Amino acid dipepetide frequency for Streptococcus satellite phage Javan299

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
1.107AlaAla: 1.107 ± 0.584
0.738AlaCys: 0.738 ± 0.556
5.533AlaAsp: 5.533 ± 1.825
5.533AlaGlu: 5.533 ± 1.376
2.582AlaPhe: 2.582 ± 1.151
1.475AlaGly: 1.475 ± 0.653
0.738AlaHis: 0.738 ± 0.488
4.795AlaIle: 4.795 ± 1.266
5.533AlaLys: 5.533 ± 1.136
5.902AlaLeu: 5.902 ± 1.476
2.582AlaMet: 2.582 ± 1.173
2.582AlaAsn: 2.582 ± 0.757
0.369AlaPro: 0.369 ± 0.357
3.32AlaGln: 3.32 ± 1.381
2.951AlaArg: 2.951 ± 0.8
3.32AlaSer: 3.32 ± 1.11
4.058AlaThr: 4.058 ± 1.175
2.582AlaVal: 2.582 ± 0.807
0.738AlaTrp: 0.738 ± 0.391
2.213AlaTyr: 2.213 ± 1.03
0.0AlaXaa: 0.0 ± 0.0
Cys
0.0CysAla: 0.0 ± 0.0
0.0CysCys: 0.0 ± 0.0
0.0CysAsp: 0.0 ± 0.0
0.369CysGlu: 0.369 ± 0.385
0.369CysPhe: 0.369 ± 0.385
0.738CysGly: 0.738 ± 0.454
0.0CysHis: 0.0 ± 0.0
0.738CysIle: 0.738 ± 0.464
0.369CysLys: 0.369 ± 0.325
0.0CysLeu: 0.0 ± 0.0
1.107CysMet: 1.107 ± 0.611
0.0CysAsn: 0.0 ± 0.0
0.369CysPro: 0.369 ± 0.412
0.369CysGln: 0.369 ± 0.361
0.738CysArg: 0.738 ± 0.409
0.369CysSer: 0.369 ± 0.325
0.738CysThr: 0.738 ± 0.473
0.0CysVal: 0.0 ± 0.0
0.0CysTrp: 0.0 ± 0.0
0.738CysTyr: 0.738 ± 0.551
0.0CysXaa: 0.0 ± 0.0
Asp
1.475AspAla: 1.475 ± 0.585
1.107AspCys: 1.107 ± 0.713
3.689AspAsp: 3.689 ± 1.063
3.32AspGlu: 3.32 ± 1.111
3.32AspPhe: 3.32 ± 0.798
2.951AspGly: 2.951 ± 0.921
0.369AspHis: 0.369 ± 0.336
6.271AspIle: 6.271 ± 1.432
7.746AspLys: 7.746 ± 1.255
5.902AspLeu: 5.902 ± 2.358
1.475AspMet: 1.475 ± 0.671
3.689AspAsn: 3.689 ± 1.425
0.738AspPro: 0.738 ± 0.5
1.844AspGln: 1.844 ± 0.691
1.844AspArg: 1.844 ± 1.044
2.582AspSer: 2.582 ± 0.947
4.058AspThr: 4.058 ± 1.125
3.32AspVal: 3.32 ± 0.992
0.738AspTrp: 0.738 ± 0.483
3.32AspTyr: 3.32 ± 1.053
0.0AspXaa: 0.0 ± 0.0
Glu
4.795GluAla: 4.795 ± 1.635
0.369GluCys: 0.369 ± 0.412
4.426GluAsp: 4.426 ± 1.269
8.115GluGlu: 8.115 ± 2.019
1.475GluPhe: 1.475 ± 0.705
3.689GluGly: 3.689 ± 1.425
0.738GluHis: 0.738 ± 0.528
8.484GluIle: 8.484 ± 1.803
9.222GluLys: 9.222 ± 1.217
13.279GluLeu: 13.279 ± 1.665
1.475GluMet: 1.475 ± 0.641
6.271GluAsn: 6.271 ± 1.413
1.844GluPro: 1.844 ± 0.927
4.058GluGln: 4.058 ± 1.534
5.902GluArg: 5.902 ± 1.705
4.426GluSer: 4.426 ± 1.09
5.164GluThr: 5.164 ± 1.167
3.32GluVal: 3.32 ± 1.038
0.738GluTrp: 0.738 ± 0.514
4.058GluTyr: 4.058 ± 1.104
0.0GluXaa: 0.0 ± 0.0
Phe
1.475PheAla: 1.475 ± 0.7
0.738PheCys: 0.738 ± 0.464
2.951PheAsp: 2.951 ± 0.913
2.951PheGlu: 2.951 ± 0.919
1.107PhePhe: 1.107 ± 0.566
0.738PheGly: 0.738 ± 0.427
1.107PheHis: 1.107 ± 0.51
3.32PheIle: 3.32 ± 1.056
2.213PheLys: 2.213 ± 1.156
5.533PheLeu: 5.533 ± 1.031
1.107PheMet: 1.107 ± 0.607
1.107PheAsn: 1.107 ± 0.537
0.369PhePro: 0.369 ± 0.44
1.844PheGln: 1.844 ± 0.669
2.213PheArg: 2.213 ± 0.929
2.582PheSer: 2.582 ± 0.762
1.107PheThr: 1.107 ± 0.618
1.475PheVal: 1.475 ± 0.679
0.369PheTrp: 0.369 ± 0.44
3.32PheTyr: 3.32 ± 1.257
0.0PheXaa: 0.0 ± 0.0
Gly
3.689GlyAla: 3.689 ± 1.414
0.738GlyCys: 0.738 ± 0.453
0.738GlyAsp: 0.738 ± 0.593
3.32GlyGlu: 3.32 ± 1.13
1.475GlyPhe: 1.475 ± 0.698
1.844GlyGly: 1.844 ± 0.901
1.107GlyHis: 1.107 ± 0.467
2.951GlyIle: 2.951 ± 0.599
3.32GlyLys: 3.32 ± 1.143
5.902GlyLeu: 5.902 ± 1.696
1.107GlyMet: 1.107 ± 0.649
3.32GlyAsn: 3.32 ± 1.86
0.0GlyPro: 0.0 ± 0.0
2.582GlyGln: 2.582 ± 1.017
1.475GlyArg: 1.475 ± 0.582
1.107GlySer: 1.107 ± 0.677
1.844GlyThr: 1.844 ± 1.01
4.058GlyVal: 4.058 ± 0.984
0.369GlyTrp: 0.369 ± 0.412
3.689GlyTyr: 3.689 ± 1.235
0.0GlyXaa: 0.0 ± 0.0
His
1.107HisAla: 1.107 ± 0.597
0.0HisCys: 0.0 ± 0.0
0.738HisAsp: 0.738 ± 0.521
1.475HisGlu: 1.475 ± 0.527
1.107HisPhe: 1.107 ± 0.686
2.951HisGly: 2.951 ± 0.937
0.738HisHis: 0.738 ± 0.514
0.738HisIle: 0.738 ± 0.582
0.369HisLys: 0.369 ± 0.44
2.213HisLeu: 2.213 ± 0.585
0.0HisMet: 0.0 ± 0.0
0.369HisAsn: 0.369 ± 0.412
0.369HisPro: 0.369 ± 0.385
0.369HisGln: 0.369 ± 0.412
0.738HisArg: 0.738 ± 0.427
1.844HisSer: 1.844 ± 0.72
1.107HisThr: 1.107 ± 0.484
0.0HisVal: 0.0 ± 0.0
0.0HisTrp: 0.0 ± 0.0
1.475HisTyr: 1.475 ± 0.605
0.0HisXaa: 0.0 ± 0.0
Ile
4.058IleAla: 4.058 ± 1.256
0.0IleCys: 0.0 ± 0.0
7.008IleAsp: 7.008 ± 1.977
6.271IleGlu: 6.271 ± 1.872
2.213IlePhe: 2.213 ± 0.74
2.951IleGly: 2.951 ± 1.069
1.107IleHis: 1.107 ± 0.686
4.058IleIle: 4.058 ± 1.246
7.746IleLys: 7.746 ± 1.364
5.164IleLeu: 5.164 ± 1.357
0.738IleMet: 0.738 ± 0.551
3.689IleAsn: 3.689 ± 1.196
1.475IlePro: 1.475 ± 0.673
2.582IleGln: 2.582 ± 0.827
2.213IleArg: 2.213 ± 0.884
4.795IleSer: 4.795 ± 1.734
5.164IleThr: 5.164 ± 1.553
1.107IleVal: 1.107 ± 0.696
1.107IleTrp: 1.107 ± 0.708
3.689IleTyr: 3.689 ± 0.818
0.0IleXaa: 0.0 ± 0.0
Lys
8.853LysAla: 8.853 ± 2.091
0.369LysCys: 0.369 ± 0.325
4.426LysAsp: 4.426 ± 1.241
10.697LysGlu: 10.697 ± 2.069
2.582LysPhe: 2.582 ± 0.787
3.32LysGly: 3.32 ± 1.162
3.32LysHis: 3.32 ± 0.829
4.795LysIle: 4.795 ± 1.328
6.64LysLys: 6.64 ± 1.423
8.853LysLeu: 8.853 ± 2.084
1.475LysMet: 1.475 ± 0.596
5.164LysAsn: 5.164 ± 1.111
2.951LysPro: 2.951 ± 0.746
7.008LysGln: 7.008 ± 0.93
5.164LysArg: 5.164 ± 1.324
3.689LysSer: 3.689 ± 1.436
6.64LysThr: 6.64 ± 1.576
4.426LysVal: 4.426 ± 1.185
0.738LysTrp: 0.738 ± 0.506
1.844LysTyr: 1.844 ± 1.04
0.0LysXaa: 0.0 ± 0.0
Leu
6.64LeuAla: 6.64 ± 1.38
0.738LeuCys: 0.738 ± 0.824
8.115LeuAsp: 8.115 ± 1.663
11.804LeuGlu: 11.804 ± 2.496
4.426LeuPhe: 4.426 ± 1.212
4.058LeuGly: 4.058 ± 1.157
0.738LeuHis: 0.738 ± 0.396
6.271LeuIle: 6.271 ± 1.335
9.591LeuLys: 9.591 ± 1.173
9.222LeuLeu: 9.222 ± 1.434
1.475LeuMet: 1.475 ± 0.708
5.902LeuAsn: 5.902 ± 1.599
3.32LeuPro: 3.32 ± 1.605
6.271LeuGln: 6.271 ± 1.582
4.058LeuArg: 4.058 ± 0.69
6.271LeuSer: 6.271 ± 1.61
8.115LeuThr: 8.115 ± 1.677
2.582LeuVal: 2.582 ± 1.033
1.475LeuTrp: 1.475 ± 0.625
1.844LeuTyr: 1.844 ± 0.702
0.0LeuXaa: 0.0 ± 0.0
Met
2.582MetAla: 2.582 ± 0.757
0.0MetCys: 0.0 ± 0.0
2.582MetAsp: 2.582 ± 0.876
2.582MetGlu: 2.582 ± 0.904
1.107MetPhe: 1.107 ± 0.693
1.475MetGly: 1.475 ± 0.624
0.0MetHis: 0.0 ± 0.0
1.475MetIle: 1.475 ± 0.651
1.844MetLys: 1.844 ± 0.752
1.107MetLeu: 1.107 ± 0.55
0.0MetMet: 0.0 ± 0.0
2.213MetAsn: 2.213 ± 0.786
0.0MetPro: 0.0 ± 0.0
1.107MetGln: 1.107 ± 0.479
1.475MetArg: 1.475 ± 0.804
1.844MetSer: 1.844 ± 0.862
2.951MetThr: 2.951 ± 1.067
1.475MetVal: 1.475 ± 0.73
0.0MetTrp: 0.0 ± 0.0
0.369MetTyr: 0.369 ± 0.322
0.0MetXaa: 0.0 ± 0.0
Asn
2.582AsnAla: 2.582 ± 0.867
0.0AsnCys: 0.0 ± 0.0
1.475AsnAsp: 1.475 ± 0.664
4.058AsnGlu: 4.058 ± 1.846
1.107AsnPhe: 1.107 ± 0.579
4.058AsnGly: 4.058 ± 1.139
1.475AsnHis: 1.475 ± 0.593
2.951AsnIle: 2.951 ± 0.985
3.32AsnLys: 3.32 ± 0.895
5.902AsnLeu: 5.902 ± 1.149
1.844AsnMet: 1.844 ± 0.734
2.582AsnAsn: 2.582 ± 1.156
1.475AsnPro: 1.475 ± 0.598
2.213AsnGln: 2.213 ± 0.758
2.951AsnArg: 2.951 ± 0.898
4.058AsnSer: 4.058 ± 1.417
3.689AsnThr: 3.689 ± 1.149
1.475AsnVal: 1.475 ± 0.617
1.475AsnTrp: 1.475 ± 0.686
1.107AsnTyr: 1.107 ± 0.541
0.0AsnXaa: 0.0 ± 0.0
Pro
1.844ProAla: 1.844 ± 0.602
0.0ProCys: 0.0 ± 0.0
2.213ProAsp: 2.213 ± 0.808
2.582ProGlu: 2.582 ± 1.171
0.738ProPhe: 0.738 ± 0.493
0.738ProGly: 0.738 ± 0.538
0.0ProHis: 0.0 ± 0.0
1.475ProIle: 1.475 ± 0.69
2.582ProLys: 2.582 ± 1.104
1.475ProLeu: 1.475 ± 0.583
0.0ProMet: 0.0 ± 0.0
1.475ProAsn: 1.475 ± 0.677
0.738ProPro: 0.738 ± 0.498
0.738ProGln: 0.738 ± 0.435
1.107ProArg: 1.107 ± 0.648
1.475ProSer: 1.475 ± 0.747
1.107ProThr: 1.107 ± 0.64
1.107ProVal: 1.107 ± 1.155
0.0ProTrp: 0.0 ± 0.0
1.107ProTyr: 1.107 ± 0.525
0.0ProXaa: 0.0 ± 0.0
Gln
7.008GlnAla: 7.008 ± 1.789
0.0GlnCys: 0.0 ± 0.0
1.107GlnAsp: 1.107 ± 0.557
5.164GlnGlu: 5.164 ± 1.265
3.32GlnPhe: 3.32 ± 0.915
1.844GlnGly: 1.844 ± 0.701
0.0GlnHis: 0.0 ± 0.0
3.32GlnIle: 3.32 ± 1.025
6.271GlnLys: 6.271 ± 1.764
3.689GlnLeu: 3.689 ± 1.053
0.369GlnMet: 0.369 ± 0.355
1.844GlnAsn: 1.844 ± 0.78
0.738GlnPro: 0.738 ± 0.527
4.058GlnGln: 4.058 ± 1.503
3.32GlnArg: 3.32 ± 0.938
3.32GlnSer: 3.32 ± 1.224
3.32GlnThr: 3.32 ± 0.998
3.32GlnVal: 3.32 ± 1.085
0.369GlnTrp: 0.369 ± 0.336
2.582GlnTyr: 2.582 ± 0.993
0.0GlnXaa: 0.0 ± 0.0
Arg
2.213ArgAla: 2.213 ± 0.741
0.0ArgCys: 0.0 ± 0.0
3.32ArgAsp: 3.32 ± 1.273
5.902ArgGlu: 5.902 ± 1.319
1.475ArgPhe: 1.475 ± 0.731
2.951ArgGly: 2.951 ± 0.765
1.844ArgHis: 1.844 ± 0.86
3.32ArgIle: 3.32 ± 1.115
4.795ArgLys: 4.795 ± 1.387
7.008ArgLeu: 7.008 ± 1.715
1.475ArgMet: 1.475 ± 0.661
1.844ArgAsn: 1.844 ± 0.795
1.107ArgPro: 1.107 ± 0.617
2.951ArgGln: 2.951 ± 0.856
1.844ArgArg: 1.844 ± 0.649
2.213ArgSer: 2.213 ± 0.836
2.213ArgThr: 2.213 ± 0.815
1.844ArgVal: 1.844 ± 0.932
0.0ArgTrp: 0.0 ± 0.0
2.213ArgTyr: 2.213 ± 1.296
0.0ArgXaa: 0.0 ± 0.0
Ser
1.844SerAla: 1.844 ± 0.793
0.0SerCys: 0.0 ± 0.0
3.689SerAsp: 3.689 ± 0.873
5.164SerGlu: 5.164 ± 1.012
1.844SerPhe: 1.844 ± 0.607
1.844SerGly: 1.844 ± 0.675
1.475SerHis: 1.475 ± 0.524
4.426SerIle: 4.426 ± 0.964
4.795SerLys: 4.795 ± 1.289
3.32SerLeu: 3.32 ± 0.906
2.213SerMet: 2.213 ± 0.929
2.582SerAsn: 2.582 ± 0.929
1.475SerPro: 1.475 ± 0.521
2.213SerGln: 2.213 ± 0.988
3.689SerArg: 3.689 ± 1.454
2.582SerSer: 2.582 ± 0.649
4.058SerThr: 4.058 ± 1.113
4.058SerVal: 4.058 ± 1.16
0.369SerTrp: 0.369 ± 0.291
4.795SerTyr: 4.795 ± 1.053
0.0SerXaa: 0.0 ± 0.0
Thr
3.32ThrAla: 3.32 ± 1.271
0.738ThrCys: 0.738 ± 0.508
3.32ThrAsp: 3.32 ± 1.213
6.271ThrGlu: 6.271 ± 1.806
2.582ThrPhe: 2.582 ± 1.05
3.32ThrGly: 3.32 ± 0.973
1.475ThrHis: 1.475 ± 0.851
2.951ThrIle: 2.951 ± 0.875
6.64ThrLys: 6.64 ± 1.899
7.008ThrLeu: 7.008 ± 0.945
3.32ThrMet: 3.32 ± 1.066
1.844ThrAsn: 1.844 ± 0.611
2.582ThrPro: 2.582 ± 1.048
4.795ThrGln: 4.795 ± 1.354
2.582ThrArg: 2.582 ± 0.801
2.582ThrSer: 2.582 ± 0.728
3.689ThrThr: 3.689 ± 0.805
2.951ThrVal: 2.951 ± 0.848
0.738ThrTrp: 0.738 ± 0.429
0.738ThrTyr: 0.738 ± 0.473
0.0ThrXaa: 0.0 ± 0.0
Val
2.582ValAla: 2.582 ± 0.871
0.738ValCys: 0.738 ± 0.556
2.213ValAsp: 2.213 ± 0.872
2.951ValGlu: 2.951 ± 1.135
1.107ValPhe: 1.107 ± 0.523
2.213ValGly: 2.213 ± 1.38
0.738ValHis: 0.738 ± 0.427
1.844ValIle: 1.844 ± 0.685
4.058ValLys: 4.058 ± 1.374
3.689ValLeu: 3.689 ± 1.301
1.475ValMet: 1.475 ± 0.67
1.107ValAsn: 1.107 ± 0.548
1.844ValPro: 1.844 ± 0.602
3.32ValGln: 3.32 ± 0.975
1.844ValArg: 1.844 ± 0.639
4.426ValSer: 4.426 ± 1.102
2.582ValThr: 2.582 ± 0.92
4.058ValVal: 4.058 ± 1.163
0.0ValTrp: 0.0 ± 0.0
1.475ValTyr: 1.475 ± 0.677
0.0ValXaa: 0.0 ± 0.0
Trp
0.738TrpAla: 0.738 ± 0.672
0.0TrpCys: 0.0 ± 0.0
0.0TrpAsp: 0.0 ± 0.0
1.107TrpGlu: 1.107 ± 0.579
0.0TrpPhe: 0.0 ± 0.0
0.0TrpGly: 0.0 ± 0.0
0.369TrpHis: 0.369 ± 0.322
0.738TrpIle: 0.738 ± 0.483
1.107TrpLys: 1.107 ± 0.53
1.475TrpLeu: 1.475 ± 0.622
0.738TrpMet: 0.738 ± 0.519
0.369TrpAsn: 0.369 ± 0.357
0.0TrpPro: 0.0 ± 0.0
0.738TrpGln: 0.738 ± 0.528
0.369TrpArg: 0.369 ± 0.375
0.738TrpSer: 0.738 ± 0.427
0.0TrpThr: 0.0 ± 0.0
0.738TrpVal: 0.738 ± 0.538
0.0TrpTrp: 0.0 ± 0.0
0.0TrpTyr: 0.0 ± 0.0
0.0TrpXaa: 0.0 ± 0.0
Tyr
0.738TyrAla: 0.738 ± 0.672
0.738TyrCys: 0.738 ± 0.497
2.213TyrAsp: 2.213 ± 0.837
2.213TyrGlu: 2.213 ± 0.891
3.689TyrPhe: 3.689 ± 0.86
1.475TyrGly: 1.475 ± 0.886
0.369TyrHis: 0.369 ± 0.44
2.213TyrIle: 2.213 ± 0.935
4.795TyrLys: 4.795 ± 1.489
6.64TyrLeu: 6.64 ± 0.998
1.844TyrMet: 1.844 ± 0.821
1.844TyrAsn: 1.844 ± 0.732
0.738TyrPro: 0.738 ± 0.427
2.582TyrGln: 2.582 ± 0.899
4.058TyrArg: 4.058 ± 1.097
2.213TyrSer: 2.213 ± 0.869
1.844TyrThr: 1.844 ± 0.718
0.369TyrVal: 0.369 ± 0.403
0.0TyrTrp: 0.0 ± 0.0
1.844TyrTyr: 1.844 ± 0.803
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 20 proteins (2712 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski