Amino acid dipepetide frequency for Human rotavirus C

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.28AlaAla: 4.28 ± 0.706
1.07AlaCys: 1.07 ± 0.499
2.319AlaAsp: 2.319 ± 0.484
2.854AlaGlu: 2.854 ± 0.933
2.675AlaPhe: 2.675 ± 0.623
2.497AlaGly: 2.497 ± 0.654
0.892AlaHis: 0.892 ± 0.327
5.529AlaIle: 5.529 ± 0.682
3.745AlaLys: 3.745 ± 0.707
5.172AlaLeu: 5.172 ± 1.124
2.497AlaMet: 2.497 ± 0.429
3.032AlaAsn: 3.032 ± 0.347
1.248AlaPro: 1.248 ± 0.36
1.783AlaGln: 1.783 ± 0.498
2.14AlaArg: 2.14 ± 0.61
4.994AlaSer: 4.994 ± 1.032
3.389AlaThr: 3.389 ± 0.502
2.675AlaVal: 2.675 ± 0.668
0.178AlaTrp: 0.178 ± 0.148
1.605AlaTyr: 1.605 ± 0.397
0.0AlaXaa: 0.0 ± 0.0
Cys
0.357CysAla: 0.357 ± 0.327
0.0CysCys: 0.0 ± 0.0
1.427CysAsp: 1.427 ± 0.839
0.535CysGlu: 0.535 ± 0.323
0.713CysPhe: 0.713 ± 0.362
0.357CysGly: 0.357 ± 0.327
0.357CysHis: 0.357 ± 0.282
1.962CysIle: 1.962 ± 0.849
1.248CysLys: 1.248 ± 0.624
1.605CysLeu: 1.605 ± 0.87
0.535CysMet: 0.535 ± 0.238
0.535CysAsn: 0.535 ± 0.321
0.713CysPro: 0.713 ± 0.528
0.892CysGln: 0.892 ± 0.447
0.0CysArg: 0.0 ± 0.0
0.892CysSer: 0.892 ± 0.474
0.535CysThr: 0.535 ± 0.322
0.892CysVal: 0.892 ± 0.588
0.0CysTrp: 0.0 ± 0.0
0.178CysTyr: 0.178 ± 0.184
0.0CysXaa: 0.0 ± 0.0
Asp
3.389AspAla: 3.389 ± 0.617
0.892AspCys: 0.892 ± 0.481
3.567AspAsp: 3.567 ± 0.665
2.854AspGlu: 2.854 ± 0.947
2.675AspPhe: 2.675 ± 0.614
3.745AspGly: 3.745 ± 0.605
0.713AspHis: 0.713 ± 0.297
6.956AspIle: 6.956 ± 1.326
3.032AspLys: 3.032 ± 0.61
2.854AspLeu: 2.854 ± 0.788
1.783AspMet: 1.783 ± 0.45
3.389AspAsn: 3.389 ± 0.474
1.07AspPro: 1.07 ± 0.299
1.605AspGln: 1.605 ± 0.444
1.962AspArg: 1.962 ± 0.75
4.28AspSer: 4.28 ± 0.884
3.21AspThr: 3.21 ± 0.808
4.459AspVal: 4.459 ± 0.661
0.357AspTrp: 0.357 ± 0.349
4.815AspTyr: 4.815 ± 0.697
0.0AspXaa: 0.0 ± 0.0
Glu
2.497GluAla: 2.497 ± 0.713
0.892GluCys: 0.892 ± 0.743
2.497GluAsp: 2.497 ± 0.568
3.745GluGlu: 3.745 ± 0.884
2.319GluPhe: 2.319 ± 0.45
1.605GluGly: 1.605 ± 0.428
0.892GluHis: 0.892 ± 0.419
5.172GluIle: 5.172 ± 0.919
5.172GluLys: 5.172 ± 1.242
4.459GluLeu: 4.459 ± 0.933
2.854GluMet: 2.854 ± 0.938
4.459GluAsn: 4.459 ± 0.896
0.357GluPro: 0.357 ± 0.24
0.892GluGln: 0.892 ± 0.451
3.032GluArg: 3.032 ± 0.706
4.637GluSer: 4.637 ± 1.111
3.032GluThr: 3.032 ± 0.754
2.675GluVal: 2.675 ± 0.632
1.605GluTrp: 1.605 ± 0.649
3.389GluTyr: 3.389 ± 0.871
0.0GluXaa: 0.0 ± 0.0
Phe
2.497PheAla: 2.497 ± 0.547
0.178PheCys: 0.178 ± 0.219
4.28PheAsp: 4.28 ± 0.841
2.497PheGlu: 2.497 ± 0.501
0.892PhePhe: 0.892 ± 0.363
1.605PheGly: 1.605 ± 0.473
0.892PheHis: 0.892 ± 0.329
4.994PheIle: 4.994 ± 1.048
4.459PheLys: 4.459 ± 0.599
2.675PheLeu: 2.675 ± 0.824
0.713PheMet: 0.713 ± 0.432
3.21PheAsn: 3.21 ± 0.978
1.783PhePro: 1.783 ± 0.527
1.427PheGln: 1.427 ± 0.605
2.14PheArg: 2.14 ± 0.615
3.389PheSer: 3.389 ± 0.553
3.032PheThr: 3.032 ± 0.684
2.14PheVal: 2.14 ± 0.502
0.357PheTrp: 0.357 ± 0.218
1.248PheTyr: 1.248 ± 0.309
0.0PheXaa: 0.0 ± 0.0
Gly
1.605GlyAla: 1.605 ± 0.519
0.535GlyCys: 0.535 ± 0.256
1.962GlyAsp: 1.962 ± 0.474
1.783GlyGlu: 1.783 ± 0.464
1.07GlyPhe: 1.07 ± 0.336
2.14GlyGly: 2.14 ± 0.828
0.892GlyHis: 0.892 ± 0.485
4.102GlyIle: 4.102 ± 0.68
2.675GlyLys: 2.675 ± 0.64
2.675GlyLeu: 2.675 ± 0.647
1.427GlyMet: 1.427 ± 0.48
2.319GlyAsn: 2.319 ± 0.713
1.07GlyPro: 1.07 ± 0.537
1.248GlyGln: 1.248 ± 0.498
2.14GlyArg: 2.14 ± 0.677
3.21GlySer: 3.21 ± 1.057
2.497GlyThr: 2.497 ± 0.849
1.427GlyVal: 1.427 ± 0.391
0.892GlyTrp: 0.892 ± 0.421
1.962GlyTyr: 1.962 ± 0.737
0.0GlyXaa: 0.0 ± 0.0
His
1.427HisAla: 1.427 ± 0.668
0.178HisCys: 0.178 ± 0.155
1.427HisAsp: 1.427 ± 0.487
1.605HisGlu: 1.605 ± 0.655
0.713HisPhe: 0.713 ± 0.426
0.713HisGly: 0.713 ± 0.44
0.713HisHis: 0.713 ± 0.238
0.892HisIle: 0.892 ± 0.576
1.07HisLys: 1.07 ± 0.333
1.605HisLeu: 1.605 ± 0.595
0.178HisMet: 0.178 ± 0.197
1.427HisAsn: 1.427 ± 0.482
0.357HisPro: 0.357 ± 0.247
0.178HisGln: 0.178 ± 0.155
0.892HisArg: 0.892 ± 0.501
1.427HisSer: 1.427 ± 0.351
1.427HisThr: 1.427 ± 0.482
1.427HisVal: 1.427 ± 0.423
0.178HisTrp: 0.178 ± 0.226
0.357HisTyr: 0.357 ± 0.217
0.0HisXaa: 0.0 ± 0.0
Ile
4.459IleAla: 4.459 ± 1.019
1.427IleCys: 1.427 ± 0.519
5.529IleAsp: 5.529 ± 0.809
5.172IleGlu: 5.172 ± 0.735
3.21IlePhe: 3.21 ± 0.643
3.032IleGly: 3.032 ± 0.811
1.07IleHis: 1.07 ± 0.418
6.599IleIle: 6.599 ± 0.991
5.707IleLys: 5.707 ± 1.056
7.669IleLeu: 7.669 ± 1.193
3.032IleMet: 3.032 ± 0.85
9.096IleAsn: 9.096 ± 1.343
3.924IlePro: 3.924 ± 0.791
3.21IleGln: 3.21 ± 0.95
2.854IleArg: 2.854 ± 0.713
6.599IleSer: 6.599 ± 0.843
6.599IleThr: 6.599 ± 0.973
5.529IleVal: 5.529 ± 0.584
0.535IleTrp: 0.535 ± 0.271
3.389IleTyr: 3.389 ± 1.087
0.0IleXaa: 0.0 ± 0.0
Lys
3.567LysAla: 3.567 ± 0.77
0.713LysCys: 0.713 ± 0.461
3.389LysAsp: 3.389 ± 0.572
3.389LysGlu: 3.389 ± 1.031
2.675LysPhe: 2.675 ± 0.955
1.962LysGly: 1.962 ± 0.643
1.605LysHis: 1.605 ± 0.666
6.777LysIle: 6.777 ± 1.48
4.815LysLys: 4.815 ± 0.584
6.599LysLeu: 6.599 ± 1.058
2.319LysMet: 2.319 ± 0.69
3.924LysAsn: 3.924 ± 0.846
1.07LysPro: 1.07 ± 0.372
2.319LysGln: 2.319 ± 0.605
3.21LysArg: 3.21 ± 1.026
5.529LysSer: 5.529 ± 1.282
5.35LysThr: 5.35 ± 1.113
3.924LysVal: 3.924 ± 0.949
0.892LysTrp: 0.892 ± 0.29
2.675LysTyr: 2.675 ± 0.612
0.0LysXaa: 0.0 ± 0.0
Leu
4.459LeuAla: 4.459 ± 0.704
1.07LeuCys: 1.07 ± 0.556
3.21LeuAsp: 3.21 ± 0.82
4.815LeuGlu: 4.815 ± 0.937
4.459LeuPhe: 4.459 ± 0.851
2.14LeuGly: 2.14 ± 0.542
1.605LeuHis: 1.605 ± 0.505
7.312LeuIle: 7.312 ± 0.779
5.707LeuLys: 5.707 ± 1.038
6.064LeuLeu: 6.064 ± 1.115
2.497LeuMet: 2.497 ± 0.602
6.421LeuAsn: 6.421 ± 1.299
2.497LeuPro: 2.497 ± 0.391
2.319LeuGln: 2.319 ± 0.9
5.172LeuArg: 5.172 ± 0.866
7.134LeuSer: 7.134 ± 0.759
5.35LeuThr: 5.35 ± 1.409
3.21LeuVal: 3.21 ± 1.255
0.892LeuTrp: 0.892 ± 0.404
4.28LeuTyr: 4.28 ± 1.191
0.0LeuXaa: 0.0 ± 0.0
Met
2.319MetAla: 2.319 ± 0.728
0.0MetCys: 0.0 ± 0.0
1.248MetAsp: 1.248 ± 0.433
0.713MetGlu: 0.713 ± 0.289
1.605MetPhe: 1.605 ± 0.556
0.535MetGly: 0.535 ± 0.454
0.713MetHis: 0.713 ± 0.325
1.962MetIle: 1.962 ± 0.435
3.389MetLys: 3.389 ± 0.912
3.389MetLeu: 3.389 ± 0.859
1.07MetMet: 1.07 ± 0.387
3.032MetAsn: 3.032 ± 0.596
1.248MetPro: 1.248 ± 0.473
0.713MetGln: 0.713 ± 0.477
1.07MetArg: 1.07 ± 0.631
2.319MetSer: 2.319 ± 0.553
2.14MetThr: 2.14 ± 0.509
1.962MetVal: 1.962 ± 0.566
0.0MetTrp: 0.0 ± 0.0
1.427MetTyr: 1.427 ± 0.415
0.0MetXaa: 0.0 ± 0.0
Asn
3.924AsnAla: 3.924 ± 0.777
1.07AsnCys: 1.07 ± 0.604
3.567AsnAsp: 3.567 ± 0.892
4.637AsnGlu: 4.637 ± 1.438
3.389AsnPhe: 3.389 ± 0.91
3.21AsnGly: 3.21 ± 1.146
1.07AsnHis: 1.07 ± 0.419
4.637AsnIle: 4.637 ± 0.919
4.102AsnLys: 4.102 ± 0.853
4.102AsnLeu: 4.102 ± 0.796
1.605AsnMet: 1.605 ± 0.251
5.172AsnAsn: 5.172 ± 0.609
2.854AsnPro: 2.854 ± 1.067
2.854AsnGln: 2.854 ± 0.519
2.854AsnArg: 2.854 ± 0.697
7.134AsnSer: 7.134 ± 1.141
5.707AsnThr: 5.707 ± 1.16
6.064AsnVal: 6.064 ± 0.945
0.892AsnTrp: 0.892 ± 0.524
5.172AsnTyr: 5.172 ± 0.545
0.0AsnXaa: 0.0 ± 0.0
Pro
1.962ProAla: 1.962 ± 0.564
0.357ProCys: 0.357 ± 0.438
2.319ProAsp: 2.319 ± 0.359
0.713ProGlu: 0.713 ± 0.318
0.713ProPhe: 0.713 ± 0.364
1.605ProGly: 1.605 ± 0.364
0.178ProHis: 0.178 ± 0.167
3.21ProIle: 3.21 ± 0.594
1.07ProLys: 1.07 ± 0.448
2.675ProLeu: 2.675 ± 0.697
0.892ProMet: 0.892 ± 0.447
1.605ProAsn: 1.605 ± 0.571
1.07ProPro: 1.07 ± 0.45
1.427ProGln: 1.427 ± 1.037
0.713ProArg: 0.713 ± 0.293
1.605ProSer: 1.605 ± 0.435
2.319ProThr: 2.319 ± 0.696
1.605ProVal: 1.605 ± 0.517
0.357ProTrp: 0.357 ± 0.297
2.14ProTyr: 2.14 ± 0.576
0.0ProXaa: 0.0 ± 0.0
Gln
1.962GlnAla: 1.962 ± 0.621
0.535GlnCys: 0.535 ± 0.371
0.892GlnAsp: 0.892 ± 0.32
1.07GlnGlu: 1.07 ± 0.395
2.319GlnPhe: 2.319 ± 0.529
0.713GlnGly: 0.713 ± 0.415
0.713GlnHis: 0.713 ± 0.291
2.675GlnIle: 2.675 ± 0.678
1.427GlnLys: 1.427 ± 0.424
5.172GlnLeu: 5.172 ± 0.826
1.605GlnMet: 1.605 ± 0.622
1.605GlnAsn: 1.605 ± 0.462
1.427GlnPro: 1.427 ± 0.606
1.962GlnGln: 1.962 ± 0.688
1.427GlnArg: 1.427 ± 0.532
2.14GlnSer: 2.14 ± 0.897
2.497GlnThr: 2.497 ± 0.73
1.248GlnVal: 1.248 ± 0.38
0.713GlnTrp: 0.713 ± 0.334
2.14GlnTyr: 2.14 ± 0.4
0.0GlnXaa: 0.0 ± 0.0
Arg
2.14ArgAla: 2.14 ± 0.428
0.535ArgCys: 0.535 ± 0.301
2.675ArgAsp: 2.675 ± 0.601
2.675ArgGlu: 2.675 ± 0.799
3.032ArgPhe: 3.032 ± 0.501
1.427ArgGly: 1.427 ± 0.691
1.248ArgHis: 1.248 ± 0.628
4.28ArgIle: 4.28 ± 0.857
1.962ArgLys: 1.962 ± 0.678
4.459ArgLeu: 4.459 ± 0.549
1.427ArgMet: 1.427 ± 0.582
3.567ArgAsn: 3.567 ± 0.678
0.713ArgPro: 0.713 ± 0.464
1.248ArgGln: 1.248 ± 0.553
3.745ArgArg: 3.745 ± 1.048
3.745ArgSer: 3.745 ± 0.746
2.319ArgThr: 2.319 ± 0.716
1.605ArgVal: 1.605 ± 0.407
0.535ArgTrp: 0.535 ± 0.433
2.14ArgTyr: 2.14 ± 0.701
0.0ArgXaa: 0.0 ± 0.0
Ser
4.459SerAla: 4.459 ± 0.8
1.07SerCys: 1.07 ± 0.276
5.707SerAsp: 5.707 ± 1.369
5.35SerGlu: 5.35 ± 1.037
3.389SerPhe: 3.389 ± 0.912
3.567SerGly: 3.567 ± 1.308
1.783SerHis: 1.783 ± 0.746
4.994SerIle: 4.994 ± 1.3
5.172SerLys: 5.172 ± 0.766
6.064SerLeu: 6.064 ± 1.239
1.248SerMet: 1.248 ± 0.486
7.491SerAsn: 7.491 ± 1.237
1.962SerPro: 1.962 ± 0.722
3.567SerGln: 3.567 ± 0.582
2.854SerArg: 2.854 ± 0.658
6.242SerSer: 6.242 ± 1.201
4.28SerThr: 4.28 ± 0.793
5.529SerVal: 5.529 ± 1.017
0.178SerTrp: 0.178 ± 0.184
4.815SerTyr: 4.815 ± 0.861
0.0SerXaa: 0.0 ± 0.0
Thr
2.675ThrAla: 2.675 ± 0.62
1.07ThrCys: 1.07 ± 0.524
3.745ThrAsp: 3.745 ± 0.9
4.994ThrGlu: 4.994 ± 1.209
3.032ThrPhe: 3.032 ± 0.659
1.783ThrGly: 1.783 ± 0.516
0.713ThrHis: 0.713 ± 0.308
7.312ThrIle: 7.312 ± 1.249
3.032ThrLys: 3.032 ± 0.73
4.459ThrLeu: 4.459 ± 1.006
1.605ThrMet: 1.605 ± 0.63
5.35ThrAsn: 5.35 ± 1.298
2.497ThrPro: 2.497 ± 0.738
2.319ThrGln: 2.319 ± 0.628
2.319ThrArg: 2.319 ± 0.704
4.102ThrSer: 4.102 ± 0.524
4.815ThrThr: 4.815 ± 1.058
5.35ThrVal: 5.35 ± 1.034
0.713ThrTrp: 0.713 ± 0.366
4.815ThrTyr: 4.815 ± 1.165
0.0ThrXaa: 0.0 ± 0.0
Val
4.102ValAla: 4.102 ± 1.059
1.427ValCys: 1.427 ± 0.833
4.102ValAsp: 4.102 ± 0.966
3.567ValGlu: 3.567 ± 1.174
1.605ValPhe: 1.605 ± 0.533
2.497ValGly: 2.497 ± 0.383
1.248ValHis: 1.248 ± 0.35
3.21ValIle: 3.21 ± 0.608
4.815ValLys: 4.815 ± 0.833
4.459ValLeu: 4.459 ± 1.02
1.783ValMet: 1.783 ± 0.502
3.032ValAsn: 3.032 ± 0.595
1.427ValPro: 1.427 ± 0.345
1.962ValGln: 1.962 ± 0.798
3.567ValArg: 3.567 ± 0.802
5.172ValSer: 5.172 ± 0.436
3.032ValThr: 3.032 ± 0.516
3.745ValVal: 3.745 ± 0.728
0.357ValTrp: 0.357 ± 0.315
3.21ValTyr: 3.21 ± 0.421
0.0ValXaa: 0.0 ± 0.0
Trp
0.178TrpAla: 0.178 ± 0.199
0.178TrpCys: 0.178 ± 0.184
0.535TrpAsp: 0.535 ± 0.219
0.535TrpGlu: 0.535 ± 0.249
0.713TrpPhe: 0.713 ± 0.304
0.357TrpGly: 0.357 ± 0.334
0.0TrpHis: 0.0 ± 0.0
1.427TrpIle: 1.427 ± 0.72
0.892TrpLys: 0.892 ± 0.447
1.07TrpLeu: 1.07 ± 0.512
0.357TrpMet: 0.357 ± 0.253
1.605TrpAsn: 1.605 ± 0.515
0.0TrpPro: 0.0 ± 0.0
0.357TrpGln: 0.357 ± 0.218
0.892TrpArg: 0.892 ± 0.431
0.357TrpSer: 0.357 ± 0.247
0.357TrpThr: 0.357 ± 0.236
0.0TrpVal: 0.0 ± 0.0
0.357TrpTrp: 0.357 ± 0.281
0.713TrpTyr: 0.713 ± 0.285
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.319TyrAla: 2.319 ± 0.772
0.535TyrCys: 0.535 ± 0.252
3.21TyrAsp: 3.21 ± 0.741
2.675TyrGlu: 2.675 ± 0.94
3.21TyrPhe: 3.21 ± 0.556
2.14TyrGly: 2.14 ± 0.889
0.892TyrHis: 0.892 ± 0.301
4.637TyrIle: 4.637 ± 0.865
3.21TyrLys: 3.21 ± 0.672
3.389TyrLeu: 3.389 ± 0.853
1.427TyrMet: 1.427 ± 0.416
3.745TyrAsn: 3.745 ± 0.801
1.248TyrPro: 1.248 ± 0.457
1.962TyrGln: 1.962 ± 0.457
2.497TyrArg: 2.497 ± 0.342
4.815TyrSer: 4.815 ± 1.184
4.815TyrThr: 4.815 ± 0.895
2.854TyrVal: 2.854 ± 0.656
0.892TyrTrp: 0.892 ± 0.417
2.497TyrTyr: 2.497 ± 0.56
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 11 proteins (5608 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski