Amino acid dipepetide frequency for Mycobacterium phage Tapioca

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
19.26AlaAla: 19.26 ± 2.695
0.904AlaCys: 0.904 ± 0.296
8.761AlaAsp: 8.761 ± 0.756
7.231AlaGlu: 7.231 ± 0.842
3.268AlaPhe: 3.268 ± 0.487
9.248AlaGly: 9.248 ± 1.397
2.712AlaHis: 2.712 ± 0.47
5.91AlaIle: 5.91 ± 0.594
3.268AlaLys: 3.268 ± 0.525
9.317AlaLeu: 9.317 ± 0.774
2.016AlaMet: 2.016 ± 0.471
3.268AlaAsn: 3.268 ± 0.591
7.023AlaPro: 7.023 ± 0.759
5.493AlaGln: 5.493 ± 0.717
7.162AlaArg: 7.162 ± 0.852
6.049AlaSer: 6.049 ± 0.628
8.135AlaThr: 8.135 ± 0.769
6.675AlaVal: 6.675 ± 0.679
1.669AlaTrp: 1.669 ± 0.378
2.225AlaTyr: 2.225 ± 0.403
0.0AlaXaa: 0.0 ± 0.0
Cys
1.46CysAla: 1.46 ± 0.353
0.209CysCys: 0.209 ± 0.134
0.973CysAsp: 0.973 ± 0.309
0.973CysGlu: 0.973 ± 0.294
0.07CysPhe: 0.07 ± 0.072
1.321CysGly: 1.321 ± 0.369
0.556CysHis: 0.556 ± 0.206
0.07CysIle: 0.07 ± 0.06
0.348CysLys: 0.348 ± 0.198
0.626CysLeu: 0.626 ± 0.182
0.209CysMet: 0.209 ± 0.124
0.417CysAsn: 0.417 ± 0.24
1.252CysPro: 1.252 ± 0.294
0.626CysGln: 0.626 ± 0.195
0.973CysArg: 0.973 ± 0.235
0.695CysSer: 0.695 ± 0.218
0.973CysThr: 0.973 ± 0.208
0.904CysVal: 0.904 ± 0.255
0.209CysTrp: 0.209 ± 0.128
0.278CysTyr: 0.278 ± 0.141
0.0CysXaa: 0.0 ± 0.0
Asp
7.162AspAla: 7.162 ± 0.635
1.182AspCys: 1.182 ± 0.28
4.798AspAsp: 4.798 ± 0.801
4.798AspGlu: 4.798 ± 0.751
1.877AspPhe: 1.877 ± 0.326
6.745AspGly: 6.745 ± 0.668
1.53AspHis: 1.53 ± 0.315
2.781AspIle: 2.781 ± 0.381
1.599AspLys: 1.599 ± 0.326
5.841AspLeu: 5.841 ± 0.616
1.599AspMet: 1.599 ± 0.266
2.155AspAsn: 2.155 ± 0.399
4.798AspPro: 4.798 ± 0.586
2.434AspGln: 2.434 ± 0.421
4.241AspArg: 4.241 ± 0.67
3.616AspSer: 3.616 ± 0.548
3.546AspThr: 3.546 ± 0.597
3.616AspVal: 3.616 ± 0.497
1.252AspTrp: 1.252 ± 0.309
1.043AspTyr: 1.043 ± 0.302
0.0AspXaa: 0.0 ± 0.0
Glu
5.354GluAla: 5.354 ± 0.637
0.834GluCys: 0.834 ± 0.28
3.755GluAsp: 3.755 ± 0.54
1.947GluGlu: 1.947 ± 0.427
2.295GluPhe: 2.295 ± 0.475
3.059GluGly: 3.059 ± 0.414
1.391GluHis: 1.391 ± 0.338
2.92GluIle: 2.92 ± 0.426
2.364GluLys: 2.364 ± 0.345
5.284GluLeu: 5.284 ± 0.647
1.391GluMet: 1.391 ± 0.424
1.877GluAsn: 1.877 ± 0.308
2.851GluPro: 2.851 ± 0.544
2.99GluGln: 2.99 ± 0.386
4.45GluArg: 4.45 ± 0.751
2.851GluSer: 2.851 ± 0.512
3.546GluThr: 3.546 ± 0.443
4.45GluVal: 4.45 ± 0.763
0.834GluTrp: 0.834 ± 0.27
1.599GluTyr: 1.599 ± 0.334
0.0GluXaa: 0.0 ± 0.0
Phe
3.407PheAla: 3.407 ± 0.612
0.348PheCys: 0.348 ± 0.182
1.947PheAsp: 1.947 ± 0.63
1.46PheGlu: 1.46 ± 0.336
1.043PhePhe: 1.043 ± 0.357
3.824PheGly: 3.824 ± 0.52
1.113PheHis: 1.113 ± 0.286
1.182PheIle: 1.182 ± 0.288
0.695PheLys: 0.695 ± 0.195
1.599PheLeu: 1.599 ± 0.366
0.556PheMet: 0.556 ± 0.232
0.904PheAsn: 0.904 ± 0.232
0.834PhePro: 0.834 ± 0.255
0.556PheGln: 0.556 ± 0.201
1.599PheArg: 1.599 ± 0.317
1.669PheSer: 1.669 ± 0.336
2.155PheThr: 2.155 ± 0.362
2.364PheVal: 2.364 ± 0.421
0.556PheTrp: 0.556 ± 0.335
0.973PheTyr: 0.973 ± 0.276
0.0PheXaa: 0.0 ± 0.0
Gly
7.927GlyAla: 7.927 ± 1.272
1.182GlyCys: 1.182 ± 0.313
5.354GlyAsp: 5.354 ± 0.695
3.894GlyGlu: 3.894 ± 0.706
2.573GlyPhe: 2.573 ± 0.561
9.804GlyGly: 9.804 ± 1.443
1.599GlyHis: 1.599 ± 0.354
4.311GlyIle: 4.311 ± 0.696
2.086GlyLys: 2.086 ± 0.387
6.953GlyLeu: 6.953 ± 0.635
2.016GlyMet: 2.016 ± 0.381
2.712GlyAsn: 2.712 ± 0.49
4.52GlyPro: 4.52 ± 0.737
4.172GlyGln: 4.172 ± 0.608
6.049GlyArg: 6.049 ± 0.568
5.076GlySer: 5.076 ± 0.681
6.119GlyThr: 6.119 ± 0.883
6.397GlyVal: 6.397 ± 0.656
2.016GlyTrp: 2.016 ± 0.292
2.99GlyTyr: 2.99 ± 0.698
0.0GlyXaa: 0.0 ± 0.0
His
1.877HisAla: 1.877 ± 0.32
0.556HisCys: 0.556 ± 0.199
1.53HisAsp: 1.53 ± 0.378
1.947HisGlu: 1.947 ± 0.425
0.417HisPhe: 0.417 ± 0.165
1.947HisGly: 1.947 ± 0.424
0.834HisHis: 0.834 ± 0.242
0.765HisIle: 0.765 ± 0.211
0.834HisLys: 0.834 ± 0.254
1.669HisLeu: 1.669 ± 0.412
0.209HisMet: 0.209 ± 0.103
0.487HisAsn: 0.487 ± 0.179
1.321HisPro: 1.321 ± 0.338
0.973HisGln: 0.973 ± 0.288
1.947HisArg: 1.947 ± 0.367
0.765HisSer: 0.765 ± 0.277
1.877HisThr: 1.877 ± 0.337
0.973HisVal: 0.973 ± 0.336
0.417HisTrp: 0.417 ± 0.167
0.973HisTyr: 0.973 ± 0.217
0.0HisXaa: 0.0 ± 0.0
Ile
5.354IleAla: 5.354 ± 0.64
0.278IleCys: 0.278 ± 0.135
3.616IleAsp: 3.616 ± 0.535
4.311IleGlu: 4.311 ± 0.504
0.834IlePhe: 0.834 ± 0.267
4.589IleGly: 4.589 ± 0.512
1.182IleHis: 1.182 ± 0.349
1.182IleIle: 1.182 ± 0.243
1.043IleLys: 1.043 ± 0.287
2.364IleLeu: 2.364 ± 0.402
0.278IleMet: 0.278 ± 0.141
1.947IleAsn: 1.947 ± 0.371
2.642IlePro: 2.642 ± 0.433
1.53IleGln: 1.53 ± 0.33
3.755IleArg: 3.755 ± 0.508
2.155IleSer: 2.155 ± 0.409
3.477IleThr: 3.477 ± 0.511
3.268IleVal: 3.268 ± 0.545
0.834IleTrp: 0.834 ± 0.224
0.973IleTyr: 0.973 ± 0.214
0.0IleXaa: 0.0 ± 0.0
Lys
4.241LysAla: 4.241 ± 0.963
0.278LysCys: 0.278 ± 0.121
1.113LysAsp: 1.113 ± 0.279
1.043LysGlu: 1.043 ± 0.234
0.834LysPhe: 0.834 ± 0.181
2.225LysGly: 2.225 ± 0.498
0.626LysHis: 0.626 ± 0.205
1.321LysIle: 1.321 ± 0.285
0.348LysLys: 0.348 ± 0.138
1.877LysLeu: 1.877 ± 0.343
0.834LysMet: 0.834 ± 0.222
0.695LysAsn: 0.695 ± 0.21
2.503LysPro: 2.503 ± 0.337
1.043LysGln: 1.043 ± 0.331
2.712LysArg: 2.712 ± 0.441
1.53LysSer: 1.53 ± 0.283
2.225LysThr: 2.225 ± 0.421
1.947LysVal: 1.947 ± 0.417
0.765LysTrp: 0.765 ± 0.235
1.043LysTyr: 1.043 ± 0.305
0.0LysXaa: 0.0 ± 0.0
Leu
9.804LeuAla: 9.804 ± 0.971
0.765LeuCys: 0.765 ± 0.245
5.284LeuAsp: 5.284 ± 0.553
3.546LeuGlu: 3.546 ± 0.445
2.851LeuPhe: 2.851 ± 0.556
8.066LeuGly: 8.066 ± 0.908
1.321LeuHis: 1.321 ± 0.269
3.755LeuIle: 3.755 ± 0.479
2.573LeuLys: 2.573 ± 0.513
6.605LeuLeu: 6.605 ± 0.862
1.043LeuMet: 1.043 ± 0.304
2.781LeuAsn: 2.781 ± 0.514
4.172LeuPro: 4.172 ± 0.644
2.851LeuGln: 2.851 ± 0.446
5.423LeuArg: 5.423 ± 0.827
3.894LeuSer: 3.894 ± 0.641
5.841LeuThr: 5.841 ± 0.71
5.563LeuVal: 5.563 ± 0.646
1.182LeuTrp: 1.182 ± 0.262
1.252LeuTyr: 1.252 ± 0.27
0.0LeuXaa: 0.0 ± 0.0
Met
3.059MetAla: 3.059 ± 0.396
0.07MetCys: 0.07 ± 0.072
0.626MetAsp: 0.626 ± 0.287
0.626MetGlu: 0.626 ± 0.267
0.904MetPhe: 0.904 ± 0.253
0.487MetGly: 0.487 ± 0.161
0.278MetHis: 0.278 ± 0.127
1.182MetIle: 1.182 ± 0.301
0.556MetLys: 0.556 ± 0.214
1.669MetLeu: 1.669 ± 0.282
0.209MetMet: 0.209 ± 0.127
0.904MetAsn: 0.904 ± 0.302
1.738MetPro: 1.738 ± 0.335
0.765MetGln: 0.765 ± 0.207
1.043MetArg: 1.043 ± 0.304
2.642MetSer: 2.642 ± 0.398
1.947MetThr: 1.947 ± 0.437
0.695MetVal: 0.695 ± 0.232
0.695MetTrp: 0.695 ± 0.295
0.348MetTyr: 0.348 ± 0.148
0.0MetXaa: 0.0 ± 0.0
Asn
3.894AsnAla: 3.894 ± 0.52
0.348AsnCys: 0.348 ± 0.142
1.947AsnAsp: 1.947 ± 0.439
0.765AsnGlu: 0.765 ± 0.247
0.904AsnPhe: 0.904 ± 0.22
3.477AsnGly: 3.477 ± 0.584
0.626AsnHis: 0.626 ± 0.214
1.808AsnIle: 1.808 ± 0.382
0.765AsnLys: 0.765 ± 0.234
2.99AsnLeu: 2.99 ± 0.518
0.487AsnMet: 0.487 ± 0.163
1.53AsnAsn: 1.53 ± 0.339
2.573AsnPro: 2.573 ± 0.35
1.46AsnGln: 1.46 ± 0.367
1.947AsnArg: 1.947 ± 0.37
1.391AsnSer: 1.391 ± 0.333
1.669AsnThr: 1.669 ± 0.241
1.877AsnVal: 1.877 ± 0.325
0.556AsnTrp: 0.556 ± 0.185
0.626AsnTyr: 0.626 ± 0.225
0.0AsnXaa: 0.0 ± 0.0
Pro
7.37ProAla: 7.37 ± 0.836
0.973ProCys: 0.973 ± 0.246
5.006ProAsp: 5.006 ± 0.62
4.38ProGlu: 4.38 ± 0.661
1.947ProPhe: 1.947 ± 0.312
5.91ProGly: 5.91 ± 0.818
1.391ProHis: 1.391 ± 0.3
2.225ProIle: 2.225 ± 0.431
1.252ProLys: 1.252 ± 0.391
3.685ProLeu: 3.685 ± 0.677
1.599ProMet: 1.599 ± 0.416
1.669ProAsn: 1.669 ± 0.332
3.755ProPro: 3.755 ± 0.483
2.155ProGln: 2.155 ± 0.354
2.99ProArg: 2.99 ± 0.479
2.781ProSer: 2.781 ± 0.469
3.824ProThr: 3.824 ± 0.524
4.38ProVal: 4.38 ± 0.553
1.321ProTrp: 1.321 ± 0.387
1.113ProTyr: 1.113 ± 0.364
0.0ProXaa: 0.0 ± 0.0
Gln
4.867GlnAla: 4.867 ± 0.865
0.556GlnCys: 0.556 ± 0.208
1.599GlnAsp: 1.599 ± 0.434
1.391GlnGlu: 1.391 ± 0.354
1.113GlnPhe: 1.113 ± 0.2
2.016GlnGly: 2.016 ± 0.34
1.182GlnHis: 1.182 ± 0.309
2.573GlnIle: 2.573 ± 0.507
1.321GlnLys: 1.321 ± 0.287
4.659GlnLeu: 4.659 ± 0.52
0.904GlnMet: 0.904 ± 0.296
0.626GlnAsn: 0.626 ± 0.218
2.295GlnPro: 2.295 ± 0.483
1.808GlnGln: 1.808 ± 0.437
3.616GlnArg: 3.616 ± 0.71
2.225GlnSer: 2.225 ± 0.373
2.503GlnThr: 2.503 ± 0.377
3.059GlnVal: 3.059 ± 0.479
0.765GlnTrp: 0.765 ± 0.226
0.626GlnTyr: 0.626 ± 0.221
0.0GlnXaa: 0.0 ± 0.0
Arg
6.675ArgAla: 6.675 ± 0.799
1.321ArgCys: 1.321 ± 0.344
5.006ArgAsp: 5.006 ± 0.57
4.311ArgGlu: 4.311 ± 0.715
1.669ArgPhe: 1.669 ± 0.431
5.076ArgGly: 5.076 ± 0.525
2.016ArgHis: 2.016 ± 0.392
3.824ArgIle: 3.824 ± 0.544
2.295ArgLys: 2.295 ± 0.419
5.145ArgLeu: 5.145 ± 0.573
2.295ArgMet: 2.295 ± 0.567
1.669ArgAsn: 1.669 ± 0.282
3.755ArgPro: 3.755 ± 0.519
3.198ArgGln: 3.198 ± 0.679
6.397ArgArg: 6.397 ± 0.853
2.642ArgSer: 2.642 ± 0.512
4.033ArgThr: 4.033 ± 0.676
4.311ArgVal: 4.311 ± 0.508
1.669ArgTrp: 1.669 ± 0.311
1.877ArgTyr: 1.877 ± 0.322
0.0ArgXaa: 0.0 ± 0.0
Ser
6.953SerAla: 6.953 ± 1.066
0.556SerCys: 0.556 ± 0.24
3.338SerAsp: 3.338 ± 0.518
2.016SerGlu: 2.016 ± 0.4
1.599SerPhe: 1.599 ± 0.286
4.867SerGly: 4.867 ± 0.718
0.556SerHis: 0.556 ± 0.199
1.669SerIle: 1.669 ± 0.337
1.46SerLys: 1.46 ± 0.352
4.172SerLeu: 4.172 ± 0.652
2.155SerMet: 2.155 ± 0.332
1.391SerAsn: 1.391 ± 0.293
3.198SerPro: 3.198 ± 0.343
1.947SerGln: 1.947 ± 0.4
3.059SerArg: 3.059 ± 0.511
3.198SerSer: 3.198 ± 0.384
3.059SerThr: 3.059 ± 0.343
3.824SerVal: 3.824 ± 0.457
1.182SerTrp: 1.182 ± 0.242
1.599SerTyr: 1.599 ± 0.327
0.0SerXaa: 0.0 ± 0.0
Thr
8.483ThrAla: 8.483 ± 0.886
0.695ThrCys: 0.695 ± 0.232
4.102ThrAsp: 4.102 ± 0.542
3.894ThrGlu: 3.894 ± 0.467
1.808ThrPhe: 1.808 ± 0.361
6.536ThrGly: 6.536 ± 0.923
1.113ThrHis: 1.113 ± 0.284
2.781ThrIle: 2.781 ± 0.412
2.573ThrLys: 2.573 ± 0.403
5.771ThrLeu: 5.771 ± 0.564
1.113ThrMet: 1.113 ± 0.219
1.877ThrAsn: 1.877 ± 0.36
4.867ThrPro: 4.867 ± 0.614
1.947ThrGln: 1.947 ± 0.363
3.963ThrArg: 3.963 ± 0.487
3.129ThrSer: 3.129 ± 0.571
4.589ThrThr: 4.589 ± 0.822
6.814ThrVal: 6.814 ± 0.909
0.834ThrTrp: 0.834 ± 0.221
1.391ThrTyr: 1.391 ± 0.313
0.0ThrXaa: 0.0 ± 0.0
Val
8.622ValAla: 8.622 ± 0.866
0.973ValCys: 0.973 ± 0.243
4.659ValAsp: 4.659 ± 0.533
5.563ValGlu: 5.563 ± 0.78
1.808ValPhe: 1.808 ± 0.363
5.284ValGly: 5.284 ± 0.543
1.252ValHis: 1.252 ± 0.281
3.616ValIle: 3.616 ± 0.603
2.851ValLys: 2.851 ± 0.556
4.38ValLeu: 4.38 ± 0.516
0.973ValMet: 0.973 ± 0.378
3.129ValAsn: 3.129 ± 0.392
3.963ValPro: 3.963 ± 0.468
2.155ValGln: 2.155 ± 0.314
5.006ValArg: 5.006 ± 0.666
3.198ValSer: 3.198 ± 0.497
5.354ValThr: 5.354 ± 0.484
4.728ValVal: 4.728 ± 0.59
0.695ValTrp: 0.695 ± 0.184
1.321ValTyr: 1.321 ± 0.334
0.0ValXaa: 0.0 ± 0.0
Trp
1.53TrpAla: 1.53 ± 0.365
0.765TrpCys: 0.765 ± 0.284
1.043TrpAsp: 1.043 ± 0.252
0.487TrpGlu: 0.487 ± 0.201
0.487TrpPhe: 0.487 ± 0.21
1.113TrpGly: 1.113 ± 0.225
0.626TrpHis: 0.626 ± 0.231
0.834TrpIle: 0.834 ± 0.274
0.417TrpLys: 0.417 ± 0.154
2.225TrpLeu: 2.225 ± 0.444
0.139TrpMet: 0.139 ± 0.105
0.626TrpAsn: 0.626 ± 0.195
0.904TrpPro: 0.904 ± 0.294
0.765TrpGln: 0.765 ± 0.188
1.252TrpArg: 1.252 ± 0.273
1.113TrpSer: 1.113 ± 0.288
1.808TrpThr: 1.808 ± 0.374
1.669TrpVal: 1.669 ± 0.248
0.487TrpTrp: 0.487 ± 0.181
0.348TrpTyr: 0.348 ± 0.168
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.295TyrAla: 2.295 ± 0.407
0.348TyrCys: 0.348 ± 0.151
2.155TyrAsp: 2.155 ± 0.419
1.46TyrGlu: 1.46 ± 0.274
0.487TyrPhe: 0.487 ± 0.184
2.155TyrGly: 2.155 ± 0.361
0.417TyrHis: 0.417 ± 0.191
0.904TyrIle: 0.904 ± 0.278
0.556TyrLys: 0.556 ± 0.182
1.738TyrLeu: 1.738 ± 0.376
0.348TyrMet: 0.348 ± 0.148
0.973TyrAsn: 0.973 ± 0.236
0.765TyrPro: 0.765 ± 0.264
0.834TyrGln: 0.834 ± 0.231
1.669TyrArg: 1.669 ± 0.344
1.182TyrSer: 1.182 ± 0.276
1.599TyrThr: 1.599 ± 0.368
2.016TyrVal: 2.016 ± 0.446
0.695TyrTrp: 0.695 ± 0.277
0.834TyrTyr: 0.834 ± 0.233
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 70 proteins (14383 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski