Amino acid dipepetide frequency for Duganella sp. Root198D2

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	18.364AlaAla: 18.364 ± 0.157	1.227AlaCys: 1.227 ± 0.026	6.159AlaAsp: 6.159 ± 0.051	6.608AlaGlu: 6.608 ± 0.084	3.917AlaPhe: 3.917 ± 0.049	10.842AlaGly: 10.842 ± 0.107	2.389AlaHis: 2.389 ± 0.04	5.586AlaIle: 5.586 ± 0.062	4.174AlaLys: 4.174 ± 0.06	13.665AlaLeu: 13.665 ± 0.12	3.597AlaMet: 3.597 ± 0.053	3.625AlaAsn: 3.625 ± 0.055	6.132AlaPro: 6.132 ± 0.082	5.422AlaGln: 5.422 ± 0.065	8.136AlaArg: 8.136 ± 0.078	7.286AlaSer: 7.286 ± 0.069	5.933AlaThr: 5.933 ± 0.063	8.223AlaVal: 8.223 ± 0.072	1.801AlaTrp: 1.801 ± 0.039	2.804AlaTyr: 2.804 ± 0.044	0.003AlaXaa: 0.003 ± 0.001
Cys	1.109CysAla: 1.109 ± 0.026	0.122CysCys: 0.122 ± 0.008	0.491CysAsp: 0.491 ± 0.016	0.461CysGlu: 0.461 ± 0.017	0.302CysPhe: 0.302 ± 0.012	0.886CysGly: 0.886 ± 0.021	0.246CysHis: 0.246 ± 0.011	0.389CysIle: 0.389 ± 0.015	0.286CysLys: 0.286 ± 0.012	0.813CysLeu: 0.813 ± 0.022	0.215CysMet: 0.215 ± 0.01	0.249CysAsn: 0.249 ± 0.01	0.419CysPro: 0.419 ± 0.015	0.278CysGln: 0.278 ± 0.01	0.511CysArg: 0.511 ± 0.017	0.525CysSer: 0.525 ± 0.02	0.44CysThr: 0.44 ± 0.017	0.599CysVal: 0.599 ± 0.019	0.138CysTrp: 0.138 ± 0.008	0.237CysTyr: 0.237 ± 0.012	0.0CysXaa: 0.0 ± 0.0
Asp	6.617AspAla: 6.617 ± 0.071	0.474AspCys: 0.474 ± 0.018	2.72AspAsp: 2.72 ± 0.043	3.049AspGlu: 3.049 ± 0.048	2.204AspPhe: 2.204 ± 0.036	5.036AspGly: 5.036 ± 0.07	1.023AspHis: 1.023 ± 0.025	2.627AspIle: 2.627 ± 0.042	2.185AspLys: 2.185 ± 0.029	4.97AspLeu: 4.97 ± 0.055	1.379AspMet: 1.379 ± 0.027	1.576AspAsn: 1.576 ± 0.035	2.766AspPro: 2.766 ± 0.043	1.715AspGln: 1.715 ± 0.031	2.864AspArg: 2.864 ± 0.04	2.718AspSer: 2.718 ± 0.036	2.445AspThr: 2.445 ± 0.04	3.653AspVal: 3.653 ± 0.042	0.929AspTrp: 0.929 ± 0.024	1.623AspTyr: 1.623 ± 0.029	0.001AspXaa: 0.001 ± 0.0
Glu	6.398GluAla: 6.398 ± 0.077	0.396GluCys: 0.396 ± 0.015	2.233GluAsp: 2.233 ± 0.036	3.022GluGlu: 3.022 ± 0.054	1.998GluPhe: 1.998 ± 0.037	3.833GluGly: 3.833 ± 0.045	1.32GluHis: 1.32 ± 0.032	2.727GluIle: 2.727 ± 0.043	2.363GluLys: 2.363 ± 0.04	6.167GluLeu: 6.167 ± 0.068	1.459GluMet: 1.459 ± 0.028	1.558GluAsn: 1.558 ± 0.031	2.188GluPro: 2.188 ± 0.035	2.976GluGln: 2.976 ± 0.049	4.378GluArg: 4.378 ± 0.061	2.638GluSer: 2.638 ± 0.037	2.556GluThr: 2.556 ± 0.045	3.917GluVal: 3.917 ± 0.056	0.813GluTrp: 0.813 ± 0.021	1.316GluTyr: 1.316 ± 0.028	0.001GluXaa: 0.001 ± 0.0
Phe	4.243PheAla: 4.243 ± 0.054	0.384PheCys: 0.384 ± 0.015	2.506PheAsp: 2.506 ± 0.037	1.997PheGlu: 1.997 ± 0.032	1.353PhePhe: 1.353 ± 0.03	3.464PheGly: 3.464 ± 0.046	0.781PheHis: 0.781 ± 0.021	1.695PheIle: 1.695 ± 0.031	1.382PheLys: 1.382 ± 0.03	3.092PheLeu: 3.092 ± 0.051	0.842PheMet: 0.842 ± 0.02	1.347PheAsn: 1.347 ± 0.03	1.458PhePro: 1.458 ± 0.026	1.099PheGln: 1.099 ± 0.025	1.936PheArg: 1.936 ± 0.036	2.402PheSer: 2.402 ± 0.035	2.066PheThr: 2.066 ± 0.035	2.488PheVal: 2.488 ± 0.034	0.492PheTrp: 0.492 ± 0.018	1.044PheTyr: 1.044 ± 0.025	0.0PheXaa: 0.0 ± 0.0
Gly	9.3GlyAla: 9.3 ± 0.098	0.754GlyCys: 0.754 ± 0.02	4.041GlyAsp: 4.041 ± 0.049	4.477GlyGlu: 4.477 ± 0.046	3.244GlyPhe: 3.244 ± 0.05	6.916GlyGly: 6.916 ± 0.09	1.818GlyHis: 1.818 ± 0.035	4.134GlyIle: 4.134 ± 0.049	4.219GlyLys: 4.219 ± 0.049	7.955GlyLeu: 7.955 ± 0.079	2.518GlyMet: 2.518 ± 0.036	2.821GlyAsn: 2.821 ± 0.065	2.749GlyPro: 2.749 ± 0.038	3.366GlyGln: 3.366 ± 0.05	4.988GlyArg: 4.988 ± 0.055	5.082GlySer: 5.082 ± 0.072	4.456GlyThr: 4.456 ± 0.066	5.934GlyVal: 5.934 ± 0.055	1.365GlyTrp: 1.365 ± 0.031	2.476GlyTyr: 2.476 ± 0.044	0.001GlyXaa: 0.001 ± 0.001
His	2.637HisAla: 2.637 ± 0.047	0.254HisCys: 0.254 ± 0.011	1.153HisAsp: 1.153 ± 0.029	1.153HisGlu: 1.153 ± 0.022	0.961HisPhe: 0.961 ± 0.02	2.01HisGly: 2.01 ± 0.036	0.568HisHis: 0.568 ± 0.019	1.031HisIle: 1.031 ± 0.024	0.695HisLys: 0.695 ± 0.02	2.106HisLeu: 2.106 ± 0.039	0.541HisMet: 0.541 ± 0.013	0.603HisAsn: 0.603 ± 0.018	1.2HisPro: 1.2 ± 0.027	0.769HisGln: 0.769 ± 0.019	1.231HisArg: 1.231 ± 0.025	1.148HisSer: 1.148 ± 0.023	0.997HisThr: 0.997 ± 0.024	1.43HisVal: 1.43 ± 0.03	0.381HisTrp: 0.381 ± 0.015	0.68HisTyr: 0.68 ± 0.018	0.002HisXaa: 0.002 ± 0.001
Ile	6.023IleAla: 6.023 ± 0.063	0.407IleCys: 0.407 ± 0.014	3.139IleAsp: 3.139 ± 0.04	3.049IleGlu: 3.049 ± 0.042	1.392IlePhe: 1.392 ± 0.026	4.135IleGly: 4.135 ± 0.055	0.853IleHis: 0.853 ± 0.022	1.816IleIle: 1.816 ± 0.033	1.773IleLys: 1.773 ± 0.035	3.698IleLeu: 3.698 ± 0.052	0.941IleMet: 0.941 ± 0.021	1.591IleAsn: 1.591 ± 0.032	2.052IlePro: 2.052 ± 0.033	1.245IleGln: 1.245 ± 0.028	2.49IleArg: 2.49 ± 0.035	2.739IleSer: 2.739 ± 0.042	2.437IleThr: 2.437 ± 0.042	3.452IleVal: 3.452 ± 0.046	0.457IleTrp: 0.457 ± 0.016	1.091IleTyr: 1.091 ± 0.027	0.001IleXaa: 0.001 ± 0.001
Lys	4.491LysAla: 4.491 ± 0.063	0.197LysCys: 0.197 ± 0.009	1.973LysAsp: 1.973 ± 0.037	2.052LysGlu: 2.052 ± 0.036	1.2LysPhe: 1.2 ± 0.025	2.779LysGly: 2.779 ± 0.05	0.799LysHis: 0.799 ± 0.023	1.743LysIle: 1.743 ± 0.029	1.694LysLys: 1.694 ± 0.038	4.364LysLeu: 4.364 ± 0.053	1.096LysMet: 1.096 ± 0.024	1.226LysAsn: 1.226 ± 0.028	2.276LysPro: 2.276 ± 0.043	1.579LysGln: 1.579 ± 0.029	2.422LysArg: 2.422 ± 0.039	2.058LysSer: 2.058 ± 0.038	1.948LysThr: 1.948 ± 0.034	2.926LysVal: 2.926 ± 0.048	0.456LysTrp: 0.456 ± 0.014	0.909LysTyr: 0.909 ± 0.022	0.001LysXaa: 0.001 ± 0.001
Leu	14.993LeuAla: 14.993 ± 0.136	0.932LeuCys: 0.932 ± 0.027	5.646LeuAsp: 5.646 ± 0.063	5.539LeuGlu: 5.539 ± 0.064	3.422LeuPhe: 3.422 ± 0.05	7.917LeuGly: 7.917 ± 0.072	2.339LeuHis: 2.339 ± 0.041	3.63LeuIle: 3.63 ± 0.05	3.932LeuLys: 3.932 ± 0.054	11.115LeuLeu: 11.115 ± 0.132	2.4LeuMet: 2.4 ± 0.036	3.061LeuAsn: 3.061 ± 0.039	6.005LeuPro: 6.005 ± 0.071	4.321LeuGln: 4.321 ± 0.057	7.307LeuArg: 7.307 ± 0.075	6.161LeuSer: 6.161 ± 0.059	4.827LeuThr: 4.827 ± 0.06	7.374LeuVal: 7.374 ± 0.063	1.182LeuTrp: 1.182 ± 0.03	2.232LeuTyr: 2.232 ± 0.038	0.003LeuXaa: 0.003 ± 0.001
Met	3.114MetAla: 3.114 ± 0.042	0.168MetCys: 0.168 ± 0.009	1.271MetAsp: 1.271 ± 0.026	1.319MetGlu: 1.319 ± 0.028	0.793MetPhe: 0.793 ± 0.02	1.838MetGly: 1.838 ± 0.035	0.555MetHis: 0.555 ± 0.017	1.106MetIle: 1.106 ± 0.025	1.243MetLys: 1.243 ± 0.027	2.994MetLeu: 2.994 ± 0.046	0.723MetMet: 0.723 ± 0.023	0.968MetAsn: 0.968 ± 0.025	1.552MetPro: 1.552 ± 0.029	1.234MetGln: 1.234 ± 0.029	1.799MetArg: 1.799 ± 0.031	1.579MetSer: 1.579 ± 0.029	1.409MetThr: 1.409 ± 0.025	1.79MetVal: 1.79 ± 0.032	0.264MetTrp: 0.264 ± 0.012	0.519MetTyr: 0.519 ± 0.018	0.001MetXaa: 0.001 ± 0.001
Asn	3.73AsnAla: 3.73 ± 0.055	0.301AsnCys: 0.301 ± 0.013	1.608AsnAsp: 1.608 ± 0.028	1.491AsnGlu: 1.491 ± 0.028	1.215AsnPhe: 1.215 ± 0.028	3.042AsnGly: 3.042 ± 0.061	0.556AsnHis: 0.556 ± 0.018	1.495AsnIle: 1.495 ± 0.031	1.124AsnLys: 1.124 ± 0.029	2.968AsnLeu: 2.968 ± 0.045	0.77AsnMet: 0.77 ± 0.02	1.104AsnAsn: 1.104 ± 0.032	1.891AsnPro: 1.891 ± 0.031	1.103AsnGln: 1.103 ± 0.022	1.861AsnArg: 1.861 ± 0.035	1.709AsnSer: 1.709 ± 0.04	1.678AsnThr: 1.678 ± 0.034	2.369AsnVal: 2.369 ± 0.037	0.533AsnTrp: 0.533 ± 0.019	0.951AsnTyr: 0.951 ± 0.022	0.001AsnXaa: 0.001 ± 0.001
Pro	7.004ProAla: 7.004 ± 0.085	0.328ProCys: 0.328 ± 0.012	2.906ProAsp: 2.906 ± 0.042	3.143ProGlu: 3.143 ± 0.046	1.678ProPhe: 1.678 ± 0.029	4.477ProGly: 4.477 ± 0.055	1.007ProHis: 1.007 ± 0.023	1.793ProIle: 1.793 ± 0.028	1.629ProLys: 1.629 ± 0.035	4.931ProLeu: 4.931 ± 0.054	1.191ProMet: 1.191 ± 0.026	1.451ProAsn: 1.451 ± 0.028	2.387ProPro: 2.387 ± 0.048	2.14ProGln: 2.14 ± 0.034	2.521ProArg: 2.521 ± 0.041	2.584ProSer: 2.584 ± 0.039	2.09ProThr: 2.09 ± 0.031	3.961ProVal: 3.961 ± 0.049	0.639ProTrp: 0.639 ± 0.019	1.212ProTyr: 1.212 ± 0.027	0.002ProXaa: 0.002 ± 0.001
Gln	5.553GlnAla: 5.553 ± 0.065	0.308GlnCys: 0.308 ± 0.013	1.798GlnAsp: 1.798 ± 0.032	1.984GlnGlu: 1.984 ± 0.039	1.493GlnPhe: 1.493 ± 0.029	3.059GlnGly: 3.059 ± 0.039	1.023GlnHis: 1.023 ± 0.025	1.622GlnIle: 1.622 ± 0.026	1.352GlnLys: 1.352 ± 0.031	4.55GlnLeu: 4.55 ± 0.054	1.116GlnMet: 1.116 ± 0.021	1.037GlnAsn: 1.037 ± 0.026	2.185GlnPro: 2.185 ± 0.039	2.299GlnGln: 2.299 ± 0.047	3.27GlnArg: 3.27 ± 0.05	2.128GlnSer: 2.128 ± 0.041	1.721GlnThr: 1.721 ± 0.038	3.147GlnVal: 3.147 ± 0.043	0.624GlnTrp: 0.624 ± 0.019	0.991GlnTyr: 0.991 ± 0.024	0.0GlnXaa: 0.0 ± 0.0
Arg	6.994ArgAla: 6.994 ± 0.059	0.507ArgCys: 0.507 ± 0.019	3.464ArgAsp: 3.464 ± 0.044	3.821ArgGlu: 3.821 ± 0.05	2.649ArgPhe: 2.649 ± 0.04	4.137ArgGly: 4.137 ± 0.047	1.648ArgHis: 1.648 ± 0.03	3.373ArgIle: 3.373 ± 0.048	2.541ArgLys: 2.541 ± 0.039	7.042ArgLeu: 7.042 ± 0.068	1.89ArgMet: 1.89 ± 0.031	2.147ArgAsn: 2.147 ± 0.033	2.689ArgPro: 2.689 ± 0.037	3.011ArgGln: 3.011 ± 0.046	4.297ArgArg: 4.297 ± 0.07	3.544ArgSer: 3.544 ± 0.042	3.079ArgThr: 3.079 ± 0.042	4.22ArgVal: 4.22 ± 0.053	1.016ArgTrp: 1.016 ± 0.024	2.025ArgTyr: 2.025 ± 0.034	0.001ArgXaa: 0.001 ± 0.0
Ser	6.794SerAla: 6.794 ± 0.067	0.511SerCys: 0.511 ± 0.016	2.919SerAsp: 2.919 ± 0.04	2.787SerGlu: 2.787 ± 0.034	2.271SerPhe: 2.271 ± 0.037	5.606SerGly: 5.606 ± 0.081	1.234SerHis: 1.234 ± 0.026	2.697SerIle: 2.697 ± 0.042	2.061SerLys: 2.061 ± 0.042	5.923SerLeu: 5.923 ± 0.056	1.552SerMet: 1.552 ± 0.032	1.887SerAsn: 1.887 ± 0.041	2.606SerPro: 2.606 ± 0.046	2.097SerGln: 2.097 ± 0.03	3.357SerArg: 3.357 ± 0.043	3.445SerSer: 3.445 ± 0.055	2.938SerThr: 2.938 ± 0.052	4.0SerVal: 4.0 ± 0.051	0.861SerTrp: 0.861 ± 0.025	1.735SerTyr: 1.735 ± 0.032	0.001SerXaa: 0.001 ± 0.0
Thr	5.672ThrAla: 5.672 ± 0.07	0.409ThrCys: 0.409 ± 0.014	2.476ThrAsp: 2.476 ± 0.043	2.37ThrGlu: 2.37 ± 0.035	1.775ThrPhe: 1.775 ± 0.034	4.409ThrGly: 4.409 ± 0.061	0.972ThrHis: 0.972 ± 0.022	2.439ThrIle: 2.439 ± 0.039	1.363ThrLys: 1.363 ± 0.028	5.744ThrLeu: 5.744 ± 0.062	1.198ThrMet: 1.198 ± 0.029	1.424ThrAsn: 1.424 ± 0.032	3.042ThrPro: 3.042 ± 0.038	1.769ThrGln: 1.769 ± 0.034	2.981ThrArg: 2.981 ± 0.042	2.838ThrSer: 2.838 ± 0.047	2.728ThrThr: 2.728 ± 0.056	4.106ThrVal: 4.106 ± 0.057	0.676ThrTrp: 0.676 ± 0.019	1.353ThrTyr: 1.353 ± 0.04	0.001ThrXaa: 0.001 ± 0.0
Val	8.882ValAla: 8.882 ± 0.076	0.63ValCys: 0.63 ± 0.018	3.776ValAsp: 3.776 ± 0.045	4.018ValGlu: 4.018 ± 0.051	2.533ValPhe: 2.533 ± 0.041	5.113ValGly: 5.113 ± 0.064	1.495ValHis: 1.495 ± 0.028	3.245ValIle: 3.245 ± 0.047	2.658ValLys: 2.658 ± 0.042	7.785ValLeu: 7.785 ± 0.073	1.802ValMet: 1.802 ± 0.034	2.412ValAsn: 2.412 ± 0.043	3.615ValPro: 3.615 ± 0.049	2.86ValGln: 2.86 ± 0.037	4.692ValArg: 4.692 ± 0.056	4.203ValSer: 4.203 ± 0.052	3.918ValThr: 3.918 ± 0.056	5.446ValVal: 5.446 ± 0.068	0.832ValTrp: 0.832 ± 0.02	1.669ValTyr: 1.669 ± 0.029	0.002ValXaa: 0.002 ± 0.001
Trp	1.19TrpAla: 1.19 ± 0.027	0.156TrpCys: 0.156 ± 0.009	0.673TrpAsp: 0.673 ± 0.02	0.615TrpGlu: 0.615 ± 0.019	0.546TrpPhe: 0.546 ± 0.02	0.898TrpGly: 0.898 ± 0.025	0.384TrpHis: 0.384 ± 0.013	0.639TrpIle: 0.639 ± 0.019	0.556TrpLys: 0.556 ± 0.018	1.868TrpLeu: 1.868 ± 0.042	0.414TrpMet: 0.414 ± 0.016	0.532TrpAsn: 0.532 ± 0.021	0.622TrpPro: 0.622 ± 0.016	0.857TrpGln: 0.857 ± 0.021	1.151TrpArg: 1.151 ± 0.026	0.877TrpSer: 0.877 ± 0.026	0.722TrpThr: 0.722 ± 0.021	0.838TrpVal: 0.838 ± 0.02	0.258TrpTrp: 0.258 ± 0.012	0.363TrpTyr: 0.363 ± 0.015	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.781TyrAla: 2.781 ± 0.04	0.255TyrCys: 0.255 ± 0.012	1.619TyrAsp: 1.619 ± 0.064	1.303TyrGlu: 1.303 ± 0.028	1.123TyrPhe: 1.123 ± 0.024	2.214TyrGly: 2.214 ± 0.03	0.538TyrHis: 0.538 ± 0.018	0.992TyrIle: 0.992 ± 0.024	0.96TyrLys: 0.96 ± 0.02	2.582TyrLeu: 2.582 ± 0.042	0.596TyrMet: 0.596 ± 0.017	0.882TyrAsn: 0.882 ± 0.024	1.24TyrPro: 1.24 ± 0.023	1.117TyrGln: 1.117 ± 0.026	1.904TyrArg: 1.904 ± 0.032	1.614TyrSer: 1.614 ± 0.03	1.357TyrThr: 1.357 ± 0.031	1.715TyrVal: 1.715 ± 0.032	0.44TyrTrp: 0.44 ± 0.016	0.829TyrTyr: 0.829 ± 0.025	0.001TyrXaa: 0.001 ± 0.001
Xaa	0.001XaaAla: 0.001 ± 0.0	0.001XaaCys: 0.001 ± 0.0	0.003XaaAsp: 0.003 ± 0.001	0.001XaaGlu: 0.001 ± 0.001	0.001XaaPhe: 0.001 ± 0.001	0.003XaaGly: 0.003 ± 0.001	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.001XaaLys: 0.001 ± 0.001	0.003XaaLeu: 0.003 ± 0.001	0.0XaaMet: 0.0 ± 0.0	0.001XaaAsn: 0.001 ± 0.001	0.002XaaPro: 0.002 ± 0.001	0.002XaaGln: 0.002 ± 0.001	0.001XaaArg: 0.001 ± 0.001	0.002XaaSer: 0.002 ± 0.001	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.001XaaTrp: 0.001 ± 0.0	0.001XaaTyr: 0.001 ± 0.001	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 5756 proteins (1964093 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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