Amino acid dipepetide frequency for Cellulophaga phage phi18:3

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.236AlaAla: 3.236 ± 0.534
0.539AlaCys: 0.539 ± 0.183
2.966AlaAsp: 2.966 ± 0.351
3.865AlaGlu: 3.865 ± 0.474
2.247AlaPhe: 2.247 ± 0.336
2.517AlaGly: 2.517 ± 0.398
0.494AlaHis: 0.494 ± 0.155
4.314AlaIle: 4.314 ± 0.442
4.809AlaLys: 4.809 ± 0.554
4.449AlaLeu: 4.449 ± 0.605
1.213AlaMet: 1.213 ± 0.23
3.82AlaAsn: 3.82 ± 0.458
0.899AlaPro: 0.899 ± 0.244
1.932AlaGln: 1.932 ± 0.244
1.663AlaArg: 1.663 ± 0.355
3.775AlaSer: 3.775 ± 0.476
3.011AlaThr: 3.011 ± 0.368
2.607AlaVal: 2.607 ± 0.316
0.674AlaTrp: 0.674 ± 0.219
1.843AlaTyr: 1.843 ± 0.279
0.0AlaXaa: 0.0 ± 0.0
Cys
0.18CysAla: 0.18 ± 0.086
0.09CysCys: 0.09 ± 0.064
0.629CysAsp: 0.629 ± 0.165
0.764CysGlu: 0.764 ± 0.221
0.539CysPhe: 0.539 ± 0.173
0.809CysGly: 0.809 ± 0.185
0.09CysHis: 0.09 ± 0.065
0.809CysIle: 0.809 ± 0.223
1.168CysLys: 1.168 ± 0.264
0.629CysLeu: 0.629 ± 0.172
0.225CysMet: 0.225 ± 0.096
0.494CysAsn: 0.494 ± 0.149
0.449CysPro: 0.449 ± 0.156
0.09CysGln: 0.09 ± 0.067
0.315CysArg: 0.315 ± 0.129
0.629CysSer: 0.629 ± 0.163
0.539CysThr: 0.539 ± 0.202
0.494CysVal: 0.494 ± 0.18
0.135CysTrp: 0.135 ± 0.073
0.584CysTyr: 0.584 ± 0.164
0.0CysXaa: 0.0 ± 0.0
Asp
3.595AspAla: 3.595 ± 0.494
0.674AspCys: 0.674 ± 0.158
3.281AspAsp: 3.281 ± 0.395
5.033AspGlu: 5.033 ± 0.465
4.179AspPhe: 4.179 ± 0.51
4.674AspGly: 4.674 ± 0.608
0.674AspHis: 0.674 ± 0.184
4.584AspIle: 4.584 ± 0.461
5.573AspLys: 5.573 ± 0.55
7.011AspLeu: 7.011 ± 0.456
1.258AspMet: 1.258 ± 0.293
4.269AspAsn: 4.269 ± 0.527
2.202AspPro: 2.202 ± 0.338
1.303AspGln: 1.303 ± 0.234
2.382AspArg: 2.382 ± 0.302
4.045AspSer: 4.045 ± 0.426
2.876AspThr: 2.876 ± 0.346
3.64AspVal: 3.64 ± 0.459
0.809AspTrp: 0.809 ± 0.156
2.472AspTyr: 2.472 ± 0.337
0.0AspXaa: 0.0 ± 0.0
Glu
4.314GluAla: 4.314 ± 0.574
0.764GluCys: 0.764 ± 0.227
4.629GluAsp: 4.629 ± 0.558
7.325GluGlu: 7.325 ± 0.685
3.82GluPhe: 3.82 ± 0.391
3.685GluGly: 3.685 ± 0.375
1.123GluHis: 1.123 ± 0.299
6.067GluIle: 6.067 ± 0.563
6.606GluLys: 6.606 ± 0.757
7.595GluLeu: 7.595 ± 0.715
1.034GluMet: 1.034 ± 0.217
5.213GluAsn: 5.213 ± 0.356
1.258GluPro: 1.258 ± 0.23
2.517GluGln: 2.517 ± 0.346
2.337GluArg: 2.337 ± 0.325
5.213GluSer: 5.213 ± 0.548
5.707GluThr: 5.707 ± 0.541
5.258GluVal: 5.258 ± 0.617
0.854GluTrp: 0.854 ± 0.19
3.595GluTyr: 3.595 ± 0.462
0.0GluXaa: 0.0 ± 0.0
Phe
2.022PheAla: 2.022 ± 0.334
0.854PheCys: 0.854 ± 0.197
4.179PheAsp: 4.179 ± 0.483
3.281PheGlu: 3.281 ± 0.357
2.337PhePhe: 2.337 ± 0.344
2.472PheGly: 2.472 ± 0.328
0.629PheHis: 0.629 ± 0.207
3.37PheIle: 3.37 ± 0.401
4.0PheLys: 4.0 ± 0.345
3.415PheLeu: 3.415 ± 0.405
1.123PheMet: 1.123 ± 0.2
3.326PheAsn: 3.326 ± 0.489
1.258PhePro: 1.258 ± 0.249
1.123PheGln: 1.123 ± 0.246
1.618PheArg: 1.618 ± 0.304
3.326PheSer: 3.326 ± 0.371
2.966PheThr: 2.966 ± 0.322
2.741PheVal: 2.741 ± 0.35
0.404PheTrp: 0.404 ± 0.132
1.798PheTyr: 1.798 ± 0.272
0.0PheXaa: 0.0 ± 0.0
Gly
2.517GlyAla: 2.517 ± 0.317
0.449GlyCys: 0.449 ± 0.134
3.73GlyAsp: 3.73 ± 0.414
3.82GlyGlu: 3.82 ± 0.413
2.876GlyPhe: 2.876 ± 0.47
3.146GlyGly: 3.146 ± 0.41
0.539GlyHis: 0.539 ± 0.164
5.078GlyIle: 5.078 ± 0.544
4.404GlyLys: 4.404 ± 0.543
4.045GlyLeu: 4.045 ± 0.404
1.483GlyMet: 1.483 ± 0.293
3.865GlyAsn: 3.865 ± 0.47
1.079GlyPro: 1.079 ± 0.203
1.843GlyGln: 1.843 ± 0.293
2.472GlyArg: 2.472 ± 0.281
5.033GlySer: 5.033 ± 0.648
4.404GlyThr: 4.404 ± 0.572
3.82GlyVal: 3.82 ± 0.386
0.809GlyTrp: 0.809 ± 0.201
2.696GlyTyr: 2.696 ± 0.556
0.0GlyXaa: 0.0 ± 0.0
His
0.225HisAla: 0.225 ± 0.108
0.36HisCys: 0.36 ± 0.129
0.404HisAsp: 0.404 ± 0.153
1.079HisGlu: 1.079 ± 0.259
0.854HisPhe: 0.854 ± 0.189
0.719HisGly: 0.719 ± 0.211
0.09HisHis: 0.09 ± 0.067
1.393HisIle: 1.393 ± 0.315
0.899HisLys: 0.899 ± 0.191
1.079HisLeu: 1.079 ± 0.228
0.404HisMet: 0.404 ± 0.151
1.258HisAsn: 1.258 ± 0.255
0.404HisPro: 0.404 ± 0.132
0.539HisGln: 0.539 ± 0.126
0.494HisArg: 0.494 ± 0.149
0.674HisSer: 0.674 ± 0.2
0.674HisThr: 0.674 ± 0.168
0.404HisVal: 0.404 ± 0.177
0.225HisTrp: 0.225 ± 0.1
0.764HisTyr: 0.764 ± 0.153
0.0HisXaa: 0.0 ± 0.0
Ile
4.584IleAla: 4.584 ± 0.614
0.899IleCys: 0.899 ± 0.213
5.977IleAsp: 5.977 ± 0.474
5.932IleGlu: 5.932 ± 0.519
2.427IlePhe: 2.427 ± 0.461
4.359IleGly: 4.359 ± 0.449
1.034IleHis: 1.034 ± 0.259
5.033IleIle: 5.033 ± 0.542
7.82IleLys: 7.82 ± 0.706
5.842IleLeu: 5.842 ± 0.625
1.573IleMet: 1.573 ± 0.278
5.797IleAsn: 5.797 ± 0.534
2.651IlePro: 2.651 ± 0.309
2.786IleGln: 2.786 ± 0.337
2.966IleArg: 2.966 ± 0.39
5.528IleSer: 5.528 ± 0.564
5.887IleThr: 5.887 ± 0.662
4.584IleVal: 4.584 ± 0.532
0.494IleTrp: 0.494 ± 0.138
2.607IleTyr: 2.607 ± 0.352
0.0IleXaa: 0.0 ± 0.0
Lys
4.539LysAla: 4.539 ± 0.442
0.944LysCys: 0.944 ± 0.24
6.247LysAsp: 6.247 ± 0.64
8.943LysGlu: 8.943 ± 1.001
3.73LysPhe: 3.73 ± 0.416
5.033LysGly: 5.033 ± 0.589
1.303LysHis: 1.303 ± 0.24
6.292LysIle: 6.292 ± 0.633
8.808LysLys: 8.808 ± 0.811
7.37LysLeu: 7.37 ± 0.684
3.146LysMet: 3.146 ± 0.375
6.067LysAsn: 6.067 ± 0.566
2.696LysPro: 2.696 ± 0.317
3.236LysGln: 3.236 ± 0.461
3.955LysArg: 3.955 ± 0.574
5.932LysSer: 5.932 ± 0.602
5.573LysThr: 5.573 ± 0.646
4.809LysVal: 4.809 ± 0.523
0.899LysTrp: 0.899 ± 0.183
3.865LysTyr: 3.865 ± 0.396
0.0LysXaa: 0.0 ± 0.0
Leu
3.865LeuAla: 3.865 ± 0.408
0.494LeuCys: 0.494 ± 0.159
5.662LeuAsp: 5.662 ± 0.464
6.921LeuGlu: 6.921 ± 0.589
3.55LeuPhe: 3.55 ± 0.365
5.168LeuGly: 5.168 ± 0.538
1.258LeuHis: 1.258 ± 0.359
6.426LeuIle: 6.426 ± 0.627
8.269LeuLys: 8.269 ± 0.786
5.977LeuLeu: 5.977 ± 0.56
1.483LeuMet: 1.483 ± 0.259
5.797LeuAsn: 5.797 ± 0.455
1.573LeuPro: 1.573 ± 0.282
2.607LeuGln: 2.607 ± 0.391
3.73LeuArg: 3.73 ± 0.533
6.337LeuSer: 6.337 ± 0.633
4.314LeuThr: 4.314 ± 0.652
3.82LeuVal: 3.82 ± 0.401
0.674LeuTrp: 0.674 ± 0.153
2.966LeuTyr: 2.966 ± 0.379
0.0LeuXaa: 0.0 ± 0.0
Met
1.618MetAla: 1.618 ± 0.28
0.449MetCys: 0.449 ± 0.13
1.438MetAsp: 1.438 ± 0.267
1.663MetGlu: 1.663 ± 0.297
0.854MetPhe: 0.854 ± 0.207
1.483MetGly: 1.483 ± 0.277
0.18MetHis: 0.18 ± 0.083
1.528MetIle: 1.528 ± 0.314
2.921MetLys: 2.921 ± 0.359
1.663MetLeu: 1.663 ± 0.297
0.449MetMet: 0.449 ± 0.133
1.663MetAsn: 1.663 ± 0.245
0.584MetPro: 0.584 ± 0.151
1.123MetGln: 1.123 ± 0.265
0.539MetArg: 0.539 ± 0.172
1.708MetSer: 1.708 ± 0.252
1.123MetThr: 1.123 ± 0.211
1.079MetVal: 1.079 ± 0.232
0.045MetTrp: 0.045 ± 0.043
0.809MetTyr: 0.809 ± 0.198
0.0MetXaa: 0.0 ± 0.0
Asn
4.0AsnAla: 4.0 ± 0.479
0.629AsnCys: 0.629 ± 0.18
4.0AsnAsp: 4.0 ± 0.38
4.674AsnGlu: 4.674 ± 0.462
3.056AsnPhe: 3.056 ± 0.333
4.224AsnGly: 4.224 ± 0.511
1.168AsnHis: 1.168 ± 0.232
5.528AsnIle: 5.528 ± 0.661
5.932AsnLys: 5.932 ± 0.539
5.303AsnLeu: 5.303 ± 0.635
2.202AsnMet: 2.202 ± 0.344
4.314AsnAsn: 4.314 ± 0.523
2.337AsnPro: 2.337 ± 0.302
1.753AsnGln: 1.753 ± 0.24
2.876AsnArg: 2.876 ± 0.311
4.584AsnSer: 4.584 ± 0.496
4.674AsnThr: 4.674 ± 0.573
3.37AsnVal: 3.37 ± 0.534
0.719AsnTrp: 0.719 ± 0.171
2.831AsnTyr: 2.831 ± 0.397
0.0AsnXaa: 0.0 ± 0.0
Pro
1.213ProAla: 1.213 ± 0.221
0.27ProCys: 0.27 ± 0.134
1.618ProAsp: 1.618 ± 0.283
2.741ProGlu: 2.741 ± 0.353
1.303ProPhe: 1.303 ± 0.26
0.809ProGly: 0.809 ± 0.18
0.315ProHis: 0.315 ± 0.121
2.112ProIle: 2.112 ± 0.332
3.326ProLys: 3.326 ± 0.433
1.887ProLeu: 1.887 ± 0.254
0.494ProMet: 0.494 ± 0.179
1.348ProAsn: 1.348 ± 0.259
0.854ProPro: 0.854 ± 0.213
0.944ProGln: 0.944 ± 0.263
0.449ProArg: 0.449 ± 0.138
1.887ProSer: 1.887 ± 0.342
2.427ProThr: 2.427 ± 0.279
2.157ProVal: 2.157 ± 0.266
0.045ProTrp: 0.045 ± 0.048
1.168ProTyr: 1.168 ± 0.178
0.0ProXaa: 0.0 ± 0.0
Gln
1.258GlnAla: 1.258 ± 0.262
0.18GlnCys: 0.18 ± 0.099
1.977GlnAsp: 1.977 ± 0.311
2.562GlnGlu: 2.562 ± 0.52
1.258GlnPhe: 1.258 ± 0.288
2.562GlnGly: 2.562 ± 0.439
0.629GlnHis: 0.629 ± 0.167
2.202GlnIle: 2.202 ± 0.328
2.786GlnLys: 2.786 ± 0.478
2.292GlnLeu: 2.292 ± 0.325
0.944GlnMet: 0.944 ± 0.244
1.932GlnAsn: 1.932 ± 0.269
0.899GlnPro: 0.899 ± 0.198
1.213GlnGln: 1.213 ± 0.272
1.168GlnArg: 1.168 ± 0.257
2.067GlnSer: 2.067 ± 0.297
2.022GlnThr: 2.022 ± 0.316
1.393GlnVal: 1.393 ± 0.239
0.404GlnTrp: 0.404 ± 0.132
1.393GlnTyr: 1.393 ± 0.209
0.0GlnXaa: 0.0 ± 0.0
Arg
1.438ArgAla: 1.438 ± 0.289
0.225ArgCys: 0.225 ± 0.1
2.157ArgAsp: 2.157 ± 0.369
3.685ArgGlu: 3.685 ± 0.526
1.663ArgPhe: 1.663 ± 0.245
1.483ArgGly: 1.483 ± 0.342
0.629ArgHis: 0.629 ± 0.173
3.64ArgIle: 3.64 ± 0.445
3.101ArgLys: 3.101 ± 0.348
2.966ArgLeu: 2.966 ± 0.352
1.303ArgMet: 1.303 ± 0.251
2.247ArgAsn: 2.247 ± 0.327
0.944ArgPro: 0.944 ± 0.159
1.393ArgGln: 1.393 ± 0.243
1.348ArgArg: 1.348 ± 0.294
1.843ArgSer: 1.843 ± 0.254
2.337ArgThr: 2.337 ± 0.209
2.247ArgVal: 2.247 ± 0.309
0.315ArgTrp: 0.315 ± 0.122
1.887ArgTyr: 1.887 ± 0.313
0.0ArgXaa: 0.0 ± 0.0
Ser
3.73SerAla: 3.73 ± 0.442
0.764SerCys: 0.764 ± 0.198
4.629SerAsp: 4.629 ± 0.45
5.258SerGlu: 5.258 ± 0.478
3.46SerPhe: 3.46 ± 0.422
5.528SerGly: 5.528 ± 0.647
0.719SerHis: 0.719 ± 0.198
5.707SerIle: 5.707 ± 0.572
7.19SerLys: 7.19 ± 0.877
5.258SerLeu: 5.258 ± 0.559
1.213SerMet: 1.213 ± 0.229
4.134SerAsn: 4.134 ± 0.718
1.483SerPro: 1.483 ± 0.244
2.157SerGln: 2.157 ± 0.337
2.607SerArg: 2.607 ± 0.372
4.539SerSer: 4.539 ± 0.485
4.09SerThr: 4.09 ± 0.47
3.236SerVal: 3.236 ± 0.396
0.629SerTrp: 0.629 ± 0.199
2.921SerTyr: 2.921 ± 0.394
0.0SerXaa: 0.0 ± 0.0
Thr
3.236ThrAla: 3.236 ± 0.433
0.225ThrCys: 0.225 ± 0.117
3.55ThrAsp: 3.55 ± 0.335
4.179ThrGlu: 4.179 ± 0.406
2.831ThrPhe: 2.831 ± 0.438
3.595ThrGly: 3.595 ± 0.503
0.854ThrHis: 0.854 ± 0.177
6.651ThrIle: 6.651 ± 0.599
5.348ThrLys: 5.348 ± 0.521
5.033ThrLeu: 5.033 ± 0.495
0.989ThrMet: 0.989 ± 0.234
4.045ThrAsn: 4.045 ± 0.591
2.696ThrPro: 2.696 ± 0.372
1.573ThrGln: 1.573 ± 0.27
2.382ThrArg: 2.382 ± 0.257
3.91ThrSer: 3.91 ± 0.483
4.449ThrThr: 4.449 ± 0.529
3.64ThrVal: 3.64 ± 0.534
0.584ThrTrp: 0.584 ± 0.172
2.517ThrTyr: 2.517 ± 0.411
0.0ThrXaa: 0.0 ± 0.0
Val
2.337ValAla: 2.337 ± 0.311
0.449ValCys: 0.449 ± 0.171
4.314ValAsp: 4.314 ± 0.409
4.0ValGlu: 4.0 ± 0.322
3.146ValPhe: 3.146 ± 0.318
2.966ValGly: 2.966 ± 0.373
0.584ValHis: 0.584 ± 0.164
3.415ValIle: 3.415 ± 0.407
6.022ValLys: 6.022 ± 0.61
4.809ValLeu: 4.809 ± 0.668
1.168ValMet: 1.168 ± 0.217
4.269ValAsn: 4.269 ± 0.533
1.618ValPro: 1.618 ± 0.249
1.573ValGln: 1.573 ± 0.273
1.887ValArg: 1.887 ± 0.355
4.853ValSer: 4.853 ± 0.46
2.562ValThr: 2.562 ± 0.341
3.64ValVal: 3.64 ± 0.486
0.494ValTrp: 0.494 ± 0.164
2.247ValTyr: 2.247 ± 0.316
0.0ValXaa: 0.0 ± 0.0
Trp
0.494TrpAla: 0.494 ± 0.139
0.045TrpCys: 0.045 ± 0.043
0.854TrpAsp: 0.854 ± 0.194
0.854TrpGlu: 0.854 ± 0.195
0.27TrpPhe: 0.27 ± 0.096
0.494TrpGly: 0.494 ± 0.144
0.18TrpHis: 0.18 ± 0.077
0.944TrpIle: 0.944 ± 0.233
0.629TrpLys: 0.629 ± 0.144
0.764TrpLeu: 0.764 ± 0.169
0.18TrpMet: 0.18 ± 0.106
0.899TrpAsn: 0.899 ± 0.174
0.09TrpPro: 0.09 ± 0.059
0.315TrpGln: 0.315 ± 0.111
0.36TrpArg: 0.36 ± 0.119
0.674TrpSer: 0.674 ± 0.229
0.764TrpThr: 0.764 ± 0.199
0.719TrpVal: 0.719 ± 0.158
0.449TrpTrp: 0.449 ± 0.147
0.27TrpTyr: 0.27 ± 0.102
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.472TyrAla: 2.472 ± 0.399
0.36TyrCys: 0.36 ± 0.158
2.292TyrAsp: 2.292 ± 0.334
2.337TyrGlu: 2.337 ± 0.369
1.843TyrPhe: 1.843 ± 0.269
2.382TyrGly: 2.382 ± 0.283
0.449TyrHis: 0.449 ± 0.136
3.685TyrIle: 3.685 ± 0.42
3.775TyrLys: 3.775 ± 0.459
3.505TyrLeu: 3.505 ± 0.422
0.989TyrMet: 0.989 ± 0.19
3.415TyrAsn: 3.415 ± 0.387
1.438TyrPro: 1.438 ± 0.28
1.123TyrGln: 1.123 ± 0.244
1.303TyrArg: 1.303 ± 0.28
2.696TyrSer: 2.696 ± 0.3
1.887TyrThr: 1.887 ± 0.287
2.696TyrVal: 2.696 ± 0.403
0.584TyrTrp: 0.584 ± 0.164
1.843TyrTyr: 1.843 ± 0.298
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 123 proteins (22253 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski