Amino acid dipepetide frequency for Streptomyces sp. AVP053U2

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	20.732AlaAla: 20.732 ± 0.17	1.09AlaCys: 1.09 ± 0.023	8.449AlaAsp: 8.449 ± 0.068	8.801AlaGlu: 8.801 ± 0.082	3.325AlaPhe: 3.325 ± 0.042	13.655AlaGly: 13.655 ± 0.11	2.999AlaHis: 2.999 ± 0.049	2.871AlaIle: 2.871 ± 0.043	2.506AlaLys: 2.506 ± 0.046	14.253AlaLeu: 14.253 ± 0.113	2.386AlaMet: 2.386 ± 0.04	1.737AlaAsn: 1.737 ± 0.032	7.457AlaPro: 7.457 ± 0.079	3.67AlaGln: 3.67 ± 0.047	10.892AlaArg: 10.892 ± 0.101	5.849AlaSer: 5.849 ± 0.063	6.755AlaThr: 6.755 ± 0.058	12.412AlaVal: 12.412 ± 0.093	1.767AlaTrp: 1.767 ± 0.032	2.592AlaTyr: 2.592 ± 0.035	0.0AlaXaa: 0.0 ± 0.0
Cys	1.09CysAla: 1.09 ± 0.026	0.108CysCys: 0.108 ± 0.008	0.482CysAsp: 0.482 ± 0.016	0.409CysGlu: 0.409 ± 0.012	0.209CysPhe: 0.209 ± 0.009	0.996CysGly: 0.996 ± 0.024	0.206CysHis: 0.206 ± 0.01	0.163CysIle: 0.163 ± 0.009	0.118CysLys: 0.118 ± 0.007	0.739CysLeu: 0.739 ± 0.02	0.122CysMet: 0.122 ± 0.007	0.119CysAsn: 0.119 ± 0.007	0.555CysPro: 0.555 ± 0.016	0.17CysGln: 0.17 ± 0.008	0.711CysArg: 0.711 ± 0.02	0.463CysSer: 0.463 ± 0.015	0.563CysThr: 0.563 ± 0.017	0.656CysVal: 0.656 ± 0.018	0.134CysTrp: 0.134 ± 0.008	0.149CysTyr: 0.149 ± 0.01	0.0CysXaa: 0.0 ± 0.0
Asp	7.739AspAla: 7.739 ± 0.065	0.43AspCys: 0.43 ± 0.014	3.789AspAsp: 3.789 ± 0.051	3.995AspGlu: 3.995 ± 0.045	1.58AspPhe: 1.58 ± 0.027	6.767AspGly: 6.767 ± 0.061	1.488AspHis: 1.488 ± 0.027	1.79AspIle: 1.79 ± 0.033	1.067AspLys: 1.067 ± 0.025	6.338AspLeu: 6.338 ± 0.066	0.789AspMet: 0.789 ± 0.02	0.944AspAsn: 0.944 ± 0.022	4.639AspPro: 4.639 ± 0.052	1.515AspGln: 1.515 ± 0.032	5.349AspArg: 5.349 ± 0.059	2.554AspSer: 2.554 ± 0.036	3.484AspThr: 3.484 ± 0.039	4.765AspVal: 4.765 ± 0.049	1.012AspTrp: 1.012 ± 0.024	1.032AspTyr: 1.032 ± 0.024	0.001AspXaa: 0.001 ± 0.001
Glu	7.572GluAla: 7.572 ± 0.084	0.366GluCys: 0.366 ± 0.014	3.102GluAsp: 3.102 ± 0.038	3.849GluGlu: 3.849 ± 0.058	1.418GluPhe: 1.418 ± 0.024	4.66GluGly: 4.66 ± 0.061	1.59GluHis: 1.59 ± 0.031	2.199GluIle: 2.199 ± 0.034	1.47GluLys: 1.47 ± 0.03	6.659GluLeu: 6.659 ± 0.067	0.873GluMet: 0.873 ± 0.02	1.101GluAsn: 1.101 ± 0.028	3.684GluPro: 3.684 ± 0.046	2.388GluGln: 2.388 ± 0.042	5.757GluArg: 5.757 ± 0.058	2.599GluSer: 2.599 ± 0.037	2.957GluThr: 2.957 ± 0.037	4.517GluVal: 4.517 ± 0.053	0.713GluTrp: 0.713 ± 0.019	1.128GluTyr: 1.128 ± 0.023	0.0GluXaa: 0.0 ± 0.0
Phe	3.462PheAla: 3.462 ± 0.045	0.255PheCys: 0.255 ± 0.01	1.929PheAsp: 1.929 ± 0.035	1.437PheGlu: 1.437 ± 0.028	0.816PhePhe: 0.816 ± 0.023	2.846PheGly: 2.846 ± 0.041	0.605PheHis: 0.605 ± 0.016	0.597PheIle: 0.597 ± 0.018	0.453PheLys: 0.453 ± 0.017	2.537PheLeu: 2.537 ± 0.037	0.393PheMet: 0.393 ± 0.014	0.513PheAsn: 0.513 ± 0.016	1.369PhePro: 1.369 ± 0.027	0.653PheGln: 0.653 ± 0.017	1.819PheArg: 1.819 ± 0.032	1.372PheSer: 1.372 ± 0.024	1.972PheThr: 1.972 ± 0.034	2.159PheVal: 2.159 ± 0.033	0.378PheTrp: 0.378 ± 0.012	0.521PheTyr: 0.521 ± 0.014	0.0PheXaa: 0.0 ± 0.0
Gly	11.288GlyAla: 11.288 ± 0.098	0.878GlyCys: 0.878 ± 0.023	5.458GlyAsp: 5.458 ± 0.061	5.537GlyGlu: 5.537 ± 0.068	2.824GlyPhe: 2.824 ± 0.042	9.245GlyGly: 9.245 ± 0.125	2.468GlyHis: 2.468 ± 0.034	3.224GlyIle: 3.224 ± 0.045	2.184GlyLys: 2.184 ± 0.042	9.3GlyLeu: 9.3 ± 0.082	1.935GlyMet: 1.935 ± 0.031	1.687GlyAsn: 1.687 ± 0.032	5.831GlyPro: 5.831 ± 0.076	2.753GlyGln: 2.753 ± 0.047	8.638GlyArg: 8.638 ± 0.091	5.512GlySer: 5.512 ± 0.068	6.826GlyThr: 6.826 ± 0.069	7.627GlyVal: 7.627 ± 0.08	1.607GlyTrp: 1.607 ± 0.032	2.042GlyTyr: 2.042 ± 0.032	0.0GlyXaa: 0.0 ± 0.0
His	2.756HisAla: 2.756 ± 0.042	0.224HisCys: 0.224 ± 0.011	1.426HisAsp: 1.426 ± 0.026	1.26HisGlu: 1.26 ± 0.025	0.626HisPhe: 0.626 ± 0.019	2.6HisGly: 2.6 ± 0.039	0.769HisHis: 0.769 ± 0.021	0.65HisIle: 0.65 ± 0.017	0.338HisLys: 0.338 ± 0.015	2.559HisLeu: 2.559 ± 0.037	0.326HisMet: 0.326 ± 0.013	0.357HisAsn: 0.357 ± 0.013	1.907HisPro: 1.907 ± 0.031	0.674HisGln: 0.674 ± 0.018	2.417HisArg: 2.417 ± 0.041	1.046HisSer: 1.046 ± 0.024	1.455HisThr: 1.455 ± 0.028	1.759HisVal: 1.759 ± 0.031	0.361HisTrp: 0.361 ± 0.015	0.447HisTyr: 0.447 ± 0.014	0.0HisXaa: 0.0 ± 0.0
Ile	4.22IleAla: 4.22 ± 0.057	0.259IleCys: 0.259 ± 0.011	2.036IleAsp: 2.036 ± 0.036	1.841IleGlu: 1.841 ± 0.034	0.592IlePhe: 0.592 ± 0.019	3.241IleGly: 3.241 ± 0.046	0.572IleHis: 0.572 ± 0.016	0.793IleIle: 0.793 ± 0.024	0.658IleLys: 0.658 ± 0.019	2.159IleLeu: 2.159 ± 0.038	0.396IleMet: 0.396 ± 0.015	0.627IleAsn: 0.627 ± 0.021	1.615IlePro: 1.615 ± 0.033	0.636IleGln: 0.636 ± 0.02	2.196IleArg: 2.196 ± 0.035	1.461IleSer: 1.461 ± 0.03	2.073IleThr: 2.073 ± 0.035	2.507IleVal: 2.507 ± 0.041	0.313IleTrp: 0.313 ± 0.012	0.439IleTyr: 0.439 ± 0.014	0.0IleXaa: 0.0 ± 0.0
