Amino acid dipepetide frequency for Big Cypress virus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
6.042AlaAla: 6.042 ± 1.054
1.678AlaCys: 1.678 ± 0.84
3.357AlaAsp: 3.357 ± 0.985
3.693AlaGlu: 3.693 ± 1.272
2.685AlaPhe: 2.685 ± 1.012
2.014AlaGly: 2.014 ± 0.486
1.678AlaHis: 1.678 ± 0.705
3.021AlaIle: 3.021 ± 0.845
2.685AlaLys: 2.685 ± 0.409
6.714AlaLeu: 6.714 ± 1.747
0.671AlaMet: 0.671 ± 0.336
2.014AlaAsn: 2.014 ± 0.486
3.357AlaPro: 3.357 ± 0.289
1.343AlaGln: 1.343 ± 0.672
1.678AlaArg: 1.678 ± 0.23
4.7AlaSer: 4.7 ± 1.65
2.35AlaThr: 2.35 ± 0.5
4.364AlaVal: 4.364 ± 2.437
0.336AlaTrp: 0.336 ± 0.168
2.35AlaTyr: 2.35 ± 1.18
0.0AlaXaa: 0.0 ± 0.0
Cys
1.007CysAla: 1.007 ± 0.504
0.0CysCys: 0.0 ± 0.0
1.007CysAsp: 1.007 ± 0.504
1.343CysGlu: 1.343 ± 0.672
1.678CysPhe: 1.678 ± 0.705
0.336CysGly: 0.336 ± 0.168
0.0CysHis: 0.0 ± 0.0
0.671CysIle: 0.671 ± 0.425
2.014CysLys: 2.014 ± 0.351
3.357CysLeu: 3.357 ± 1.391
0.336CysMet: 0.336 ± 0.168
1.007CysAsn: 1.007 ± 0.286
0.336CysPro: 0.336 ± 0.168
0.0CysGln: 0.0 ± 0.0
1.343CysArg: 1.343 ± 0.198
1.678CysSer: 1.678 ± 0.847
1.007CysThr: 1.007 ± 0.286
2.014CysVal: 2.014 ± 0.572
0.0CysTrp: 0.0 ± 0.0
0.336CysTyr: 0.336 ± 0.168
0.0CysXaa: 0.0 ± 0.0
Asp
3.693AspAla: 3.693 ± 1.849
0.336AspCys: 0.336 ± 0.58
3.021AspAsp: 3.021 ± 0.821
4.028AspGlu: 4.028 ± 1.194
5.707AspPhe: 5.707 ± 0.772
3.021AspGly: 3.021 ± 0.395
1.678AspHis: 1.678 ± 0.847
4.028AspIle: 4.028 ± 0.348
3.357AspLys: 3.357 ± 0.985
3.693AspLeu: 3.693 ± 0.57
1.007AspMet: 1.007 ± 0.451
2.35AspAsn: 2.35 ± 1.177
1.678AspPro: 1.678 ± 0.84
1.007AspGln: 1.007 ± 0.286
2.014AspArg: 2.014 ± 1.009
5.371AspSer: 5.371 ± 0.392
4.028AspThr: 4.028 ± 1.316
5.035AspVal: 5.035 ± 0.843
0.0AspTrp: 0.0 ± 0.0
1.678AspTyr: 1.678 ± 0.23
0.0AspXaa: 0.0 ± 0.0
Glu
3.021GluAla: 3.021 ± 0.821
2.35GluCys: 2.35 ± 0.462
2.014GluAsp: 2.014 ± 1.009
3.693GluGlu: 3.693 ± 1.849
6.042GluPhe: 6.042 ± 0.79
1.678GluGly: 1.678 ± 0.23
1.007GluHis: 1.007 ± 0.504
4.364GluIle: 4.364 ± 1.483
3.693GluLys: 3.693 ± 0.355
5.371GluLeu: 5.371 ± 1.317
1.343GluMet: 1.343 ± 0.672
3.693GluAsn: 3.693 ± 1.045
1.343GluPro: 1.343 ± 0.672
1.007GluGln: 1.007 ± 1.003
2.685GluArg: 2.685 ± 0.659
3.693GluSer: 3.693 ± 1.15
3.021GluThr: 3.021 ± 0.821
3.021GluVal: 3.021 ± 1.513
0.0GluTrp: 0.0 ± 0.0
2.685GluTyr: 2.685 ± 1.345
0.0GluXaa: 0.0 ± 0.0
Phe
2.685PheAla: 2.685 ± 0.638
2.685PheCys: 2.685 ± 0.988
6.714PheAsp: 6.714 ± 0.988
4.028PheGlu: 4.028 ± 0.593
6.378PhePhe: 6.378 ± 1.595
2.685PheGly: 2.685 ± 1.345
2.35PheHis: 2.35 ± 0.5
5.035PheIle: 5.035 ± 1.429
2.685PheLys: 2.685 ± 0.638
8.056PheLeu: 8.056 ± 3.037
1.007PheMet: 1.007 ± 0.504
5.371PheAsn: 5.371 ± 2.689
1.678PhePro: 1.678 ± 2.162
2.014PheGln: 2.014 ± 0.572
1.343PheArg: 1.343 ± 0.198
5.707PheSer: 5.707 ± 0.971
7.385PheThr: 7.385 ± 1.723
4.028PheVal: 4.028 ± 1.056
0.671PheTrp: 0.671 ± 0.336
1.007PheTyr: 1.007 ± 0.286
0.0PheXaa: 0.0 ± 0.0
Gly
2.014GlyAla: 2.014 ± 0.572
0.671GlyCys: 0.671 ± 0.425
3.021GlyAsp: 3.021 ± 1.513
1.007GlyGlu: 1.007 ± 0.504
3.021GlyPhe: 3.021 ± 1.853
2.685GlyGly: 2.685 ± 0.395
1.007GlyHis: 1.007 ± 0.286
3.021GlyIle: 3.021 ± 1.513
3.357GlyLys: 3.357 ± 0.972
3.021GlyLeu: 3.021 ± 0.845
0.671GlyMet: 0.671 ± 0.336
3.357GlyAsn: 3.357 ± 0.985
0.671GlyPro: 0.671 ± 0.336
1.678GlyGln: 1.678 ± 0.84
0.671GlyArg: 0.671 ± 0.425
1.343GlySer: 1.343 ± 0.672
1.007GlyThr: 1.007 ± 0.286
2.014GlyVal: 2.014 ± 1.009
0.336GlyTrp: 0.336 ± 0.168
1.343GlyTyr: 1.343 ± 0.672
0.0GlyXaa: 0.0 ± 0.0
His
1.007HisAla: 1.007 ± 0.286
1.007HisCys: 1.007 ± 1.003
1.343HisAsp: 1.343 ± 0.198
1.343HisGlu: 1.343 ± 0.672
1.007HisPhe: 1.007 ± 0.504
0.671HisGly: 0.671 ± 0.336
0.0HisHis: 0.0 ± 0.0
1.678HisIle: 1.678 ± 0.23
1.007HisLys: 1.007 ± 1.169
2.014HisLeu: 2.014 ± 1.009
0.0HisMet: 0.0 ± 0.0
0.671HisAsn: 0.671 ± 0.336
1.007HisPro: 1.007 ± 0.504
1.007HisGln: 1.007 ± 0.286
0.336HisArg: 0.336 ± 0.168
3.021HisSer: 3.021 ± 0.845
3.357HisThr: 3.357 ± 0.289
2.685HisVal: 2.685 ± 0.659
0.0HisTrp: 0.0 ± 0.0
2.014HisTyr: 2.014 ± 0.572
0.0HisXaa: 0.0 ± 0.0
Ile
5.707IleAla: 5.707 ± 3.265
1.678IleCys: 1.678 ± 0.23
3.357IleAsp: 3.357 ± 0.289
4.364IleGlu: 4.364 ± 1.483
4.364IlePhe: 4.364 ± 0.848
3.357IleGly: 3.357 ± 0.289
1.007IleHis: 1.007 ± 0.504
1.678IleIle: 1.678 ± 1.515
3.021IleLys: 3.021 ± 0.857
6.042IleLeu: 6.042 ± 1.69
1.343IleMet: 1.343 ± 0.85
4.7IleAsn: 4.7 ± 0.615
3.693IlePro: 3.693 ± 0.512
0.671IleGln: 0.671 ± 0.336
5.035IleArg: 5.035 ± 0.929
7.385IleSer: 7.385 ± 0.305
2.685IleThr: 2.685 ± 1.345
4.028IleVal: 4.028 ± 1.382
0.336IleTrp: 0.336 ± 0.168
1.343IleTyr: 1.343 ± 0.198
0.0IleXaa: 0.0 ± 0.0
Lys
1.343LysAla: 1.343 ± 0.198
0.336LysCys: 0.336 ± 0.168
2.014LysAsp: 2.014 ± 1.009
3.357LysGlu: 3.357 ± 0.985
5.035LysPhe: 5.035 ± 0.69
1.343LysGly: 1.343 ± 0.198
2.35LysHis: 2.35 ± 0.5
4.028LysIle: 4.028 ± 1.316
5.707LysLys: 5.707 ± 1.393
7.721LysLeu: 7.721 ± 1.513
1.343LysMet: 1.343 ± 0.471
6.714LysAsn: 6.714 ± 0.734
3.693LysPro: 3.693 ± 1.045
2.014LysGln: 2.014 ± 0.691
4.364LysArg: 4.364 ± 1.483
4.364LysSer: 4.364 ± 2.527
5.035LysThr: 5.035 ± 1.517
2.35LysVal: 2.35 ± 0.542
1.343LysTrp: 1.343 ± 2.541
3.021LysTyr: 3.021 ± 0.821
0.0LysXaa: 0.0 ± 0.0
Leu
4.7LeuAla: 4.7 ± 1.085
1.678LeuCys: 1.678 ± 0.847
3.357LeuAsp: 3.357 ± 0.985
6.714LeuGlu: 6.714 ± 2.654
4.028LeuPhe: 4.028 ± 1.833
3.021LeuGly: 3.021 ± 0.845
2.35LeuHis: 2.35 ± 0.542
5.371LeuIle: 5.371 ± 1.355
6.378LeuLys: 6.378 ± 0.161
9.063LeuLeu: 9.063 ± 3.084
1.343LeuMet: 1.343 ± 0.198
5.371LeuAsn: 5.371 ± 0.819
4.364LeuPro: 4.364 ± 1.026
2.685LeuGln: 2.685 ± 0.409
3.693LeuArg: 3.693 ± 0.65
12.42LeuSer: 12.42 ± 3.05
5.707LeuThr: 5.707 ± 1.479
4.364LeuVal: 4.364 ± 1.016
0.671LeuTrp: 0.671 ± 0.757
2.685LeuTyr: 2.685 ± 1.345
0.0LeuXaa: 0.0 ± 0.0
Met
0.336MetAla: 0.336 ± 0.168
0.671MetCys: 0.671 ± 0.336
0.671MetAsp: 0.671 ± 0.336
1.007MetGlu: 1.007 ± 0.286
0.671MetPhe: 0.671 ± 0.336
0.0MetGly: 0.0 ± 0.0
0.0MetHis: 0.0 ± 0.0
1.343MetIle: 1.343 ± 0.198
1.343MetLys: 1.343 ± 0.672
1.678MetLeu: 1.678 ± 0.486
0.0MetMet: 0.0 ± 0.0
1.678MetAsn: 1.678 ± 0.23
0.671MetPro: 0.671 ± 0.336
0.336MetGln: 0.336 ± 0.168
2.014MetArg: 2.014 ± 0.351
2.014MetSer: 2.014 ± 0.486
0.671MetThr: 0.671 ± 0.336
0.671MetVal: 0.671 ± 0.336
0.0MetTrp: 0.0 ± 0.0
0.336MetTyr: 0.336 ± 0.58
0.0MetXaa: 0.0 ± 0.0
Asn
3.693AsnAla: 3.693 ± 0.57
1.343AsnCys: 1.343 ± 0.672
4.7AsnAsp: 4.7 ± 1.085
3.357AsnGlu: 3.357 ± 0.46
5.707AsnPhe: 5.707 ± 0.918
3.021AsnGly: 3.021 ± 1.513
1.678AsnHis: 1.678 ± 0.23
4.028AsnIle: 4.028 ± 0.593
2.685AsnLys: 2.685 ± 1.345
4.7AsnLeu: 4.7 ± 0.615
0.671AsnMet: 0.671 ± 0.336
4.7AsnAsn: 4.7 ± 1.65
2.685AsnPro: 2.685 ± 0.638
1.343AsnGln: 1.343 ± 0.54
2.35AsnArg: 2.35 ± 1.177
5.035AsnSer: 5.035 ± 3.18
4.364AsnThr: 4.364 ± 0.192
3.021AsnVal: 3.021 ± 0.395
0.0AsnTrp: 0.0 ± 0.0
3.021AsnTyr: 3.021 ± 1.513
0.0AsnXaa: 0.0 ± 0.0
Pro
3.693ProAla: 3.693 ± 1.706
0.671ProCys: 0.671 ± 0.336
1.343ProAsp: 1.343 ± 0.198
3.021ProGlu: 3.021 ± 0.76
2.685ProPhe: 2.685 ± 0.395
1.678ProGly: 1.678 ± 0.23
1.343ProHis: 1.343 ± 0.672
2.014ProIle: 2.014 ± 1.009
3.693ProLys: 3.693 ± 1.223
1.343ProLeu: 1.343 ± 0.198
1.007ProMet: 1.007 ± 0.504
1.678ProAsn: 1.678 ± 0.847
1.678ProPro: 1.678 ± 0.705
0.671ProGln: 0.671 ± 0.336
2.014ProArg: 2.014 ± 2.79
2.685ProSer: 2.685 ± 0.409
2.35ProThr: 2.35 ± 1.177
5.035ProVal: 5.035 ± 1.429
0.336ProTrp: 0.336 ± 0.168
2.35ProTyr: 2.35 ± 0.462
0.0ProXaa: 0.0 ± 0.0
Gln
1.007GlnAla: 1.007 ± 0.504
0.0GlnCys: 0.0 ± 0.0
0.671GlnAsp: 0.671 ± 0.425
1.007GlnGlu: 1.007 ± 0.504
2.685GlnPhe: 2.685 ± 1.345
0.336GlnGly: 0.336 ± 0.168
0.336GlnHis: 0.336 ± 0.168
2.35GlnIle: 2.35 ± 0.462
2.685GlnLys: 2.685 ± 0.409
1.678GlnLeu: 1.678 ± 0.84
0.0GlnMet: 0.0 ± 0.0
1.343GlnAsn: 1.343 ± 0.672
1.007GlnPro: 1.007 ± 0.286
0.671GlnGln: 0.671 ± 0.336
2.685GlnArg: 2.685 ± 0.638
3.357GlnSer: 3.357 ± 1.391
2.35GlnThr: 2.35 ± 1.18
0.336GlnVal: 0.336 ± 0.894
0.336GlnTrp: 0.336 ± 0.168
1.343GlnTyr: 1.343 ± 1.007
0.0GlnXaa: 0.0 ± 0.0
Arg
2.685ArgAla: 2.685 ± 0.395
0.671ArgCys: 0.671 ± 0.336
4.028ArgAsp: 4.028 ± 0.703
2.35ArgGlu: 2.35 ± 0.5
3.693ArgPhe: 3.693 ± 0.512
1.343ArgGly: 1.343 ± 0.672
0.671ArgHis: 0.671 ± 0.336
3.357ArgIle: 3.357 ± 0.46
3.693ArgLys: 3.693 ± 0.355
3.693ArgLeu: 3.693 ± 1.15
0.336ArgMet: 0.336 ± 0.168
4.7ArgAsn: 4.7 ± 0.77
1.678ArgPro: 1.678 ± 0.84
1.678ArgGln: 1.678 ± 0.486
1.343ArgArg: 1.343 ± 0.672
2.014ArgSer: 2.014 ± 0.351
3.021ArgThr: 3.021 ± 0.845
3.021ArgVal: 3.021 ± 0.312
0.0ArgTrp: 0.0 ± 0.0
1.007ArgTyr: 1.007 ± 0.504
0.0ArgXaa: 0.0 ± 0.0
Ser
4.364SerAla: 4.364 ± 0.192
0.336SerCys: 0.336 ± 0.168
4.364SerAsp: 4.364 ± 0.58
4.364SerGlu: 4.364 ± 0.617
5.707SerPhe: 5.707 ± 4.917
4.028SerGly: 4.028 ± 0.475
3.693SerHis: 3.693 ± 0.65
7.385SerIle: 7.385 ± 1.164
6.714SerLys: 6.714 ± 1.773
8.728SerLeu: 8.728 ± 1.082
2.014SerMet: 2.014 ± 0.351
4.7SerAsn: 4.7 ± 1.46
3.357SerPro: 3.357 ± 2.341
3.021SerGln: 3.021 ± 0.395
3.021SerArg: 3.021 ± 0.76
7.721SerSer: 7.721 ± 1.979
7.049SerThr: 7.049 ± 1.083
5.035SerVal: 5.035 ± 1.517
0.671SerTrp: 0.671 ± 0.336
2.685SerTyr: 2.685 ± 0.659
0.0SerXaa: 0.0 ± 0.0
Thr
3.693ThrAla: 3.693 ± 0.57
0.671ThrCys: 0.671 ± 0.336
2.014ThrAsp: 2.014 ± 0.691
2.685ThrGlu: 2.685 ± 0.988
4.7ThrPhe: 4.7 ± 1.001
1.343ThrGly: 1.343 ± 0.672
1.678ThrHis: 1.678 ± 0.847
5.371ThrIle: 5.371 ± 0.819
4.7ThrLys: 4.7 ± 0.093
6.042ThrLeu: 6.042 ± 1.111
0.336ThrMet: 0.336 ± 0.168
3.357ThrAsn: 3.357 ± 0.46
3.021ThrPro: 3.021 ± 0.76
2.014ThrGln: 2.014 ± 0.351
5.035ThrArg: 5.035 ± 0.929
6.714ThrSer: 6.714 ± 0.734
4.364ThrThr: 4.364 ± 1.845
6.042ThrVal: 6.042 ± 0.109
0.0ThrTrp: 0.0 ± 0.0
3.021ThrTyr: 3.021 ± 0.312
0.0ThrXaa: 0.0 ± 0.0
Val
3.693ValAla: 3.693 ± 1.15
1.678ValCys: 1.678 ± 0.23
5.371ValAsp: 5.371 ± 1.984
1.343ValGlu: 1.343 ± 0.672
3.357ValPhe: 3.357 ± 0.678
2.35ValGly: 2.35 ± 1.18
2.014ValHis: 2.014 ± 0.572
4.7ValIle: 4.7 ± 1.085
4.028ValLys: 4.028 ± 1.194
4.364ValLeu: 4.364 ± 2.271
1.678ValMet: 1.678 ± 0.747
3.021ValAsn: 3.021 ± 1.513
4.028ValPro: 4.028 ± 0.593
1.678ValGln: 1.678 ± 0.486
1.343ValArg: 1.343 ± 0.54
7.049ValSer: 7.049 ± 3.344
5.707ValThr: 5.707 ± 0.513
4.364ValVal: 4.364 ± 4.35
0.0ValTrp: 0.0 ± 0.0
3.021ValTyr: 3.021 ± 1.297
0.0ValXaa: 0.0 ± 0.0
Trp
0.671TrpAla: 0.671 ± 0.757
0.0TrpCys: 0.0 ± 0.0
0.336TrpAsp: 0.336 ± 0.168
0.336TrpGlu: 0.336 ± 0.168
0.671TrpPhe: 0.671 ± 0.336
0.336TrpGly: 0.336 ± 0.168
0.0TrpHis: 0.0 ± 0.0
0.336TrpIle: 0.336 ± 0.894
0.336TrpLys: 0.336 ± 0.168
0.336TrpLeu: 0.336 ± 0.168
0.336TrpMet: 0.336 ± 0.168
0.0TrpAsn: 0.0 ± 0.0
0.0TrpPro: 0.0 ± 0.0
0.0TrpGln: 0.0 ± 0.0
0.671TrpArg: 0.671 ± 0.336
0.336TrpSer: 0.336 ± 0.168
0.336TrpThr: 0.336 ± 0.894
0.336TrpVal: 0.336 ± 0.894
0.0TrpTrp: 0.0 ± 0.0
0.0TrpTyr: 0.0 ± 0.0
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.678TyrAla: 1.678 ± 0.84
1.007TyrCys: 1.007 ± 1.169
4.028TyrAsp: 4.028 ± 0.593
2.685TyrGlu: 2.685 ± 1.345
3.693TyrPhe: 3.693 ± 0.355
0.671TyrGly: 0.671 ± 0.336
0.336TyrHis: 0.336 ± 0.168
2.014TyrIle: 2.014 ± 0.691
4.028TyrLys: 4.028 ± 0.348
2.35TyrLeu: 2.35 ± 1.128
0.336TyrMet: 0.336 ± 0.168
1.678TyrAsn: 1.678 ± 0.84
1.343TyrPro: 1.343 ± 0.85
1.343TyrGln: 1.343 ± 0.54
1.343TyrArg: 1.343 ± 0.672
2.35TyrSer: 2.35 ± 0.5
1.007TyrThr: 1.007 ± 0.504
3.021TyrVal: 3.021 ± 0.821
0.336TyrTrp: 0.336 ± 0.168
1.678TyrTyr: 1.678 ± 0.705
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3 proteins (2980 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski