Amino acid dipepetide frequency for Pelobacter propionicus (strain DSM 2379 / NBRC 103807 / OttBd1)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	10.051AlaAla: 10.051 ± 0.111	1.354AlaCys: 1.354 ± 0.037	4.894AlaAsp: 4.894 ± 0.066	6.114AlaGlu: 6.114 ± 0.072	3.336AlaPhe: 3.336 ± 0.051	7.949AlaGly: 7.949 ± 0.087	1.704AlaHis: 1.704 ± 0.034	5.453AlaIle: 5.453 ± 0.085	3.379AlaLys: 3.379 ± 0.064	10.232AlaLeu: 10.232 ± 0.101	2.77AlaMet: 2.77 ± 0.047	2.477AlaAsn: 2.477 ± 0.057	3.653AlaPro: 3.653 ± 0.064	2.688AlaGln: 2.688 ± 0.05	6.347AlaArg: 6.347 ± 0.083	5.401AlaSer: 5.401 ± 0.078	4.976AlaThr: 4.976 ± 0.086	6.664AlaVal: 6.664 ± 0.084	1.002AlaTrp: 1.002 ± 0.032	2.143AlaTyr: 2.143 ± 0.044	0.0AlaXaa: 0.0 ± 0.0
Cys	1.2CysAla: 1.2 ± 0.032	0.309CysCys: 0.309 ± 0.019	0.745CysAsp: 0.745 ± 0.024	0.62CysGlu: 0.62 ± 0.026	0.62CysPhe: 0.62 ± 0.025	1.443CysGly: 1.443 ± 0.041	0.42CysHis: 0.42 ± 0.032	0.659CysIle: 0.659 ± 0.025	0.389CysLys: 0.389 ± 0.018	1.379CysLeu: 1.379 ± 0.035	0.324CysMet: 0.324 ± 0.017	0.423CysAsn: 0.423 ± 0.02	0.761CysPro: 0.761 ± 0.03	0.442CysGln: 0.442 ± 0.019	1.031CysArg: 1.031 ± 0.029	1.004CysSer: 1.004 ± 0.034	0.589CysThr: 0.589 ± 0.023	0.812CysVal: 0.812 ± 0.029	0.162CysTrp: 0.162 ± 0.011	0.403CysTyr: 0.403 ± 0.019	0.0CysXaa: 0.0 ± 0.0
Asp	4.614AspAla: 4.614 ± 0.072	0.718AspCys: 0.718 ± 0.024	2.931AspAsp: 2.931 ± 0.066	3.511AspGlu: 3.511 ± 0.059	2.278AspPhe: 2.278 ± 0.046	4.163AspGly: 4.163 ± 0.082	1.04AspHis: 1.04 ± 0.031	3.46AspIle: 3.46 ± 0.064	1.976AspLys: 1.976 ± 0.046	5.504AspLeu: 5.504 ± 0.076	1.391AspMet: 1.391 ± 0.039	1.747AspAsn: 1.747 ± 0.044	2.538AspPro: 2.538 ± 0.052	1.752AspGln: 1.752 ± 0.042	3.621AspArg: 3.621 ± 0.059	3.179AspSer: 3.179 ± 0.052	2.595AspThr: 2.595 ± 0.076	3.395AspVal: 3.395 ± 0.057	0.561AspTrp: 0.561 ± 0.024	1.68AspTyr: 1.68 ± 0.04	0.0AspXaa: 0.0 ± 0.0
Glu	5.67GluAla: 5.67 ± 0.085	0.734GluCys: 0.734 ± 0.025	2.476GluAsp: 2.476 ± 0.047	4.762GluGlu: 4.762 ± 0.082	2.127GluPhe: 2.127 ± 0.045	4.269GluGly: 4.269 ± 0.072	1.277GluHis: 1.277 ± 0.033	4.184GluIle: 4.184 ± 0.067	3.682GluLys: 3.682 ± 0.064	7.313GluLeu: 7.313 ± 0.093	1.916GluMet: 1.916 ± 0.039	2.223GluAsn: 2.223 ± 0.046	2.225GluPro: 2.225 ± 0.05	3.061GluGln: 3.061 ± 0.052	5.364GluArg: 5.364 ± 0.092	3.524GluSer: 3.524 ± 0.054	3.503GluThr: 3.503 ± 0.062	3.825GluVal: 3.825 ± 0.057	0.664GluTrp: 0.664 ± 0.023	1.813GluTyr: 1.813 ± 0.036	0.0GluXaa: 0.0 ± 0.0
Phe	3.178PheAla: 3.178 ± 0.06	0.666PheCys: 0.666 ± 0.024	2.329PheAsp: 2.329 ± 0.048	1.985PheGlu: 1.985 ± 0.041	1.839PhePhe: 1.839 ± 0.046	3.204PheGly: 3.204 ± 0.048	0.871PheHis: 0.871 ± 0.03	2.203PheIle: 2.203 ± 0.045	1.442PheLys: 1.442 ± 0.035	3.905PheLeu: 3.905 ± 0.066	1.021PheMet: 1.021 ± 0.029	1.401PheAsn: 1.401 ± 0.037	1.789PhePro: 1.789 ± 0.049	1.223PheGln: 1.223 ± 0.031	2.678PheArg: 2.678 ± 0.054	3.237PheSer: 3.237 ± 0.057	2.17PheThr: 2.17 ± 0.044	2.572PheVal: 2.572 ± 0.048	0.452PheTrp: 0.452 ± 0.018	1.11PheTyr: 1.11 ± 0.033	0.0PheXaa: 0.0 ± 0.0
Gly	6.461GlyAla: 6.461 ± 0.089	1.284GlyCys: 1.284 ± 0.034	4.081GlyAsp: 4.081 ± 0.073	5.198GlyGlu: 5.198 ± 0.076	3.315GlyPhe: 3.315 ± 0.06	6.356GlyGly: 6.356 ± 0.121	1.627GlyHis: 1.627 ± 0.04	5.321GlyIle: 5.321 ± 0.07	4.057GlyLys: 4.057 ± 0.067	7.336GlyLeu: 7.336 ± 0.078	2.481GlyMet: 2.481 ± 0.047	2.689GlyAsn: 2.689 ± 0.087	2.121GlyPro: 2.121 ± 0.044	2.56GlyGln: 2.56 ± 0.055	5.372GlyArg: 5.372 ± 0.07	4.738GlySer: 4.738 ± 0.064	4.273GlyThr: 4.273 ± 0.068	5.796GlyVal: 5.796 ± 0.08	0.949GlyTrp: 0.949 ± 0.032	2.569GlyTyr: 2.569 ± 0.053	0.0GlyXaa: 0.0 ± 0.0
His	1.766HisAla: 1.766 ± 0.039	0.367HisCys: 0.367 ± 0.018	1.29HisAsp: 1.29 ± 0.036	1.2HisGlu: 1.2 ± 0.032	0.88HisPhe: 0.88 ± 0.026	1.815HisGly: 1.815 ± 0.039	0.556HisHis: 0.556 ± 0.023	1.121HisIle: 1.121 ± 0.032	0.632HisLys: 0.632 ± 0.024	2.246HisLeu: 2.246 ± 0.051	0.436HisMet: 0.436 ± 0.018	0.716HisAsn: 0.716 ± 0.024	1.346HisPro: 1.346 ± 0.033	0.723HisGln: 0.723 ± 0.023	1.371HisArg: 1.371 ± 0.035	1.147HisSer: 1.147 ± 0.033	1.012HisThr: 1.012 ± 0.027	1.226HisVal: 1.226 ± 0.029	0.239HisTrp: 0.239 ± 0.014	0.636HisTyr: 0.636 ± 0.022	0.0HisXaa: 0.0 ± 0.0
Ile	5.711IleAla: 5.711 ± 0.077	0.826IleCys: 0.826 ± 0.028	3.465IleAsp: 3.465 ± 0.064	3.427IleGlu: 3.427 ± 0.056	2.169IlePhe: 2.169 ± 0.041	4.496IleGly: 4.496 ± 0.063	1.288IleHis: 1.288 ± 0.036	3.579IleIle: 3.579 ± 0.06	2.39IleLys: 2.39 ± 0.052	5.504IleLeu: 5.504 ± 0.07	1.418IleMet: 1.418 ± 0.035	2.135IleAsn: 2.135 ± 0.041	3.238IlePro: 3.238 ± 0.05	1.886IleGln: 1.886 ± 0.04	4.198IleArg: 4.198 ± 0.064	4.2IleSer: 4.2 ± 0.061	3.517IleThr: 3.517 ± 0.063	4.174IleVal: 4.174 ± 0.064	0.5IleTrp: 0.5 ± 0.025	1.468IleTyr: 1.468 ± 0.035	0.0IleXaa: 0.0 ± 0.0
Lys	3.709LysAla: 3.709 ± 0.07	0.387LysCys: 0.387 ± 0.019	2.039LysAsp: 2.039 ± 0.043	2.942LysGlu: 2.942 ± 0.056	1.167LysPhe: 1.167 ± 0.027	3.258LysGly: 3.258 ± 0.059	0.759LysHis: 0.759 ± 0.028	2.711LysIle: 2.711 ± 0.055	2.763LysLys: 2.763 ± 0.063	4.117LysLeu: 4.117 ± 0.07	1.164LysMet: 1.164 ± 0.03	1.696LysAsn: 1.696 ± 0.043	2.033LysPro: 2.033 ± 0.042	1.698LysGln: 1.698 ± 0.043	3.087LysArg: 3.087 ± 0.058	2.711LysSer: 2.711 ± 0.049	2.376LysThr: 2.376 ± 0.05	2.785LysVal: 2.785 ± 0.061	0.383LysTrp: 0.383 ± 0.017	1.069LysTyr: 1.069 ± 0.032	0.0LysXaa: 0.0 ± 0.0
Leu	10.913LeuAla: 10.913 ± 0.133	1.389LeuCys: 1.389 ± 0.037	5.584LeuAsp: 5.584 ± 0.076	6.997LeuGlu: 6.997 ± 0.094	4.566LeuPhe: 4.566 ± 0.072	7.517LeuGly: 7.517 ± 0.081	2.101LeuHis: 2.101 ± 0.039	5.384LeuIle: 5.384 ± 0.067	5.043LeuLys: 5.043 ± 0.078	12.147LeuLeu: 12.147 ± 0.136	2.537LeuMet: 2.537 ± 0.05	3.345LeuAsn: 3.345 ± 0.06	5.27LeuPro: 5.27 ± 0.071	3.178LeuGln: 3.178 ± 0.059	6.911LeuArg: 6.911 ± 0.1	7.064LeuSer: 7.064 ± 0.08	5.517LeuThr: 5.517 ± 0.068	7.411LeuVal: 7.411 ± 0.08	0.899LeuTrp: 0.899 ± 0.028	2.559LeuTyr: 2.559 ± 0.053	0.0LeuXaa: 0.0 ± 0.0
Met	2.904MetAla: 2.904 ± 0.048	0.205MetCys: 0.205 ± 0.012	1.379MetAsp: 1.379 ± 0.035	1.873MetGlu: 1.873 ± 0.039	0.773MetPhe: 0.773 ± 0.029	2.03MetGly: 2.03 ± 0.047	0.464MetHis: 0.464 ± 0.021	1.434MetIle: 1.434 ± 0.036	1.499MetLys: 1.499 ± 0.036	2.752MetLeu: 2.752 ± 0.058	0.627MetMet: 0.627 ± 0.022	1.027MetAsn: 1.027 ± 0.028	1.285MetPro: 1.285 ± 0.033	0.859MetGln: 0.859 ± 0.028	1.588MetArg: 1.588 ± 0.034	1.486MetSer: 1.486 ± 0.033	1.564MetThr: 1.564 ± 0.038	1.951MetVal: 1.951 ± 0.043	0.156MetTrp: 0.156 ± 0.012	0.46MetTyr: 0.46 ± 0.021	0.0MetXaa: 0.0 ± 0.0
Asn	2.675AsnAla: 2.675 ± 0.052	0.442AsnCys: 0.442 ± 0.02	1.833AsnAsp: 1.833 ± 0.073	1.671AsnGlu: 1.671 ± 0.04	1.074AsnPhe: 1.074 ± 0.029	2.652AsnGly: 2.652 ± 0.059	0.676AsnHis: 0.676 ± 0.025	2.214AsnIle: 2.214 ± 0.05	1.211AsnLys: 1.211 ± 0.037	3.598AsnLeu: 3.598 ± 0.062	0.767AsnMet: 0.767 ± 0.026	1.265AsnAsn: 1.265 ± 0.046	1.966AsnPro: 1.966 ± 0.044	1.133AsnGln: 1.133 ± 0.035	2.498AsnArg: 2.498 ± 0.048	2.0AsnSer: 2.0 ± 0.051	1.44AsnThr: 1.44 ± 0.036	2.098AsnVal: 2.098 ± 0.055	0.361AsnTrp: 0.361 ± 0.019	0.939AsnTyr: 0.939 ± 0.03	0.0AsnXaa: 0.0 ± 0.0
Pro	4.373ProAla: 4.373 ± 0.065	0.564ProCys: 0.564 ± 0.023	2.941ProAsp: 2.941 ± 0.049	3.623ProGlu: 3.623 ± 0.057	2.027ProPhe: 2.027 ± 0.044	3.746ProGly: 3.746 ± 0.062	1.057ProHis: 1.057 ± 0.029	1.877ProIle: 1.877 ± 0.047	1.466ProLys: 1.466 ± 0.039	5.213ProLeu: 5.213 ± 0.08	0.971ProMet: 0.971 ± 0.031	1.12ProAsn: 1.12 ± 0.029	2.397ProPro: 2.397 ± 0.059	1.586ProGln: 1.586 ± 0.038	2.593ProArg: 2.593 ± 0.05	2.619ProSer: 2.619 ± 0.046	2.085ProThr: 2.085 ± 0.044	3.49ProVal: 3.49 ± 0.065	0.537ProTrp: 0.537 ± 0.023	1.181ProTyr: 1.181 ± 0.032	0.0ProXaa: 0.0 ± 0.0
Gln	3.646GlnAla: 3.646 ± 0.063	0.367GlnCys: 0.367 ± 0.019	1.417GlnAsp: 1.417 ± 0.036	2.383GlnGlu: 2.383 ± 0.048	1.093GlnPhe: 1.093 ± 0.031	2.786GlnGly: 2.786 ± 0.054	0.675GlnHis: 0.675 ± 0.024	1.922GlnIle: 1.922 ± 0.045	1.641GlnLys: 1.641 ± 0.039	3.518GlnLeu: 3.518 ± 0.056	0.88GlnMet: 0.88 ± 0.026	1.051GlnAsn: 1.051 ± 0.028	1.448GlnPro: 1.448 ± 0.04	1.537GlnGln: 1.537 ± 0.039	2.549GlnArg: 2.549 ± 0.054	1.785GlnSer: 1.785 ± 0.042	1.58GlnThr: 1.58 ± 0.041	2.561GlnVal: 2.561 ± 0.047	0.37GlnTrp: 0.37 ± 0.02	0.813GlnTyr: 0.813 ± 0.027	0.0GlnXaa: 0.0 ± 0.0
Arg	5.197ArgAla: 5.197 ± 0.082	0.861ArgCys: 0.861 ± 0.03	3.734ArgAsp: 3.734 ± 0.061	5.551ArgGlu: 5.551 ± 0.083	3.06ArgPhe: 3.06 ± 0.059	4.711ArgGly: 4.711 ± 0.074	1.717ArgHis: 1.717 ± 0.039	4.782ArgIle: 4.782 ± 0.069	2.999ArgLys: 2.999 ± 0.054	7.735ArgLeu: 7.735 ± 0.114	2.01ArgMet: 2.01 ± 0.047	2.307ArgAsn: 2.307 ± 0.045	2.59ArgPro: 2.59 ± 0.046	2.892ArgGln: 2.892 ± 0.054	5.042ArgArg: 5.042 ± 0.086	3.945ArgSer: 3.945 ± 0.062	3.111ArgThr: 3.111 ± 0.046	4.671ArgVal: 4.671 ± 0.072	0.749ArgTrp: 0.749 ± 0.026	1.974ArgTyr: 1.974 ± 0.038	0.0ArgXaa: 0.0 ± 0.0
Ser	5.537SerAla: 5.537 ± 0.08	0.983SerCys: 0.983 ± 0.032	3.172SerAsp: 3.172 ± 0.057	3.207SerGlu: 3.207 ± 0.052	2.78SerPhe: 2.78 ± 0.053	5.881SerGly: 5.881 ± 0.083	1.385SerHis: 1.385 ± 0.032	3.638SerIle: 3.638 ± 0.061	2.027SerLys: 2.027 ± 0.049	7.156SerLeu: 7.156 ± 0.074	1.576SerMet: 1.576 ± 0.038	1.711SerAsn: 1.711 ± 0.043	3.032SerPro: 3.032 ± 0.055	2.024SerGln: 2.024 ± 0.046	4.594SerArg: 4.594 ± 0.067	4.271SerSer: 4.271 ± 0.076	2.967SerThr: 2.967 ± 0.059	4.034SerVal: 4.034 ± 0.059	0.777SerTrp: 0.777 ± 0.026	1.743SerTyr: 1.743 ± 0.044	0.0SerXaa: 0.0 ± 0.0
Thr	5.126ThrAla: 5.126 ± 0.073	0.709ThrCys: 0.709 ± 0.025	2.495ThrAsp: 2.495 ± 0.05	2.845ThrGlu: 2.845 ± 0.054	1.945ThrPhe: 1.945 ± 0.04	4.654ThrGly: 4.654 ± 0.072	1.004ThrHis: 1.004 ± 0.03	3.363ThrIle: 3.363 ± 0.051	1.873ThrLys: 1.873 ± 0.048	5.751ThrLeu: 5.751 ± 0.073	1.258ThrMet: 1.258 ± 0.034	1.507ThrAsn: 1.507 ± 0.04	3.027ThrPro: 3.027 ± 0.06	1.341ThrGln: 1.341 ± 0.034	3.14ThrArg: 3.14 ± 0.053	3.157ThrSer: 3.157 ± 0.054	3.051ThrThr: 3.051 ± 0.06	4.112ThrVal: 4.112 ± 0.063	0.524ThrTrp: 0.524 ± 0.021	1.254ThrTyr: 1.254 ± 0.034	0.0ThrXaa: 0.0 ± 0.0
Val	6.952ValAla: 6.952 ± 0.085	0.976ValCys: 0.976 ± 0.026	3.711ValAsp: 3.711 ± 0.054	4.644ValGlu: 4.644 ± 0.065	2.628ValPhe: 2.628 ± 0.046	4.655ValGly: 4.655 ± 0.079	1.219ValHis: 1.219 ± 0.036	4.402ValIle: 4.402 ± 0.06	2.97ValLys: 2.97 ± 0.058	6.573ValLeu: 6.573 ± 0.089	2.01ValMet: 2.01 ± 0.043	2.32ValAsn: 2.32 ± 0.043	3.002ValPro: 3.002 ± 0.054	1.926ValGln: 1.926 ± 0.046	4.664ValArg: 4.664 ± 0.069	4.71ValSer: 4.71 ± 0.07	4.126ValThr: 4.126 ± 0.066	5.517ValVal: 5.517 ± 0.084	0.683ValTrp: 0.683 ± 0.027	1.68ValTyr: 1.68 ± 0.04	0.0ValXaa: 0.0 ± 0.0
Trp	0.7TrpAla: 0.7 ± 0.026	0.133TrpCys: 0.133 ± 0.011	0.542TrpAsp: 0.542 ± 0.021	0.638TrpGlu: 0.638 ± 0.026	0.455TrpPhe: 0.455 ± 0.02	0.781TrpGly: 0.781 ± 0.028	0.259TrpHis: 0.259 ± 0.015	0.55TrpIle: 0.55 ± 0.022	0.523TrpLys: 0.523 ± 0.023	1.255TrpLeu: 1.255 ± 0.039	0.269TrpMet: 0.269 ± 0.014	0.437TrpAsn: 0.437 ± 0.021	0.417TrpPro: 0.417 ± 0.019	0.528TrpGln: 0.528 ± 0.023	0.792TrpArg: 0.792 ± 0.027	0.638TrpSer: 0.638 ± 0.024	0.399TrpThr: 0.399 ± 0.018	0.644TrpVal: 0.644 ± 0.023	0.143TrpTrp: 0.143 ± 0.013	0.318TrpTyr: 0.318 ± 0.014	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.206TyrAla: 2.206 ± 0.046	0.461TyrCys: 0.461 ± 0.019	1.595TyrAsp: 1.595 ± 0.043	1.418TyrGlu: 1.418 ± 0.036	1.143TyrPhe: 1.143 ± 0.037	2.217TyrGly: 2.217 ± 0.044	0.624TyrHis: 0.624 ± 0.022	1.332TyrIle: 1.332 ± 0.037	0.894TyrLys: 0.894 ± 0.032	3.095TyrLeu: 3.095 ± 0.051	0.491TyrMet: 0.491 ± 0.021	0.915TyrAsn: 0.915 ± 0.03	1.329TyrPro: 1.329 ± 0.036	0.985TyrGln: 0.985 ± 0.029	2.199TyrArg: 2.199 ± 0.046	1.682TyrSer: 1.682 ± 0.043	1.285TyrThr: 1.285 ± 0.034	1.63TyrVal: 1.63 ± 0.036	0.308TyrTrp: 0.308 ± 0.015	0.878TyrTyr: 0.878 ± 0.029	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3694 proteins (1202724 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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