Lys	2.692LysAla: 2.692 ± 0.046	0.097LysCys: 0.097 ± 0.007	1.273LysAsp: 1.273 ± 0.025	1.202LysGlu: 1.202 ± 0.029	0.399LysPhe: 0.399 ± 0.015	1.737LysGly: 1.737 ± 0.037	0.391LysHis: 0.391 ± 0.012	0.735LysIle: 0.735 ± 0.022	0.777LysLys: 0.777 ± 0.027	1.813LysLeu: 1.813 ± 0.035	0.363LysMet: 0.363 ± 0.016	0.482LysAsn: 0.482 ± 0.018	1.237LysPro: 1.237 ± 0.028	0.627LysGln: 0.627 ± 0.019	1.477LysArg: 1.477 ± 0.029	1.054LysSer: 1.054 ± 0.027	1.182LysThr: 1.182 ± 0.027	1.691LysVal: 1.691 ± 0.034	0.236LysTrp: 0.236 ± 0.011	0.415LysTyr: 0.415 ± 0.014	0.001LysXaa: 0.001 ± 0.001
Leu	14.607LeuAla: 14.607 ± 0.117	0.855LeuCys: 0.855 ± 0.022	6.805LeuAsp: 6.805 ± 0.064	4.942LeuGlu: 4.942 ± 0.056	2.553LeuPhe: 2.553 ± 0.036	8.945LeuGly: 8.945 ± 0.075	2.395LeuHis: 2.395 ± 0.035	2.977LeuIle: 2.977 ± 0.044	1.941LeuLys: 1.941 ± 0.035	11.25LeuLeu: 11.25 ± 0.102	1.551LeuMet: 1.551 ± 0.03	1.557LeuAsn: 1.557 ± 0.028	6.579LeuPro: 6.579 ± 0.071	2.157LeuGln: 2.157 ± 0.031	9.03LeuArg: 9.03 ± 0.082	5.131LeuSer: 5.131 ± 0.056	6.89LeuThr: 6.89 ± 0.069	8.702LeuVal: 8.702 ± 0.085	1.279LeuTrp: 1.279 ± 0.028	1.759LeuTyr: 1.759 ± 0.03	0.0LeuXaa: 0.0 ± 0.0
Met	2.168MetAla: 2.168 ± 0.034	0.148MetCys: 0.148 ± 0.008	0.882MetAsp: 0.882 ± 0.022	0.756MetGlu: 0.756 ± 0.021	0.434MetPhe: 0.434 ± 0.015	1.236MetGly: 1.236 ± 0.029	0.353MetHis: 0.353 ± 0.014	0.628MetIle: 0.628 ± 0.018	0.388MetLys: 0.388 ± 0.015	1.633MetLeu: 1.633 ± 0.031	0.279MetMet: 0.279 ± 0.012	0.423MetAsn: 0.423 ± 0.014	1.077MetPro: 1.077 ± 0.023	0.424MetGln: 0.424 ± 0.012	1.449MetArg: 1.449 ± 0.023	1.283MetSer: 1.283 ± 0.024	1.555MetThr: 1.555 ± 0.03	1.218MetVal: 1.218 ± 0.023	0.207MetTrp: 0.207 ± 0.009	0.294MetTyr: 0.294 ± 0.012	0.0MetXaa: 0.0 ± 0.0
Asn	2.05AsnAla: 2.05 ± 0.033	0.161AsnCys: 0.161 ± 0.009	0.915AsnAsp: 0.915 ± 0.023	0.83AsnGlu: 0.83 ± 0.022	0.425AsnPhe: 0.425 ± 0.015	1.799AsnGly: 1.799 ± 0.035	0.394AsnHis: 0.394 ± 0.013	0.566AsnIle: 0.566 ± 0.02	0.359AsnLys: 0.359 ± 0.015	1.534AsnLeu: 1.534 ± 0.034	0.275AsnMet: 0.275 ± 0.012	0.367AsnAsn: 0.367 ± 0.015	1.282AsnPro: 1.282 ± 0.03	0.469AsnGln: 0.469 ± 0.017	1.334AsnArg: 1.334 ± 0.024	0.85AsnSer: 0.85 ± 0.021	1.066AsnThr: 1.066 ± 0.027	1.284AsnVal: 1.284 ± 0.029	0.274AsnTrp: 0.274 ± 0.011	0.377AsnTyr: 0.377 ± 0.015	0.0AsnXaa: 0.0 ± 0.0
Pro	9.362ProAla: 9.362 ± 0.097	0.411ProCys: 0.411 ± 0.014	4.695ProAsp: 4.695 ± 0.057	4.462ProGlu: 4.462 ± 0.049	1.552ProPhe: 1.552 ± 0.029	7.385ProGly: 7.385 ± 0.083	1.532ProHis: 1.532 ± 0.029	1.067ProIle: 1.067 ± 0.022	1.095ProLys: 1.095 ± 0.027	5.402ProLeu: 5.402 ± 0.065	0.975ProMet: 0.975 ± 0.022	0.833ProAsn: 0.833 ± 0.024	3.964ProPro: 3.964 ± 0.074	1.796ProGln: 1.796 ± 0.037	4.393ProArg: 4.393 ± 0.061	3.38ProSer: 3.38 ± 0.049	3.153ProThr: 3.153 ± 0.038	5.866ProVal: 5.866 ± 0.057	0.894ProTrp: 0.894 ± 0.021	1.319ProTyr: 1.319 ± 0.027	0.0ProXaa: 0.0 ± 0.0
Gln	3.719GlnAla: 3.719 ± 0.047	0.18GlnCys: 0.18 ± 0.009	1.511GlnAsp: 1.511 ± 0.029	1.572GlnGlu: 1.572 ± 0.025	0.611GlnPhe: 0.611 ± 0.017	2.336GlnGly: 2.336 ± 0.039	0.709GlnHis: 0.709 ± 0.019	0.956GlnIle: 0.956 ± 0.02	0.583GlnLys: 0.583 ± 0.017	2.82GlnLeu: 2.82 ± 0.042	0.48GlnMet: 0.48 ± 0.016	0.486GlnAsn: 0.486 ± 0.019	1.726GlnPro: 1.726 ± 0.039	1.3GlnGln: 1.3 ± 0.033	2.442GlnArg: 2.442 ± 0.035	1.227GlnSer: 1.227 ± 0.03	1.284GlnThr: 1.284 ± 0.026	2.372GlnVal: 2.372 ± 0.036	0.445GlnTrp: 0.445 ± 0.014	0.571GlnTyr: 0.571 ± 0.018	0.0GlnXaa: 0.0 ± 0.0
Arg	10.447ArgAla: 10.447 ± 0.095	0.704ArgCys: 0.704 ± 0.021	4.543ArgAsp: 4.543 ± 0.057	5.046ArgGlu: 5.046 ± 0.062	2.366ArgPhe: 2.366 ± 0.036	6.452ArgGly: 6.452 ± 0.066	2.346ArgHis: 2.346 ± 0.037	3.175ArgIle: 3.175 ± 0.043	1.638ArgLys: 1.638 ± 0.031	9.275ArgLeu: 9.275 ± 0.081	1.822ArgMet: 1.822 ± 0.032	1.332ArgAsn: 1.332 ± 0.024	5.65ArgPro: 5.65 ± 0.08	2.453ArgGln: 2.453 ± 0.04	8.579ArgArg: 8.579 ± 0.107	4.343ArgSer: 4.343 ± 0.055	5.952ArgThr: 5.952 ± 0.066	6.166ArgVal: 6.166 ± 0.06	1.388ArgTrp: 1.388 ± 0.031	1.83ArgTyr: 1.83 ± 0.027	0.0ArgXaa: 0.0 ± 0.0
Ser	6.713SerAla: 6.713 ± 0.059	0.413SerCys: 0.413 ± 0.014	2.655SerAsp: 2.655 ± 0.037	2.447SerGlu: 2.447 ± 0.038	1.443SerPhe: 1.443 ± 0.029	6.073SerGly: 6.073 ± 0.062	1.053SerHis: 1.053 ± 0.024	1.253SerIle: 1.253 ± 0.026	0.926SerLys: 0.926 ± 0.024	4.734SerLeu: 4.734 ± 0.051	1.027SerMet: 1.027 ± 0.02	0.822SerAsn: 0.822 ± 0.024	3.285SerPro: 3.285 ± 0.047	1.179SerGln: 1.179 ± 0.027	3.948SerArg: 3.948 ± 0.045	2.911SerSer: 2.911 ± 0.05	2.999SerThr: 2.999 ± 0.044	4.308SerVal: 4.308 ± 0.046	0.858SerTrp: 0.858 ± 0.021	1.093SerTyr: 1.093 ± 0.021	0.0SerXaa: 0.0 ± 0.0
Thr	9.022ThrAla: 9.022 ± 0.079	0.458ThrCys: 0.458 ± 0.015	3.796ThrAsp: 3.796 ± 0.047	3.389ThrGlu: 3.389 ± 0.041	1.508ThrPhe: 1.508 ± 0.028	7.193ThrGly: 7.193 ± 0.072	1.259ThrHis: 1.259 ± 0.022	1.468ThrIle: 1.468 ± 0.028	1.047ThrLys: 1.047 ± 0.026	5.641ThrLeu: 5.641 ± 0.057	0.936ThrMet: 0.936 ± 0.021	0.926ThrAsn: 0.926 ± 0.021	4.259ThrPro: 4.259 ± 0.053	1.289ThrGln: 1.289 ± 0.025	4.263ThrArg: 4.263 ± 0.043	3.138ThrSer: 3.138 ± 0.04	3.84ThrThr: 3.84 ± 0.053	6.169ThrVal: 6.169 ± 0.066	0.882ThrTrp: 0.882 ± 0.021	1.279ThrTyr: 1.279 ± 0.027	0.002ThrXaa: 0.002 ± 0.001
Val	10.337ValAla: 10.337 ± 0.088	0.781ValCys: 0.781 ± 0.019	5.085ValAsp: 5.085 ± 0.052	4.885ValGlu: 4.885 ± 0.056	2.354ValPhe: 2.354 ± 0.039	6.527ValGly: 6.527 ± 0.071	2.108ValHis: 2.108 ± 0.029	2.579ValIle: 2.579 ± 0.041	1.627ValLys: 1.627 ± 0.034	9.611ValLeu: 9.611 ± 0.077	1.378ValMet: 1.378 ± 0.029	1.571ValAsn: 1.571 ± 0.03	5.627ValPro: 5.627 ± 0.057	2.035ValGln: 2.035 ± 0.034	7.691ValArg: 7.691 ± 0.072	4.204ValSer: 4.204 ± 0.048	5.662ValThr: 5.662 ± 0.062	8.125ValVal: 8.125 ± 0.088	1.147ValTrp: 1.147 ± 0.025	1.503ValTyr: 1.503 ± 0.024	0.0ValXaa: 0.0 ± 0.0
Trp	1.624TrpAla: 1.624 ± 0.033	0.17TrpCys: 0.17 ± 0.01	0.786TrpAsp: 0.786 ± 0.019	0.706TrpGlu: 0.706 ± 0.019	0.477TrpPhe: 0.477 ± 0.016	1.016TrpGly: 1.016 ± 0.026	0.361TrpHis: 0.361 ± 0.014	0.502TrpIle: 0.502 ± 0.015	0.346TrpLys: 0.346 ± 0.013	1.704TrpLeu: 1.704 ± 0.031	0.286TrpMet: 0.286 ± 0.01	0.382TrpAsn: 0.382 ± 0.015	0.778TrpPro: 0.778 ± 0.021	0.604TrpGln: 0.604 ± 0.017	1.329TrpArg: 1.329 ± 0.024	0.889TrpSer: 0.889 ± 0.022	0.996TrpThr: 0.996 ± 0.025	0.918TrpVal: 0.918 ± 0.022	0.332TrpTrp: 0.332 ± 0.014	0.343TrpTyr: 0.343 ± 0.013	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.595TyrAla: 2.595 ± 0.032	0.171TyrCys: 0.171 ± 0.009	1.451TyrAsp: 1.451 ± 0.033	1.234TyrGlu: 1.234 ± 0.026	0.573TyrPhe: 0.573 ± 0.018	2.158TyrGly: 2.158 ± 0.035	0.361TyrHis: 0.361 ± 0.015	0.441TyrIle: 0.441 ± 0.015	0.359TyrLys: 0.359 ± 0.015	1.945TyrLeu: 1.945 ± 0.03	0.241TyrMet: 0.241 ± 0.012	0.347TyrAsn: 0.347 ± 0.013	1.016TyrPro: 1.016 ± 0.025	0.538TyrGln: 0.538 ± 0.016	1.791TyrArg: 1.791 ± 0.031	0.875TyrSer: 0.875 ± 0.021	1.097TyrThr: 1.097 ± 0.024	1.618TyrVal: 1.618 ± 0.03	0.32TyrTrp: 0.32 ± 0.012	0.389TyrTyr: 0.389 ± 0.014	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.001XaaAla: 0.001 ± 0.001	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.001	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.001XaaIle: 0.001 ± 0.001	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.004XaaXaa: 0.004 ± 0.004

Statistics based on 6655 proteins (2175375 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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