Amino acid dipepetide frequency for Acholeplasma palmae (strain ATCC 49389 / J233)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.041AlaAla: 3.041 ± 0.111
0.352AlaCys: 0.352 ± 0.028
2.351AlaAsp: 2.351 ± 0.075
2.534AlaGlu: 2.534 ± 0.087
2.723AlaPhe: 2.723 ± 0.082
2.925AlaGly: 2.925 ± 0.11
0.987AlaHis: 0.987 ± 0.046
5.393AlaIle: 5.393 ± 0.125
4.488AlaLys: 4.488 ± 0.123
6.394AlaLeu: 6.394 ± 0.117
1.27AlaMet: 1.27 ± 0.056
2.646AlaAsn: 2.646 ± 0.092
1.285AlaPro: 1.285 ± 0.058
1.681AlaGln: 1.681 ± 0.069
1.769AlaArg: 1.769 ± 0.07
3.652AlaSer: 3.652 ± 0.082
3.022AlaThr: 3.022 ± 0.084
3.587AlaVal: 3.587 ± 0.101
0.305AlaTrp: 0.305 ± 0.025
2.644AlaTyr: 2.644 ± 0.081
0.0AlaXaa: 0.0 ± 0.0
Cys
0.239CysAla: 0.239 ± 0.024
0.058CysCys: 0.058 ± 0.011
0.316CysAsp: 0.316 ± 0.028
0.258CysGlu: 0.258 ± 0.023
0.236CysPhe: 0.236 ± 0.023
0.383CysGly: 0.383 ± 0.034
0.116CysHis: 0.116 ± 0.017
0.408CysIle: 0.408 ± 0.031
0.271CysLys: 0.271 ± 0.025
0.473CysLeu: 0.473 ± 0.031
0.114CysMet: 0.114 ± 0.015
0.251CysAsn: 0.251 ± 0.023
0.193CysPro: 0.193 ± 0.023
0.163CysGln: 0.163 ± 0.02
0.129CysArg: 0.129 ± 0.015
0.26CysSer: 0.26 ± 0.024
0.144CysThr: 0.144 ± 0.017
0.239CysVal: 0.239 ± 0.023
0.021CysTrp: 0.021 ± 0.008
0.269CysTyr: 0.269 ± 0.029
0.0CysXaa: 0.0 ± 0.0
Asp
3.166AspAla: 3.166 ± 0.098
0.245AspCys: 0.245 ± 0.023
2.768AspAsp: 2.768 ± 0.087
4.434AspGlu: 4.434 ± 0.107
3.007AspPhe: 3.007 ± 0.085
2.932AspGly: 2.932 ± 0.129
0.959AspHis: 0.959 ± 0.049
5.434AspIle: 5.434 ± 0.108
5.24AspLys: 5.24 ± 0.125
5.775AspLeu: 5.775 ± 0.129
1.105AspMet: 1.105 ± 0.043
2.798AspAsn: 2.798 ± 0.071
1.498AspPro: 1.498 ± 0.059
1.674AspGln: 1.674 ± 0.065
1.599AspArg: 1.599 ± 0.058
3.089AspSer: 3.089 ± 0.093
2.796AspThr: 2.796 ± 0.072
3.407AspVal: 3.407 ± 0.105
0.34AspTrp: 0.34 ± 0.029
3.02AspTyr: 3.02 ± 0.077
0.0AspXaa: 0.0 ± 0.0
Glu
3.86GluAla: 3.86 ± 0.11
0.215GluCys: 0.215 ± 0.025
3.43GluAsp: 3.43 ± 0.085
5.524GluGlu: 5.524 ± 0.149
2.947GluPhe: 2.947 ± 0.084
3.381GluGly: 3.381 ± 0.108
1.064GluHis: 1.064 ± 0.054
7.035GluIle: 7.035 ± 0.13
7.955GluLys: 7.955 ± 0.172
7.574GluLeu: 7.574 ± 0.139
1.616GluMet: 1.616 ± 0.057
5.173GluAsn: 5.173 ± 0.116
1.442GluPro: 1.442 ± 0.065
2.498GluGln: 2.498 ± 0.09
2.212GluArg: 2.212 ± 0.061
3.716GluSer: 3.716 ± 0.087
4.383GluThr: 4.383 ± 0.092
4.959GluVal: 4.959 ± 0.108
0.419GluTrp: 0.419 ± 0.032
3.273GluTyr: 3.273 ± 0.095
0.0GluXaa: 0.0 ± 0.0
Phe
2.078PheAla: 2.078 ± 0.071
0.243PheCys: 0.243 ± 0.025
2.93PheAsp: 2.93 ± 0.075
2.949PheGlu: 2.949 ± 0.084
2.136PhePhe: 2.136 ± 0.08
2.652PheGly: 2.652 ± 0.082
0.632PheHis: 0.632 ± 0.04
4.956PheIle: 4.956 ± 0.136
4.344PheLys: 4.344 ± 0.107
4.365PheLeu: 4.365 ± 0.141
1.113PheMet: 1.113 ± 0.049
3.016PheAsn: 3.016 ± 0.101
1.038PhePro: 1.038 ± 0.052
1.019PheGln: 1.019 ± 0.053
1.24PheArg: 1.24 ± 0.066
3.572PheSer: 3.572 ± 0.109
2.48PheThr: 2.48 ± 0.083
2.575PheVal: 2.575 ± 0.08
0.292PheTrp: 0.292 ± 0.029
2.16PheTyr: 2.16 ± 0.08
0.0PheXaa: 0.0 ± 0.0
Gly
2.878GlyAla: 2.878 ± 0.083
0.333GlyCys: 0.333 ± 0.029
2.5GlyAsp: 2.5 ± 0.095
2.803GlyGlu: 2.803 ± 0.084
2.85GlyPhe: 2.85 ± 0.086
3.299GlyGly: 3.299 ± 0.122
1.04GlyHis: 1.04 ± 0.049
5.593GlyIle: 5.593 ± 0.127
4.905GlyLys: 4.905 ± 0.113
5.485GlyLeu: 5.485 ± 0.123
1.244GlyMet: 1.244 ± 0.055
2.96GlyAsn: 2.96 ± 0.136
1.085GlyPro: 1.085 ± 0.052
1.608GlyGln: 1.608 ± 0.056
1.771GlyArg: 1.771 ± 0.07
3.349GlySer: 3.349 ± 0.112
3.383GlyThr: 3.383 ± 0.127
3.656GlyVal: 3.656 ± 0.113
0.462GlyTrp: 0.462 ± 0.033
2.968GlyTyr: 2.968 ± 0.106
0.0GlyXaa: 0.0 ± 0.0
His
0.974HisAla: 0.974 ± 0.045
0.09HisCys: 0.09 ± 0.014
0.898HisAsp: 0.898 ± 0.043
1.21HisGlu: 1.21 ± 0.053
0.847HisPhe: 0.847 ± 0.047
0.944HisGly: 0.944 ± 0.052
0.475HisHis: 0.475 ± 0.041
1.638HisIle: 1.638 ± 0.061
1.266HisLys: 1.266 ± 0.062
1.821HisLeu: 1.821 ± 0.074
0.404HisMet: 0.404 ± 0.028
0.886HisAsn: 0.886 ± 0.046
0.696HisPro: 0.696 ± 0.045
0.703HisGln: 0.703 ± 0.042
0.548HisArg: 0.548 ± 0.031
0.815HisSer: 0.815 ± 0.044
0.901HisThr: 0.901 ± 0.043
0.954HisVal: 0.954 ± 0.053
0.11HisTrp: 0.11 ± 0.017
0.782HisTyr: 0.782 ± 0.042
0.0HisXaa: 0.0 ± 0.0
Ile
5.367IleAla: 5.367 ± 0.114
0.492IleCys: 0.492 ± 0.038
5.919IleAsp: 5.919 ± 0.115
6.835IleGlu: 6.835 ± 0.116
4.073IlePhe: 4.073 ± 0.119
5.468IleGly: 5.468 ± 0.139
1.53IleHis: 1.53 ± 0.067
8.935IleIle: 8.935 ± 0.176
9.1IleLys: 9.1 ± 0.178
9.412IleLeu: 9.412 ± 0.193
1.9IleMet: 1.9 ± 0.075
5.709IleAsn: 5.709 ± 0.132
2.99IlePro: 2.99 ± 0.078
2.614IleGln: 2.614 ± 0.084
2.846IleArg: 2.846 ± 0.079
6.341IleSer: 6.341 ± 0.121
6.053IleThr: 6.053 ± 0.175
5.982IleVal: 5.982 ± 0.112
0.497IleTrp: 0.497 ± 0.034
4.135IleTyr: 4.135 ± 0.105
0.0IleXaa: 0.0 ± 0.0
Lys
4.658LysAla: 4.658 ± 0.126
0.243LysCys: 0.243 ± 0.024
5.954LysAsp: 5.954 ± 0.12
9.498LysGlu: 9.498 ± 0.165
2.824LysPhe: 2.824 ± 0.076
4.402LysGly: 4.402 ± 0.112
1.354LysHis: 1.354 ± 0.059
8.346LysIle: 8.346 ± 0.159
9.363LysLys: 9.363 ± 0.19
7.718LysLeu: 7.718 ± 0.139
2.596LysMet: 2.596 ± 0.082
6.861LysAsn: 6.861 ± 0.145
2.21LysPro: 2.21 ± 0.07
3.121LysGln: 3.121 ± 0.09
3.243LysArg: 3.243 ± 0.091
4.325LysSer: 4.325 ± 0.096
5.597LysThr: 5.597 ± 0.112
5.896LysVal: 5.896 ± 0.117
0.658LysTrp: 0.658 ± 0.044
4.408LysTyr: 4.408 ± 0.11
0.0LysXaa: 0.0 ± 0.0
Leu
5.627LeuAla: 5.627 ± 0.114
0.488LeuCys: 0.488 ± 0.034
6.063LeuAsp: 6.063 ± 0.137
8.241LeuGlu: 8.241 ± 0.176
4.537LeuPhe: 4.537 ± 0.137
5.425LeuGly: 5.425 ± 0.142
1.251LeuHis: 1.251 ± 0.058
8.943LeuIle: 8.943 ± 0.2
9.257LeuLys: 9.257 ± 0.174
9.438LeuLeu: 9.438 ± 0.216
2.28LeuMet: 2.28 ± 0.076
6.274LeuAsn: 6.274 ± 0.114
2.79LeuPro: 2.79 ± 0.079
2.081LeuGln: 2.081 ± 0.073
2.983LeuArg: 2.983 ± 0.085
7.108LeuSer: 7.108 ± 0.144
6.016LeuThr: 6.016 ± 0.139
6.635LeuVal: 6.635 ± 0.138
0.585LeuTrp: 0.585 ± 0.035
4.009LeuTyr: 4.009 ± 0.103
0.0LeuXaa: 0.0 ± 0.0
Met
1.333MetAla: 1.333 ± 0.057
0.103MetCys: 0.103 ± 0.015
1.036MetAsp: 1.036 ± 0.05
1.236MetGlu: 1.236 ± 0.049
0.98MetPhe: 0.98 ± 0.052
1.234MetGly: 1.234 ± 0.057
0.415MetHis: 0.415 ± 0.032
2.515MetIle: 2.515 ± 0.083
2.296MetLys: 2.296 ± 0.07
1.962MetLeu: 1.962 ± 0.072
0.58MetMet: 0.58 ± 0.03
1.511MetAsn: 1.511 ± 0.05
0.84MetPro: 0.84 ± 0.044
0.651MetGln: 0.651 ± 0.034
0.701MetArg: 0.701 ± 0.044
1.431MetSer: 1.431 ± 0.064
1.283MetThr: 1.283 ± 0.055
1.395MetVal: 1.395 ± 0.061
0.14MetTrp: 0.14 ± 0.016
0.817MetTyr: 0.817 ± 0.044
0.0MetXaa: 0.0 ± 0.0
Asn
2.893AsnAla: 2.893 ± 0.1
0.224AsnCys: 0.224 ± 0.021
3.628AsnAsp: 3.628 ± 0.088
4.802AsnGlu: 4.802 ± 0.107
2.558AsnPhe: 2.558 ± 0.068
3.256AsnGly: 3.256 ± 0.126
1.3AsnHis: 1.3 ± 0.05
5.687AsnIle: 5.687 ± 0.12
6.128AsnLys: 6.128 ± 0.122
5.986AsnLeu: 5.986 ± 0.102
1.234AsnMet: 1.234 ± 0.049
3.948AsnAsn: 3.948 ± 0.111
2.093AsnPro: 2.093 ± 0.079
2.618AsnGln: 2.618 ± 0.089
1.874AsnArg: 1.874 ± 0.064
3.183AsnSer: 3.183 ± 0.121
2.874AsnThr: 2.874 ± 0.112
3.293AsnVal: 3.293 ± 0.095
0.466AsnTrp: 0.466 ± 0.035
3.162AsnTyr: 3.162 ± 0.093
0.0AsnXaa: 0.0 ± 0.0
Pro
1.244ProAla: 1.244 ± 0.066
0.107ProCys: 0.107 ± 0.016
1.244ProAsp: 1.244 ± 0.052
2.152ProGlu: 2.152 ± 0.08
1.451ProPhe: 1.451 ± 0.053
1.399ProGly: 1.399 ± 0.064
0.516ProHis: 0.516 ± 0.032
2.577ProIle: 2.577 ± 0.081
2.513ProLys: 2.513 ± 0.078
2.474ProLeu: 2.474 ± 0.093
0.582ProMet: 0.582 ± 0.038
1.715ProAsn: 1.715 ± 0.054
0.404ProPro: 0.404 ± 0.031
0.787ProGln: 0.787 ± 0.045
0.785ProArg: 0.785 ± 0.038
1.649ProSer: 1.649 ± 0.07
1.571ProThr: 1.571 ± 0.064
1.902ProVal: 1.902 ± 0.076
0.191ProTrp: 0.191 ± 0.025
1.397ProTyr: 1.397 ± 0.052
0.0ProXaa: 0.0 ± 0.0
Gln
1.825GlnAla: 1.825 ± 0.081
0.073GlnCys: 0.073 ± 0.013
1.324GlnAsp: 1.324 ± 0.063
2.377GlnGlu: 2.377 ± 0.076
1.335GlnPhe: 1.335 ± 0.052
1.492GlnGly: 1.492 ± 0.06
0.413GlnHis: 0.413 ± 0.026
2.953GlnIle: 2.953 ± 0.071
2.882GlnLys: 2.882 ± 0.093
3.155GlnLeu: 3.155 ± 0.078
0.916GlnMet: 0.916 ± 0.045
1.93GlnAsn: 1.93 ± 0.067
0.645GlnPro: 0.645 ± 0.036
0.952GlnGln: 0.952 ± 0.043
1.154GlnArg: 1.154 ± 0.057
1.625GlnSer: 1.625 ± 0.066
2.13GlnThr: 2.13 ± 0.072
1.949GlnVal: 1.949 ± 0.051
0.221GlnTrp: 0.221 ± 0.02
1.487GlnTyr: 1.487 ± 0.069
0.0GlnXaa: 0.0 ± 0.0
Arg
1.653ArgAla: 1.653 ± 0.06
0.107ArgCys: 0.107 ± 0.015
1.367ArgAsp: 1.367 ± 0.059
2.003ArgGlu: 2.003 ± 0.072
1.421ArgPhe: 1.421 ± 0.054
1.575ArgGly: 1.575 ± 0.07
0.552ArgHis: 0.552 ± 0.033
3.086ArgIle: 3.086 ± 0.08
3.138ArgLys: 3.138 ± 0.094
3.065ArgLeu: 3.065 ± 0.088
0.883ArgMet: 0.883 ± 0.041
1.962ArgAsn: 1.962 ± 0.067
0.969ArgPro: 0.969 ± 0.053
1.083ArgGln: 1.083 ± 0.053
1.255ArgArg: 1.255 ± 0.06
1.636ArgSer: 1.636 ± 0.057
1.655ArgThr: 1.655 ± 0.064
2.162ArgVal: 2.162 ± 0.068
0.202ArgTrp: 0.202 ± 0.022
1.487ArgTyr: 1.487 ± 0.066
0.0ArgXaa: 0.0 ± 0.0
Ser
2.887SerAla: 2.887 ± 0.091
0.282SerCys: 0.282 ± 0.024
3.458SerAsp: 3.458 ± 0.092
3.871SerGlu: 3.871 ± 0.106
3.256SerPhe: 3.256 ± 0.094
3.714SerGly: 3.714 ± 0.095
1.03SerHis: 1.03 ± 0.047
6.007SerIle: 6.007 ± 0.124
5.468SerLys: 5.468 ± 0.113
6.306SerLeu: 6.306 ± 0.134
1.227SerMet: 1.227 ± 0.047
3.867SerAsn: 3.867 ± 0.121
1.369SerPro: 1.369 ± 0.055
1.922SerGln: 1.922 ± 0.057
1.868SerArg: 1.868 ± 0.064
3.564SerSer: 3.564 ± 0.112
2.925SerThr: 2.925 ± 0.082
3.678SerVal: 3.678 ± 0.104
0.458SerTrp: 0.458 ± 0.03
3.082SerTyr: 3.082 ± 0.097
0.0SerXaa: 0.0 ± 0.0
Thr
2.798ThrAla: 2.798 ± 0.08
0.208ThrCys: 0.208 ± 0.021
3.054ThrAsp: 3.054 ± 0.109
