Amino acid dipepetide frequency for Actinomadura rudentiformis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	20.219AlaAla: 20.219 ± 0.109	1.052AlaCys: 1.052 ± 0.019	7.905AlaAsp: 7.905 ± 0.056	8.645AlaGlu: 8.645 ± 0.072	3.784AlaPhe: 3.784 ± 0.037	12.745AlaGly: 12.745 ± 0.075	2.593AlaHis: 2.593 ± 0.03	4.577AlaIle: 4.577 ± 0.045	3.007AlaLys: 3.007 ± 0.038	13.696AlaLeu: 13.696 ± 0.083	2.675AlaMet: 2.675 ± 0.028	2.08AlaAsn: 2.08 ± 0.025	6.385AlaPro: 6.385 ± 0.062	3.635AlaGln: 3.635 ± 0.038	10.021AlaArg: 10.021 ± 0.066	5.755AlaSer: 5.755 ± 0.052	7.041AlaThr: 7.041 ± 0.058	11.163AlaVal: 11.163 ± 0.068	1.886AlaTrp: 1.886 ± 0.022	2.64AlaTyr: 2.64 ± 0.029	0.0AlaXaa: 0.0 ± 0.0
Cys	0.941CysAla: 0.941 ± 0.017	0.096CysCys: 0.096 ± 0.006	0.523CysAsp: 0.523 ± 0.016	0.435CysGlu: 0.435 ± 0.012	0.225CysPhe: 0.225 ± 0.009	0.97CysGly: 0.97 ± 0.018	0.196CysHis: 0.196 ± 0.008	0.161CysIle: 0.161 ± 0.007	0.129CysLys: 0.129 ± 0.007	0.731CysLeu: 0.731 ± 0.017	0.151CysMet: 0.151 ± 0.007	0.133CysAsn: 0.133 ± 0.006	0.481CysPro: 0.481 ± 0.014	0.187CysGln: 0.187 ± 0.008	0.636CysArg: 0.636 ± 0.014	0.433CysSer: 0.433 ± 0.013	0.468CysThr: 0.468 ± 0.012	0.64CysVal: 0.64 ± 0.015	0.113CysTrp: 0.113 ± 0.006	0.176CysTyr: 0.176 ± 0.007	0.0CysXaa: 0.0 ± 0.0
Asp	6.946AspAla: 6.946 ± 0.054	0.413AspCys: 0.413 ± 0.013	3.785AspAsp: 3.785 ± 0.039	3.939AspGlu: 3.939 ± 0.041	1.574AspPhe: 1.574 ± 0.022	5.917AspGly: 5.917 ± 0.055	1.501AspHis: 1.501 ± 0.024	2.002AspIle: 2.002 ± 0.028	1.228AspLys: 1.228 ± 0.021	6.767AspLeu: 6.767 ± 0.049	0.928AspMet: 0.928 ± 0.018	0.997AspAsn: 0.997 ± 0.017	4.527AspPro: 4.527 ± 0.043	1.776AspGln: 1.776 ± 0.026	5.066AspArg: 5.066 ± 0.043	2.284AspSer: 2.284 ± 0.029	2.768AspThr: 2.768 ± 0.027	4.821AspVal: 4.821 ± 0.038	0.979AspTrp: 0.979 ± 0.019	1.167AspTyr: 1.167 ± 0.019	0.0AspXaa: 0.0 ± 0.0
Glu	6.985GluAla: 6.985 ± 0.06	0.388GluCys: 0.388 ± 0.01	2.709GluAsp: 2.709 ± 0.03	3.29GluGlu: 3.29 ± 0.038	1.505GluPhe: 1.505 ± 0.022	4.176GluGly: 4.176 ± 0.04	1.556GluHis: 1.556 ± 0.025	2.713GluIle: 2.713 ± 0.031	1.278GluLys: 1.278 ± 0.022	6.877GluLeu: 6.877 ± 0.059	0.99GluMet: 0.99 ± 0.018	1.006GluAsn: 1.006 ± 0.018	3.556GluPro: 3.556 ± 0.04	2.086GluGln: 2.086 ± 0.027	5.876GluArg: 5.876 ± 0.05	2.561GluSer: 2.561 ± 0.031	2.967GluThr: 2.967 ± 0.034	4.541GluVal: 4.541 ± 0.048	0.834GluTrp: 0.834 ± 0.017	1.081GluTyr: 1.081 ± 0.018	0.0GluXaa: 0.0 ± 0.0
