Amino acid dipepetide frequency for Salmonella enterica subsp. arizonae

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	9.779AlaAla: 9.779 ± 0.115	1.252AlaCys: 1.252 ± 0.036	4.914AlaAsp: 4.914 ± 0.066	5.433AlaGlu: 5.433 ± 0.07	3.562AlaPhe: 3.562 ± 0.057	7.514AlaGly: 7.514 ± 0.088	1.874AlaHis: 1.874 ± 0.039	5.79AlaIle: 5.79 ± 0.066	3.902AlaLys: 3.902 ± 0.064	11.439AlaLeu: 11.439 ± 0.123	3.067AlaMet: 3.067 ± 0.054	3.105AlaAsn: 3.105 ± 0.05	3.695AlaPro: 3.695 ± 0.066	4.385AlaGln: 4.385 ± 0.071	5.641AlaArg: 5.641 ± 0.082	5.466AlaSer: 5.466 ± 0.076	4.936AlaThr: 4.936 ± 0.075	6.465AlaVal: 6.465 ± 0.078	1.648AlaTrp: 1.648 ± 0.036	2.009AlaTyr: 2.009 ± 0.046	0.0AlaXaa: 0.0 ± 0.0
Cys	1.117CysAla: 1.117 ± 0.028	0.216CysCys: 0.216 ± 0.015	0.653CysAsp: 0.653 ± 0.025	0.648CysGlu: 0.648 ± 0.025	0.479CysPhe: 0.479 ± 0.02	1.152CysGly: 1.152 ± 0.03	0.353CysHis: 0.353 ± 0.018	0.655CysIle: 0.655 ± 0.024	0.383CysLys: 0.383 ± 0.018	1.125CysLeu: 1.125 ± 0.033	0.315CysMet: 0.315 ± 0.017	0.353CysAsn: 0.353 ± 0.018	0.576CysPro: 0.576 ± 0.024	0.503CysGln: 0.503 ± 0.022	0.845CysArg: 0.845 ± 0.027	0.77CysSer: 0.77 ± 0.027	0.523CysThr: 0.523 ± 0.018	0.791CysVal: 0.791 ± 0.026	0.275CysTrp: 0.275 ± 0.014	0.369CysTyr: 0.369 ± 0.017	0.0CysXaa: 0.0 ± 0.0
Asp	5.268AspAla: 5.268 ± 0.072	0.522AspCys: 0.522 ± 0.021	2.946AspAsp: 2.946 ± 0.06	3.438AspGlu: 3.438 ± 0.065	2.002AspPhe: 2.002 ± 0.04	3.762AspGly: 3.762 ± 0.074	0.994AspHis: 0.994 ± 0.03	3.597AspIle: 3.597 ± 0.059	2.588AspLys: 2.588 ± 0.051	4.506AspLeu: 4.506 ± 0.061	1.382AspMet: 1.382 ± 0.031	2.385AspAsn: 2.385 ± 0.056	2.186AspPro: 2.186 ± 0.041	1.417AspGln: 1.417 ± 0.032	2.55AspArg: 2.55 ± 0.052	2.874AspSer: 2.874 ± 0.057	2.692AspThr: 2.692 ± 0.077	3.737AspVal: 3.737 ± 0.064	0.843AspTrp: 0.843 ± 0.026	1.885AspTyr: 1.885 ± 0.039	0.0AspXaa: 0.0 ± 0.0
Glu	5.106GluAla: 5.106 ± 0.079	0.528GluCys: 0.528 ± 0.022	2.336GluAsp: 2.336 ± 0.049	3.296GluGlu: 3.296 ± 0.068	1.774GluPhe: 1.774 ± 0.042	3.574GluGly: 3.574 ± 0.058	1.361GluHis: 1.361 ± 0.038	3.281GluIle: 3.281 ± 0.062	3.383GluLys: 3.383 ± 0.062	5.672GluLeu: 5.672 ± 0.067	1.806GluMet: 1.806 ± 0.039	2.495GluAsn: 2.495 ± 0.045	2.053GluPro: 2.053 ± 0.04	3.171GluGln: 3.171 ± 0.063	3.668GluArg: 3.668 ± 0.062	2.958GluSer: 2.958 ± 0.054	2.993GluThr: 2.993 ± 0.05	3.549GluVal: 3.549 ± 0.063	0.747GluTrp: 0.747 ± 0.025	1.58GluTyr: 1.58 ± 0.033	0.0GluXaa: 0.0 ± 0.0
Phe	3.584PheAla: 3.584 ± 0.058	0.616PheCys: 0.616 ± 0.023	2.249PheAsp: 2.249 ± 0.046	1.701PheGlu: 1.701 ± 0.042	1.777PhePhe: 1.777 ± 0.053	2.99PheGly: 2.99 ± 0.055	0.848PheHis: 0.848 ± 0.026	2.648PheIle: 2.648 ± 0.053	1.271PheLys: 1.271 ± 0.03	3.381PheLeu: 3.381 ± 0.062	1.042PheMet: 1.042 ± 0.033	1.742PheAsn: 1.742 ± 0.036	1.519PhePro: 1.519 ± 0.034	1.068PheGln: 1.068 ± 0.028	2.038PheArg: 2.038 ± 0.042	3.118PheSer: 3.118 ± 0.049	2.573PheThr: 2.573 ± 0.055	2.403PheVal: 2.403 ± 0.039	0.652PheTrp: 0.652 ± 0.024	1.224PheTyr: 1.224 ± 0.031	0.0PheXaa: 0.0 ± 0.0
Gly	6.145GlyAla: 6.145 ± 0.089	1.088GlyCys: 1.088 ± 0.032	3.722GlyAsp: 3.722 ± 0.065	4.416GlyGlu: 4.416 ± 0.059	3.09GlyPhe: 3.09 ± 0.05	5.262GlyGly: 5.262 ± 0.075	1.619GlyHis: 1.619 ± 0.037	4.97GlyIle: 4.97 ± 0.067	3.961GlyLys: 3.961 ± 0.063	7.14GlyLeu: 7.14 ± 0.097	2.404GlyMet: 2.404 ± 0.04	2.932GlyAsn: 2.932 ± 0.07	1.978GlyPro: 1.978 ± 0.043	2.813GlyGln: 2.813 ± 0.049	3.947GlyArg: 3.947 ± 0.06	3.944GlySer: 3.944 ± 0.056	3.687GlyThr: 3.687 ± 0.068	5.728GlyVal: 5.728 ± 0.067	1.328GlyTrp: 1.328 ± 0.029	2.614GlyTyr: 2.614 ± 0.049	0.0GlyXaa: 0.0 ± 0.0
His	1.872HisAla: 1.872 ± 0.042	0.35HisCys: 0.35 ± 0.017	1.194HisAsp: 1.194 ± 0.028	1.122HisGlu: 1.122 ± 0.032	1.089HisPhe: 1.089 ± 0.03	1.714HisGly: 1.714 ± 0.035	0.796HisHis: 0.796 ± 0.026	1.418HisIle: 1.418 ± 0.031	0.767HisLys: 0.767 ± 0.026	2.245HisLeu: 2.245 ± 0.045	0.612HisMet: 0.612 ± 0.023	0.9HisAsn: 0.9 ± 0.028	1.337HisPro: 1.337 ± 0.03	1.155HisGln: 1.155 ± 0.031	1.272HisArg: 1.272 ± 0.034	1.261HisSer: 1.261 ± 0.034	1.125HisThr: 1.125 ± 0.03	1.309HisVal: 1.309 ± 0.031	0.397HisTrp: 0.397 ± 0.019	0.991HisTyr: 0.991 ± 0.028	0.0HisXaa: 0.0 ± 0.0
Ile	6.451IleAla: 6.451 ± 0.08	0.776IleCys: 0.776 ± 0.024	3.504IleAsp: 3.504 ± 0.069	3.241IleGlu: 3.241 ± 0.06	2.153IlePhe: 2.153 ± 0.045	4.44IleGly: 4.44 ± 0.075	1.241IleHis: 1.241 ± 0.03	3.676IleIle: 3.676 ± 0.063	2.439IleLys: 2.439 ± 0.039	5.168IleLeu: 5.168 ± 0.071	1.352IleMet: 1.352 ± 0.035	2.772IleAsn: 2.772 ± 0.054	2.756IlePro: 2.756 ± 0.044	1.863IleGln: 1.863 ± 0.04	3.123IleArg: 3.123 ± 0.05	3.904IleSer: 3.904 ± 0.059	3.752IleThr: 3.752 ± 0.07	4.06IleVal: 4.06 ± 0.062	0.788IleTrp: 0.788 ± 0.026	1.602IleTyr: 1.602 ± 0.032	0.0IleXaa: 0.0 ± 0.0
Lys	4.25LysAla: 4.25 ± 0.074	0.338LysCys: 0.338 ± 0.018	2.058LysAsp: 2.058 ± 0.049	2.54LysGlu: 2.54 ± 0.047	1.158LysPhe: 1.158 ± 0.033	2.979LysGly: 2.979 ± 0.053	0.907LysHis: 0.907 ± 0.026	2.495LysIle: 2.495 ± 0.046	2.379LysLys: 2.379 ± 0.046	4.266LysLeu: 4.266 ± 0.066	1.312LysMet: 1.312 ± 0.034	1.9LysAsn: 1.9 ± 0.041	2.173LysPro: 2.173 ± 0.045	1.858LysGln: 1.858 ± 0.039	2.745LysArg: 2.745 ± 0.048	2.373LysSer: 2.373 ± 0.042	2.71LysThr: 2.71 ± 0.05	2.865LysVal: 2.865 ± 0.048	0.474LysTrp: 0.474 ± 0.021	1.244LysTyr: 1.244 ± 0.033	0.0LysXaa: 0.0 ± 0.0
Leu	11.077LeuAla: 11.077 ± 0.107	1.338LeuCys: 1.338 ± 0.038	5.251LeuAsp: 5.251 ± 0.077	5.372LeuGlu: 5.372 ± 0.072	4.256LeuPhe: 4.256 ± 0.074	6.714LeuGly: 6.714 ± 0.081	2.301LeuHis: 2.301 ± 0.041	5.853LeuIle: 5.853 ± 0.073	4.621LeuLys: 4.621 ± 0.061	11.649LeuLeu: 11.649 ± 0.148	2.95LeuMet: 2.95 ± 0.055	4.356LeuAsn: 4.356 ± 0.069	5.766LeuPro: 5.766 ± 0.081	3.931LeuGln: 3.931 ± 0.066	6.375LeuArg: 6.375 ± 0.088	7.246LeuSer: 7.246 ± 0.079	6.61LeuThr: 6.61 ± 0.089	6.712LeuVal: 6.712 ± 0.081	1.474LeuTrp: 1.474 ± 0.033	2.67LeuTyr: 2.67 ± 0.047	0.0LeuXaa: 0.0 ± 0.0
Met	3.031MetAla: 3.031 ± 0.055	0.253MetCys: 0.253 ± 0.014	1.216MetAsp: 1.216 ± 0.031	1.295MetGlu: 1.295 ± 0.028	0.953MetPhe: 0.953 ± 0.031	1.988MetGly: 1.988 ± 0.045	0.564MetHis: 0.564 ± 0.02	1.525MetIle: 1.525 ± 0.035	1.465MetLys: 1.465 ± 0.037	3.248MetLeu: 3.248 ± 0.057	0.948MetMet: 0.948 ± 0.032	1.147MetAsn: 1.147 ± 0.032	1.467MetPro: 1.467 ± 0.039	1.252MetGln: 1.252 ± 0.033	1.626MetArg: 1.626 ± 0.035	1.9MetSer: 1.9 ± 0.044	1.838MetThr: 1.838 ± 0.039	2.035MetVal: 2.035 ± 0.043	0.293MetTrp: 0.293 ± 0.015	0.556MetTyr: 0.556 ± 0.02	0.0MetXaa: 0.0 ± 0.0
Asn	3.71AsnAla: 3.71 ± 0.057	0.391AsnCys: 0.391 ± 0.02	2.127AsnAsp: 2.127 ± 0.046	1.983AsnGlu: 1.983 ± 0.038	1.357AsnPhe: 1.357 ± 0.034	3.171AsnGly: 3.171 ± 0.066	0.902AsnHis: 0.902 ± 0.029	2.562AsnIle: 2.562 ± 0.057	1.633AsnLys: 1.633 ± 0.038	3.555AsnLeu: 3.555 ± 0.053	0.997AsnMet: 0.997 ± 0.03	1.684AsnAsn: 1.684 ± 0.044	2.122AsnPro: 2.122 ± 0.043	1.579AsnGln: 1.579 ± 0.037	2.072AsnArg: 2.072 ± 0.039	2.128AsnSer: 2.128 ± 0.041	2.168AsnThr: 2.168 ± 0.047	2.666AsnVal: 2.666 ± 0.047	0.583AsnTrp: 0.583 ± 0.02	1.296AsnTyr: 1.296 ± 0.037	0.0AsnXaa: 0.0 ± 0.0
Pro	4.466ProAla: 4.466 ± 0.063	0.455ProCys: 0.455 ± 0.021	2.902ProAsp: 2.902 ± 0.047	3.359ProGlu: 3.359 ± 0.06	1.861ProPhe: 1.861 ± 0.042	3.579ProGly: 3.579 ± 0.058	1.038ProHis: 1.038 ± 0.028	1.884ProIle: 1.884 ± 0.041	1.522ProLys: 1.522 ± 0.04	5.13ProLeu: 5.13 ± 0.067	1.138ProMet: 1.138 ± 0.028	1.254ProAsn: 1.254 ± 0.035	1.828ProPro: 1.828 ± 0.042	2.183ProGln: 2.183 ± 0.05	2.075ProArg: 2.075 ± 0.047	2.159ProSer: 2.159 ± 0.044	2.204ProThr: 2.204 ± 0.045	3.972ProVal: 3.972 ± 0.063	0.76ProTrp: 0.76 ± 0.026	1.253ProTyr: 1.253 ± 0.036	0.0ProXaa: 0.0 ± 0.0
Gln	4.4GlnAla: 4.4 ± 0.072	0.411GlnCys: 0.411 ± 0.017	1.732GlnAsp: 1.732 ± 0.035	2.208GlnGlu: 2.208 ± 0.05	1.453GlnPhe: 1.453 ± 0.032	2.913GlnGly: 2.913 ± 0.051	1.191GlnHis: 1.191 ± 0.032	2.286GlnIle: 2.286 ± 0.038	1.844GlnLys: 1.844 ± 0.042	4.724GlnLeu: 4.724 ± 0.077	1.193GlnMet: 1.193 ± 0.032	1.522GlnAsn: 1.522 ± 0.038	2.083GlnPro: 2.083 ± 0.05	3.015GlnGln: 3.015 ± 0.066	2.943GlnArg: 2.943 ± 0.055	2.288GlnSer: 2.288 ± 0.045	2.303GlnThr: 2.303 ± 0.045	2.734GlnVal: 2.734 ± 0.05	0.697GlnTrp: 0.697 ± 0.023	1.223GlnTyr: 1.223 ± 0.034	0.0GlnXaa: 0.0 ± 0.0
Arg	4.661ArgAla: 4.661 ± 0.069	0.78ArgCys: 0.78 ± 0.029	3.009ArgAsp: 3.009 ± 0.047	3.772ArgGlu: 3.772 ± 0.064	2.644ArgPhe: 2.644 ± 0.045	3.346ArgGly: 3.346 ± 0.058	1.726ArgHis: 1.726 ± 0.041	3.394ArgIle: 3.394 ± 0.049	2.531ArgLys: 2.531 ± 0.046	6.663ArgLeu: 6.663 ± 0.077	1.863ArgMet: 1.863 ± 0.039	2.088ArgAsn: 2.088 ± 0.038	2.331ArgPro: 2.331 ± 0.045	3.2ArgGln: 3.2 ± 0.055	4.016ArgArg: 4.016 ± 0.066	2.888ArgSer: 2.888 ± 0.055	2.651ArgThr: 2.651 ± 0.051	3.771ArgVal: 3.771 ± 0.057	1.102ArgTrp: 1.102 ± 0.032	2.356ArgTyr: 2.356 ± 0.05	0.0ArgXaa: 0.0 ± 0.0
Ser	5.654SerAla: 5.654 ± 0.081	0.658SerCys: 0.658 ± 0.024	3.099SerAsp: 3.099 ± 0.055	3.111SerGlu: 3.111 ± 0.05	2.285SerPhe: 2.285 ± 0.044	5.337SerGly: 5.337 ± 0.079	1.432SerHis: 1.432 ± 0.032	3.09SerIle: 3.09 ± 0.056	2.017SerLys: 2.017 ± 0.045	6.702SerLeu: 6.702 ± 0.07	1.585SerMet: 1.585 ± 0.029	1.864SerAsn: 1.864 ± 0.042	2.693SerPro: 2.693 ± 0.049	2.489SerGln: 2.489 ± 0.041	3.584SerArg: 3.584 ± 0.049	3.505SerSer: 3.505 ± 0.064	3.045SerThr: 3.045 ± 0.052	4.263SerVal: 4.263 ± 0.059	1.011SerTrp: 1.011 ± 0.029	1.624SerTyr: 1.624 ± 0.037	0.0SerXaa: 0.0 ± 0.0
Thr	5.101ThrAla: 5.101 ± 0.071	0.603ThrCys: 0.603 ± 0.02	2.707ThrAsp: 2.707 ± 0.06	2.7ThrGlu: 2.7 ± 0.048	2.12ThrPhe: 2.12 ± 0.041	4.554ThrGly: 4.554 ± 0.072	1.318ThrHis: 1.318 ± 0.033	3.162ThrIle: 3.162 ± 0.06	1.588ThrLys: 1.588 ± 0.033	7.576ThrLeu: 7.576 ± 0.104	1.208ThrMet: 1.208 ± 0.03	1.7ThrAsn: 1.7 ± 0.052	3.411ThrPro: 3.411 ± 0.058	2.256ThrGln: 2.256 ± 0.044	3.167ThrArg: 3.167 ± 0.051	3.005ThrSer: 3.005 ± 0.063	3.012ThrThr: 3.012 ± 0.065	4.001ThrVal: 4.001 ± 0.096	0.867ThrTrp: 0.867 ± 0.028	1.267ThrTyr: 1.267 ± 0.035	0.0ThrXaa: 0.0 ± 0.0
Val	6.682ValAla: 6.682 ± 0.073	0.875ValCys: 0.875 ± 0.029	3.667ValAsp: 3.667 ± 0.062	3.83ValGlu: 3.83 ± 0.067	2.522ValPhe: 2.522 ± 0.049	4.651ValGly: 4.651 ± 0.068	1.216ValHis: 1.216 ± 0.032	4.474ValIle: 4.474 ± 0.071	3.127ValLys: 3.127 ± 0.051	6.964ValLeu: 6.964 ± 0.085	2.215ValMet: 2.215 ± 0.044	2.878ValAsn: 2.878 ± 0.056	2.937ValPro: 2.937 ± 0.054	2.234ValGln: 2.234 ± 0.045	3.724ValArg: 3.724 ± 0.057	4.502ValSer: 4.502 ± 0.069	4.311ValThr: 4.311 ± 0.085	5.41ValVal: 5.41 ± 0.079	1.03ValTrp: 1.03 ± 0.027	1.788ValTyr: 1.788 ± 0.04	0.0ValXaa: 0.0 ± 0.0
Trp	1.039TrpAla: 1.039 ± 0.03	0.215TrpCys: 0.215 ± 0.014	0.613TrpAsp: 0.613 ± 0.026	0.612TrpGlu: 0.612 ± 0.024	0.686TrpPhe: 0.686 ± 0.027	0.901TrpGly: 0.901 ± 0.031	0.478TrpHis: 0.478 ± 0.02	0.8TrpIle: 0.8 ± 0.025	0.578TrpLys: 0.578 ± 0.02	2.321TrpLeu: 2.321 ± 0.047	0.518TrpMet: 0.518 ± 0.02	0.507TrpAsn: 0.507 ± 0.019	0.704TrpPro: 0.704 ± 0.025	1.171TrpGln: 1.171 ± 0.032	1.388TrpArg: 1.388 ± 0.038	0.9TrpSer: 0.9 ± 0.03	0.633TrpThr: 0.633 ± 0.023	0.926TrpVal: 0.926 ± 0.033	0.271TrpTrp: 0.271 ± 0.014	0.448TrpTyr: 0.448 ± 0.019	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.483TyrAla: 2.483 ± 0.042	0.437TyrCys: 0.437 ± 0.019	1.675TyrAsp: 1.675 ± 0.044	1.255TyrGlu: 1.255 ± 0.033	1.223TyrPhe: 1.223 ± 0.032	2.247TyrGly: 2.247 ± 0.043	0.768TyrHis: 0.768 ± 0.025	1.502TyrIle: 1.502 ± 0.04	1.025TyrLys: 1.025 ± 0.028	3.052TyrLeu: 3.052 ± 0.049	0.694TyrMet: 0.694 ± 0.023	1.101TyrAsn: 1.101 ± 0.028	1.404TyrPro: 1.404 ± 0.03	1.618TyrGln: 1.618 ± 0.036	1.993TyrArg: 1.993 ± 0.038	1.858TyrSer: 1.858 ± 0.045	1.557TyrThr: 1.557 ± 0.039	1.64TyrVal: 1.64 ± 0.04	0.467TyrTrp: 0.467 ± 0.022	0.986TyrTyr: 0.986 ± 0.027	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 5445 proteins (1271038 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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