3.568ThrGlu: 3.568 ± 0.11
2.62ThrPhe: 2.62 ± 0.07
3.254ThrGly: 3.254 ± 0.094
1.221ThrHis: 1.221 ± 0.049
5.691ThrIle: 5.691 ± 0.149
5.137ThrLys: 5.137 ± 0.11
6.027ThrLeu: 6.027 ± 0.128
1.002ThrMet: 1.002 ± 0.045
3.325ThrAsn: 3.325 ± 0.116
1.995ThrPro: 1.995 ± 0.069
1.896ThrGln: 1.896 ± 0.055
1.649ThrArg: 1.649 ± 0.059
3.439ThrSer: 3.439 ± 0.098
3.448ThrThr: 3.448 ± 0.107
3.88ThrVal: 3.88 ± 0.124
0.434ThrTrp: 0.434 ± 0.033
2.794ThrTyr: 2.794 ± 0.077
0.0ThrXaa: 0.0 ± 0.0
Val
3.589ValAla: 3.589 ± 0.116
0.355ValCys: 0.355 ± 0.031
3.546ValAsp: 3.546 ± 0.089
4.142ValGlu: 4.142 ± 0.128
3.256ValPhe: 3.256 ± 0.09
3.641ValGly: 3.641 ± 0.129
0.864ValHis: 0.864 ± 0.047
6.289ValIle: 6.289 ± 0.134
5.094ValLys: 5.094 ± 0.115
6.854ValLeu: 6.854 ± 0.178
1.369ValMet: 1.369 ± 0.057
3.323ValAsn: 3.323 ± 0.09
1.649ValPro: 1.649 ± 0.064
1.255ValGln: 1.255 ± 0.058
1.863ValArg: 1.863 ± 0.072
4.692ValSer: 4.692 ± 0.105
4.019ValThr: 4.019 ± 0.135
4.548ValVal: 4.548 ± 0.114
0.441ValTrp: 0.441 ± 0.034
2.923ValTyr: 2.923 ± 0.093
0.0ValXaa: 0.0 ± 0.0
Trp
0.352TrpAla: 0.352 ± 0.031
0.049TrpCys: 0.049 ± 0.01
0.38TrpAsp: 0.38 ± 0.036
0.419TrpGlu: 0.419 ± 0.03
0.398TrpPhe: 0.398 ± 0.033
0.372TrpGly: 0.372 ± 0.035
0.146TrpHis: 0.146 ± 0.017
0.664TrpIle: 0.664 ± 0.037
0.413TrpLys: 0.413 ± 0.031
0.72TrpLeu: 0.72 ± 0.042
0.144TrpMet: 0.144 ± 0.017
0.462TrpAsn: 0.462 ± 0.033
0.144TrpPro: 0.144 ± 0.02
0.251TrpGln: 0.251 ± 0.026
0.228TrpArg: 0.228 ± 0.022
0.333TrpSer: 0.333 ± 0.028
0.273TrpThr: 0.273 ± 0.021
0.365TrpVal: 0.365 ± 0.029
0.069TrpTrp: 0.069 ± 0.013
0.404TrpTyr: 0.404 ± 0.05
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.588TyrAla: 2.588 ± 0.09
0.273TyrCys: 0.273 ± 0.026
3.117TyrAsp: 3.117 ± 0.102
3.822TyrGlu: 3.822 ± 0.126
2.336TyrPhe: 2.336 ± 0.076
2.424TyrGly: 2.424 ± 0.082
1.096TyrHis: 1.096 ± 0.051
4.047TyrIle: 4.047 ± 0.096
4.017TyrLys: 4.017 ± 0.094
5.025TyrLeu: 5.025 ± 0.121
0.875TyrMet: 0.875 ± 0.045
2.59TyrAsn: 2.59 ± 0.098
1.324TyrPro: 1.324 ± 0.057
2.263TyrGln: 2.263 ± 0.08
1.548TyrArg: 1.548 ± 0.065
2.461TyrSer: 2.461 ± 0.086
2.487TyrThr: 2.487 ± 0.091
2.652TyrVal: 2.652 ± 0.086
0.277TyrTrp: 0.277 ± 0.035
2.39TyrTyr: 2.39 ± 0.094
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1433 proteins (465257 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski