ± 0.007	1.425MetLys: 1.425 ± 0.008	2.213MetLeu: 2.213 ± 0.011	0.627MetMet: 0.627 ± 0.006	0.924MetAsn: 0.924 ± 0.007	1.151MetPro: 1.151 ± 0.008	1.109MetGln: 1.109 ± 0.008	1.404MetArg: 1.404 ± 0.009	1.824MetSer: 1.824 ± 0.011	1.162MetThr: 1.162 ± 0.008	1.606MetVal: 1.606 ± 0.009	0.293MetTrp: 0.293 ± 0.004	0.593MetTyr: 0.593 ± 0.006	0.0MetXaa: 0.0 ± 0.0
Asn	2.768AsnAla: 2.768 ± 0.011	0.74AsnCys: 0.74 ± 0.008	1.852AsnAsp: 1.852 ± 0.009	2.296AsnGlu: 2.296 ± 0.015	1.574AsnPhe: 1.574 ± 0.011	2.906AsnGly: 2.906 ± 0.016	0.928AsnHis: 0.928 ± 0.007	1.954AsnIle: 1.954 ± 0.012	1.884AsnLys: 1.884 ± 0.01	4.127AsnLeu: 4.127 ± 0.025	0.973AsnMet: 0.973 ± 0.009	1.597AsnAsn: 1.597 ± 0.011	2.09AsnPro: 2.09 ± 0.012	1.508AsnGln: 1.508 ± 0.009	2.016AsnArg: 2.016 ± 0.009	3.377AsnSer: 3.377 ± 0.017	1.858AsnThr: 1.858 ± 0.009	2.675AsnVal: 2.675 ± 0.013	0.527AsnTrp: 0.527 ± 0.005	1.032AsnTyr: 1.032 ± 0.008	0.0AsnXaa: 0.0 ± 0.0
Pro	3.935ProAla: 3.935 ± 0.019	0.79ProCys: 0.79 ± 0.007	2.377ProAsp: 2.377 ± 0.011	3.217ProGlu: 3.217 ± 0.025	1.743ProPhe: 1.743 ± 0.011	3.301ProGly: 3.301 ± 0.018	1.214ProHis: 1.214 ± 0.008	2.037ProIle: 2.037 ± 0.012	2.441ProLys: 2.441 ± 0.013	4.527ProLeu: 4.527 ± 0.017	1.061ProMet: 1.061 ± 0.008	1.962ProAsn: 1.962 ± 0.014	3.912ProPro: 3.912 ± 0.033	2.036ProGln: 2.036 ± 0.013	2.916ProArg: 2.916 ± 0.014	5.264ProSer: 5.264 ± 0.021	2.889ProThr: 2.889 ± 0.014	3.489ProVal: 3.489 ± 0.018	0.644ProTrp: 0.644 ± 0.006	1.182ProTyr: 1.182 ± 0.007	0.0ProXaa: 0.0 ± 0.0
Gln	3.214GlnAla: 3.214 ± 0.018	0.679GlnCys: 0.679 ± 0.006	1.868GlnAsp: 1.868 ± 0.011	2.758GlnGlu: 2.758 ± 0.016	1.366GlnPhe: 1.366 ± 0.009	2.58GlnGly: 2.58 ± 0.013	1.138GlnHis: 1.138 ± 0.01	1.812GlnIle: 1.812 ± 0.01	2.171GlnLys: 2.171 ± 0.011	4.042GlnLeu: 4.042 ± 0.017	1.005GlnMet: 1.005 ± 0.009	1.562GlnAsn: 1.562 ± 0.011	1.997GlnPro: 1.997 ± 0.014	2.648GlnGln: 2.648 ± 0.033	2.681GlnArg: 2.681 ± 0.012	3.252GlnSer: 3.252 ± 0.014	1.904GlnThr: 1.904 ± 0.01	2.726GlnVal: 2.726 ± 0.013	0.508GlnTrp: 0.508 ± 0.005	0.955GlnTyr: 0.955 ± 0.008	0.0GlnXaa: 0.0 ± 0.0
Arg	4.211ArgAla: 4.211 ± 0.015	1.143ArgCys: 1.143 ± 0.009	3.073ArgAsp: 3.073 ± 0.015	3.894ArgGlu: 3.894 ± 0.019	2.112ArgPhe: 2.112 ± 0.011	4.001ArgGly: 4.001 ± 0.02	1.499ArgHis: 1.499 ± 0.01	2.844ArgIle: 2.844 ± 0.013	3.624ArgLys: 3.624 ± 0.015	5.576ArgLeu: 5.576 ± 0.017	1.507ArgMet: 1.507 ± 0.011	2.471ArgAsn: 2.471 ± 0.011	2.874ArgPro: 2.874 ± 0.013	2.33ArgGln: 2.33 ± 0.013	4.72ArgArg: 4.72 ± 0.021	5.125ArgSer: 5.125 ± 0.02	2.915ArgThr: 2.915 ± 0.012	3.8ArgVal: 3.8 ± 0.016	0.809ArgTrp: 0.809 ± 0.007	1.414ArgTyr: 1.414 ± 0.009	0.0ArgXaa: 0.0 ± 0.0
Ser	6.147SerAla: 6.147 ± 0.023	1.531SerCys: 1.531 ± 0.011	4.149SerAsp: 4.149 ± 0.015	4.838SerGlu: 4.838 ± 0.019	3.362SerPhe: 3.362 ± 0.015	6.26SerGly: 6.26 ± 0.026	2.044SerHis: 2.044 ± 0.011	3.772SerIle: 3.772 ± 0.016	4.52SerLys: 4.52 ± 0.019	8.432SerLeu: 8.432 ± 0.046	2.13SerMet: 2.13 ± 0.01	3.543SerAsn: 3.543 ± 0.016	4.917SerPro: 4.917 ± 0.023	3.353SerGln: 3.353 ± 0.018	5.276SerArg: 5.276 ± 0.021	10.253SerSer: 10.253 ± 0.04	5.058SerThr: 5.058 ± 0.02	5.424SerVal: 5.424 ± 0.019	1.091SerTrp: 1.091 ± 0.008	1.976SerTyr: 1.976 ± 0.011	0.001SerXaa: 0.001 ± 0.0
Thr	3.953ThrAla: 3.953 ± 0.017	0.92ThrCys: 0.92 ± 0.008	2.341ThrAsp: 2.341 ± 0.011	2.926ThrGlu: 2.926 ± 0.014	1.953ThrPhe: 1.953 ± 0.009	3.542ThrGly: 3.542 ± 0.017	1.121ThrHis: 1.121 ± 0.008	2.512ThrIle: 2.512 ± 0.012	2.62ThrLys: 2.62 ± 0.013	4.958ThrLeu: 4.958 ± 0.016	1.274ThrMet: 1.274 ± 0.008	1.989ThrAsn: 1.989 ± 0.012	3.098ThrPro: 3.098 ± 0.016	1.83ThrGln: 1.83 ± 0.012	2.799ThrArg: 2.799 ± 0.013	5.144ThrSer: 5.144 ± 0.025	3.12ThrThr: 3.12 ± 0.016	3.502ThrVal: 3.502 ± 0.015	0.681ThrTrp: 0.681 ± 0.007	1.277ThrTyr: 1.277 ± 0.009	0.0ThrXaa: 0.0 ± 0.0
Val	5.819ValAla: 5.819 ± 0.031	1.215ValCys: 1.215 ± 0.008	3.898ValAsp: 3.898 ± 0.014	4.922ValGlu: 4.922 ± 0.022	2.467ValPhe: 2.467 ± 0.014	4.642ValGly: 4.642 ± 0.017	1.692ValHis: 1.692 ± 0.009	2.914ValIle: 2.914 ± 0.013	3.779ValLys: 3.779 ± 0.015	6.451ValLeu: 6.451 ± 0.02	1.62ValMet: 1.62 ± 0.009	2.436ValAsn: 2.436 ± 0.012	3.517ValPro: 3.517 ± 0.019	2.801ValGln: 2.801 ± 0.013	3.735ValArg: 3.735 ± 0.017	5.412ValSer: 5.412 ± 0.02	3.553ValThr: 3.553 ± 0.015	5.39ValVal: 5.39 ± 0.021	0.821ValTrp: 0.821 ± 0.008	1.774ValTyr: 1.774 ± 0.011	0.0ValXaa: 0.0 ± 0.0
Trp	0.814TrpAla: 0.814 ± 0.006	0.255TrpCys: 0.255 ± 0.004	0.685TrpAsp: 0.685 ± 0.007	0.77TrpGlu: 0.77 ± 0.007	0.466TrpPhe: 0.466 ± 0.006	0.79TrpGly: 0.79 ± 0.007	0.328TrpHis: 0.328 ± 0.005	0.598TrpIle: 0.598 ± 0.006	0.807TrpLys: 0.807 ± 0.007	1.195TrpLeu: 1.195 ± 0.008	0.368TrpMet: 0.368 ± 0.004	0.618TrpAsn: 0.618 ± 0.006	0.51TrpPro: 0.51 ± 0.005	0.534TrpGln: 0.534 ± 0.006	0.946TrpArg: 0.946 ± 0.007	1.027TrpSer: 1.027 ± 0.008	0.687TrpThr: 0.687 ± 0.006	0.788TrpVal: 0.788 ± 0.008	0.236TrpTrp: 0.236 ± 0.004	0.313TrpTyr: 0.313 ± 0.004	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.628TyrAla: 1.628 ± 0.01	0.523TyrCys: 0.523 ± 0.004	1.38TyrAsp: 1.38 ± 0.009	1.517TyrGlu: 1.517 ± 0.012	1.103TyrPhe: 1.103 ± 0.008	1.902TyrGly: 1.902 ± 0.013	0.65TyrHis: 0.65 ± 0.006	1.231TyrIle: 1.231 ± 0.009	1.261TyrLys: 1.261 ± 0.009	2.458TyrLeu: 2.458 ± 0.012	0.667TyrMet: 0.667 ± 0.006	1.101TyrAsn: 1.101 ± 0.007	1.169TyrPro: 1.169 ± 0.008	0.915TyrGln: 0.915 ± 0.006	1.388TyrArg: 1.388 ± 0.009	2.03TyrSer: 2.03 ± 0.011	1.228TyrThr: 1.228 ± 0.008	1.639TyrVal: 1.639 ± 0.01	0.344TyrTrp: 0.344 ± 0.004	0.798TyrTyr: 0.798 ± 0.008	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.003XaaMet: 0.003 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.029XaaXaa: 0.029 ± 0.008

Statistics based on 47782 proteins (19763506 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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