Amino acid dipepetide frequency for Alcaligenaceae bacterium 429

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	12.195AlaAla: 12.195 ± 0.151	1.093AlaCys: 1.093 ± 0.033	5.23AlaAsp: 5.23 ± 0.079	6.342AlaGlu: 6.342 ± 0.094	3.75AlaPhe: 3.75 ± 0.063	8.069AlaGly: 8.069 ± 0.091	2.238AlaHis: 2.238 ± 0.053	5.935AlaIle: 5.935 ± 0.079	3.885AlaLys: 3.885 ± 0.066	12.772AlaLeu: 12.772 ± 0.126	3.125AlaMet: 3.125 ± 0.059	3.178AlaAsn: 3.178 ± 0.07	4.106AlaPro: 4.106 ± 0.063	5.291AlaGln: 5.291 ± 0.08	5.476AlaArg: 5.476 ± 0.077	6.217AlaSer: 6.217 ± 0.074	5.41AlaThr: 5.41 ± 0.078	7.847AlaVal: 7.847 ± 0.1	1.553AlaTrp: 1.553 ± 0.043	2.603AlaTyr: 2.603 ± 0.054	0.0AlaXaa: 0.0 ± 0.0
Cys	1.023CysAla: 1.023 ± 0.031	0.148CysCys: 0.148 ± 0.013	0.447CysAsp: 0.447 ± 0.02	0.467CysGlu: 0.467 ± 0.022	0.379CysPhe: 0.379 ± 0.019	0.887CysGly: 0.887 ± 0.032	0.274CysHis: 0.274 ± 0.019	0.483CysIle: 0.483 ± 0.021	0.32CysLys: 0.32 ± 0.019	0.962CysLeu: 0.962 ± 0.032	0.245CysMet: 0.245 ± 0.017	0.247CysAsn: 0.247 ± 0.014	0.448CysPro: 0.448 ± 0.021	0.358CysGln: 0.358 ± 0.018	0.468CysArg: 0.468 ± 0.026	0.613CysSer: 0.613 ± 0.023	0.524CysThr: 0.524 ± 0.02	0.771CysVal: 0.771 ± 0.029	0.128CysTrp: 0.128 ± 0.012	0.267CysTyr: 0.267 ± 0.016	0.0CysXaa: 0.0 ± 0.0
Asp	5.426AspAla: 5.426 ± 0.061	0.423AspCys: 0.423 ± 0.024	2.764AspAsp: 2.764 ± 0.057	3.124AspGlu: 3.124 ± 0.049	1.959AspPhe: 1.959 ± 0.047	3.761AspGly: 3.761 ± 0.067	1.056AspHis: 1.056 ± 0.036	2.963AspIle: 2.963 ± 0.051	1.8AspLys: 1.8 ± 0.048	5.029AspLeu: 5.029 ± 0.068	1.331AspMet: 1.331 ± 0.035	1.581AspAsn: 1.581 ± 0.033	2.47AspPro: 2.47 ± 0.054	2.042AspGln: 2.042 ± 0.048	2.457AspArg: 2.457 ± 0.053	2.792AspSer: 2.792 ± 0.053	2.679AspThr: 2.679 ± 0.054	4.111AspVal: 4.111 ± 0.083	0.886AspTrp: 0.886 ± 0.033	1.634AspTyr: 1.634 ± 0.04	0.0AspXaa: 0.0 ± 0.0
Glu	5.988GluAla: 5.988 ± 0.085	0.438GluCys: 0.438 ± 0.02	2.465GluAsp: 2.465 ± 0.044	3.072GluGlu: 3.072 ± 0.063	1.994GluPhe: 1.994 ± 0.047	3.734GluGly: 3.734 ± 0.062	1.676GluHis: 1.676 ± 0.045	2.924GluIle: 2.924 ± 0.058	2.399GluLys: 2.399 ± 0.053	6.177GluLeu: 6.177 ± 0.09	1.415GluMet: 1.415 ± 0.041	1.998GluAsn: 1.998 ± 0.044	2.288GluPro: 2.288 ± 0.052	3.795GluGln: 3.795 ± 0.064	3.893GluArg: 3.893 ± 0.065	3.05GluSer: 3.05 ± 0.06	2.62GluThr: 2.62 ± 0.055	3.987GluVal: 3.987 ± 0.07	0.797GluTrp: 0.797 ± 0.031	1.406GluTyr: 1.406 ± 0.034	0.0GluXaa: 0.0 ± 0.0
Phe	3.561PheAla: 3.561 ± 0.061	0.423PheCys: 0.423 ± 0.021	2.285PheAsp: 2.285 ± 0.046	1.952PheGlu: 1.952 ± 0.047	1.479PhePhe: 1.479 ± 0.045	3.216PheGly: 3.216 ± 0.054	0.751PheHis: 0.751 ± 0.03	2.071PheIle: 2.071 ± 0.052	1.297PheLys: 1.297 ± 0.037	3.432PheLeu: 3.432 ± 0.072	1.04PheMet: 1.04 ± 0.031	1.367PheAsn: 1.367 ± 0.039	1.589PhePro: 1.589 ± 0.04	1.267PheGln: 1.267 ± 0.035	1.564PheArg: 1.564 ± 0.04	2.828PheSer: 2.828 ± 0.058	2.116PheThr: 2.116 ± 0.048	2.785PheVal: 2.785 ± 0.061	0.588PheTrp: 0.588 ± 0.026	1.088PheTyr: 1.088 ± 0.033	0.0PheXaa: 0.0 ± 0.0
Gly	7.082GlyAla: 7.082 ± 0.109	0.837GlyCys: 0.837 ± 0.03	3.499GlyAsp: 3.499 ± 0.057	3.941GlyGlu: 3.941 ± 0.071	3.142GlyPhe: 3.142 ± 0.057	5.605GlyGly: 5.605 ± 0.095	1.713GlyHis: 1.713 ± 0.038	4.521GlyIle: 4.521 ± 0.084	3.366GlyLys: 3.366 ± 0.068	8.488GlyLeu: 8.488 ± 0.101	2.4GlyMet: 2.4 ± 0.045	2.251GlyAsn: 2.251 ± 0.052	2.494GlyPro: 2.494 ± 0.047	3.157GlyGln: 3.157 ± 0.051	3.966GlyArg: 3.966 ± 0.066	4.597GlySer: 4.597 ± 0.073	4.019GlyThr: 4.019 ± 0.074	6.388GlyVal: 6.388 ± 0.083	1.326GlyTrp: 1.326 ± 0.038	2.397GlyTyr: 2.397 ± 0.049	0.0GlyXaa: 0.0 ± 0.0
His	2.524HisAla: 2.524 ± 0.055	0.322HisCys: 0.322 ± 0.018	1.257HisAsp: 1.257 ± 0.038	1.233HisGlu: 1.233 ± 0.037	0.928HisPhe: 0.928 ± 0.031	1.753HisGly: 1.753 ± 0.035	0.719HisHis: 0.719 ± 0.032	1.434HisIle: 1.434 ± 0.043	0.74HisLys: 0.74 ± 0.024	2.199HisLeu: 2.199 ± 0.053	0.55HisMet: 0.55 ± 0.028	0.786HisAsn: 0.786 ± 0.027	1.404HisPro: 1.404 ± 0.04	1.111HisGln: 1.111 ± 0.036	1.203HisArg: 1.203 ± 0.034	1.394HisSer: 1.394 ± 0.044	1.301HisThr: 1.301 ± 0.037	1.573HisVal: 1.573 ± 0.037	0.377HisTrp: 0.377 ± 0.02	0.818HisTyr: 0.818 ± 0.031	0.0HisXaa: 0.0 ± 0.0
Ile	6.405IleAla: 6.405 ± 0.08	0.515IleCys: 0.515 ± 0.022	2.969IleAsp: 2.969 ± 0.057	3.351IleGlu: 3.351 ± 0.063	1.755IlePhe: 1.755 ± 0.041	4.46IleGly: 4.46 ± 0.074	1.048IleHis: 1.048 ± 0.038	2.704IleIle: 2.704 ± 0.055	1.812IleLys: 1.812 ± 0.044	4.864IleLeu: 4.864 ± 0.08	1.244IleMet: 1.244 ± 0.036	1.936IleAsn: 1.936 ± 0.044	2.715IlePro: 2.715 ± 0.058	2.224IleGln: 2.224 ± 0.046	3.002IleArg: 3.002 ± 0.058	3.642IleSer: 3.642 ± 0.071	3.268IleThr: 3.268 ± 0.06	4.173IleVal: 4.173 ± 0.068	0.61IleTrp: 0.61 ± 0.025	1.252IleTyr: 1.252 ± 0.041	0.0IleXaa: 0.0 ± 0.0
Lys	4.162LysAla: 4.162 ± 0.079	0.157LysCys: 0.157 ± 0.013	1.773LysAsp: 1.773 ± 0.05	2.056LysGlu: 2.056 ± 0.043	0.92LysPhe: 0.92 ± 0.031	2.601LysGly: 2.601 ± 0.059	0.921LysHis: 0.921 ± 0.029	1.646LysIle: 1.646 ± 0.044	1.569LysLys: 1.569 ± 0.048	3.666LysLeu: 3.666 ± 0.059	0.877LysMet: 0.877 ± 0.03	1.281LysAsn: 1.281 ± 0.035	1.846LysPro: 1.846 ± 0.044	1.835LysGln: 1.835 ± 0.046	2.387LysArg: 2.387 ± 0.051	1.904LysSer: 1.904 ± 0.044	2.042LysThr: 2.042 ± 0.045	2.656LysVal: 2.656 ± 0.057	0.411LysTrp: 0.411 ± 0.022	0.768LysTyr: 0.768 ± 0.026	0.0LysXaa: 0.0 ± 0.0
Leu	11.91LeuAla: 11.91 ± 0.124	1.177LeuCys: 1.177 ± 0.039	5.582LeuAsp: 5.582 ± 0.083	5.88LeuGlu: 5.88 ± 0.09	3.908LeuPhe: 3.908 ± 0.078	8.358LeuGly: 8.358 ± 0.098	2.577LeuHis: 2.577 ± 0.053	5.606LeuIle: 5.606 ± 0.079	3.581LeuLys: 3.581 ± 0.055	12.152LeuLeu: 12.152 ± 0.189	2.774LeuMet: 2.774 ± 0.058	3.616LeuAsn: 3.616 ± 0.063	5.737LeuPro: 5.737 ± 0.073	5.295LeuGln: 5.295 ± 0.091	6.615LeuArg: 6.615 ± 0.086	7.685LeuSer: 7.685 ± 0.097	5.626LeuThr: 5.626 ± 0.071	7.484LeuVal: 7.484 ± 0.102	1.311LeuTrp: 1.311 ± 0.041	2.689LeuTyr: 2.689 ± 0.051	0.0LeuXaa: 0.0 ± 0.0
Met	2.854MetAla: 2.854 ± 0.054	0.196MetCys: 0.196 ± 0.012	1.184MetAsp: 1.184 ± 0.033	1.154MetGlu: 1.154 ± 0.032	0.84MetPhe: 0.84 ± 0.029	2.037MetGly: 2.037 ± 0.045	0.568MetHis: 0.568 ± 0.022	1.22MetIle: 1.22 ± 0.035	0.999MetLys: 0.999 ± 0.03	3.11MetLeu: 3.11 ± 0.056	0.769MetMet: 0.769 ± 0.03	0.957MetAsn: 0.957 ± 0.034	1.414MetPro: 1.414 ± 0.042	1.384MetGln: 1.384 ± 0.031	1.696MetArg: 1.696 ± 0.039	1.982MetSer: 1.982 ± 0.039	1.621MetThr: 1.621 ± 0.038	2.02MetVal: 2.02 ± 0.046	0.259MetTrp: 0.259 ± 0.014	0.504MetTyr: 0.504 ± 0.024	0.0MetXaa: 0.0 ± 0.0
Asn	3.403AsnAla: 3.403 ± 0.063	0.28AsnCys: 0.28 ± 0.016	1.576AsnAsp: 1.576 ± 0.04	1.588AsnGlu: 1.588 ± 0.039	1.152AsnPhe: 1.152 ± 0.031	2.511AsnGly: 2.511 ± 0.052	0.743AsnHis: 0.743 ± 0.029	1.8AsnIle: 1.8 ± 0.044	1.238AsnLys: 1.238 ± 0.036	3.261AsnLeu: 3.261 ± 0.058	0.82AsnMet: 0.82 ± 0.031	1.173AsnAsn: 1.173 ± 0.032	2.05AsnPro: 2.05 ± 0.043	1.425AsnGln: 1.425 ± 0.035	1.753AsnArg: 1.753 ± 0.042	1.886AsnSer: 1.886 ± 0.055	1.993AsnThr: 1.993 ± 0.05	2.426AsnVal: 2.426 ± 0.055	0.499AsnTrp: 0.499 ± 0.022	0.946AsnTyr: 0.946 ± 0.035	0.0AsnXaa: 0.0 ± 0.0
Pro	4.917ProAla: 4.917 ± 0.076	0.345ProCys: 0.345 ± 0.017	2.815ProAsp: 2.815 ± 0.054	3.768ProGlu: 3.768 ± 0.057	1.794ProPhe: 1.794 ± 0.044	3.165ProGly: 3.165 ± 0.056	1.114ProHis: 1.114 ± 0.036	2.356ProIle: 2.356 ± 0.054	1.548ProLys: 1.548 ± 0.039	4.799ProLeu: 4.799 ± 0.075	1.197ProMet: 1.197 ± 0.036	1.521ProAsn: 1.521 ± 0.034	1.685ProPro: 1.685 ± 0.045	1.85ProGln: 1.85 ± 0.043	2.015ProArg: 2.015 ± 0.05	2.875ProSer: 2.875 ± 0.058	2.68ProThr: 2.68 ± 0.055	3.906ProVal: 3.906 ± 0.063	0.68ProTrp: 0.68 ± 0.026	1.265ProTyr: 1.265 ± 0.036	0.0ProXaa: 0.0 ± 0.0
Gln	5.787GlnAla: 5.787 ± 0.095	0.363GlnCys: 0.363 ± 0.02	2.018GlnAsp: 2.018 ± 0.046	2.493GlnGlu: 2.493 ± 0.061	1.421GlnPhe: 1.421 ± 0.039	3.401GlnGly: 3.401 ± 0.061	1.574GlnHis: 1.574 ± 0.049	2.224GlnIle: 2.224 ± 0.047	1.523GlnLys: 1.523 ± 0.038	5.054GlnLeu: 5.054 ± 0.087	1.089GlnMet: 1.089 ± 0.033	1.521GlnAsn: 1.521 ± 0.039	2.243GlnPro: 2.243 ± 0.049	3.46GlnGln: 3.46 ± 0.098	3.53GlnArg: 3.53 ± 0.062	2.694GlnSer: 2.694 ± 0.052	2.314GlnThr: 2.314 ± 0.048	3.15GlnVal: 3.15 ± 0.06	0.788GlnTrp: 0.788 ± 0.028	1.163GlnTyr: 1.163 ± 0.036	0.0GlnXaa: 0.0 ± 0.0
Arg	5.134ArgAla: 5.134 ± 0.078	0.544ArgCys: 0.544 ± 0.023	2.777ArgAsp: 2.777 ± 0.051	3.313ArgGlu: 3.313 ± 0.06	2.407ArgPhe: 2.407 ± 0.051	3.399ArgGly: 3.399 ± 0.055	1.51ArgHis: 1.51 ± 0.04	3.525ArgIle: 3.525 ± 0.066	2.144ArgLys: 2.144 ± 0.047	6.419ArgLeu: 6.419 ± 0.083	1.58ArgMet: 1.58 ± 0.034	1.869ArgAsn: 1.869 ± 0.041	2.378ArgPro: 2.378 ± 0.05	2.882ArgGln: 2.882 ± 0.064	3.448ArgArg: 3.448 ± 0.059	3.394ArgSer: 3.394 ± 0.055	2.892ArgThr: 2.892 ± 0.053	3.937ArgVal: 3.937 ± 0.064	0.886ArgTrp: 0.886 ± 0.026	1.985ArgTyr: 1.985 ± 0.042	0.0ArgXaa: 0.0 ± 0.0
Ser	6.155SerAla: 6.155 ± 0.084	0.538SerCys: 0.538 ± 0.023	2.992SerAsp: 2.992 ± 0.049	3.008SerGlu: 3.008 ± 0.054	2.55SerPhe: 2.55 ± 0.054	5.148SerGly: 5.148 ± 0.077	1.388SerHis: 1.388 ± 0.038	3.454SerIle: 3.454 ± 0.071	2.045SerLys: 2.045 ± 0.048	7.11SerLeu: 7.11 ± 0.093	1.805SerMet: 1.805 ± 0.043	1.963SerAsn: 1.963 ± 0.046	2.787SerPro: 2.787 ± 0.06	2.53SerGln: 2.53 ± 0.046	3.429SerArg: 3.429 ± 0.059	4.154SerSer: 4.154 ± 0.07	3.675SerThr: 3.675 ± 0.068	4.812SerVal: 4.812 ± 0.073	0.982SerTrp: 0.982 ± 0.032	1.776SerTyr: 1.776 ± 0.046	0.0SerXaa: 0.0 ± 0.0
Thr	5.507ThrAla: 5.507 ± 0.072	0.395ThrCys: 0.395 ± 0.02	2.604ThrAsp: 2.604 ± 0.05	2.854ThrGlu: 2.854 ± 0.059	1.723ThrPhe: 1.723 ± 0.044	4.344ThrGly: 4.344 ± 0.07	1.326ThrHis: 1.326 ± 0.037	2.969ThrIle: 2.969 ± 0.054	1.445ThrLys: 1.445 ± 0.04	6.666ThrLeu: 6.666 ± 0.091	1.298ThrMet: 1.298 ± 0.035	1.523ThrAsn: 1.523 ± 0.042	3.319ThrPro: 3.319 ± 0.063	2.526ThrGln: 2.526 ± 0.049	2.844ThrArg: 2.844 ± 0.052	3.042ThrSer: 3.042 ± 0.052	3.152ThrThr: 3.152 ± 0.062	4.421ThrVal: 4.421 ± 0.071	0.681ThrTrp: 0.681 ± 0.029	1.227ThrTyr: 1.227 ± 0.037	0.0ThrXaa: 0.0 ± 0.0
Val	8.196ValAla: 8.196 ± 0.103	0.805ValCys: 0.805 ± 0.027	3.956ValAsp: 3.956 ± 0.071	4.393ValGlu: 4.393 ± 0.069	2.925ValPhe: 2.925 ± 0.05	5.536ValGly: 5.536 ± 0.087	1.475ValHis: 1.475 ± 0.036	4.209ValIle: 4.209 ± 0.068	2.434ValLys: 2.434 ± 0.053	8.534ValLeu: 8.534 ± 0.108	2.199ValMet: 2.199 ± 0.041	2.466ValAsn: 2.466 ± 0.056	3.431ValPro: 3.431 ± 0.064	3.264ValGln: 3.264 ± 0.058	4.107ValArg: 4.107 ± 0.067	4.922ValSer: 4.922 ± 0.069	3.85ValThr: 3.85 ± 0.067	6.459ValVal: 6.459 ± 0.111	1.073ValTrp: 1.073 ± 0.033	1.815ValTyr: 1.815 ± 0.04	0.0ValXaa: 0.0 ± 0.0
Trp	1.225TrpAla: 1.225 ± 0.032	0.154TrpCys: 0.154 ± 0.013	0.617TrpAsp: 0.617 ± 0.025	0.689TrpGlu: 0.689 ± 0.027	0.594TrpPhe: 0.594 ± 0.025	0.938TrpGly: 0.938 ± 0.031	0.384TrpHis: 0.384 ± 0.019	0.752TrpIle: 0.752 ± 0.027	0.468TrpLys: 0.468 ± 0.024	2.153TrpLeu: 2.153 ± 0.056	0.438TrpMet: 0.438 ± 0.019	0.514TrpAsn: 0.514 ± 0.025	0.621TrpPro: 0.621 ± 0.028	0.849TrpGln: 0.849 ± 0.03	0.96TrpArg: 0.96 ± 0.035	0.868TrpSer: 0.868 ± 0.03	0.56TrpThr: 0.56 ± 0.023	1.117TrpVal: 1.117 ± 0.036	0.26TrpTrp: 0.26 ± 0.015	0.369TrpTyr: 0.369 ± 0.021	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.863TyrAla: 2.863 ± 0.058	0.306TyrCys: 0.306 ± 0.017	1.478TyrAsp: 1.478 ± 0.04	1.436TyrGlu: 1.436 ± 0.036	1.079TyrPhe: 1.079 ± 0.035	2.267TyrGly: 2.267 ± 0.053	0.57TyrHis: 0.57 ± 0.023	1.153TyrIle: 1.153 ± 0.034	0.863TyrLys: 0.863 ± 0.027	2.716TyrLeu: 2.716 ± 0.052	0.57TyrMet: 0.57 ± 0.026	0.774TyrAsn: 0.774 ± 0.03	1.272TyrPro: 1.272 ± 0.039	1.264TyrGln: 1.264 ± 0.037	1.61TyrArg: 1.61 ± 0.039	1.764TyrSer: 1.764 ± 0.043	1.527TyrThr: 1.527 ± 0.037	2.025TyrVal: 2.025 ± 0.04	0.434TyrTrp: 0.434 ± 0.02	0.78TyrTyr: 0.78 ± 0.029	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3405 proteins (1057531 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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