Amino acid dipepetide frequency for Aureococcus anophagefferens (Harmful bloom alga)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	30.07AlaAla: 30.07 ± 0.254	2.731AlaCys: 2.731 ± 0.029	8.39AlaAsp: 8.39 ± 0.063	7.629AlaGlu: 7.629 ± 0.064	4.575AlaPhe: 4.575 ± 0.031	10.365AlaGly: 10.365 ± 0.065	2.757AlaHis: 2.757 ± 0.027	3.438AlaIle: 3.438 ± 0.03	5.483AlaLys: 5.483 ± 0.049	14.931AlaLeu: 14.931 ± 0.104	2.254AlaMet: 2.254 ± 0.019	2.688AlaAsn: 2.688 ± 0.022	10.756AlaPro: 10.756 ± 0.104	2.956AlaGln: 2.956 ± 0.025	12.698AlaArg: 12.698 ± 0.12	8.888AlaSer: 8.888 ± 0.06	7.498AlaThr: 7.498 ± 0.054	9.891AlaVal: 9.891 ± 0.056	2.024AlaTrp: 2.024 ± 0.025	2.918AlaTyr: 2.918 ± 0.025	0.001AlaXaa: 0.001 ± 0.0
Cys	2.768CysAla: 2.768 ± 0.03	0.523CysCys: 0.523 ± 0.014	1.388CysAsp: 1.388 ± 0.021	1.005CysGlu: 1.005 ± 0.016	0.711CysPhe: 0.711 ± 0.011	1.889CysGly: 1.889 ± 0.024	0.378CysHis: 0.378 ± 0.008	0.427CysIle: 0.427 ± 0.009	0.543CysLys: 0.543 ± 0.012	1.526CysLeu: 1.526 ± 0.017	0.245CysMet: 0.245 ± 0.007	0.376CysAsn: 0.376 ± 0.008	0.934CysPro: 0.934 ± 0.023	0.339CysGln: 0.339 ± 0.008	1.188CysArg: 1.188 ± 0.017	1.011CysSer: 1.011 ± 0.017	0.704CysThr: 0.704 ± 0.012	1.6CysVal: 1.6 ± 0.021	0.275CysTrp: 0.275 ± 0.008	0.497CysTyr: 0.497 ± 0.011	0.0CysXaa: 0.0 ± 0.0
Asp	12.65AspAla: 12.65 ± 0.085	1.038AspCys: 1.038 ± 0.017	7.589AspAsp: 7.589 ± 0.085	4.646AspGlu: 4.646 ± 0.036	2.173AspPhe: 2.173 ± 0.022	7.565AspGly: 7.565 ± 0.071	1.246AspHis: 1.246 ± 0.018	1.474AspIle: 1.474 ± 0.019	1.825AspLys: 1.825 ± 0.022	5.48AspLeu: 5.48 ± 0.035	0.935AspMet: 0.935 ± 0.014	1.035AspAsn: 1.035 ± 0.017	3.13AspPro: 3.13 ± 0.029	1.145AspGln: 1.145 ± 0.016	4.072AspArg: 4.072 ± 0.034	2.543AspSer: 2.543 ± 0.026	1.998AspThr: 1.998 ± 0.023	5.955AspVal: 5.955 ± 0.049	0.88AspTrp: 0.88 ± 0.014	1.51AspTyr: 1.51 ± 0.021	0.001AspXaa: 0.001 ± 0.0
Glu	8.61GluAla: 8.61 ± 0.074	0.888GluCys: 0.888 ± 0.015	3.58GluAsp: 3.58 ± 0.036	3.517GluGlu: 3.517 ± 0.043	1.637GluPhe: 1.637 ± 0.018	3.592GluGly: 3.592 ± 0.025	1.255GluHis: 1.255 ± 0.015	1.892GluIle: 1.892 ± 0.021	2.404GluLys: 2.404 ± 0.029	5.779GluLeu: 5.779 ± 0.043	0.971GluMet: 0.971 ± 0.014	1.361GluAsn: 1.361 ± 0.02	3.184GluPro: 3.184 ± 0.033	1.491GluGln: 1.491 ± 0.024	5.056GluArg: 5.056 ± 0.046	2.953GluSer: 2.953 ± 0.028	2.84GluThr: 2.84 ± 0.023	3.33GluVal: 3.33 ± 0.029	0.671GluTrp: 0.671 ± 0.013	1.145GluTyr: 1.145 ± 0.018	0.0GluXaa: 0.0 ± 0.0
Phe	4.527PheAla: 4.527 ± 0.033	0.674PheCys: 0.674 ± 0.012	2.784PheAsp: 2.784 ± 0.024	2.213PheGlu: 2.213 ± 0.019	1.363PhePhe: 1.363 ± 0.018	3.08PheGly: 3.08 ± 0.027	0.734PheHis: 0.734 ± 0.013	0.78PheIle: 0.78 ± 0.016	1.105PheLys: 1.105 ± 0.016	2.95PheLeu: 2.95 ± 0.03	0.531PheMet: 0.531 ± 0.01	0.824PheAsn: 0.824 ± 0.014	1.422PhePro: 1.422 ± 0.018	0.791PheGln: 0.791 ± 0.013	2.024PheArg: 2.024 ± 0.022	2.049PheSer: 2.049 ± 0.021	1.339PheThr: 1.339 ± 0.019	2.771PheVal: 2.771 ± 0.025	0.457PheTrp: 0.457 ± 0.009	0.906PheTyr: 0.906 ± 0.013	0.0PheXaa: 0.0 ± 0.0
Gly	12.959GlyAla: 12.959 ± 0.095	1.524GlyCys: 1.524 ± 0.019	7.113GlyAsp: 7.113 ± 0.06	4.2GlyGlu: 4.2 ± 0.031	2.737GlyPhe: 2.737 ± 0.027	9.212GlyGly: 9.212 ± 0.089	1.714GlyHis: 1.714 ± 0.024	1.833GlyIle: 1.833 ± 0.023	2.708GlyLys: 2.708 ± 0.029	6.67GlyLeu: 6.67 ± 0.053	1.172GlyMet: 1.172 ± 0.016	1.711GlyAsn: 1.711 ± 0.02	3.81GlyPro: 3.81 ± 0.04	1.624GlyGln: 1.624 ± 0.02	6.192GlyArg: 6.192 ± 0.081	4.896GlySer: 4.896 ± 0.039	3.453GlyThr: 3.453 ± 0.033	5.81GlyVal: 5.81 ± 0.04	1.101GlyTrp: 1.101 ± 0.015	1.833GlyTyr: 1.833 ± 0.023	0.0GlyXaa: 0.0 ± 0.0
His	3.006HisAla: 3.006 ± 0.03	0.447HisCys: 0.447 ± 0.009	1.306HisAsp: 1.306 ± 0.015	1.185HisGlu: 1.185 ± 0.02	0.801HisPhe: 0.801 ± 0.011	2.055HisGly: 2.055 ± 0.025	0.604HisHis: 0.604 ± 0.014	0.509HisIle: 0.509 ± 0.011	0.648HisLys: 0.648 ± 0.012	1.852HisLeu: 1.852 ± 0.021	0.323HisMet: 0.323 ± 0.008	0.478HisAsn: 0.478 ± 0.009	1.106HisPro: 1.106 ± 0.015	0.471HisGln: 0.471 ± 0.009	1.586HisArg: 1.586 ± 0.021	0.962HisSer: 0.962 ± 0.014	0.806HisThr: 0.806 ± 0.013	1.877HisVal: 1.877 ± 0.021	0.338HisTrp: 0.338 ± 0.008	0.584HisTyr: 0.584 ± 0.011	0.0HisXaa: 0.0 ± 0.0
Ile	3.161IleAla: 3.161 ± 0.027	0.536IleCys: 0.536 ± 0.009	1.878IleAsp: 1.878 ± 0.022	1.548IleGlu: 1.548 ± 0.021	1.093IlePhe: 1.093 ± 0.017	1.759IleGly: 1.759 ± 0.023	0.591IleHis: 0.591 ± 0.011	0.911IleIle: 0.911 ± 0.019	1.115IleLys: 1.115 ± 0.018	2.334IleLeu: 2.334 ± 0.028	0.531IleMet: 0.531 ± 0.011	0.756IleAsn: 0.756 ± 0.015	1.237IlePro: 1.237 ± 0.017	0.737IleGln: 0.737 ± 0.014	1.524IleArg: 1.524 ± 0.018	1.596IleSer: 1.596 ± 0.021	1.299IleThr: 1.299 ± 0.021	2.08IleVal: 2.08 ± 0.025	0.322IleTrp: 0.322 ± 0.008	0.698IleTyr: 0.698 ± 0.013	0.0IleXaa: 0.0 ± 0.0
Lys	4.597LysAla: 4.597 ± 0.04	0.56LysCys: 0.56 ± 0.011	1.893LysAsp: 1.893 ± 0.025	1.948LysGlu: 1.948 ± 0.028	1.164LysPhe: 1.164 ± 0.019	2.273LysGly: 2.273 ± 0.024	0.936LysHis: 0.936 ± 0.015	1.363LysIle: 1.363 ± 0.019	2.756LysLys: 2.756 ± 0.04	3.668LysLeu: 3.668 ± 0.03	0.779LysMet: 0.779 ± 0.014	0.982LysAsn: 0.982 ± 0.015	2.038LysPro: 2.038 ± 0.025	1.186LysGln: 1.186 ± 0.017	3.34LysArg: 3.34 ± 0.03	2.015LysSer: 2.015 ± 0.026	1.957LysThr: 1.957 ± 0.019	2.274LysVal: 2.274 ± 0.025	0.479LysTrp: 0.479 ± 0.009	0.897LysTyr: 0.897 ± 0.015	0.0LysXaa: 0.0 ± 0.0
Leu	13.449LeuAla: 13.449 ± 0.083	1.748LeuCys: 1.748 ± 0.019	6.555LeuAsp: 6.555 ± 0.039	6.014LeuGlu: 6.014 ± 0.047	2.957LeuPhe: 2.957 ± 0.025	7.72LeuGly: 7.72 ± 0.066	1.975LeuHis: 1.975 ± 0.02	2.017LeuIle: 2.017 ± 0.026	3.453LeuLys: 3.453 ± 0.029	8.794LeuLeu: 8.794 ± 0.055	1.348LeuMet: 1.348 ± 0.017	1.942LeuAsn: 1.942 ± 0.024	4.7LeuPro: 4.7 ± 0.036	2.422LeuGln: 2.422 ± 0.027	8.316LeuArg: 8.316 ± 0.065	5.227LeuSer: 5.227 ± 0.034	3.673LeuThr: 3.673 ± 0.034	6.86LeuVal: 6.86 ± 0.04	1.154LeuTrp: 1.154 ± 0.015	1.99LeuTyr: 1.99 ± 0.022	0.0LeuXaa: 0.0 ± 0.0
Met	2.012MetAla: 2.012 ± 0.019	0.271MetCys: 0.271 ± 0.007	0.978MetAsp: 0.978 ± 0.014	0.87MetGlu: 0.87 ± 0.017	0.491MetPhe: 0.491 ± 0.011	1.162MetGly: 1.162 ± 0.015	0.375MetHis: 0.375 ± 0.008	0.554MetIle: 0.554 ± 0.013	0.675MetLys: 0.675 ± 0.012	1.604MetLeu: 1.604 ± 0.018	0.405MetMet: 0.405 ± 0.01	0.45MetAsn: 0.45 ± 0.01	0.832MetPro: 0.832 ± 0.013	0.464MetGln: 0.464 ± 0.009	1.278MetArg: 1.278 ± 0.019	0.993MetSer: 0.993 ± 0.015	0.864MetThr: 0.864 ± 0.013	1.086MetVal: 1.086 ± 0.015	0.192MetTrp: 0.192 ± 0.006	0.366MetTyr: 0.366 ± 0.01	0.0MetXaa: 0.0 ± 0.0
Asn	2.904AsnAla: 2.904 ± 0.024	0.43AsnCys: 0.43 ± 0.01	1.368AsnAsp: 1.368 ± 0.021	1.178AsnGlu: 1.178 ± 0.015	0.911AsnPhe: 0.911 ± 0.014	1.789AsnGly: 1.789 ± 0.02	0.458AsnHis: 0.458 ± 0.008	0.719AsnIle: 0.719 ± 0.014	0.807AsnLys: 0.807 ± 0.015	2.009AsnLeu: 2.009 ± 0.024	0.448AsnMet: 0.448 ± 0.01	0.585AsnAsn: 0.585 ± 0.012	1.176AsnPro: 1.176 ± 0.014	0.547AsnGln: 0.547 ± 0.012	1.306AsnArg: 1.306 ± 0.017	1.188AsnSer: 1.188 ± 0.018	0.919AsnThr: 0.919 ± 0.016	1.804AsnVal: 1.804 ± 0.018	0.321AsnTrp: 0.321 ± 0.008	0.61AsnTyr: 0.61 ± 0.011	0.0AsnXaa: 0.0 ± 0.0
Pro	8.485ProAla: 8.485 ± 0.072	0.829ProCys: 0.829 ± 0.018	3.244ProAsp: 3.244 ± 0.025	3.364ProGlu: 3.364 ± 0.028	1.65ProPhe: 1.65 ± 0.02	4.655ProGly: 4.655 ± 0.036	1.052ProHis: 1.052 ± 0.013	1.152ProIle: 1.152 ± 0.017	2.161ProLys: 2.161 ± 0.022	4.611ProLeu: 4.611 ± 0.035	0.766ProMet: 0.766 ± 0.013	1.137ProAsn: 1.137 ± 0.016	6.472ProPro: 6.472 ± 0.068	1.2ProGln: 1.2 ± 0.019	5.527ProArg: 5.527 ± 0.065	3.85ProSer: 3.85 ± 0.064	3.195ProThr: 3.195 ± 0.07	3.186ProVal: 3.186 ± 0.027	0.759ProTrp: 0.759 ± 0.012	1.106ProTyr: 1.106 ± 0.015	0.0ProXaa: 0.0 ± 0.0
Gln	2.526GlnAla: 2.526 ± 0.025	0.419GlnCys: 0.419 ± 0.01	1.052GlnAsp: 1.052 ± 0.015	1.145GlnGlu: 1.145 ± 0.018	0.799GlnPhe: 0.799 ± 0.013	1.572GlnGly: 1.572 ± 0.024	0.599GlnHis: 0.599 ± 0.012	0.895GlnIle: 0.895 ± 0.015	1.029GlnLys: 1.029 ± 0.016	2.609GlnLeu: 2.609 ± 0.028	0.472GlnMet: 0.472 ± 0.012	0.611GlnAsn: 0.611 ± 0.013	1.215GlnPro: 1.215 ± 0.018	0.927GlnGln: 0.927 ± 0.023	2.33GlnArg: 2.33 ± 0.029	1.309GlnSer: 1.309 ± 0.019	1.12GlnThr: 1.12 ± 0.016	1.42GlnVal: 1.42 ± 0.017	0.333GlnTrp: 0.333 ± 0.008	0.565GlnTyr: 0.565 ± 0.01	0.0GlnXaa: 0.0 ± 0.0
Arg	11.949ArgAla: 11.949 ± 0.111	1.534ArgCys: 1.534 ± 0.019	5.434ArgAsp: 5.434 ± 0.05	4.378ArgGlu: 4.378 ± 0.04	2.316ArgPhe: 2.316 ± 0.025	7.283ArgGly: 7.283 ± 0.107	1.802ArgHis: 1.802 ± 0.026	1.719ArgIle: 1.719 ± 0.024	2.749ArgLys: 2.749 ± 0.03	7.225ArgLeu: 7.225 ± 0.046	1.01ArgMet: 1.01 ± 0.015	1.543ArgAsn: 1.543 ± 0.018	4.524ArgPro: 4.524 ± 0.047	1.749ArgGln: 1.749 ± 0.022	10.204ArgArg: 10.204 ± 0.194	4.556ArgSer: 4.556 ± 0.04	3.102ArgThr: 3.102 ± 0.023	5.884ArgVal: 5.884 ± 0.044	1.048ArgTrp: 1.048 ± 0.016	1.553ArgTyr: 1.553 ± 0.019	0.0ArgXaa: 0.0 ± 0.0
Ser	7.022SerAla: 7.022 ± 0.048	1.104SerCys: 1.104 ± 0.016	3.421SerAsp: 3.421 ± 0.026	2.779SerGlu: 2.779 ± 0.023	2.18SerPhe: 2.18 ± 0.026	4.678SerGly: 4.678 ± 0.042	1.123SerHis: 1.123 ± 0.014	1.724SerIle: 1.724 ± 0.022	2.27SerLys: 2.27 ± 0.026	5.594SerLeu: 5.594 ± 0.038	1.101SerMet: 1.101 ± 0.016	1.379SerAsn: 1.379 ± 0.019	3.762SerPro: 3.762 ± 0.036	1.4SerGln: 1.4 ± 0.017	4.251SerArg: 4.251 ± 0.042	4.289SerSer: 4.289 ± 0.04	3.069SerThr: 3.069 ± 0.031	3.81SerVal: 3.81 ± 0.032	0.89SerTrp: 0.89 ± 0.013	1.402SerTyr: 1.402 ± 0.021	0.0SerXaa: 0.0 ± 0.0
Thr	5.648ThrAla: 5.648 ± 0.042	1.019ThrCys: 1.019 ± 0.017	2.176ThrAsp: 2.176 ± 0.024	1.993ThrGlu: 1.993 ± 0.021	1.824ThrPhe: 1.824 ± 0.022	3.229ThrGly: 3.229 ± 0.033	0.981ThrHis: 0.981 ± 0.015	1.646ThrIle: 1.646 ± 0.021	1.778ThrLys: 1.778 ± 0.023	4.724ThrLeu: 4.724 ± 0.036	0.964ThrMet: 0.964 ± 0.013	1.115ThrAsn: 1.115 ± 0.016	3.07ThrPro: 3.07 ± 0.039	1.073ThrGln: 1.073 ± 0.014	3.145ThrArg: 3.145 ± 0.025	2.978ThrSer: 2.978 ± 0.029	2.812ThrThr: 2.812 ± 0.03	3.334ThrVal: 3.334 ± 0.032	0.735ThrTrp: 0.735 ± 0.011	1.27ThrTyr: 1.27 ± 0.019	0.0ThrXaa: 0.0 ± 0.0
Val	11.952ValAla: 11.952 ± 0.076	1.259ValCys: 1.259 ± 0.014	5.886ValAsp: 5.886 ± 0.043	4.454ValGlu: 4.454 ± 0.028	2.567ValPhe: 2.567 ± 0.025	5.442ValGly: 5.442 ± 0.046	1.506ValHis: 1.506 ± 0.019	1.731ValIle: 1.731 ± 0.018	2.371ValLys: 2.371 ± 0.021	6.767ValLeu: 6.767 ± 0.036	1.035ValMet: 1.035 ± 0.017	1.491ValAsn: 1.491 ± 0.018	3.512ValPro: 3.512 ± 0.027	1.563ValGln: 1.563 ± 0.018	4.761ValArg: 4.761 ± 0.039	3.889ValSer: 3.889 ± 0.036	3.113ValThr: 3.113 ± 0.031	7.149ValVal: 7.149 ± 0.051	0.833ValTrp: 0.833 ± 0.012	1.606ValTyr: 1.606 ± 0.018	0.0ValXaa: 0.0 ± 0.0
Trp	1.547TrpAla: 1.547 ± 0.018	0.296TrpCys: 0.296 ± 0.007	0.916TrpAsp: 0.916 ± 0.016	0.57TrpGlu: 0.57 ± 0.01	0.483TrpPhe: 0.483 ± 0.01	0.847TrpGly: 0.847 ± 0.013	0.366TrpHis: 0.366 ± 0.008	0.405TrpIle: 0.405 ± 0.009	0.486TrpLys: 0.486 ± 0.009	1.336TrpLeu: 1.336 ± 0.018	0.251TrpMet: 0.251 ± 0.006	0.404TrpAsn: 0.404 ± 0.009	0.657TrpPro: 0.657 ± 0.012	0.359TrpGln: 0.359 ± 0.007	1.342TrpArg: 1.342 ± 0.018	0.879TrpSer: 0.879 ± 0.011	0.799TrpThr: 0.799 ± 0.014	0.805TrpVal: 0.805 ± 0.012	0.247TrpTrp: 0.247 ± 0.007	0.421TrpTyr: 0.421 ± 0.014	0.0TrpXaa: 0.0 ± 0.0
Tyr	3.1TyrAla: 3.1 ± 0.03	0.498TyrCys: 0.498 ± 0.012	1.936TyrAsp: 1.936 ± 0.023	1.519TyrGlu: 1.519 ± 0.021	0.892TyrPhe: 0.892 ± 0.012	2.105TyrGly: 2.105 ± 0.029	0.492TyrHis: 0.492 ± 0.009	0.515TyrIle: 0.515 ± 0.012	0.737TyrLys: 0.737 ± 0.014	1.853TyrLeu: 1.853 ± 0.02	0.381TyrMet: 0.381 ± 0.009	0.61TyrAsn: 0.61 ± 0.012	0.866TyrPro: 0.866 ± 0.012	0.505TyrGln: 0.505 ± 0.011	1.42TyrArg: 1.42 ± 0.017	1.179TyrSer: 1.179 ± 0.02	0.952TyrThr: 0.952 ± 0.015	1.962TyrVal: 1.962 ± 0.023	0.355TyrTrp: 0.355 ± 0.008	0.753TyrTyr: 0.753 ± 0.015	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.001XaaAla: 0.001 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.001XaaGly: 0.001 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 11501 proteins (6025983 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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