Amino acid dipepetide frequency for Cellulophaga phage phi46:3

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.252AlaAla: 3.252 ± 0.446
0.579AlaCys: 0.579 ± 0.179
3.163AlaAsp: 3.163 ± 0.294
3.697AlaGlu: 3.697 ± 0.403
2.138AlaPhe: 2.138 ± 0.282
1.826AlaGly: 1.826 ± 0.299
0.445AlaHis: 0.445 ± 0.123
4.41AlaIle: 4.41 ± 0.56
5.033AlaLys: 5.033 ± 0.59
4.499AlaLeu: 4.499 ± 0.474
1.693AlaMet: 1.693 ± 0.243
3.474AlaAsn: 3.474 ± 0.43
0.846AlaPro: 0.846 ± 0.231
2.094AlaGln: 2.094 ± 0.319
2.183AlaArg: 2.183 ± 0.357
3.385AlaSer: 3.385 ± 0.517
2.895AlaThr: 2.895 ± 0.335
3.252AlaVal: 3.252 ± 0.325
0.535AlaTrp: 0.535 ± 0.204
2.004AlaTyr: 2.004 ± 0.277
0.0AlaXaa: 0.0 ± 0.0
Cys
0.089CysAla: 0.089 ± 0.069
0.089CysCys: 0.089 ± 0.063
0.624CysAsp: 0.624 ± 0.2
0.98CysGlu: 0.98 ± 0.228
0.535CysPhe: 0.535 ± 0.14
0.445CysGly: 0.445 ± 0.158
0.045CysHis: 0.045 ± 0.043
0.846CysIle: 0.846 ± 0.2
1.203CysLys: 1.203 ± 0.308
0.757CysLeu: 0.757 ± 0.223
0.089CysMet: 0.089 ± 0.054
0.535CysAsn: 0.535 ± 0.161
0.356CysPro: 0.356 ± 0.158
0.178CysGln: 0.178 ± 0.097
0.312CysArg: 0.312 ± 0.116
0.535CysSer: 0.535 ± 0.144
0.579CysThr: 0.579 ± 0.208
0.445CysVal: 0.445 ± 0.154
0.089CysTrp: 0.089 ± 0.066
0.49CysTyr: 0.49 ± 0.177
0.0CysXaa: 0.0 ± 0.0
Asp
3.831AspAla: 3.831 ± 0.505
0.713AspCys: 0.713 ± 0.166
3.296AspAsp: 3.296 ± 0.448
4.454AspGlu: 4.454 ± 0.474
4.989AspPhe: 4.989 ± 0.567
5.167AspGly: 5.167 ± 0.484
0.624AspHis: 0.624 ± 0.143
4.944AspIle: 4.944 ± 0.426
5.434AspLys: 5.434 ± 0.554
6.325AspLeu: 6.325 ± 0.484
1.247AspMet: 1.247 ± 0.25
4.766AspAsn: 4.766 ± 0.551
1.96AspPro: 1.96 ± 0.351
1.47AspGln: 1.47 ± 0.268
2.45AspArg: 2.45 ± 0.328
4.187AspSer: 4.187 ± 0.359
3.608AspThr: 3.608 ± 0.434
3.563AspVal: 3.563 ± 0.414
0.579AspTrp: 0.579 ± 0.149
2.004AspTyr: 2.004 ± 0.349
0.0AspXaa: 0.0 ± 0.0
Glu
4.633GluAla: 4.633 ± 0.564
0.668GluCys: 0.668 ± 0.212
4.454GluAsp: 4.454 ± 0.575
7.127GluGlu: 7.127 ± 0.727
3.474GluPhe: 3.474 ± 0.398
3.964GluGly: 3.964 ± 0.444
0.846GluHis: 0.846 ± 0.191
6.37GluIle: 6.37 ± 0.613
6.548GluLys: 6.548 ± 0.74
7.082GluLeu: 7.082 ± 0.64
1.425GluMet: 1.425 ± 0.238
5.612GluAsn: 5.612 ± 0.463
1.292GluPro: 1.292 ± 0.221
2.272GluGln: 2.272 ± 0.359
2.094GluArg: 2.094 ± 0.283
4.722GluSer: 4.722 ± 0.534
5.969GluThr: 5.969 ± 0.721
4.633GluVal: 4.633 ± 0.607
0.713GluTrp: 0.713 ± 0.193
3.563GluTyr: 3.563 ± 0.458
0.0GluXaa: 0.0 ± 0.0
Phe
1.737PheAla: 1.737 ± 0.298
0.713PheCys: 0.713 ± 0.178
3.252PheAsp: 3.252 ± 0.386
3.43PheGlu: 3.43 ± 0.455
2.138PhePhe: 2.138 ± 0.336
2.539PheGly: 2.539 ± 0.334
0.535PheHis: 0.535 ± 0.176
3.296PheIle: 3.296 ± 0.359
4.232PheLys: 4.232 ± 0.446
3.252PheLeu: 3.252 ± 0.423
1.203PheMet: 1.203 ± 0.176
3.742PheAsn: 3.742 ± 0.534
1.292PhePro: 1.292 ± 0.246
0.891PheGln: 0.891 ± 0.223
1.648PheArg: 1.648 ± 0.325
3.207PheSer: 3.207 ± 0.469
2.851PheThr: 2.851 ± 0.398
2.361PheVal: 2.361 ± 0.277
0.312PheTrp: 0.312 ± 0.119
1.693PheTyr: 1.693 ± 0.321
0.0PheXaa: 0.0 ± 0.0
Gly
2.806GlyAla: 2.806 ± 0.359
0.535GlyCys: 0.535 ± 0.159
4.053GlyAsp: 4.053 ± 0.475
3.964GlyGlu: 3.964 ± 0.446
2.762GlyPhe: 2.762 ± 0.411
3.073GlyGly: 3.073 ± 0.483
0.445GlyHis: 0.445 ± 0.16
4.989GlyIle: 4.989 ± 0.595
4.588GlyLys: 4.588 ± 0.401
3.875GlyLeu: 3.875 ± 0.538
1.024GlyMet: 1.024 ± 0.253
3.163GlyAsn: 3.163 ± 0.429
1.024GlyPro: 1.024 ± 0.223
1.47GlyGln: 1.47 ± 0.25
2.094GlyArg: 2.094 ± 0.282
5.568GlySer: 5.568 ± 0.612
4.187GlyThr: 4.187 ± 0.554
4.098GlyVal: 4.098 ± 0.424
1.114GlyTrp: 1.114 ± 0.255
2.673GlyTyr: 2.673 ± 0.448
0.0GlyXaa: 0.0 ± 0.0
His
0.445HisAla: 0.445 ± 0.12
0.223HisCys: 0.223 ± 0.099
0.401HisAsp: 0.401 ± 0.141
0.891HisGlu: 0.891 ± 0.246
0.757HisPhe: 0.757 ± 0.209
0.401HisGly: 0.401 ± 0.156
0.089HisHis: 0.089 ± 0.064
1.203HisIle: 1.203 ± 0.235
0.98HisLys: 0.98 ± 0.206
0.935HisLeu: 0.935 ± 0.247
0.356HisMet: 0.356 ± 0.147
1.024HisAsn: 1.024 ± 0.235
0.579HisPro: 0.579 ± 0.162
0.624HisGln: 0.624 ± 0.146
0.535HisArg: 0.535 ± 0.181
0.668HisSer: 0.668 ± 0.178
0.713HisThr: 0.713 ± 0.213
0.401HisVal: 0.401 ± 0.142
0.312HisTrp: 0.312 ± 0.12
0.846HisTyr: 0.846 ± 0.222
0.0HisXaa: 0.0 ± 0.0
Ile
5.033IleAla: 5.033 ± 0.641
0.98IleCys: 0.98 ± 0.221
6.102IleAsp: 6.102 ± 0.426
6.058IleGlu: 6.058 ± 0.573
2.361IlePhe: 2.361 ± 0.377
4.766IleGly: 4.766 ± 0.486
1.024IleHis: 1.024 ± 0.238
5.345IleIle: 5.345 ± 0.55
8.597IleLys: 8.597 ± 0.564
5.568IleLeu: 5.568 ± 0.576
1.47IleMet: 1.47 ± 0.216
6.192IleAsn: 6.192 ± 0.619
2.628IlePro: 2.628 ± 0.333
2.762IleGln: 2.762 ± 0.324
2.762IleArg: 2.762 ± 0.408
5.568IleSer: 5.568 ± 0.536
5.434IleThr: 5.434 ± 0.644
4.098IleVal: 4.098 ± 0.431
0.579IleTrp: 0.579 ± 0.16
2.851IleTyr: 2.851 ± 0.44
0.0IleXaa: 0.0 ± 0.0
Lys
4.232LysAla: 4.232 ± 0.481
0.713LysCys: 0.713 ± 0.191
6.058LysAsp: 6.058 ± 0.577
9.31LysGlu: 9.31 ± 0.989
3.43LysPhe: 3.43 ± 0.39
4.766LysGly: 4.766 ± 0.552
1.514LysHis: 1.514 ± 0.296
6.503LysIle: 6.503 ± 0.546
8.953LysLys: 8.953 ± 0.774
7.305LysLeu: 7.305 ± 0.578
2.851LysMet: 2.851 ± 0.364
6.503LysAsn: 6.503 ± 0.551
2.806LysPro: 2.806 ± 0.365
2.984LysGln: 2.984 ± 0.343
3.563LysArg: 3.563 ± 0.547
6.236LysSer: 6.236 ± 0.673
6.102LysThr: 6.102 ± 0.604
4.9LysVal: 4.9 ± 0.483
0.802LysTrp: 0.802 ± 0.145
4.098LysTyr: 4.098 ± 0.51
0.0LysXaa: 0.0 ± 0.0
Leu
3.742LeuAla: 3.742 ± 0.394
0.624LeuCys: 0.624 ± 0.181
5.568LeuAsp: 5.568 ± 0.514
6.147LeuGlu: 6.147 ± 0.653
3.385LeuPhe: 3.385 ± 0.399
4.098LeuGly: 4.098 ± 0.533
1.292LeuHis: 1.292 ± 0.279
6.147LeuIle: 6.147 ± 0.619
8.196LeuLys: 8.196 ± 0.673
5.434LeuLeu: 5.434 ± 0.561
1.425LeuMet: 1.425 ± 0.251
6.102LeuAsn: 6.102 ± 0.477
1.737LeuPro: 1.737 ± 0.224
3.296LeuGln: 3.296 ± 0.431
2.628LeuArg: 2.628 ± 0.464
5.88LeuSer: 5.88 ± 0.547
4.855LeuThr: 4.855 ± 0.621
4.053LeuVal: 4.053 ± 0.432
0.624LeuTrp: 0.624 ± 0.182
3.341LeuTyr: 3.341 ± 0.388
0.0LeuXaa: 0.0 ± 0.0
Met
1.648MetAla: 1.648 ± 0.344
0.267MetCys: 0.267 ± 0.115
1.871MetAsp: 1.871 ± 0.265
1.826MetGlu: 1.826 ± 0.314
0.668MetPhe: 0.668 ± 0.194
1.024MetGly: 1.024 ± 0.242
0.089MetHis: 0.089 ± 0.066
1.425MetIle: 1.425 ± 0.262
3.163MetLys: 3.163 ± 0.409
1.604MetLeu: 1.604 ± 0.292
0.356MetMet: 0.356 ± 0.111
1.737MetAsn: 1.737 ± 0.276
0.535MetPro: 0.535 ± 0.169
1.247MetGln: 1.247 ± 0.307
0.713MetArg: 0.713 ± 0.22
1.425MetSer: 1.425 ± 0.22
0.713MetThr: 0.713 ± 0.195
0.98MetVal: 0.98 ± 0.212
0.089MetTrp: 0.089 ± 0.052
0.757MetTyr: 0.757 ± 0.201
0.0MetXaa: 0.0 ± 0.0
Asn
4.053AsnAla: 4.053 ± 0.44
0.579AsnCys: 0.579 ± 0.187
4.365AsnAsp: 4.365 ± 0.382
4.276AsnGlu: 4.276 ± 0.394
3.163AsnPhe: 3.163 ± 0.335
4.677AsnGly: 4.677 ± 0.486
1.425AsnHis: 1.425 ± 0.298
5.835AsnIle: 5.835 ± 0.744
5.924AsnLys: 5.924 ± 0.557
5.479AsnLeu: 5.479 ± 0.595
1.737AsnMet: 1.737 ± 0.307
4.677AsnAsn: 4.677 ± 0.652
2.673AsnPro: 2.673 ± 0.405
2.272AsnGln: 2.272 ± 0.281
3.029AsnArg: 3.029 ± 0.333
4.321AsnSer: 4.321 ± 0.5
4.454AsnThr: 4.454 ± 0.451
3.341AsnVal: 3.341 ± 0.428
0.713AsnTrp: 0.713 ± 0.18
3.163AsnTyr: 3.163 ± 0.46
0.0AsnXaa: 0.0 ± 0.0
Pro
1.158ProAla: 1.158 ± 0.259
0.223ProCys: 0.223 ± 0.107
2.004ProAsp: 2.004 ± 0.288
2.405ProGlu: 2.405 ± 0.363
1.114ProPhe: 1.114 ± 0.261
0.98ProGly: 0.98 ± 0.195
0.223ProHis: 0.223 ± 0.087
2.45ProIle: 2.45 ± 0.316
2.806ProLys: 2.806 ± 0.332
2.272ProLeu: 2.272 ± 0.332
0.535ProMet: 0.535 ± 0.177
1.648ProAsn: 1.648 ± 0.283
0.668ProPro: 0.668 ± 0.155
0.757ProGln: 0.757 ± 0.211
0.624ProArg: 0.624 ± 0.141
1.96ProSer: 1.96 ± 0.309
2.405ProThr: 2.405 ± 0.303
2.049ProVal: 2.049 ± 0.256
0.134ProTrp: 0.134 ± 0.08
1.247ProTyr: 1.247 ± 0.204
0.0ProXaa: 0.0 ± 0.0
Gln
1.247GlnAla: 1.247 ± 0.232
0.267GlnCys: 0.267 ± 0.129
1.915GlnAsp: 1.915 ± 0.333
2.806GlnGlu: 2.806 ± 0.513
1.292GlnPhe: 1.292 ± 0.259
2.717GlnGly: 2.717 ± 0.393
0.624GlnHis: 0.624 ± 0.184
2.138GlnIle: 2.138 ± 0.258
3.296GlnLys: 3.296 ± 0.478
2.539GlnLeu: 2.539 ± 0.379
0.891GlnMet: 0.891 ± 0.213
1.871GlnAsn: 1.871 ± 0.283
0.98GlnPro: 0.98 ± 0.231
1.292GlnGln: 1.292 ± 0.276
0.757GlnArg: 0.757 ± 0.192
2.361GlnSer: 2.361 ± 0.33
1.915GlnThr: 1.915 ± 0.366
1.336GlnVal: 1.336 ± 0.299
0.445GlnTrp: 0.445 ± 0.141
1.559GlnTyr: 1.559 ± 0.268
0.0GlnXaa: 0.0 ± 0.0
Arg
1.069ArgAla: 1.069 ± 0.226
0.223ArgCys: 0.223 ± 0.094
1.96ArgAsp: 1.96 ± 0.313
2.762ArgGlu: 2.762 ± 0.381
1.782ArgPhe: 1.782 ± 0.26
1.47ArgGly: 1.47 ± 0.376
0.579ArgHis: 0.579 ± 0.181
3.519ArgIle: 3.519 ± 0.398
2.539ArgLys: 2.539 ± 0.393
3.296ArgLeu: 3.296 ± 0.366
1.158ArgMet: 1.158 ± 0.25
2.361ArgAsn: 2.361 ± 0.342
1.069ArgPro: 1.069 ± 0.206
1.648ArgGln: 1.648 ± 0.26
1.381ArgArg: 1.381 ± 0.217
1.782ArgSer: 1.782 ± 0.301
2.094ArgThr: 2.094 ± 0.254
2.094ArgVal: 2.094 ± 0.285
0.312ArgTrp: 0.312 ± 0.117
1.693ArgTyr: 1.693 ± 0.251
0.0ArgXaa: 0.0 ± 0.0
Ser
3.519SerAla: 3.519 ± 0.412
0.579SerCys: 0.579 ± 0.189
5.078SerAsp: 5.078 ± 0.474
5.612SerGlu: 5.612 ± 0.426
3.029SerPhe: 3.029 ± 0.368
5.301SerGly: 5.301 ± 0.621
0.757SerHis: 0.757 ± 0.2
5.523SerIle: 5.523 ± 0.484
6.904SerLys: 6.904 ± 0.696
5.212SerLeu: 5.212 ± 0.609
1.024SerMet: 1.024 ± 0.212
4.633SerAsn: 4.633 ± 0.68
1.292SerPro: 1.292 ± 0.282
2.45SerGln: 2.45 ± 0.372
2.183SerArg: 2.183 ± 0.361
4.365SerSer: 4.365 ± 0.517
4.677SerThr: 4.677 ± 0.513
3.786SerVal: 3.786 ± 0.435
0.713SerTrp: 0.713 ± 0.19
2.584SerTyr: 2.584 ± 0.328
0.0SerXaa: 0.0 ± 0.0
Thr
3.252ThrAla: 3.252 ± 0.429
0.356ThrCys: 0.356 ± 0.153
3.964ThrAsp: 3.964 ± 0.385
4.588ThrGlu: 4.588 ± 0.427
2.628ThrPhe: 2.628 ± 0.437
4.009ThrGly: 4.009 ± 0.496
0.624ThrHis: 0.624 ± 0.17
6.815ThrIle: 6.815 ± 0.693
5.078ThrLys: 5.078 ± 0.497
4.276ThrLeu: 4.276 ± 0.424
1.247ThrMet: 1.247 ± 0.228
4.143ThrAsn: 4.143 ± 0.411
2.762ThrPro: 2.762 ± 0.302
1.559ThrGln: 1.559 ± 0.244
2.405ThrArg: 2.405 ± 0.298
4.41ThrSer: 4.41 ± 0.582
4.766ThrThr: 4.766 ± 0.647
4.499ThrVal: 4.499 ± 0.525
0.668ThrTrp: 0.668 ± 0.187
2.584ThrTyr: 2.584 ± 0.4
0.0ThrXaa: 0.0 ± 0.0
Val
2.806ValAla: 2.806 ± 0.346
0.401ValCys: 0.401 ± 0.113
4.232ValAsp: 4.232 ± 0.459
3.697ValGlu: 3.697 ± 0.321
2.316ValPhe: 2.316 ± 0.318
3.252ValGly: 3.252 ± 0.396
0.624ValHis: 0.624 ± 0.183
3.697ValIle: 3.697 ± 0.441
5.88ValLys: 5.88 ± 0.581
4.989ValLeu: 4.989 ± 0.589
1.381ValMet: 1.381 ± 0.23
3.608ValAsn: 3.608 ± 0.379
1.915ValPro: 1.915 ± 0.242
1.737ValGln: 1.737 ± 0.277
1.737ValArg: 1.737 ± 0.292
4.855ValSer: 4.855 ± 0.427
3.43ValThr: 3.43 ± 0.414
4.187ValVal: 4.187 ± 0.481
0.713ValTrp: 0.713 ± 0.18
1.782ValTyr: 1.782 ± 0.283
0.0ValXaa: 0.0 ± 0.0
Trp
0.624TrpAla: 0.624 ± 0.168
0.0TrpCys: 0.0 ± 0.0
0.802TrpAsp: 0.802 ± 0.165
0.891TrpGlu: 0.891 ± 0.185
0.445TrpPhe: 0.445 ± 0.147
0.445TrpGly: 0.445 ± 0.124
0.178TrpHis: 0.178 ± 0.093
1.336TrpIle: 1.336 ± 0.291
0.713TrpLys: 0.713 ± 0.19
0.668TrpLeu: 0.668 ± 0.187
0.134TrpMet: 0.134 ± 0.063
0.935TrpAsn: 0.935 ± 0.224
0.045TrpPro: 0.045 ± 0.048
0.178TrpGln: 0.178 ± 0.094
0.356TrpArg: 0.356 ± 0.127
0.535TrpSer: 0.535 ± 0.162
0.891TrpThr: 0.891 ± 0.199
0.579TrpVal: 0.579 ± 0.142
0.223TrpTrp: 0.223 ± 0.107
0.445TrpTyr: 0.445 ± 0.15
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.227TyrAla: 2.227 ± 0.341
0.49TyrCys: 0.49 ± 0.169
2.45TyrAsp: 2.45 ± 0.374
2.539TyrGlu: 2.539 ± 0.34
1.915TyrPhe: 1.915 ± 0.286
2.584TyrGly: 2.584 ± 0.321
0.401TyrHis: 0.401 ± 0.127
3.43TyrIle: 3.43 ± 0.487
3.563TyrLys: 3.563 ± 0.464
3.207TyrLeu: 3.207 ± 0.384
0.846TyrMet: 0.846 ± 0.163
3.43TyrAsn: 3.43 ± 0.437
1.203TyrPro: 1.203 ± 0.297
1.069TyrGln: 1.069 ± 0.235
1.336TyrArg: 1.336 ± 0.288
3.252TyrSer: 3.252 ± 0.295
2.094TyrThr: 2.094 ± 0.317
2.584TyrVal: 2.584 ± 0.45
0.757TyrTrp: 0.757 ± 0.201
1.826TyrTyr: 1.826 ± 0.306
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 121 proteins (22451 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski