Amino acid dipepetide frequency for Oligotropha carboxidovorans (strain ATCC 49405 / DSM 1227 / KCTC 32145 / OM5)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
17.114AlaAla: 17.114 ± 0.194
1.101AlaCys: 1.101 ± 0.033
6.477AlaAsp: 6.477 ± 0.084
6.836AlaGlu: 6.836 ± 0.091
4.277AlaPhe: 4.277 ± 0.064
9.51AlaGly: 9.51 ± 0.096
2.321AlaHis: 2.321 ± 0.042
6.758AlaIle: 6.758 ± 0.086
4.84AlaLys: 4.84 ± 0.087
12.938AlaLeu: 12.938 ± 0.135
3.486AlaMet: 3.486 ± 0.058
3.292AlaAsn: 3.292 ± 0.065
5.894AlaPro: 5.894 ± 0.1
4.166AlaGln: 4.166 ± 0.061
8.764AlaArg: 8.764 ± 0.112
6.976AlaSer: 6.976 ± 0.082
6.529AlaThr: 6.529 ± 0.087
8.461AlaVal: 8.461 ± 0.093
1.395AlaTrp: 1.395 ± 0.038
2.491AlaTyr: 2.491 ± 0.046
0.0AlaXaa: 0.0 ± 0.0
Cys
1.002CysAla: 1.002 ± 0.033
0.129CysCys: 0.129 ± 0.011
0.5CysAsp: 0.5 ± 0.023
0.439CysGlu: 0.439 ± 0.019
0.31CysPhe: 0.31 ± 0.017
0.895CysGly: 0.895 ± 0.03
0.24CysHis: 0.24 ± 0.014
0.418CysIle: 0.418 ± 0.022
0.232CysLys: 0.232 ± 0.015
0.734CysLeu: 0.734 ± 0.027
0.174CysMet: 0.174 ± 0.014
0.209CysAsn: 0.209 ± 0.013
0.451CysPro: 0.451 ± 0.021
0.206CysGln: 0.206 ± 0.012
0.543CysArg: 0.543 ± 0.022
0.48CysSer: 0.48 ± 0.022
0.418CysThr: 0.418 ± 0.019
0.689CysVal: 0.689 ± 0.028
0.118CysTrp: 0.118 ± 0.01
0.191CysTyr: 0.191 ± 0.013
0.0CysXaa: 0.0 ± 0.0
Asp
6.617AspAla: 6.617 ± 0.088
0.456AspCys: 0.456 ± 0.02
3.237AspAsp: 3.237 ± 0.063
3.457AspGlu: 3.457 ± 0.067
2.047AspPhe: 2.047 ± 0.044
4.638AspGly: 4.638 ± 0.078
1.328AspHis: 1.328 ± 0.041
3.243AspIle: 3.243 ± 0.059
2.002AspLys: 2.002 ± 0.042
5.707AspLeu: 5.707 ± 0.074
1.227AspMet: 1.227 ± 0.027
1.479AspAsn: 1.479 ± 0.034
3.235AspPro: 3.235 ± 0.059
1.631AspGln: 1.631 ± 0.043
3.899AspArg: 3.899 ± 0.056
2.308AspSer: 2.308 ± 0.054
2.691AspThr: 2.691 ± 0.059
4.195AspVal: 4.195 ± 0.063
0.867AspTrp: 0.867 ± 0.025
1.443AspTyr: 1.443 ± 0.036
0.0AspXaa: 0.0 ± 0.0
Glu
7.271GluAla: 7.271 ± 0.086
0.352GluCys: 0.352 ± 0.018
2.588GluAsp: 2.588 ± 0.052
2.829GluGlu: 2.829 ± 0.066
1.774GluPhe: 1.774 ± 0.037
4.104GluGly: 4.104 ± 0.063
1.223GluHis: 1.223 ± 0.034
3.512GluIle: 3.512 ± 0.06
2.416GluLys: 2.416 ± 0.049
4.978GluLeu: 4.978 ± 0.065
1.518GluMet: 1.518 ± 0.039
1.555GluAsn: 1.555 ± 0.043
2.598GluPro: 2.598 ± 0.055
2.116GluGln: 2.116 ± 0.044
5.027GluArg: 5.027 ± 0.083
2.565GluSer: 2.565 ± 0.048
3.379GluThr: 3.379 ± 0.059
3.744GluVal: 3.744 ± 0.057
0.667GluTrp: 0.667 ± 0.025
0.94GluTyr: 0.94 ± 0.029
0.0GluXaa: 0.0 ± 0.0
Phe
4.556PheAla: 4.556 ± 0.06
0.369PheCys: 0.369 ± 0.021
2.521PheAsp: 2.521 ± 0.053
2.067PheGlu: 2.067 ± 0.043
1.369PhePhe: 1.369 ± 0.042
3.672PheGly: 3.672 ± 0.07
0.734PheHis: 0.734 ± 0.028
1.853PheIle: 1.853 ± 0.041
1.168PheLys: 1.168 ± 0.03
3.251PheLeu: 3.251 ± 0.063
0.801PheMet: 0.801 ± 0.025
1.163PheAsn: 1.163 ± 0.033
1.577PhePro: 1.577 ± 0.04
1.005PheGln: 1.005 ± 0.029
2.213PheArg: 2.213 ± 0.041
2.242PheSer: 2.242 ± 0.042
2.092PheThr: 2.092 ± 0.05
2.944PheVal: 2.944 ± 0.061
0.512PheTrp: 0.512 ± 0.023
0.895PheTyr: 0.895 ± 0.031
0.0PheXaa: 0.0 ± 0.0
Gly
8.8GlyAla: 8.8 ± 0.102
0.789GlyCys: 0.789 ± 0.029
4.171GlyAsp: 4.171 ± 0.087
4.691GlyGlu: 4.691 ± 0.063
3.508GlyPhe: 3.508 ± 0.061
6.847GlyGly: 6.847 ± 0.114
1.9GlyHis: 1.9 ± 0.037
4.552GlyIle: 4.552 ± 0.067
3.481GlyLys: 3.481 ± 0.065
8.196GlyLeu: 8.196 ± 0.095
2.038GlyMet: 2.038 ± 0.047
2.147GlyAsn: 2.147 ± 0.053
3.306GlyPro: 3.306 ± 0.052
2.565GlyGln: 2.565 ± 0.056
5.674GlyArg: 5.674 ± 0.076
4.539GlySer: 4.539 ± 0.07
4.527GlyThr: 4.527 ± 0.071
6.085GlyVal: 6.085 ± 0.084
1.288GlyTrp: 1.288 ± 0.042
2.257GlyTyr: 2.257 ± 0.046
0.0GlyXaa: 0.0 ± 0.0
His
2.481HisAla: 2.481 ± 0.048
0.238HisCys: 0.238 ± 0.016
1.284HisAsp: 1.284 ± 0.037
1.084HisGlu: 1.084 ± 0.03
0.821HisPhe: 0.821 ± 0.028
1.905HisGly: 1.905 ± 0.045
0.598HisHis: 0.598 ± 0.033
1.006HisIle: 1.006 ± 0.031
0.556HisLys: 0.556 ± 0.023
2.034HisLeu: 2.034 ± 0.044
0.47HisMet: 0.47 ± 0.021
0.498HisAsn: 0.498 ± 0.022
1.32HisPro: 1.32 ± 0.033
0.624HisGln: 0.624 ± 0.024
1.482HisArg: 1.482 ± 0.039
0.993HisSer: 0.993 ± 0.027
0.871HisThr: 0.871 ± 0.028
1.527HisVal: 1.527 ± 0.04
0.321HisTrp: 0.321 ± 0.018
0.546HisTyr: 0.546 ± 0.025
0.0HisXaa: 0.0 ± 0.0
Ile
7.707IleAla: 7.707 ± 0.087
0.518IleCys: 0.518 ± 0.02
3.787IleAsp: 3.787 ± 0.054
3.776IleGlu: 3.776 ± 0.064
1.745IlePhe: 1.745 ± 0.045
5.144IleGly: 5.144 ± 0.078
0.975IleHis: 0.975 ± 0.031
2.482IleIle: 2.482 ± 0.051
1.828IleLys: 1.828 ± 0.046
4.542IleLeu: 4.542 ± 0.068
1.005IleMet: 1.005 ± 0.029
1.55IleAsn: 1.55 ± 0.042
2.399IlePro: 2.399 ± 0.045
1.249IleGln: 1.249 ± 0.035
3.392IleArg: 3.392 ± 0.057
3.072IleSer: 3.072 ± 0.061
2.908IleThr: 2.908 ± 0.057
4.779IleVal: 4.779 ± 0.074
0.63IleTrp: 0.63 ± 0.026
1.219IleTyr: 1.219 ± 0.035
0.0IleXaa: 0.0 ± 0.0
Lys
4.752LysAla: 4.752 ± 0.074
0.178LysCys: 0.178 ± 0.012
1.97LysAsp: 1.97 ± 0.05
1.834LysGlu: 1.834 ± 0.039
1.098LysPhe: 1.098 ± 0.035
2.793LysGly: 2.793 ± 0.056
0.704LysHis: 0.704 ± 0.026
2.079LysIle: 2.079 ± 0.048
1.714LysLys: 1.714 ± 0.053
3.692LysLeu: 3.692 ± 0.055
0.882LysMet: 0.882 ± 0.031
1.098LysAsn: 1.098 ± 0.032
2.515LysPro: 2.515 ± 0.055
1.161LysGln: 1.161 ± 0.034
2.736LysArg: 2.736 ± 0.047
2.216LysSer: 2.216 ± 0.047
2.366LysThr: 2.366 ± 0.048
2.744LysVal: 2.744 ± 0.048
0.42LysTrp: 0.42 ± 0.018
0.703LysTyr: 0.703 ± 0.029
0.0LysXaa: 0.0 ± 0.0
Leu
13.084LeuAla: 13.084 ± 0.125
0.819LeuCys: 0.819 ± 0.03
5.648LeuAsp: 5.648 ± 0.069
4.69LeuGlu: 4.69 ± 0.061
3.64LeuPhe: 3.64 ± 0.068
7.806LeuGly: 7.806 ± 0.086
1.835LeuHis: 1.835 ± 0.044
5.223LeuIle: 5.223 ± 0.074
3.888LeuLys: 3.888 ± 0.061
8.927LeuLeu: 8.927 ± 0.13
2.38LeuMet: 2.38 ± 0.046
2.71LeuAsn: 2.71 ± 0.046
5.47LeuPro: 5.47 ± 0.084
2.721LeuGln: 2.721 ± 0.051
6.869LeuArg: 6.869 ± 0.084
6.327LeuSer: 6.327 ± 0.083
5.711LeuThr: 5.711 ± 0.079
7.241LeuVal: 7.241 ± 0.085
1.072LeuTrp: 1.072 ± 0.037
1.948LeuTyr: 1.948 ± 0.045
0.0LeuXaa: 0.0 ± 0.0
Met
2.93MetAla: 2.93 ± 0.054
0.164MetCys: 0.164 ± 0.012
1.044MetAsp: 1.044 ± 0.032
1.015MetGlu: 1.015 ± 0.033
0.734MetPhe: 0.734 ± 0.026
1.578MetGly: 1.578 ± 0.036
0.442MetHis: 0.442 ± 0.02
1.411MetIle: 1.411 ± 0.043
1.093MetLys: 1.093 ± 0.03
2.438MetLeu: 2.438 ± 0.047
0.684MetMet: 0.684 ± 0.027
0.755MetAsn: 0.755 ± 0.024
1.524MetPro: 1.524 ± 0.037
0.864MetGln: 0.864 ± 0.027
1.811MetArg: 1.811 ± 0.04
1.732MetSer: 1.732 ± 0.039
1.861MetThr: 1.861 ± 0.04
1.673MetVal: 1.673 ± 0.036
0.229MetTrp: 0.229 ± 0.015
0.332MetTyr: 0.332 ± 0.018
0.0MetXaa: 0.0 ± 0.0
Asn
3.343AsnAla: 3.343 ± 0.054
0.242AsnCys: 0.242 ± 0.015
1.576AsnAsp: 1.576 ± 0.046
1.508AsnGlu: 1.508 ± 0.035
1.043AsnPhe: 1.043 ± 0.027
2.598AsnGly: 2.598 ± 0.062
0.534AsnHis: 0.534 ± 0.021
1.525AsnIle: 1.525 ± 0.04
0.888AsnLys: 0.888 ± 0.027
2.666AsnLeu: 2.666 ± 0.055
0.633AsnMet: 0.633 ± 0.022
0.839AsnAsn: 0.839 ± 0.032
1.846AsnPro: 1.846 ± 0.044
0.766AsnGln: 0.766 ± 0.03
1.863AsnArg: 1.863 ± 0.044
1.311AsnSer: 1.311 ± 0.041
1.35AsnThr: 1.35 ± 0.039
2.147AsnVal: 2.147 ± 0.048
0.46AsnTrp: 0.46 ± 0.019
0.718AsnTyr: 0.718 ± 0.027
0.0AsnXaa: 0.0 ± 0.0
Pro
6.398ProAla: 6.398 ± 0.093
0.334ProCys: 0.334 ± 0.017
3.491ProAsp: 3.491 ± 0.062
3.308ProGlu: 3.308 ± 0.053
2.002ProPhe: 2.002 ± 0.046
4.248ProGly: 4.248 ± 0.061
1.1ProHis: 1.1 ± 0.031
2.452ProIle: 2.452 ± 0.047
1.941ProLys: 1.941 ± 0.047
4.725ProLeu: 4.725 ± 0.066
1.157ProMet: 1.157 ± 0.037
1.561ProAsn: 1.561 ± 0.037
2.926ProPro: 2.926 ± 0.073
1.878ProGln: 1.878 ± 0.045
3.105ProArg: 3.105 ± 0.074
3.039ProSer: 3.039 ± 0.057
2.649ProThr: 2.649 ± 0.051
4.071ProVal: 4.071 ± 0.059
0.679ProTrp: 0.679 ± 0.025
1.208ProTyr: 1.208 ± 0.032
0.0ProXaa: 0.0 ± 0.0
Gln
3.963GlnAla: 3.963 ± 0.073
0.225GlnCys: 0.225 ± 0.014
1.441GlnAsp: 1.441 ± 0.042
1.347GlnGlu: 1.347 ± 0.036
1.105GlnPhe: 1.105 ± 0.032
2.263GlnGly: 2.263 ± 0.047
0.659GlnHis: 0.659 ± 0.025
1.995GlnIle: 1.995 ± 0.039
1.161GlnLys: 1.161 ± 0.029
2.777GlnLeu: 2.777 ± 0.051
0.799GlnMet: 0.799 ± 0.028
0.99GlnAsn: 0.99 ± 0.034
1.837GlnPro: 1.837 ± 0.045
1.255GlnGln: 1.255 ± 0.041
2.561GlnArg: 2.561 ± 0.058
1.878GlnSer: 1.878 ± 0.041
1.81GlnThr: 1.81 ± 0.046
2.223GlnVal: 2.223 ± 0.054
0.426GlnTrp: 0.426 ± 0.021
0.656GlnTyr: 0.656 ± 0.028
0.0GlnXaa: 0.0 ± 0.0
Arg
8.048ArgAla: 8.048 ± 0.11
0.538ArgCys: 0.538 ± 0.025
4.045ArgAsp: 4.045 ± 0.072
4.387ArgGlu: 4.387 ± 0.072
2.808ArgPhe: 2.808 ± 0.049
4.942ArgGly: 4.942 ± 0.075
1.645ArgHis: 1.645 ± 0.04
4.153ArgIle: 4.153 ± 0.069
2.728ArgLys: 2.728 ± 0.046
7.538ArgLeu: 7.538 ± 0.096
1.802ArgMet: 1.802 ± 0.039
2.016ArgAsn: 2.016 ± 0.04
3.466ArgPro: 3.466 ± 0.075
2.452ArgGln: 2.452 ± 0.052
5.629ArgArg: 5.629 ± 0.091
3.627ArgSer: 3.627 ± 0.058
3.618ArgThr: 3.618 ± 0.054
4.889ArgVal: 4.889 ± 0.077
0.947ArgTrp: 0.947 ± 0.032
1.813ArgTyr: 1.813 ± 0.04
0.0ArgXaa: 0.0 ± 0.0
Ser
6.449SerAla: 6.449 ± 0.08
0.481SerCys: 0.481 ± 0.021
3.103SerAsp: 3.103 ± 0.056
3.061SerGlu: 3.061 ± 0.05
2.376SerPhe: 2.376 ± 0.051
5.353SerGly: 5.353 ± 0.072
1.156SerHis: 1.156 ± 0.035
3.019SerIle: 3.019 ± 0.051
1.868SerLys: 1.868 ± 0.05
5.513SerLeu: 5.513 ± 0.076
1.357SerMet: 1.357 ± 0.034
1.525SerAsn: 1.525 ± 0.04
2.902SerPro: 2.902 ± 0.049
1.739SerGln: 1.739 ± 0.039
3.855SerArg: 3.855 ± 0.065
3.262SerSer: 3.262 ± 0.067
2.826SerThr: 2.826 ± 0.049
4.183SerVal: 4.183 ± 0.061
0.746SerTrp: 0.746 ± 0.028
1.319SerTyr: 1.319 ± 0.033
0.0SerXaa: 0.0 ± 0.0
Thr
6.248ThrAla: 6.248 ± 0.084
0.457ThrCys: 0.457 ± 0.02
2.927ThrAsp: 2.927 ± 0.051
2.73ThrGlu: 2.73 ± 0.052
2.166ThrPhe: 2.166 ± 0.054
4.775ThrGly: 4.775 ± 0.072
1.086ThrHis: 1.086 ± 0.034
3.145ThrIle: 3.145 ± 0.056
1.841ThrLys: 1.841 ± 0.041
6.083ThrLeu: 6.083 ± 0.08
1.219ThrMet: 1.219 ± 0.034
1.386ThrAsn: 1.386 ± 0.038
3.405ThrPro: 3.405 ± 0.053
1.594ThrGln: 1.594 ± 0.044
3.596ThrArg: 3.596 ± 0.057
3.136ThrSer: 3.136 ± 0.058
3.096ThrThr: 3.096 ± 0.057
4.37ThrVal: 4.37 ± 0.074
0.631ThrTrp: 0.631 ± 0.022
1.21ThrTyr: 1.21 ± 0.035
0.0ThrXaa: 0.0 ± 0.0
Val
9.186ValAla: 9.186 ± 0.096
0.62ValCys: 0.62 ± 0.025
3.896ValAsp: 3.896 ± 0.057
4.41ValGlu: 4.41 ± 0.054
2.727ValPhe: 2.727 ± 0.054
5.441ValGly: 5.441 ± 0.08
1.394ValHis: 1.394 ± 0.038
4.193ValIle: 4.193 ± 0.079
2.746ValLys: 2.746 ± 0.053
7.372ValLeu: 7.372 ± 0.095
1.928ValMet: 1.928 ± 0.043
2.033ValAsn: 2.033 ± 0.042
3.865ValPro: 3.865 ± 0.063
2.111ValGln: 2.111 ± 0.041
5.103ValArg: 5.103 ± 0.08
4.408ValSer: 4.408 ± 0.063
4.537ValThr: 4.537 ± 0.067
6.137ValVal: 6.137 ± 0.076
0.903ValTrp: 0.903 ± 0.032
1.508ValTyr: 1.508 ± 0.04
0.0ValXaa: 0.0 ± 0.0
Trp
1.157TrpAla: 1.157 ± 0.037
0.125TrpCys: 0.125 ± 0.01
0.549TrpAsp: 0.549 ± 0.029
0.501TrpGlu: 0.501 ± 0.021
0.495TrpPhe: 0.495 ± 0.02
0.829TrpGly: 0.829 ± 0.03
0.319TrpHis: 0.319 ± 0.018
0.716TrpIle: 0.716 ± 0.027
0.521TrpLys: 0.521 ± 0.023
1.604TrpLeu: 1.604 ± 0.04
0.342TrpMet: 0.342 ± 0.017
0.435TrpAsn: 0.435 ± 0.016
0.689TrpPro: 0.689 ± 0.025
0.564TrpGln: 0.564 ± 0.02
1.157TrpArg: 1.157 ± 0.036
0.845TrpSer: 0.845 ± 0.031
0.726TrpThr: 0.726 ± 0.027
0.79TrpVal: 0.79 ± 0.026
0.223TrpTrp: 0.223 ± 0.017
0.264TrpTyr: 0.264 ± 0.014
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.521TyrAla: 2.521 ± 0.052
0.246TyrCys: 0.246 ± 0.015
1.452TyrAsp: 1.452 ± 0.039
1.189TyrGlu: 1.189 ± 0.032
0.958TyrPhe: 0.958 ± 0.028
2.02TyrGly: 2.02 ± 0.042
0.463TyrHis: 0.463 ± 0.019
0.972TyrIle: 0.972 ± 0.028
0.747TyrLys: 0.747 ± 0.028
2.292TyrLeu: 2.292 ± 0.048
0.412TyrMet: 0.412 ± 0.017
0.617TyrAsn: 0.617 ± 0.026
1.043TyrPro: 1.043 ± 0.031
0.705TyrGln: 0.705 ± 0.027
1.809TyrArg: 1.809 ± 0.038
1.137TyrSer: 1.137 ± 0.028
1.136TyrThr: 1.136 ± 0.039
1.626TyrVal: 1.626 ± 0.039
0.316TyrTrp: 0.316 ± 0.016
0.613TyrTyr: 0.613 ± 0.028
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3624 proteins (1130278 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski