Amino acid dipepetide frequency for Testicularia cyperi

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	14.066AlaAla: 14.066 ± 0.109	1.007AlaCys: 1.007 ± 0.017	5.42AlaAsp: 5.42 ± 0.041	5.494AlaGlu: 5.494 ± 0.054	3.137AlaPhe: 3.137 ± 0.031	7.539AlaGly: 7.539 ± 0.061	2.14AlaHis: 2.14 ± 0.022	3.894AlaIle: 3.894 ± 0.036	4.668AlaLys: 4.668 ± 0.052	8.268AlaLeu: 8.268 ± 0.061	1.986AlaMet: 1.986 ± 0.024	3.375AlaAsn: 3.375 ± 0.033	5.897AlaPro: 5.897 ± 0.058	4.212AlaGln: 4.212 ± 0.046	6.256AlaArg: 6.256 ± 0.05	12.011AlaSer: 12.011 ± 0.084	6.497AlaThr: 6.497 ± 0.049	5.765AlaVal: 5.765 ± 0.046	1.05AlaTrp: 1.05 ± 0.017	2.031AlaTyr: 2.031 ± 0.026	0.0AlaXaa: 0.0 ± 0.0
Cys	0.856CysAla: 0.856 ± 0.017	0.266CysCys: 0.266 ± 0.012	0.548CysAsp: 0.548 ± 0.015	0.434CysGlu: 0.434 ± 0.012	0.442CysPhe: 0.442 ± 0.011	0.738CysGly: 0.738 ± 0.018	0.273CysHis: 0.273 ± 0.009	0.563CysIle: 0.563 ± 0.013	0.418CysLys: 0.418 ± 0.012	1.076CysLeu: 1.076 ± 0.02	0.22CysMet: 0.22 ± 0.008	0.357CysAsn: 0.357 ± 0.011	0.57CysPro: 0.57 ± 0.014	0.387CysGln: 0.387 ± 0.011	0.737CysArg: 0.737 ± 0.017	0.954CysSer: 0.954 ± 0.019	0.656CysThr: 0.656 ± 0.016	0.679CysVal: 0.679 ± 0.018	0.158CysTrp: 0.158 ± 0.006	0.264CysTyr: 0.264 ± 0.007	0.0CysXaa: 0.0 ± 0.0
Asp	6.17AspAla: 6.17 ± 0.049	0.485AspCys: 0.485 ± 0.012	5.265AspAsp: 5.265 ± 0.08	4.593AspGlu: 4.593 ± 0.057	1.866AspPhe: 1.866 ± 0.023	4.241AspGly: 4.241 ± 0.036	1.284AspHis: 1.284 ± 0.022	2.141AspIle: 2.141 ± 0.025	2.171AspLys: 2.171 ± 0.031	5.041AspLeu: 5.041 ± 0.037	1.095AspMet: 1.095 ± 0.015	1.606AspAsn: 1.606 ± 0.022	3.508AspPro: 3.508 ± 0.029	2.101AspGln: 2.101 ± 0.023	3.488AspArg: 3.488 ± 0.036	4.727AspSer: 4.727 ± 0.044	2.923AspThr: 2.923 ± 0.027	3.52AspVal: 3.52 ± 0.033	0.751AspTrp: 0.751 ± 0.015	1.234AspTyr: 1.234 ± 0.023	0.0AspXaa: 0.0 ± 0.0
Glu	5.85GluAla: 5.85 ± 0.055	0.476GluCys: 0.476 ± 0.012	3.798GluAsp: 3.798 ± 0.046	4.409GluGlu: 4.409 ± 0.057	1.486GluPhe: 1.486 ± 0.021	3.156GluGly: 3.156 ± 0.031	1.349GluHis: 1.349 ± 0.02	2.304GluIle: 2.304 ± 0.031	2.658GluLys: 2.658 ± 0.03	4.962GluLeu: 4.962 ± 0.051	1.208GluMet: 1.208 ± 0.019	1.547GluAsn: 1.547 ± 0.022	2.492GluPro: 2.492 ± 0.032	2.647GluGln: 2.647 ± 0.032	3.91GluArg: 3.91 ± 0.042	4.218GluSer: 4.218 ± 0.038	3.027GluThr: 3.027 ± 0.031	2.864GluVal: 2.864 ± 0.033	0.684GluTrp: 0.684 ± 0.015	1.203GluTyr: 1.203 ± 0.022	0.0GluXaa: 0.0 ± 0.0
Phe	3.131PheAla: 3.131 ± 0.032	0.459PheCys: 0.459 ± 0.01	2.145PheAsp: 2.145 ± 0.025	1.808PheGlu: 1.808 ± 0.026	1.385PhePhe: 1.385 ± 0.026	2.865PheGly: 2.865 ± 0.035	0.74PheHis: 0.74 ± 0.016	1.177PheIle: 1.177 ± 0.022	1.172PheLys: 1.172 ± 0.019	2.915PheLeu: 2.915 ± 0.034	0.577PheMet: 0.577 ± 0.012	1.08PheAsn: 1.08 ± 0.018	1.584PhePro: 1.584 ± 0.022	1.155PheGln: 1.155 ± 0.02	1.824PheArg: 1.824 ± 0.023	2.861PheSer: 2.861 ± 0.031	1.615PheThr: 1.615 ± 0.023	2.21PheVal: 2.21 ± 0.029	0.482PheTrp: 0.482 ± 0.012	0.853PheTyr: 0.853 ± 0.016	0.0PheXaa: 0.0 ± 0.0
Gly	6.905GlyAla: 6.905 ± 0.058	0.707GlyCys: 0.707 ± 0.015	3.551GlyAsp: 3.551 ± 0.035	3.125GlyGlu: 3.125 ± 0.03	2.46GlyPhe: 2.46 ± 0.032	6.98GlyGly: 6.98 ± 0.092	1.791GlyHis: 1.791 ± 0.027	2.959GlyIle: 2.959 ± 0.029	3.371GlyLys: 3.371 ± 0.035	5.972GlyLeu: 5.972 ± 0.042	1.514GlyMet: 1.514 ± 0.024	2.367GlyAsn: 2.367 ± 0.035	3.68GlyPro: 3.68 ± 0.042	2.729GlyGln: 2.729 ± 0.034	4.469GlyArg: 4.469 ± 0.039	7.803GlySer: 7.803 ± 0.074	4.182GlyThr: 4.182 ± 0.039	3.961GlyVal: 3.961 ± 0.033	0.943GlyTrp: 0.943 ± 0.019	1.719GlyTyr: 1.719 ± 0.026	0.0GlyXaa: 0.0 ± 0.0
His	2.398HisAla: 2.398 ± 0.026	0.285HisCys: 0.285 ± 0.008	1.425HisAsp: 1.425 ± 0.02	1.195HisGlu: 1.195 ± 0.02	0.867HisPhe: 0.867 ± 0.015	1.783HisGly: 1.783 ± 0.026	1.098HisHis: 1.098 ± 0.03	0.991HisIle: 0.991 ± 0.018	0.803HisLys: 0.803 ± 0.017	2.406HisLeu: 2.406 ± 0.027	0.427HisMet: 0.427 ± 0.01	0.746HisAsn: 0.746 ± 0.016	1.787HisPro: 1.787 ± 0.023	1.165HisGln: 1.165 ± 0.027	1.722HisArg: 1.722 ± 0.026	2.223HisSer: 2.223 ± 0.029	1.365HisThr: 1.365 ± 0.021	1.435HisVal: 1.435 ± 0.019	0.259HisTrp: 0.259 ± 0.009	0.556HisTyr: 0.556 ± 0.013	0.0HisXaa: 0.0 ± 0.0
Ile	3.812IleAla: 3.812 ± 0.037	0.559IleCys: 0.559 ± 0.014	2.643IleAsp: 2.643 ± 0.026	2.388IleGlu: 2.388 ± 0.032	1.401IlePhe: 1.401 ± 0.02	2.663IleGly: 2.663 ± 0.03	0.978IleHis: 0.978 ± 0.016	1.522IleIle: 1.522 ± 0.025	1.779IleLys: 1.779 ± 0.024	3.555IleLeu: 3.555 ± 0.038	0.693IleMet: 0.693 ± 0.013	1.385IleAsn: 1.385 ± 0.018	2.341IlePro: 2.341 ± 0.026	1.619IleGln: 1.619 ± 0.022	2.604IleArg: 2.604 ± 0.031	3.369IleSer: 3.369 ± 0.032	2.108IleThr: 2.108 ± 0.023	2.627IleVal: 2.627 ± 0.031	0.497IleTrp: 0.497 ± 0.012	0.97IleTyr: 0.97 ± 0.018	0.0IleXaa: 0.0 ± 0.0
Lys	4.439LysAla: 4.439 ± 0.049	0.369LysCys: 0.369 ± 0.011	2.478LysAsp: 2.478 ± 0.032	2.496LysGlu: 2.496 ± 0.031	1.08LysPhe: 1.08 ± 0.018	2.668LysGly: 2.668 ± 0.033	0.998LysHis: 0.998 ± 0.018	1.732LysIle: 1.732 ± 0.025	2.788LysLys: 2.788 ± 0.048	3.818LysLeu: 3.818 ± 0.039	0.892LysMet: 0.892 ± 0.018	1.334LysAsn: 1.334 ± 0.021	2.486LysPro: 2.486 ± 0.026	1.87LysGln: 1.87 ± 0.024	3.305LysArg: 3.305 ± 0.034	3.536LysSer: 3.536 ± 0.035	2.507LysThr: 2.507 ± 0.031	2.491LysVal: 2.491 ± 0.032	0.482LysTrp: 0.482 ± 0.011	0.948LysTyr: 0.948 ± 0.018	0.0LysXaa: 0.0 ± 0.0
Leu	8.992LeuAla: 8.992 ± 0.062	1.133LeuCys: 1.133 ± 0.018	5.418LeuAsp: 5.418 ± 0.048	5.037LeuGlu: 5.037 ± 0.048	3.024LeuPhe: 3.024 ± 0.035	5.978LeuGly: 5.978 ± 0.042	2.246LeuHis: 2.246 ± 0.024	3.247LeuIle: 3.247 ± 0.032	3.433LeuLys: 3.433 ± 0.04	8.356LeuLeu: 8.356 ± 0.08	1.552LeuMet: 1.552 ± 0.02	2.69LeuAsn: 2.69 ± 0.029	5.748LeuPro: 5.748 ± 0.046	3.861LeuGln: 3.861 ± 0.039	5.924LeuArg: 5.924 ± 0.052	8.089LeuSer: 8.089 ± 0.059	4.559LeuThr: 4.559 ± 0.04	5.38LeuVal: 5.38 ± 0.058	0.951LeuTrp: 0.951 ± 0.018	1.955LeuTyr: 1.955 ± 0.028	0.0LeuXaa: 0.0 ± 0.0
Met	2.044MetAla: 2.044 ± 0.025	0.199MetCys: 0.199 ± 0.008	1.08MetAsp: 1.08 ± 0.02	0.948MetGlu: 0.948 ± 0.017	0.558MetPhe: 0.558 ± 0.012	1.303MetGly: 1.303 ± 0.02	0.48MetHis: 0.48 ± 0.013	0.743MetIle: 0.743 ± 0.016	0.675MetLys: 0.675 ± 0.014	1.85MetLeu: 1.85 ± 0.022	0.478MetMet: 0.478 ± 0.012	0.544MetAsn: 0.544 ± 0.013	1.362MetPro: 1.362 ± 0.024	0.905MetGln: 0.905 ± 0.018	1.216MetArg: 1.216 ± 0.02	1.961MetSer: 1.961 ± 0.023	1.114MetThr: 1.114 ± 0.016	1.109MetVal: 1.109 ± 0.017	0.214MetTrp: 0.214 ± 0.007	0.408MetTyr: 0.408 ± 0.011	0.0MetXaa: 0.0 ± 0.0
Asn	3.394AsnAla: 3.394 ± 0.033	0.298AsnCys: 0.298 ± 0.01	1.886AsnAsp: 1.886 ± 0.024	1.631AsnGlu: 1.631 ± 0.022	1.038AsnPhe: 1.038 ± 0.02	2.941AsnGly: 2.941 ± 0.038	0.745AsnHis: 0.745 ± 0.015	1.32AsnIle: 1.32 ± 0.023	1.343AsnLys: 1.343 ± 0.022	2.837AsnLeu: 2.837 ± 0.03	0.628AsnMet: 0.628 ± 0.013	1.216AsnAsn: 1.216 ± 0.024	2.055AsnPro: 2.055 ± 0.025	1.193AsnGln: 1.193 ± 0.019	1.882AsnArg: 1.882 ± 0.022	2.801AsnSer: 2.801 ± 0.031	1.909AsnThr: 1.909 ± 0.023	2.05AsnVal: 2.05 ± 0.026	0.382AsnTrp: 0.382 ± 0.01	0.722AsnTyr: 0.722 ± 0.014	0.0AsnXaa: 0.0 ± 0.0
Pro	6.568ProAla: 6.568 ± 0.061	0.49ProCys: 0.49 ± 0.013	3.01ProAsp: 3.01 ± 0.027	3.054ProGlu: 3.054 ± 0.031	1.933ProPhe: 1.933 ± 0.023	4.069ProGly: 4.069 ± 0.048	1.495ProHis: 1.495 ± 0.023	2.275ProIle: 2.275 ± 0.027	2.295ProLys: 2.295 ± 0.028	4.921ProLeu: 4.921 ± 0.036	1.051ProMet: 1.051 ± 0.021	2.03ProAsn: 2.03 ± 0.025	5.159ProPro: 5.159 ± 0.081	2.427ProGln: 2.427 ± 0.04	3.551ProArg: 3.551 ± 0.037	7.71ProSer: 7.71 ± 0.07	4.193ProThr: 4.193 ± 0.034	3.482ProVal: 3.482 ± 0.037	0.596ProTrp: 0.596 ± 0.012	1.266ProTyr: 1.266 ± 0.019	0.0ProXaa: 0.0 ± 0.0
Gln	4.177GlnAla: 4.177 ± 0.041	0.363GlnCys: 0.363 ± 0.01	2.303GlnAsp: 2.303 ± 0.028	2.157GlnGlu: 2.157 ± 0.027	1.037GlnPhe: 1.037 ± 0.017	2.409GlnGly: 2.409 ± 0.028	1.528GlnHis: 1.528 ± 0.028	1.804GlnIle: 1.804 ± 0.023	1.687GlnLys: 1.687 ± 0.024	3.869GlnLeu: 3.869 ± 0.039	0.892GlnMet: 0.892 ± 0.017	1.356GlnAsn: 1.356 ± 0.023	2.836GlnPro: 2.836 ± 0.04	3.95GlnGln: 3.95 ± 0.123	3.062GlnArg: 3.062 ± 0.031	3.686GlnSer: 3.686 ± 0.036	2.481GlnThr: 2.481 ± 0.024	2.115GlnVal: 2.115 ± 0.026	0.405GlnTrp: 0.405 ± 0.01	0.941GlnTyr: 0.941 ± 0.019	0.0GlnXaa: 0.0 ± 0.0
Arg	5.998ArgAla: 5.998 ± 0.044	0.737ArgCys: 0.737 ± 0.017	3.551ArgAsp: 3.551 ± 0.038	3.497ArgGlu: 3.497 ± 0.045	2.147ArgPhe: 2.147 ± 0.023	3.909ArgGly: 3.909 ± 0.039	1.701ArgHis: 1.701 ± 0.022	2.841ArgIle: 2.841 ± 0.029	3.352ArgLys: 3.352 ± 0.033	5.79ArgLeu: 5.79 ± 0.051	1.329ArgMet: 1.329 ± 0.019	2.186ArgAsn: 2.186 ± 0.025	4.061ArgPro: 4.061 ± 0.044	2.938ArgGln: 2.938 ± 0.032	5.749ArgArg: 5.749 ± 0.063	6.594ArgSer: 6.594 ± 0.063	3.576ArgThr: 3.576 ± 0.036	3.27ArgVal: 3.27 ± 0.037	0.781ArgTrp: 0.781 ± 0.015	1.49ArgTyr: 1.49 ± 0.022	0.0ArgXaa: 0.0 ± 0.0
Ser	10.852SerAla: 10.852 ± 0.084	0.87SerCys: 0.87 ± 0.016	5.075SerAsp: 5.075 ± 0.051	4.116SerGlu: 4.116 ± 0.033	3.059SerPhe: 3.059 ± 0.033	7.232SerGly: 7.232 ± 0.066	2.481SerHis: 2.481 ± 0.035	3.851SerIle: 3.851 ± 0.037	3.968SerLys: 3.968 ± 0.043	8.187SerLeu: 8.187 ± 0.049	1.859SerMet: 1.859 ± 0.024	3.548SerAsn: 3.548 ± 0.037	6.353SerPro: 6.353 ± 0.071	4.027SerGln: 4.027 ± 0.044	6.459SerArg: 6.459 ± 0.061	15.042SerSer: 15.042 ± 0.136	7.478SerThr: 7.478 ± 0.062	5.136SerVal: 5.136 ± 0.044	0.941SerTrp: 0.941 ± 0.019	1.876SerTyr: 1.876 ± 0.022	0.0SerXaa: 0.0 ± 0.0
Thr	6.442ThrAla: 6.442 ± 0.055	0.616ThrCys: 0.616 ± 0.015	2.92ThrAsp: 2.92 ± 0.026	2.712ThrGlu: 2.712 ± 0.028	1.904ThrPhe: 1.904 ± 0.022	4.362ThrGly: 4.362 ± 0.047	1.372ThrHis: 1.372 ± 0.019	2.345ThrIle: 2.345 ± 0.028	2.318ThrLys: 2.318 ± 0.032	5.165ThrLeu: 5.165 ± 0.042	1.029ThrMet: 1.029 ± 0.018	1.888ThrAsn: 1.888 ± 0.023	4.385ThrPro: 4.385 ± 0.047	2.074ThrGln: 2.074 ± 0.025	3.386ThrArg: 3.386 ± 0.031	6.916ThrSer: 6.916 ± 0.051	4.22ThrThr: 4.22 ± 0.049	3.536ThrVal: 3.536 ± 0.031	0.638ThrTrp: 0.638 ± 0.014	1.242ThrTyr: 1.242 ± 0.021	0.0ThrXaa: 0.0 ± 0.0
Val	5.725ValAla: 5.725 ± 0.046	0.745ValCys: 0.745 ± 0.017	3.621ValAsp: 3.621 ± 0.036	3.454ValGlu: 3.454 ± 0.033	1.948ValPhe: 1.948 ± 0.029	3.96ValGly: 3.96 ± 0.038	1.363ValHis: 1.363 ± 0.019	2.264ValIle: 2.264 ± 0.026	2.429ValLys: 2.429 ± 0.032	5.334ValLeu: 5.334 ± 0.059	1.062ValMet: 1.062 ± 0.02	1.743ValAsn: 1.743 ± 0.023	3.567ValPro: 3.567 ± 0.033	2.423ValGln: 2.423 ± 0.026	3.705ValArg: 3.705 ± 0.032	5.059ValSer: 5.059 ± 0.043	3.036ValThr: 3.036 ± 0.028	3.924ValVal: 3.924 ± 0.041	0.727ValTrp: 0.727 ± 0.013	1.346ValTyr: 1.346 ± 0.019	0.0ValXaa: 0.0 ± 0.0
Trp	0.914TrpAla: 0.914 ± 0.018	0.176TrpCys: 0.176 ± 0.007	0.691TrpAsp: 0.691 ± 0.013	0.55TrpGlu: 0.55 ± 0.012	0.396TrpPhe: 0.396 ± 0.011	0.661TrpGly: 0.661 ± 0.014	0.278TrpHis: 0.278 ± 0.008	0.606TrpIle: 0.606 ± 0.014	0.579TrpLys: 0.579 ± 0.014	1.111TrpLeu: 1.111 ± 0.019	0.282TrpMet: 0.282 ± 0.008	0.489TrpAsn: 0.489 ± 0.013	0.517TrpPro: 0.517 ± 0.012	0.501TrpGln: 0.501 ± 0.013	0.783TrpArg: 0.783 ± 0.014	1.042TrpSer: 1.042 ± 0.016	0.781TrpThr: 0.781 ± 0.015	0.564TrpVal: 0.564 ± 0.013	0.204TrpTrp: 0.204 ± 0.008	0.298TrpTyr: 0.298 ± 0.01	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.98TyrAla: 1.98 ± 0.025	0.359TyrCys: 0.359 ± 0.011	1.384TyrAsp: 1.384 ± 0.025	1.149TyrGlu: 1.149 ± 0.02	0.869TyrPhe: 0.869 ± 0.016	1.733TyrGly: 1.733 ± 0.028	0.595TyrHis: 0.595 ± 0.013	0.932TyrIle: 0.932 ± 0.018	0.808TyrLys: 0.808 ± 0.016	2.142TyrLeu: 2.142 ± 0.024	0.416TyrMet: 0.416 ± 0.011	0.788TyrAsn: 0.788 ± 0.017	1.189TyrPro: 1.189 ± 0.02	0.871TyrGln: 0.871 ± 0.016	1.466TyrArg: 1.466 ± 0.023	1.808TyrSer: 1.808 ± 0.019	1.24TyrThr: 1.24 ± 0.02	1.318TyrVal: 1.318 ± 0.022	0.277TyrTrp: 0.277 ± 0.008	0.616TyrTyr: 0.616 ± 0.015	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.002XaaXaa: 0.002 ± 0.001

Statistics based on 7036 proteins (3782685 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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