Phe	3.722PheAla: 3.722 ± 0.038	0.282PheCys: 0.282 ± 0.01	2.032PheAsp: 2.032 ± 0.03	1.547PheGlu: 1.547 ± 0.023	0.905PhePhe: 0.905 ± 0.017	3.114PheGly: 3.114 ± 0.037	0.632PheHis: 0.632 ± 0.016	0.874PheIle: 0.874 ± 0.019	0.591PheLys: 0.591 ± 0.016	2.65PheLeu: 2.65 ± 0.031	0.482PheMet: 0.482 ± 0.014	0.635PheAsn: 0.635 ± 0.016	1.441PhePro: 1.441 ± 0.025	0.764PheGln: 0.764 ± 0.014	1.892PheArg: 1.892 ± 0.023	1.509PheSer: 1.509 ± 0.023	2.056PheThr: 2.056 ± 0.024	2.368PheVal: 2.368 ± 0.028	0.451PheTrp: 0.451 ± 0.013	0.619PheTyr: 0.619 ± 0.016	0.0PheXaa: 0.0 ± 0.0
Gly	10.276GlyAla: 10.276 ± 0.06	0.826GlyCys: 0.826 ± 0.019	5.316GlyAsp: 5.316 ± 0.048	5.091GlyGlu: 5.091 ± 0.046	2.936GlyPhe: 2.936 ± 0.032	8.704GlyGly: 8.704 ± 0.076	2.237GlyHis: 2.237 ± 0.033	3.611GlyIle: 3.611 ± 0.041	2.573GlyLys: 2.573 ± 0.038	9.58GlyLeu: 9.58 ± 0.059	2.101GlyMet: 2.101 ± 0.03	1.753GlyAsn: 1.753 ± 0.028	5.005GlyPro: 5.005 ± 0.046	2.827GlyGln: 2.827 ± 0.036	7.838GlyArg: 7.838 ± 0.052	4.981GlySer: 4.981 ± 0.041	5.871GlyThr: 5.871 ± 0.054	7.403GlyVal: 7.403 ± 0.053	1.736GlyTrp: 1.736 ± 0.025	2.199GlyTyr: 2.199 ± 0.029	0.0GlyXaa: 0.0 ± 0.0
His	2.613HisAla: 2.613 ± 0.027	0.213HisCys: 0.213 ± 0.007	1.368HisAsp: 1.368 ± 0.02	1.226HisGlu: 1.226 ± 0.023	0.606HisPhe: 0.606 ± 0.015	2.242HisGly: 2.242 ± 0.025	0.691HisHis: 0.691 ± 0.017	0.703HisIle: 0.703 ± 0.014	0.362HisLys: 0.362 ± 0.011	2.379HisLeu: 2.379 ± 0.029	0.366HisMet: 0.366 ± 0.011	0.383HisAsn: 0.383 ± 0.011	1.712HisPro: 1.712 ± 0.026	0.654HisGln: 0.654 ± 0.015	2.037HisArg: 2.037 ± 0.03	0.947HisSer: 0.947 ± 0.016	1.117HisThr: 1.117 ± 0.021	1.75HisVal: 1.75 ± 0.029	0.367HisTrp: 0.367 ± 0.012	0.499HisTyr: 0.499 ± 0.012	0.0HisXaa: 0.0 ± 0.0
Ile	5.397IleAla: 5.397 ± 0.048	0.338IleCys: 0.338 ± 0.011	2.595IleAsp: 2.595 ± 0.029	2.41IleGlu: 2.41 ± 0.033	0.944IlePhe: 0.944 ± 0.018	3.869IleGly: 3.869 ± 0.033	0.692IleHis: 0.692 ± 0.014	1.273IleIle: 1.273 ± 0.023	0.925IleLys: 0.925 ± 0.017	2.892IleLeu: 2.892 ± 0.035	0.601IleMet: 0.601 ± 0.015	0.848IleAsn: 0.848 ± 0.017	2.082IlePro: 2.082 ± 0.029	0.878IleGln: 0.878 ± 0.016	2.621IleArg: 2.621 ± 0.028	2.048IleSer: 2.048 ± 0.025	2.58IleThr: 2.58 ± 0.032	3.376IleVal: 3.376 ± 0.03	0.468IleTrp: 0.468 ± 0.013	0.638IleTyr: 0.638 ± 0.015	0.0IleXaa: 0.0 ± 0.0
Lys	3.049LysAla: 3.049 ± 0.037	0.119LysCys: 0.119 ± 0.006	1.273LysAsp: 1.273 ± 0.022	1.19LysGlu: 1.19 ± 0.019	0.478LysPhe: 0.478 ± 0.013	1.908LysGly: 1.908 ± 0.031	0.491LysHis: 0.491 ± 0.013	1.057LysIle: 1.057 ± 0.021	0.784LysLys: 0.784 ± 0.025	2.075LysLeu: 2.075 ± 0.024	0.413LysMet: 0.413 ± 0.013	0.538LysAsn: 0.538 ± 0.016	1.599LysPro: 1.599 ± 0.027	0.708LysGln: 0.708 ± 0.018	1.615LysArg: 1.615 ± 0.028	1.156LysSer: 1.156 ± 0.023	1.361LysThr: 1.361 ± 0.023	2.125LysVal: 2.125 ± 0.032	0.301LysTrp: 0.301 ± 0.01	0.439LysTyr: 0.439 ± 0.014	0.0LysXaa: 0.0 ± 0.0
Leu	15.233LeuAla: 15.233 ± 0.079	0.787LeuCys: 0.787 ± 0.015	6.684LeuAsp: 6.684 ± 0.052	4.97LeuGlu: 4.97 ± 0.048	2.609LeuPhe: 2.609 ± 0.035	9.185LeuGly: 9.185 ± 0.064	2.127LeuHis: 2.127 ± 0.029	3.932LeuIle: 3.932 ± 0.038	2.06LeuLys: 2.06 ± 0.03	10.654LeuLeu: 10.654 ± 0.088	1.729LeuMet: 1.729 ± 0.022	1.996LeuAsn: 1.996 ± 0.025	6.339LeuPro: 6.339 ± 0.057	2.333LeuGln: 2.333 ± 0.03	8.722LeuArg: 8.722 ± 0.065	5.379LeuSer: 5.379 ± 0.045	6.59LeuThr: 6.59 ± 0.04	8.482LeuVal: 8.482 ± 0.066	1.287LeuTrp: 1.287 ± 0.023	1.837LeuTyr: 1.837 ± 0.028	0.0LeuXaa: 0.0 ± 0.0
Met	2.485MetAla: 2.485 ± 0.025	0.135MetCys: 0.135 ± 0.007	0.94MetAsp: 0.94 ± 0.017	0.844MetGlu: 0.844 ± 0.018	0.556MetPhe: 0.556 ± 0.015	1.426MetGly: 1.426 ± 0.022	0.368MetHis: 0.368 ± 0.011	0.892MetIle: 0.892 ± 0.018	0.471MetLys: 0.471 ± 0.014	1.95MetLeu: 1.95 ± 0.024	0.342MetMet: 0.342 ± 0.011	0.493MetAsn: 0.493 ± 0.011	1.233MetPro: 1.233 ± 0.021	0.461MetGln: 0.461 ± 0.012	1.647MetArg: 1.647 ± 0.023	1.346MetSer: 1.346 ± 0.02	1.546MetThr: 1.546 ± 0.023	1.5MetVal: 1.5 ± 0.024	0.242MetTrp: 0.242 ± 0.01	0.319MetTyr: 0.319 ± 0.011	0.0MetXaa: 0.0 ± 0.0
Asn	2.457AsnAla: 2.457 ± 0.028	0.174AsnCys: 0.174 ± 0.007	1.079AsnAsp: 1.079 ± 0.019	1.018AsnGlu: 1.018 ± 0.021	0.482AsnPhe: 0.482 ± 0.013	2.213AsnGly: 2.213 ± 0.033	0.404AsnHis: 0.404 ± 0.011	0.68AsnIle: 0.68 ± 0.017	0.429AsnLys: 0.429 ± 0.012	1.789AsnLeu: 1.789 ± 0.026	0.314AsnMet: 0.314 ± 0.01	0.417AsnAsn: 0.417 ± 0.012	1.438AsnPro: 1.438 ± 0.023	0.541AsnGln: 0.541 ± 0.015	1.331AsnArg: 1.331 ± 0.023	0.832AsnSer: 0.832 ± 0.017	1.053AsnThr: 1.053 ± 0.019	1.63AsnVal: 1.63 ± 0.024	0.3AsnTrp: 0.3 ± 0.011	0.415AsnTyr: 0.415 ± 0.012	0.0AsnXaa: 0.0 ± 0.0
Pro	8.328ProAla: 8.328 ± 0.067	0.363ProCys: 0.363 ± 0.011	4.455ProAsp: 4.455 ± 0.034	4.245ProGlu: 4.245 ± 0.042	1.663ProPhe: 1.663 ± 0.021	6.693ProGly: 6.693 ± 0.054	1.262ProHis: 1.262 ± 0.022	1.814ProIle: 1.814 ± 0.024	1.367ProLys: 1.367 ± 0.026	5.086ProLeu: 5.086 ± 0.042	1.114ProMet: 1.114 ± 0.019	1.085ProAsn: 1.085 ± 0.02	4.06ProPro: 4.06 ± 0.071	1.745ProGln: 1.745 ± 0.032	3.943ProArg: 3.943 ± 0.039	3.248ProSer: 3.248 ± 0.036	3.037ProThr: 3.037 ± 0.035	5.107ProVal: 5.107 ± 0.046	0.945ProTrp: 0.945 ± 0.02	1.347ProTyr: 1.347 ± 0.024	0.0ProXaa: 0.0 ± 0.0
Gln	4.024GlnAla: 4.024 ± 0.048	0.168GlnCys: 0.168 ± 0.008	1.307GlnAsp: 1.307 ± 0.023	1.454GlnGlu: 1.454 ± 0.022	0.709GlnPhe: 0.709 ± 0.016	2.279GlnGly: 2.279 ± 0.032	0.593GlnHis: 0.593 ± 0.014	1.327GlnIle: 1.327 ± 0.021	0.617GlnLys: 0.617 ± 0.016	2.847GlnLeu: 2.847 ± 0.032	0.561GlnMet: 0.561 ± 0.015	0.562GlnAsn: 0.562 ± 0.014	1.768GlnPro: 1.768 ± 0.032	1.166GlnGln: 1.166 ± 0.032	2.548GlnArg: 2.548 ± 0.029	1.27GlnSer: 1.27 ± 0.019	1.42GlnThr: 1.42 ± 0.022	2.594GlnVal: 2.594 ± 0.031	0.476GlnTrp: 0.476 ± 0.012	0.518GlnTyr: 0.518 ± 0.013	0.0GlnXaa: 0.0 ± 0.0
Arg	9.545ArgAla: 9.545 ± 0.071	0.632ArgCys: 0.632 ± 0.015	4.556ArgAsp: 4.556 ± 0.043	4.65ArgGlu: 4.65 ± 0.043	2.481ArgPhe: 2.481 ± 0.03	5.752ArgGly: 5.752 ± 0.048	2.159ArgHis: 2.159 ± 0.03	3.351ArgIle: 3.351 ± 0.032	1.777ArgLys: 1.777 ± 0.028	9.504ArgLeu: 9.504 ± 0.068	1.925ArgMet: 1.925 ± 0.024	1.511ArgAsn: 1.511 ± 0.025	5.11ArgPro: 5.11 ± 0.046	2.471ArgGln: 2.471 ± 0.033	8.135ArgArg: 8.135 ± 0.062	4.266ArgSer: 4.266 ± 0.042	4.916ArgThr: 4.916 ± 0.044	5.927ArgVal: 5.927 ± 0.044	1.476ArgTrp: 1.476 ± 0.022	1.836ArgTyr: 1.836 ± 0.027	0.0ArgXaa: 0.0 ± 0.0
Ser	6.244SerAla: 6.244 ± 0.046	0.399SerCys: 0.399 ± 0.012	2.664SerAsp: 2.664 ± 0.028	2.373SerGlu: 2.373 ± 0.028	1.614SerPhe: 1.614 ± 0.022	5.757SerGly: 5.757 ± 0.051	1.014SerHis: 1.014 ± 0.018	1.738SerIle: 1.738 ± 0.021	1.179SerLys: 1.179 ± 0.024	4.772SerLeu: 4.772 ± 0.041	1.221SerMet: 1.221 ± 0.02	0.888SerAsn: 0.888 ± 0.018	3.296SerPro: 3.296 ± 0.037	1.33SerGln: 1.33 ± 0.02	3.817SerArg: 3.817 ± 0.032	2.783SerSer: 2.783 ± 0.035	2.89SerThr: 2.89 ± 0.037	3.938SerVal: 3.938 ± 0.035	0.93SerTrp: 0.93 ± 0.018	1.219SerTyr: 1.219 ± 0.023	0.0SerXaa: 0.0 ± 0.0
Thr	8.008ThrAla: 8.008 ± 0.055	0.456ThrCys: 0.456 ± 0.014	3.221ThrAsp: 3.221 ± 0.035	3.048ThrGlu: 3.048 ± 0.032	1.865ThrPhe: 1.865 ± 0.028	6.409ThrGly: 6.409 ± 0.05	1.081ThrHis: 1.081 ± 0.019	2.186ThrIle: 2.186 ± 0.03	1.28ThrLys: 1.28 ± 0.021	5.647ThrLeu: 5.647 ± 0.045	1.156ThrMet: 1.156 ± 0.02	1.009ThrAsn: 1.009 ± 0.019	3.935ThrPro: 3.935 ± 0.045	1.337ThrGln: 1.337 ± 0.02	4.042ThrArg: 4.042 ± 0.038	3.04ThrSer: 3.04 ± 0.032	3.634ThrThr: 3.634 ± 0.038	5.433ThrVal: 5.433 ± 0.045	0.93ThrTrp: 0.93 ± 0.02	1.282ThrTyr: 1.282 ± 0.023	0.0ThrXaa: 0.0 ± 0.0
Val	10.852ValAla: 10.852 ± 0.079	0.655ValCys: 0.655 ± 0.012	4.712ValAsp: 4.712 ± 0.044	4.58ValGlu: 4.58 ± 0.043	2.482ValPhe: 2.482 ± 0.029	6.235ValGly: 6.235 ± 0.051	1.825ValHis: 1.825 ± 0.025	3.377ValIle: 3.377 ± 0.035	1.777ValLys: 1.777 ± 0.027	9.083ValLeu: 9.083 ± 0.066	1.518ValMet: 1.518 ± 0.023	1.798ValAsn: 1.798 ± 0.028	5.048ValPro: 5.048 ± 0.046	2.146ValGln: 2.146 ± 0.024	6.878ValArg: 6.878 ± 0.052	4.28ValSer: 4.28 ± 0.038	5.581ValThr: 5.581 ± 0.046	7.528ValVal: 7.528 ± 0.052	1.142ValTrp: 1.142 ± 0.02	1.527ValTyr: 1.527 ± 0.023	0.0ValXaa: 0.0 ± 0.0
Trp	1.66TrpAla: 1.66 ± 0.022	0.149TrpCys: 0.149 ± 0.007	0.829TrpAsp: 0.829 ± 0.018	0.742TrpGlu: 0.742 ± 0.016	0.513TrpPhe: 0.513 ± 0.012	1.067TrpGly: 1.067 ± 0.02	0.416TrpHis: 0.416 ± 0.012	0.646TrpIle: 0.646 ± 0.015	0.392TrpLys: 0.392 ± 0.012	1.825TrpLeu: 1.825 ± 0.026	0.307TrpMet: 0.307 ± 0.012	0.445TrpAsn: 0.445 ± 0.013	0.864TrpPro: 0.864 ± 0.018	0.562TrpGln: 0.562 ± 0.013	1.493TrpArg: 1.493 ± 0.024	0.968TrpSer: 0.968 ± 0.017	1.028TrpThr: 1.028 ± 0.02	0.987TrpVal: 0.987 ± 0.02	0.369TrpTrp: 0.369 ± 0.012	0.351TrpTyr: 0.351 ± 0.01	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.52TyrAla: 2.52 ± 0.032	0.182TyrCys: 0.182 ± 0.008	1.43TyrAsp: 1.43 ± 0.024	1.277TyrGlu: 1.277 ± 0.02	0.636TyrPhe: 0.636 ± 0.015	2.203TyrGly: 2.203 ± 0.03	0.399TyrHis: 0.399 ± 0.011	0.562TyrIle: 0.562 ± 0.014	0.449TyrLys: 0.449 ± 0.014	2.13TyrLeu: 2.13 ± 0.026	0.3TyrMet: 0.3 ± 0.009	0.42TyrAsn: 0.42 ± 0.013	1.028TyrPro: 1.028 ± 0.019	0.602TyrGln: 0.602 ± 0.013	1.821TyrArg: 1.821 ± 0.028	0.98TyrSer: 0.98 ± 0.019	1.075TyrThr: 1.075 ± 0.022	1.713TyrVal: 1.713 ± 0.024	0.382TyrTrp: 0.382 ± 0.011	0.459TyrTyr: 0.459 ± 0.013	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 9446 proteins (3027437 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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